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The map label for this gene is 15669434

Identifier: 15669434

GI number: 15669434

Start: 1191364

End: 1192449

Strand: Direct

Name: 15669434

Synonym: MJ1249

Alternate gene names: NA

Gene position: 1191364-1192449 (Clockwise)

Preceding gene: 15669432

Following gene: 15669435

Centisome position: 71.55

GC content: 35.08

Gene sequence:

>1086_bases
ATGAAATTTGGATGGGTTAATGTTATTGGAGATAACTGGGAAGAGAAAAAGAAGATAGTAACAACAGCATTAGAGTCATC
AATCCCAGTAGTTGTTGCTGAACCAGAAGATATTGAAAAAATTAAAGAACTTGGAAATATTAAAGTTGCCTCCCATTCCT
TAGACGCGGATATTGTTTTAGTAAATAAAAATGACAACATAGAGTTTTTAAAAGAGGCAAAGAACTTAGGAAAAGAAACA
GCCATATACATTCCAATTGAATCAAAGGAAGATGAAGAGTTTGCTTCAGAGGTTGCAAGGTTTGGATTTGTTGATAACAT
TATCTTAGAGGGGAGAGATTGGACAATCATTCCATTAGAAAATTTAATAGCTGATTTATTCCATAGGGATGTTAAGATTG
TAGCAAGTGTTAATTCAGTTGATGAGGCAAAGGTTGCCTATGAAATTTTAGAGAAAGGGACTGATGGGGTTCTCTTAAAT
CCAAAAAACTTAGAGGATATAAAGGAGTTATCAAAATTAATTGAAGAGATGAATAAAGAGAAAGTGGCTTTAGATGTAGC
AACAGTAACAAAGGTTGAGCCAATAGGTAGTGGAGACAGGGTTTGTATAGATACCTGCTCACTAATGAAGATAGGAGAAG
GAATGTTAATTGGCTCCTACTCAAGAGCTCTCTTCTTAGTTCATTCTGAGACTGTTGAGAACCCTTACGTAGCTACAAGG
CCATTCAGAGTTAATGCTGGACCTGTTCATGCATACATATTATGCCCTGGTAATAAAACAAAATATCTCAGTGAGCTAAA
AGCTGGAGATAAGGTTTTGATTGTAGATAAGGATGGAAATACAAGGGAGGCAATAGTTGGCAGGGTAAAGATTGAAAGAA
GACCTTTAGTGTTAATTGAGGCAGAGTATAAAGGGGATATTATTAGAACTATACTGCAGAATGCTGAAACTATAAGATTG
GTTAATGAAAAAGGAGAACCAATTTCTGTTGTTGATTTAAAACCTGGAGACAAAGTTTTAATAAAACCAGAGGAGTATGC
AAGGCATTTTGGAATGGCAATAAAAGAGACGATTATTGAAAAGTGA

Upstream 100 bases:

>100_bases
TTATATTAGAACAACGTGTAAAAATAGGAAAATTATTAAATTGAGAAGTTAAATATAGGGGTAGGCAATAAAATCTAAAA
CAATAACTTAGGGTGAAACT

Downstream 100 bases:

>100_bases
TAATATATGAGAGGAATAAACCCAGTATTGTTTAAAATATCTTTTTTATTAATAATTCTGGTTTCCTTAATATTGTCTTT
ATTTTATTATAATTTTCTAT

Product: 3-dehydroquinate synthase

Products: NA

Alternate protein names: DHQ synthase

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MKFGWVNVIGDNWEEKKKIVTTALESSIPVVVAEPEDIEKIKELGNIKVASHSLDADIVLVNKNDNIEFLKEAKNLGKET
AIYIPIESKEDEEFASEVARFGFVDNIILEGRDWTIIPLENLIADLFHRDVKIVASVNSVDEAKVAYEILEKGTDGVLLN
PKNLEDIKELSKLIEEMNKEKVALDVATVTKVEPIGSGDRVCIDTCSLMKIGEGMLIGSYSRALFLVHSETVENPYVATR
PFRVNAGPVHAYILCPGNKTKYLSELKAGDKVLIVDKDGNTREAIVGRVKIERRPLVLIEAEYKGDIIRTILQNAETIRL
VNEKGEPISVVDLKPGDKVLIKPEEYARHFGMAIKETIIEK

Sequences:

>Translated_361_residues
MKFGWVNVIGDNWEEKKKIVTTALESSIPVVVAEPEDIEKIKELGNIKVASHSLDADIVLVNKNDNIEFLKEAKNLGKET
AIYIPIESKEDEEFASEVARFGFVDNIILEGRDWTIIPLENLIADLFHRDVKIVASVNSVDEAKVAYEILEKGTDGVLLN
PKNLEDIKELSKLIEEMNKEKVALDVATVTKVEPIGSGDRVCIDTCSLMKIGEGMLIGSYSRALFLVHSETVENPYVATR
PFRVNAGPVHAYILCPGNKTKYLSELKAGDKVLIVDKDGNTREAIVGRVKIERRPLVLIEAEYKGDIIRTILQNAETIRL
VNEKGEPISVVDLKPGDKVLIKPEEYARHFGMAIKETIIEK
>Mature_361_residues
MKFGWVNVIGDNWEEKKKIVTTALESSIPVVVAEPEDIEKIKELGNIKVASHSLDADIVLVNKNDNIEFLKEAKNLGKET
AIYIPIESKEDEEFASEVARFGFVDNIILEGRDWTIIPLENLIADLFHRDVKIVASVNSVDEAKVAYEILEKGTDGVLLN
PKNLEDIKELSKLIEEMNKEKVALDVATVTKVEPIGSGDRVCIDTCSLMKIGEGMLIGSYSRALFLVHSETVENPYVATR
PFRVNAGPVHAYILCPGNKTKYLSELKAGDKVLIVDKDGNTREAIVGRVKIERRPLVLIEAEYKGDIIRTILQNAETIRL
VNEKGEPISVVDLKPGDKVLIKPEEYARHFGMAIKETIIEK

Specific function: Catalyzes the oxidative deamination and cyclization of 2-amino-3,7-dideoxy-D-threo-hept-6-ulosonic acid (ADH) to yield 3- dehydroquinate (DHQ), which is fed into the canonical shikimic pathway of aromatic amino acid biosynthesis

COG id: COG1465

COG function: function code E; Predicted alternative 3-dehydroquinate synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type DHQ synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHQS_METJA (Q58646)

Other databases:

- EMBL:   L77117
- PIR:   H64455
- RefSeq:   NP_248244.1
- ProteinModelPortal:   Q58646
- GeneID:   1452146
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1249
- NMPDR:   fig|243232.1.peg.1281
- TIGR:   MJ1249
- HOGENOM:   HBG670179
- OMA:   DRVCIDT
- ProtClustDB:   PRK02290
- BioCyc:   MetaCyc:MONOMER-14595
- BioCyc:   MJAN243232:MJ_1249-MONOMER
- HAMAP:   MF_01244
- InterPro:   IPR002812
- PIRSF:   PIRSF006655
- ProDom:   PD017907

Pfam domain/function: PF01959 DHQS

EC number: NA

Molecular weight: Translated: 40260; Mature: 40260

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKFGWVNVIGDNWEEKKKIVTTALESSIPVVVAEPEDIEKIKELGNIKVASHSLDADIVL
CCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCEEEEEECCCCEEEE
VNKNDNIEFLKEAKNLGKETAIYIPIESKEDEEFASEVARFGFVDNIILEGRDWTIIPLE
EECCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHEEECCCCEEEEEHH
NLIADLFHRDVKIVASVNSVDEAKVAYEILEKGTDGVLLNPKNLEDIKELSKLIEEMNKE
HHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCC
KVALDVATVTKVEPIGSGDRVCIDTCSLMKIGEGMLIGSYSRALFLVHSETVENPYVATR
EEEEEEEEEEEECCCCCCCEEEEECHHHHHCCCCEEEECCCEEEEEEEECCCCCCEEEEC
PFRVNAGPVHAYILCPGNKTKYLSELKAGDKVLIVDKDGNTREAIVGRVKIERRPLVLIE
CEEECCCCEEEEEEECCCCHHHHHHHCCCCEEEEEECCCCCHHHEEEEEEECCCCEEEEE
AEYKGDIIRTILQNAETIRLVNEKGEPISVVDLKPGDKVLIKPEEYARHFGMAIKETIIE
ECCCCHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHC
K
C
>Mature Secondary Structure
MKFGWVNVIGDNWEEKKKIVTTALESSIPVVVAEPEDIEKIKELGNIKVASHSLDADIVL
CCEEEEEEECCCHHHHHHHHHHHHHCCCCEEEECCHHHHHHHHHCCEEEEEECCCCEEEE
VNKNDNIEFLKEAKNLGKETAIYIPIESKEDEEFASEVARFGFVDNIILEGRDWTIIPLE
EECCCCHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCHHHEEECCCCEEEEEHH
NLIADLFHRDVKIVASVNSVDEAKVAYEILEKGTDGVLLNPKNLEDIKELSKLIEEMNKE
HHHHHHHHCCEEEEEECCCCHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHCCCC
KVALDVATVTKVEPIGSGDRVCIDTCSLMKIGEGMLIGSYSRALFLVHSETVENPYVATR
EEEEEEEEEEEECCCCCCCEEEEECHHHHHCCCCEEEECCCEEEEEEEECCCCCCEEEEC
PFRVNAGPVHAYILCPGNKTKYLSELKAGDKVLIVDKDGNTREAIVGRVKIERRPLVLIE
CEEECCCCEEEEEEECCCCHHHHHHHCCCCEEEEEECCCCCHHHEEEEEEECCCCEEEEE
AEYKGDIIRTILQNAETIRLVNEKGEPISVVDLKPGDKVLIKPEEYARHFGMAIKETIIE
ECCCCHHHHHHHCCCCEEEEECCCCCEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHC
K
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087