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The map label for this gene is ubiE [C]

Identifier: 15669437

GI number: 15669437

Start: 1193746

End: 1194501

Strand: Reverse

Name: ubiE [C]

Synonym: MJ1252

Alternate gene names: 15669437

Gene position: 1194501-1193746 (Counterclockwise)

Preceding gene: 15669439

Following gene: 15669433

Centisome position: 71.74

GC content: 27.91

Gene sequence:

>756_bases
ATGTGTAAAGCATTCTGCAGTTGCTACAGTTATCATTACCATCACCGTGAGAAAATGGGAATTAAAGAGTATTATGACAA
GTTGGCTAAGAGTTATGATAAGCTATATAAAAACAAGTATATGAGGATTGTGGAAAGGGAAATTATACAGAAAGAGATTA
AAGATGGTGACTTTGTCTTAGATATTGGTTGCGGAACTGGAGAGCAGTTAAAAATTTTAAATAATGCAGTTGGTTTAGAT
ATATCATTAGAAATGGCTAAAATAGCAAAAAATAAAACAAATAAGCCAGTAGTTGTTGCTAATGCTGAATTTCTCCCATT
TAAAAATAAGAGTTTTGATAAGGCAATATCTTTCTTTGGAGCTTTAAATCATTGTAATTTAAAGAGAGCTTTAAGAGAAG
TTAATAGGGTTTTAAAGGATGATGGAATTTTTATATTCACTGTGGCAAACATCTACGATATAAAATGGATTATAAAAAAC
ATTTTAAAAGGAAATTTTAAAAAGGTAAAAAATGCCATGAAAAAAAGAAAAGGAACAATAACAAAAGTAATTGATGGAGA
AAAAATAAAAGTAAAAACAAGATTCTATGATTTTAAGGAGGTTGAAGATGCCTTAAAAAAAGAAGGTTTTGAGGTAGTTT
ATACATTTGGGACAAATATTACCAATTCTCCATTAGATAAATTTATTTACAAAAGCTTTTTAAAAAACTTTGCATCATAC
ATTGGATTTGTTGCGAAAAAGGTAAAAAATAGATAA

Upstream 100 bases:

>100_bases
CATTTTTCATTAATTTTAAATCCTCCTCACTAAATAAATACTTAAATTCAAAATCTTCATAACCAGCTGCTGCCTTGTGA
ATAGTTAAGCCAATATTTGC

Downstream 100 bases:

>100_bases
CCGTTTAAATTCTTTTACTTATTTTTCAATTTCTCTTTTCCAGCTTTTTTAATAGCATCATACATCATCTCAACAGCTTT
AGGATTCTCTTCCAACAAAT

Product: GerC2 protein

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 251; Mature: 251

Protein sequence:

>251_residues
MCKAFCSCYSYHYHHREKMGIKEYYDKLAKSYDKLYKNKYMRIVEREIIQKEIKDGDFVLDIGCGTGEQLKILNNAVGLD
ISLEMAKIAKNKTNKPVVVANAEFLPFKNKSFDKAISFFGALNHCNLKRALREVNRVLKDDGIFIFTVANIYDIKWIIKN
ILKGNFKKVKNAMKKRKGTITKVIDGEKIKVKTRFYDFKEVEDALKKEGFEVVYTFGTNITNSPLDKFIYKSFLKNFASY
IGFVAKKVKNR

Sequences:

>Translated_251_residues
MCKAFCSCYSYHYHHREKMGIKEYYDKLAKSYDKLYKNKYMRIVEREIIQKEIKDGDFVLDIGCGTGEQLKILNNAVGLD
ISLEMAKIAKNKTNKPVVVANAEFLPFKNKSFDKAISFFGALNHCNLKRALREVNRVLKDDGIFIFTVANIYDIKWIIKN
ILKGNFKKVKNAMKKRKGTITKVIDGEKIKVKTRFYDFKEVEDALKKEGFEVVYTFGTNITNSPLDKFIYKSFLKNFASY
IGFVAKKVKNR
>Mature_251_residues
MCKAFCSCYSYHYHHREKMGIKEYYDKLAKSYDKLYKNKYMRIVEREIIQKEIKDGDFVLDIGCGTGEQLKILNNAVGLD
ISLEMAKIAKNKTNKPVVVANAEFLPFKNKSFDKAISFFGALNHCNLKRALREVNRVLKDDGIFIFTVANIYDIKWIIKN
ILKGNFKKVKNAMKKRKGTITKVIDGEKIKVKTRFYDFKEVEDALKKEGFEVVYTFGTNITNSPLDKFIYKSFLKNFASY
IGFVAKKVKNR

Specific function: Methyltransferase Required For The Conversion Of Dimethylmenaquinone (Dmkh2) To Menaquinone (Mkh2) And The Conversion Of 2-Polyprenyl-6-Methoxy-1,4-Benzoquinol (Ddmqh2) To 2-Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol (Dmqh2). [C]

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To M.jannaschii MJ0638 and MJ1123 and M.tuberculosis Rv2003c

Homologues:

Organism=Homo sapiens, GI153251913, Length=138, Percent_Identity=33.3333333333333, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y1252_METJA (Q58648)

Other databases:

- EMBL:   L77117
- PIR:   B64456
- RefSeq:   NP_248247.1
- ProteinModelPortal:   Q58648
- GeneID:   1452149
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1252
- NMPDR:   fig|243232.1.peg.1284
- TIGR:   MJ1252
- OMA:   ATTVIYV
- ProtClustDB:   CLSK2517706
- BioCyc:   MJAN243232:MJ_1252-MONOMER
- InterPro:   IPR013216

Pfam domain/function: PF08241 Methyltransf_11

EC number: 2.1.1.- [C]

Molecular weight: Translated: 29162; Mature: 29162

Theoretical pI: Translated: 10.26; Mature: 10.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCKAFCSCYSYHYHHREKMGIKEYYDKLAKSYDKLYKNKYMRIVEREIIQKEIKDGDFVL
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
DIGCGTGEQLKILNNAVGLDISLEMAKIAKNKTNKPVVVANAEFLPFKNKSFDKAISFFG
EECCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
ALNHCNLKRALREVNRVLKDDGIFIFTVANIYDIKWIIKNILKGNFKKVKNAMKKRKGTI
HHCCCHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
TKVIDGEKIKVKTRFYDFKEVEDALKKEGFEVVYTFGTNITNSPLDKFIYKSFLKNFASY
EEEECCCEEEEEEHHCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
IGFVAKKVKNR
HHHHHHHHCCC
>Mature Secondary Structure
MCKAFCSCYSYHYHHREKMGIKEYYDKLAKSYDKLYKNKYMRIVEREIIQKEIKDGDFVL
CCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
DIGCGTGEQLKILNNAVGLDISLEMAKIAKNKTNKPVVVANAEFLPFKNKSFDKAISFFG
EECCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCEEEECCCCCCCCCCCHHHHHHHHH
ALNHCNLKRALREVNRVLKDDGIFIFTVANIYDIKWIIKNILKGNFKKVKNAMKKRKGTI
HHCCCHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCE
TKVIDGEKIKVKTRFYDFKEVEDALKKEGFEVVYTFGTNITNSPLDKFIYKSFLKNFASY
EEEECCCEEEEEEHHCCHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHH
IGFVAKKVKNR
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087