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The map label for this gene is rnz [H]

Identifier: 15669696

GI number: 15669696

Start: 1473615

End: 1474589

Strand: Reverse

Name: rnz [H]

Synonym: MJ1502

Alternate gene names: 15669696

Gene position: 1474589-1473615 (Counterclockwise)

Preceding gene: 15669697

Following gene: 15669695

Centisome position: 88.57

GC content: 30.77

Gene sequence:

>975_bases
TTGAGGAATAACTCCAAAAAGATGATTATTATGAAGCTAATATTCTTAGGAACTGGAGCGGCAGTTCCATCAAAAAATAG
AAATCATATTGGAATAGCATTCAAATTTGGAGGAGAGGTTTTTTTATTTGATTGTGGTGAAAATATCCAGAGGCAGATGC
TTTTTACTGAAGTATCTCCAATGAAAATTAATCACATATTTATAACTCATTTACATGGAGACCATATATTGGGCATTCCA
GGACTTTTACAGAGTATGGGATTTTTTGGAAGAGAGAAAGAGCTTAAAATCTTCGGCCCTGAAGGAACAAAGGAAATTAT
AGAGAACTCATTAAAACTTGGAACCCATTATATAGAATTTCCAATAAAAGTTTATGAAATTTATACAAAAGAGCCAATAA
CCATCTATAAAGAAGAAAATTATGAGATAATTGCCTATCCAACTGAACATGGCATTCCATCTTACGCTTATATATTTAAA
GAAATAAAAAAACCACGTTTAGATATTGAGAAAGCTAAAAAACTTGGAGTTAAAATTGGCCCAGATTTAAAAAAACTAAA
AAATGGAGAGGCAGTTAAAAATATCTATGGAGAGATAATAAAACCAGAGTATGTTTTGTTACCACCAAAAAAAGGATTTT
GTTTAGCTTACAGTGGAGACACTCTTCCATTAGAAGATTTTGGGAAATATTTAAAAGAGTTGGGATGTGATGTATTAATC
CATGAAGCAACATTTGATGATTCAGCCAAAGATGCTGCTAAAGAGAATATGCATTCTACAATAGGAGATGCCGTTAATAT
AGCCAAATTAGCAAATGTAAAGGCATTAATTTTAACCCATATCTCAGCAAGATATGACAAGGAGGAGTATTTCAACTTAT
ATAAAATGAACGTTAAACAGTATAATGAGAGCTTTAAAATTATTATCAGCGAAGATTTAAAATCTTATGATATAAAAAAA
GATTTATTGGGGTGA

Upstream 100 bases:

>100_bases
AAGATTATAAAAAAGACTATGGAAGAGTGGTGCAACAATATGAAAAAATGGGTAGAAGAATTAGAATTCGAGGATGTTGT
TAAAGAATATTTAGAGAATA

Downstream 100 bases:

>100_bases
AAAAATGAAAATAGCAATATTAGGAGGTACTGGGGACCAAGGATTTGGTTTAGCTTTAAGATTGGCTAAAAACAATAAGA
TAATCATAGGTTCAAGAAAG

Product: hypothetical protein

Products: NA

Alternate protein names: RNase Z; tRNA 3 endonuclease; tRNase Z [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MRNNSKKMIIMKLIFLGTGAAVPSKNRNHIGIAFKFGGEVFLFDCGENIQRQMLFTEVSPMKINHIFITHLHGDHILGIP
GLLQSMGFFGREKELKIFGPEGTKEIIENSLKLGTHYIEFPIKVYEIYTKEPITIYKEENYEIIAYPTEHGIPSYAYIFK
EIKKPRLDIEKAKKLGVKIGPDLKKLKNGEAVKNIYGEIIKPEYVLLPPKKGFCLAYSGDTLPLEDFGKYLKELGCDVLI
HEATFDDSAKDAAKENMHSTIGDAVNIAKLANVKALILTHISARYDKEEYFNLYKMNVKQYNESFKIIISEDLKSYDIKK
DLLG

Sequences:

>Translated_324_residues
MRNNSKKMIIMKLIFLGTGAAVPSKNRNHIGIAFKFGGEVFLFDCGENIQRQMLFTEVSPMKINHIFITHLHGDHILGIP
GLLQSMGFFGREKELKIFGPEGTKEIIENSLKLGTHYIEFPIKVYEIYTKEPITIYKEENYEIIAYPTEHGIPSYAYIFK
EIKKPRLDIEKAKKLGVKIGPDLKKLKNGEAVKNIYGEIIKPEYVLLPPKKGFCLAYSGDTLPLEDFGKYLKELGCDVLI
HEATFDDSAKDAAKENMHSTIGDAVNIAKLANVKALILTHISARYDKEEYFNLYKMNVKQYNESFKIIISEDLKSYDIKK
DLLG
>Mature_324_residues
MRNNSKKMIIMKLIFLGTGAAVPSKNRNHIGIAFKFGGEVFLFDCGENIQRQMLFTEVSPMKINHIFITHLHGDHILGIP
GLLQSMGFFGREKELKIFGPEGTKEIIENSLKLGTHYIEFPIKVYEIYTKEPITIYKEENYEIIAYPTEHGIPSYAYIFK
EIKKPRLDIEKAKKLGVKIGPDLKKLKNGEAVKNIYGEIIKPEYVLLPPKKGFCLAYSGDTLPLEDFGKYLKELGCDVLI
HEATFDDSAKDAAKENMHSTIGDAVNIAKLANVKALILTHISARYDKEEYFNLYKMNVKQYNESFKIIISEDLKSYDIKK
DLLG

Specific function: Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA [H]

COG id: COG1234

COG function: function code R; Metal-dependent hydrolases of the beta-lactamase superfamily III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the RNase Z family [H]

Homologues:

Organism=Homo sapiens, GI8922122, Length=316, Percent_Identity=34.1772151898734, Blast_Score=167, Evalue=9e-42,
Organism=Escherichia coli, GI87082078, Length=290, Percent_Identity=37.5862068965517, Blast_Score=191, Evalue=5e-50,
Organism=Caenorhabditis elegans, GI71985814, Length=286, Percent_Identity=28.6713286713287, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71985808, Length=286, Percent_Identity=28.6713286713287, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR013471 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.26.11 [H]

Molecular weight: Translated: 36894; Mature: 36894

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNNSKKMIIMKLIFLGTGAAVPSKNRNHIGIAFKFGGEVFLFDCGENIQRQMLFTEVSP
CCCCCHHEEEEEEEHHCCCCCCCCCCCCEEEEEEEECCEEEEEECCCHHHHHHHHHCCCC
MKINHIFITHLHGDHILGIPGLLQSMGFFGREKELKIFGPEGTKEIIENSLKLGTHYIEF
EEEEEEEEEEECCCEEECCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEC
PIKVYEIYTKEPITIYKEENYEIIAYPTEHGIPSYAYIFKEIKKPRLDIEKAKKLGVKIG
CEEEEEEECCCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEC
PDLKKLKNGEAVKNIYGEIIKPEYVLLPPKKGFCLAYSGDTLPLEDFGKYLKELGCDVLI
CCHHHHCCCHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEE
HEATFDDSAKDAAKENMHSTIGDAVNIAKLANVKALILTHISARYDKEEYFNLYKMNVKQ
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHEEEHHH
YNESFKIIISEDLKSYDIKKDLLG
CCCCEEEEEECCCCCCCCHHHHCC
>Mature Secondary Structure
MRNNSKKMIIMKLIFLGTGAAVPSKNRNHIGIAFKFGGEVFLFDCGENIQRQMLFTEVSP
CCCCCHHEEEEEEEHHCCCCCCCCCCCCEEEEEEEECCEEEEEECCCHHHHHHHHHCCCC
MKINHIFITHLHGDHILGIPGLLQSMGFFGREKELKIFGPEGTKEIIENSLKLGTHYIEF
EEEEEEEEEEECCCEEECCHHHHHHHCCCCCCCCEEEECCCCHHHHHHHHHHHCCEEEEC
PIKVYEIYTKEPITIYKEENYEIIAYPTEHGIPSYAYIFKEIKKPRLDIEKAKKLGVKIG
CEEEEEEECCCCEEEEECCCEEEEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCEEC
PDLKKLKNGEAVKNIYGEIIKPEYVLLPPKKGFCLAYSGDTLPLEDFGKYLKELGCDVLI
CCHHHHCCCHHHHHHHHHHCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHHHCCCEEEE
HEATFDDSAKDAAKENMHSTIGDAVNIAKLANVKALILTHISARYDKEEYFNLYKMNVKQ
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCHHHHHHHHEEEHHH
YNESFKIIISEDLKSYDIKKDLLG
CCCCEEEEEECCCCCCCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 12032089 [H]