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The map label for this gene is ahcY

Identifier: 15669578

GI number: 15669578

Start: 1335803

End: 1337050

Strand: Direct

Name: ahcY

Synonym: MJ1388

Alternate gene names: 15669578

Gene position: 1335803-1337050 (Clockwise)

Preceding gene: 15669576

Following gene: 15669582

Centisome position: 80.23

GC content: 35.9

Gene sequence:

>1248_bases
ATGTATGAAGTTAGGGACATAAACCTCTGGAAAGAAGGAGAGAGAAAAATACAATGGGCAAAACAACACATGCCTGTTTT
AAATTTAATTAGAGAAAGATTTAAAGAAGAAAAGCCATTTAAAGGAATAACAATAGGAATGGCTCTACACTTAGAAGCAA
AAACAGCTGTTTTAGCAGAGACATTGATGGAAGGAGGGGCAGAGATTGCTATAACTGGATGCAATCCTTTATCCACTCAG
GATGATGTTGCCGCTGCTTGTGCTAAAAAAGGAATGCATGTTTATGCATGGAGAGGAGAGACAGTAGAGGAGTATTATGA
AAACCTAAACAAGGTTTTAGACCACAAACCAGATATTGTTATAGATGATGGCTGTGATTTAATATTTTTATTGCATACAA
AGAGAACTGAACTTTTGGATAACATAATGGGAGGTTGTGAAGAAACTACAACTGGAATCATCAGATTAAAAGCTATGGAA
AAAGAAGGAGCTTTAAAATTTCCAGTTATGGATGTAAATGATGCATATACGAAACATCTATTTGACAACAGATATGGAAC
TGGGCAAAGTGCCTTAGATGGAATTCTGAGAGCTACAAACTTATTAATTGCTGGAAAGACTGTTGTTGTTGCTGGTTATG
GATGGTGTGGTAGAGGAGTAGCAATGAGAGCTAAAGGCTTAGGAGCAGAGGTCGTAGTTACAGAAGTTAATCCAATTAGA
GCCTTAGAGGCAAGAATGGATGGATTTAGAGTCATGAAGATGGAGAAAGCTGCGGAGATTGGAGATATATTTATAACAAC
AACTGGATGTAAGGATGTTATTAGAAAGGAACATATATTGAAGATGAGGAATGGAGCTATCTTAGCAAATGCTGGACACT
TTGACAATGAGATTAATAAAAAGCACTTAGAAGAGTTAGCTAAATCAATAAAAGAAGTTAGAAATTGTGTAACTGAATAC
GACTTAGGAAATAAGAAAATATATTTATTGGGAGAGGGTAGGTTGGTTAATTTGGCATGTGCAGATGGGCATCCATGTGA
GGTTATGGACATGAGTTTTGCCAACCAAGCTTTAGCGGCTGAATACATCTTAAAAAATCATGAGAAGTTAGAGCCAAGGG
TTTATAACATTCCTTACGAACAGGACTTAATGATTGCCTCTCTAAAATTGAAAGCTATGGGTATTGAAATTGATGAACTA
ACTAAAGAGCAAAAAAAATATTTAGAAGATTGGAGAGAAGGAACTTAA

Upstream 100 bases:

>100_bases
AATTTATAAATAATAAAAGCTTTTCTTCACTAAAAAATAGTAATTTATATATCTCTGCTACCCTACTAATTTTTAAAATT
AATTCTTTAAGGTGAAATGA

Downstream 100 bases:

>100_bases
CTTCTTAGATTCTTTAAAAATAAAAAAGCTGCTTTGACTATTGTTATATATATTTAACCCCTCCCCCACAATTTTAATTG
TTTCTTAATCATTTTTTAAA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase

Number of amino acids: Translated: 415; Mature: 415

Protein sequence:

>415_residues
MYEVRDINLWKEGERKIQWAKQHMPVLNLIRERFKEEKPFKGITIGMALHLEAKTAVLAETLMEGGAEIAITGCNPLSTQ
DDVAAACAKKGMHVYAWRGETVEEYYENLNKVLDHKPDIVIDDGCDLIFLLHTKRTELLDNIMGGCEETTTGIIRLKAME
KEGALKFPVMDVNDAYTKHLFDNRYGTGQSALDGILRATNLLIAGKTVVVAGYGWCGRGVAMRAKGLGAEVVVTEVNPIR
ALEARMDGFRVMKMEKAAEIGDIFITTTGCKDVIRKEHILKMRNGAILANAGHFDNEINKKHLEELAKSIKEVRNCVTEY
DLGNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALAAEYILKNHEKLEPRVYNIPYEQDLMIASLKLKAMGIEIDEL
TKEQKKYLEDWREGT

Sequences:

>Translated_415_residues
MYEVRDINLWKEGERKIQWAKQHMPVLNLIRERFKEEKPFKGITIGMALHLEAKTAVLAETLMEGGAEIAITGCNPLSTQ
DDVAAACAKKGMHVYAWRGETVEEYYENLNKVLDHKPDIVIDDGCDLIFLLHTKRTELLDNIMGGCEETTTGIIRLKAME
KEGALKFPVMDVNDAYTKHLFDNRYGTGQSALDGILRATNLLIAGKTVVVAGYGWCGRGVAMRAKGLGAEVVVTEVNPIR
ALEARMDGFRVMKMEKAAEIGDIFITTTGCKDVIRKEHILKMRNGAILANAGHFDNEINKKHLEELAKSIKEVRNCVTEY
DLGNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALAAEYILKNHEKLEPRVYNIPYEQDLMIASLKLKAMGIEIDEL
TKEQKKYLEDWREGT
>Mature_415_residues
MYEVRDINLWKEGERKIQWAKQHMPVLNLIRERFKEEKPFKGITIGMALHLEAKTAVLAETLMEGGAEIAITGCNPLSTQ
DDVAAACAKKGMHVYAWRGETVEEYYENLNKVLDHKPDIVIDDGCDLIFLLHTKRTELLDNIMGGCEETTTGIIRLKAME
KEGALKFPVMDVNDAYTKHLFDNRYGTGQSALDGILRATNLLIAGKTVVVAGYGWCGRGVAMRAKGLGAEVVVTEVNPIR
ALEARMDGFRVMKMEKAAEIGDIFITTTGCKDVIRKEHILKMRNGAILANAGHFDNEINKKHLEELAKSIKEVRNCVTEY
DLGNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALAAEYILKNHEKLEPRVYNIPYEQDLMIASLKLKAMGIEIDEL
TKEQKKYLEDWREGT

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family

Homologues:

Organism=Homo sapiens, GI9951915, Length=411, Percent_Identity=45.4987834549878, Blast_Score=332, Evalue=5e-91,
Organism=Homo sapiens, GI239937451, Length=389, Percent_Identity=46.2724935732648, Blast_Score=321, Evalue=7e-88,
Organism=Homo sapiens, GI195539349, Length=412, Percent_Identity=39.0776699029126, Blast_Score=280, Evalue=2e-75,
Organism=Homo sapiens, GI298286489, Length=412, Percent_Identity=39.0776699029126, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI24308043, Length=412, Percent_Identity=39.0776699029126, Blast_Score=279, Evalue=3e-75,
Organism=Homo sapiens, GI195539337, Length=412, Percent_Identity=39.0776699029126, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI21361647, Length=412, Percent_Identity=38.5922330097087, Blast_Score=260, Evalue=2e-69,
Organism=Caenorhabditis elegans, GI17506425, Length=415, Percent_Identity=43.3734939759036, Blast_Score=322, Evalue=2e-88,
Organism=Saccharomyces cerevisiae, GI6320882, Length=433, Percent_Identity=42.9561200923788, Blast_Score=328, Evalue=7e-91,
Organism=Drosophila melanogaster, GI24642172, Length=412, Percent_Identity=46.1165048543689, Blast_Score=332, Evalue=3e-91,
Organism=Drosophila melanogaster, GI24656245, Length=401, Percent_Identity=39.9002493765586, Blast_Score=280, Evalue=2e-75,
Organism=Drosophila melanogaster, GI45553387, Length=411, Percent_Identity=38.9294403892944, Blast_Score=265, Evalue=3e-71,
Organism=Drosophila melanogaster, GI45553385, Length=411, Percent_Identity=38.9294403892944, Blast_Score=265, Evalue=4e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAHH_METJA (Q58783)

Other databases:

- EMBL:   L77117
- PIR:   C64473
- RefSeq:   NP_248391.1
- ProteinModelPortal:   Q58783
- SMR:   Q58783
- GeneID:   1452291
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1388
- NMPDR:   fig|243232.1.peg.1428
- TIGR:   MJ1388
- HOGENOM:   HBG352029
- OMA:   ALHLEAK
- ProtClustDB:   PRK05476
- BioCyc:   MJAN243232:MJ_1388-MONOMER
- BRENDA:   3.3.1.1
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00563
- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082
- PANTHER:   PTHR23420
- PIRSF:   PIRSF001109
- TIGRFAMs:   TIGR00936

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD

EC number: =3.3.1.1

Molecular weight: Translated: 46608; Mature: 46608

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00738 ADOHCYASE_1; PS00739 ADOHCYASE_2

Important sites: BINDING 123-123 BINDING 148-148 BINDING 178-178 BINDING 182-182 BINDING 183-183 BINDING 235-235 BINDING 337-337

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYEVRDINLWKEGERKIQWAKQHMPVLNLIRERFKEEKPFKGITIGMALHLEAKTAVLAE
CCCEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHH
TLMEGGAEIAITGCNPLSTQDDVAAACAKKGMHVYAWRGETVEEYYENLNKVLDHKPDIV
HHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCEE
IDDGCDLIFLLHTKRTELLDNIMGGCEETTTGIIRLKAMEKEGALKFPVMDVNDAYTKHL
EECCCCEEEEEECCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEECCEECCCHHHHHHH
FDNRYGTGQSALDGILRATNLLIAGKTVVVAGYGWCGRGVAMRAKGLGAEVVVTEVNPIR
HCCCCCCCHHHHHHHHHHHHEEEECCEEEEEECCCCCCCCEEHCCCCCCEEEEECCCHHH
ALEARMDGFRVMKMEKAAEIGDIFITTTGCKDVIRKEHILKMRNGAILANAGHFDNEINK
HHHHHHCCEEEEEHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCH
KHLEELAKSIKEVRNCVTEYDLGNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALAA
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEECCCCCCEEEECHHHHHHHHH
EYILKNHEKLEPRVYNIPYEQDLMIASLKLKAMGIEIDELTKEQKKYLEDWREGT
HHHHHCCCCCCCEEEECCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MYEVRDINLWKEGERKIQWAKQHMPVLNLIRERFKEEKPFKGITIGMALHLEAKTAVLAE
CCCEEECCCCCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCCCEEEEEEEEECHHHHHHHH
TLMEGGAEIAITGCNPLSTQDDVAAACAKKGMHVYAWRGETVEEYYENLNKVLDHKPDIV
HHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHCCCCCEE
IDDGCDLIFLLHTKRTELLDNIMGGCEETTTGIIRLKAMEKEGALKFPVMDVNDAYTKHL
EECCCCEEEEEECCHHHHHHHHHCCCCCCCCEEEEEEEECCCCCEECCEECCCHHHHHHH
FDNRYGTGQSALDGILRATNLLIAGKTVVVAGYGWCGRGVAMRAKGLGAEVVVTEVNPIR
HCCCCCCCHHHHHHHHHHHHEEEECCEEEEEECCCCCCCCEEHCCCCCCEEEEECCCHHH
ALEARMDGFRVMKMEKAAEIGDIFITTTGCKDVIRKEHILKMRNGAILANAGHFDNEINK
HHHHHHCCEEEEEHHHHHCCCCEEEEECCHHHHHHHHHHHHHCCCEEEEECCCCCCCCCH
KHLEELAKSIKEVRNCVTEYDLGNKKIYLLGEGRLVNLACADGHPCEVMDMSFANQALAA
HHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCEEEEEEECCCCCCEEEECHHHHHHHHH
EYILKNHEKLEPRVYNIPYEQDLMIASLKLKAMGIEIDELTKEQKKYLEDWREGT
HHHHHCCCCCCCEEEECCCCCCEEEEEEEEEEECCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087