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The map label for this gene is thrC

Identifier: 15669656

GI number: 15669656

Start: 1434196

End: 1435413

Strand: Reverse

Name: thrC

Synonym: MJ1465

Alternate gene names: 15669656

Gene position: 1435413-1434196 (Counterclockwise)

Preceding gene: 15669657

Following gene: 15669654

Centisome position: 86.21

GC content: 35.55

Gene sequence:

>1218_bases
ATGTTACAAAGATGTATTAAATGTGGAAAAACTTACGATGTGGATGAGATAATCTACACCTGCGAATGTGGTGGCTTATT
GGAGATTATTTATGATTATGAAGAGATTAAAGATAAAGTTTCAGAAGAAAAACTAAGAAAGAGAGAAATTGGAGTCTGGA
GATATTTGGAATACTTACCAGTAAAAGACGAAAGTAAAATTGTAAGTCTATGTGAAGGAGGAACTCCATTATATAGATGT
AACAACTTGGAAAAAGAGCTTGGAATTAAAGAACTCTATGTAAAAAATGAAGGGGCTAATCCAACTGGAAGCTTTAAAGA
TAGGGGGATGACTGTTGGAGTAACAAGGGCAAATGAGTTGGGTGTTGAGGTTGTTGGCTGTGCTTCAACAGGAAATACAT
CCGCTTCTTTAGCCGCTTACTCAGCAAGAAGTGGAAAGAAATGTATTGTTCTATTACCAGAAGGAAAAGTTGCCTTAGGA
AAGTTAGCTCAAGCAATGTTCTATGGAGCTAAGGTTATTCAAGTCAAAGGGAACTTTGATGATGCATTAGATATGGTTAA
ACAATTAGCAAAAGAGAAGTTGATTTATTTATTAAATTCAATAAATCCATTTAGATTAGAGGGACAGAAAACCATAGCAT
TTGAAATATGTGACCAATTAAACTGGCAAGTCCCAGATAGAGTTATTGTTCCAGTTGGAAATGCTGGAAACATCTCAGCT
ATATGGAAAGGATTTAAAGAATTTGAAATTACTGGCATTATAGATGAACTCCCAAAAATGACCGGAATTCAGGCAGATGG
AGCTAAGCCAATTGTTGAAGCATTTAGAAAGAGAGCTAAAGACATCATCCCATATAAAAATCCAGAGACAATTGCAACAG
CTATAAGGATTGGAAATCCAGTAAATGCCCCAAAGGCTTTAGATGCCATATACTCCTCTGGAGGTTATGCTGAAGCAGTT
ACTGATGAAGAGATTGTTGAAGCTCAAAAGCTATTGGCAAGAAAAGAGGGAATTTTTGTTGAACCAGCTTCAGCTTCATC
AATAGCTGGGCTTAAAAAGTTATTAGAAGAAGGAATTATTGATAGAGATGAAAGAATTGTTTGTATAACAACAGGGCATG
GGTTGAAAGACCCAGATGCAGCTATAAGGGCAAGTGAAGAGCCGATAAAGATTGAATGTGATATGAATGTTTTAAAAAGA
ATTTTGAAAGAGTTATAA

Upstream 100 bases:

>100_bases
AGAATACAATTCTAATTGAATGATAACACCGTTAGATATCAAGTAACCTTAACAAATCTATAAACTGCAAAAGTCCTATT
CAATGTTATGAGGTGGCATA

Downstream 100 bases:

>100_bases
ACAATAATATTTTATTATTATATTTTTTATGTCTCTAAAATAACTTCAAAATAACTCCATAGAAATCATAAATCTATATA
TAAATCTATATATACGGTCT

Product: threonine synthase

Products: NA

Alternate protein names: TS

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MLQRCIKCGKTYDVDEIIYTCECGGLLEIIYDYEEIKDKVSEEKLRKREIGVWRYLEYLPVKDESKIVSLCEGGTPLYRC
NNLEKELGIKELYVKNEGANPTGSFKDRGMTVGVTRANELGVEVVGCASTGNTSASLAAYSARSGKKCIVLLPEGKVALG
KLAQAMFYGAKVIQVKGNFDDALDMVKQLAKEKLIYLLNSINPFRLEGQKTIAFEICDQLNWQVPDRVIVPVGNAGNISA
IWKGFKEFEITGIIDELPKMTGIQADGAKPIVEAFRKRAKDIIPYKNPETIATAIRIGNPVNAPKALDAIYSSGGYAEAV
TDEEIVEAQKLLARKEGIFVEPASASSIAGLKKLLEEGIIDRDERIVCITTGHGLKDPDAAIRASEEPIKIECDMNVLKR
ILKEL

Sequences:

>Translated_405_residues
MLQRCIKCGKTYDVDEIIYTCECGGLLEIIYDYEEIKDKVSEEKLRKREIGVWRYLEYLPVKDESKIVSLCEGGTPLYRC
NNLEKELGIKELYVKNEGANPTGSFKDRGMTVGVTRANELGVEVVGCASTGNTSASLAAYSARSGKKCIVLLPEGKVALG
KLAQAMFYGAKVIQVKGNFDDALDMVKQLAKEKLIYLLNSINPFRLEGQKTIAFEICDQLNWQVPDRVIVPVGNAGNISA
IWKGFKEFEITGIIDELPKMTGIQADGAKPIVEAFRKRAKDIIPYKNPETIATAIRIGNPVNAPKALDAIYSSGGYAEAV
TDEEIVEAQKLLARKEGIFVEPASASSIAGLKKLLEEGIIDRDERIVCITTGHGLKDPDAAIRASEEPIKIECDMNVLKR
ILKEL
>Mature_405_residues
MLQRCIKCGKTYDVDEIIYTCECGGLLEIIYDYEEIKDKVSEEKLRKREIGVWRYLEYLPVKDESKIVSLCEGGTPLYRC
NNLEKELGIKELYVKNEGANPTGSFKDRGMTVGVTRANELGVEVVGCASTGNTSASLAAYSARSGKKCIVLLPEGKVALG
KLAQAMFYGAKVIQVKGNFDDALDMVKQLAKEKLIYLLNSINPFRLEGQKTIAFEICDQLNWQVPDRVIVPVGNAGNISA
IWKGFKEFEITGIIDELPKMTGIQADGAKPIVEAFRKRAKDIIPYKNPETIATAIRIGNPVNAPKALDAIYSSGGYAEAV
TDEEIVEAQKLLARKEGIFVEPASASSIAGLKKLLEEGIIDRDERIVCITTGHGLKDPDAAIRASEEPIKIECDMNVLKR
ILKEL

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family

Homologues:

Organism=Escherichia coli, GI1790207, Length=329, Percent_Identity=26.1398176291793, Blast_Score=65, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24643623, Length=190, Percent_Identity=35.2631578947368, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI20129101, Length=190, Percent_Identity=35.2631578947368, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: 1344 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): THRC_METJA (Q58860)

Other databases:

- EMBL:   L77117
- PIR:   H64482
- RefSeq:   NP_248469.1
- ProteinModelPortal:   Q58860
- SMR:   Q58860
- GeneID:   1452369
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1465
- NMPDR:   fig|243232.1.peg.1506
- TIGR:   MJ1465
- HOGENOM:   HBG694883
- OMA:   VSVKADF
- ProtClustDB:   PRK06260
- BioCyc:   MetaCyc:MONOMER-14634
- BioCyc:   MJAN243232:MJ_1465-MONOMER
- BRENDA:   4.2.3.1
- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450
- TIGRFAMs:   TIGR00260

Pfam domain/function: PF00291 PALP; SSF53686 PyrdxlP-dep_enz_bsu

EC number: =4.2.3.1

Molecular weight: Translated: 44601; Mature: 44601

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: BINDING 132-132 BINDING 371-371

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQRCIKCGKTYDVDEIIYTCECGGLLEIIYDYEEIKDKVSEEKLRKREIGVWRYLEYLP
CCHHHHHCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VKDESKIVSLCEGGTPLYRCNNLEKELGIKELYVKNEGANPTGSFKDRGMTVGVTRANEL
CCCCCHHHHHHCCCCCEEECCCCHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCC
GVEVVGCASTGNTSASLAAYSARSGKKCIVLLPEGKVALGKLAQAMFYGAKVIQVKGNFD
CEEEEEECCCCCCCCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCH
DALDMVKQLAKEKLIYLLNSINPFRLEGQKTIAFEICDQLNWQVPDRVIVPVGNAGNISA
HHHHHHHHHHHHHHHHHHHCCCCEEECCCEEHHHHHHHHCCCCCCCEEEEECCCCCCHHH
IWKGFKEFEITGIIDELPKMTGIQADGAKPIVEAFRKRAKDIIPYKNPETIATAIRIGNP
HHCCHHHEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCC
VNAPKALDAIYSSGGYAEAVTDEEIVEAQKLLARKEGIFVEPASASSIAGLKKLLEEGII
CCCHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHCCC
DRDERIVCITTGHGLKDPDAAIRASEEPIKIECDMNVLKRILKEL
CCCCEEEEEECCCCCCCCHHHHCCCCCCEEEEECHHHHHHHHHHC
>Mature Secondary Structure
MLQRCIKCGKTYDVDEIIYTCECGGLLEIIYDYEEIKDKVSEEKLRKREIGVWRYLEYLP
CCHHHHHCCCCCCHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VKDESKIVSLCEGGTPLYRCNNLEKELGIKELYVKNEGANPTGSFKDRGMTVGVTRANEL
CCCCCHHHHHHCCCCCEEECCCCHHHCCCEEEEEECCCCCCCCCCCCCCEEEEEEECCCC
GVEVVGCASTGNTSASLAAYSARSGKKCIVLLPEGKVALGKLAQAMFYGAKVIQVKGNFD
CEEEEEECCCCCCCCCEEEECCCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEECCCH
DALDMVKQLAKEKLIYLLNSINPFRLEGQKTIAFEICDQLNWQVPDRVIVPVGNAGNISA
HHHHHHHHHHHHHHHHHHHCCCCEEECCCEEHHHHHHHHCCCCCCCEEEEECCCCCCHHH
IWKGFKEFEITGIIDELPKMTGIQADGAKPIVEAFRKRAKDIIPYKNPETIATAIRIGNP
HHCCHHHEEEEHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCC
VNAPKALDAIYSSGGYAEAVTDEEIVEAQKLLARKEGIFVEPASASSIAGLKKLLEEGII
CCCHHHHHHHHCCCCCEECCCHHHHHHHHHHHHHHCCCEECCCCCHHHHHHHHHHHHCCC
DRDERIVCITTGHGLKDPDAAIRASEEPIKIECDMNVLKRILKEL
CCCCEEEEEECCCCCCCCHHHHCCCCCCEEEEECHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087