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The map label for this gene is guaB [C]

Identifier: 15669410

GI number: 15669410

Start: 1167094

End: 1167936

Strand: Direct

Name: guaB [C]

Synonym: MJ1225

Alternate gene names: 15669410

Gene position: 1167094-1167936 (Clockwise)

Preceding gene: 15669406

Following gene: 15669411

Centisome position: 70.1

GC content: 34.28

Gene sequence:

>843_bases
ATGTTTGTGAGAGTCATGAAAATTGCCCAAAATAAAAAGATTGTAACTGTTTATCCTACAACTACAATAAGAAAAGCCCT
TATGACTATGAATGAGAATAAATACAGAAGATTGCCAGTGGTAAATGCGGGAAATAACAAAGTTGTTGGTATAATTACAA
GTATGGATATTGTAGATTTCATGGGTGGGGGTTCAAAATACAACTTAATTAGAGAGAAGCATGAAAGGAATTTTTTAGCA
GCAATAAATGAACCAGTTAGAGAGATAATGGAGGAGAATGTTATAACTTTAAAGGAGAATGCAGATATTGATGAAGCAAT
AGAGACATTCTTAACAAAAAATGTTGGGGGGGCTCCAATAGTTAATGACGAGAACCAACTCATTTCATTAATTACAGAAA
GAGATGTGATAAGGGCTTTATTGGATAAGATAGACGAAAATGAGGTTATTGATGATTATATAACAAGGGACGTTATTGTA
GCCACACCAGGAGAGAGGTTGAAAGATGTTGCGAGAACTATGGTGAGAAATGGGTTTAGAAGACTGCCAGTTGTTAGTGA
GGGGAGATTGGTAGGGATTATAACATCAACGGACTTTATAAAACTTTTAGGTAGTGATTGGGCTTTCAACCACATGCAAA
CTGGTAATGTTAGAGAGATAACAAATGTTAGAATGGAAGAGATTATGAAGAGGGATGTTATAACTGCAAAAGAGGGAGAT
AAATTAAAGAAGATAGCTGAAATAATGGTAACCAATGATATAGGGGCTTTACCAGTAGTTGATGAAAACTTAAGGATAAA
AGGAATTATCACAGAGAAGGATGTTTTAAAATACTTTGCTTAA

Upstream 100 bases:

>100_bases
CTCATCACAAGGATAATCATTTTATACGTTAAATGAAATATTAATATTATGTGTAAGAATTCAAATTTAAATTTAAACTA
TTGAAAATTTCCTGTGAGGG

Downstream 100 bases:

>100_bases
ATAAATTATTTTTTATTTTTTGTGGGGGGTTGTTATGAATGTTGAGGAAATTGAAGAAGAATATAAAACTTCTATAAAAA
CTGGATTATCAACTGAAGAA

Product: hypothetical protein

Products: H+; Nicotinamide adenine dinucleotide - reduced; Xanthosine 5'-phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MFVRVMKIAQNKKIVTVYPTTTIRKALMTMNENKYRRLPVVNAGNNKVVGIITSMDIVDFMGGGSKYNLIREKHERNFLA
AINEPVREIMEENVITLKENADIDEAIETFLTKNVGGAPIVNDENQLISLITERDVIRALLDKIDENEVIDDYITRDVIV
ATPGERLKDVARTMVRNGFRRLPVVSEGRLVGIITSTDFIKLLGSDWAFNHMQTGNVREITNVRMEEIMKRDVITAKEGD
KLKKIAEIMVTNDIGALPVVDENLRIKGIITEKDVLKYFA

Sequences:

>Translated_280_residues
MFVRVMKIAQNKKIVTVYPTTTIRKALMTMNENKYRRLPVVNAGNNKVVGIITSMDIVDFMGGGSKYNLIREKHERNFLA
AINEPVREIMEENVITLKENADIDEAIETFLTKNVGGAPIVNDENQLISLITERDVIRALLDKIDENEVIDDYITRDVIV
ATPGERLKDVARTMVRNGFRRLPVVSEGRLVGIITSTDFIKLLGSDWAFNHMQTGNVREITNVRMEEIMKRDVITAKEGD
KLKKIAEIMVTNDIGALPVVDENLRIKGIITEKDVLKYFA
>Mature_280_residues
MFVRVMKIAQNKKIVTVYPTTTIRKALMTMNENKYRRLPVVNAGNNKVVGIITSMDIVDFMGGGSKYNLIREKHERNFLA
AINEPVREIMEENVITLKENADIDEAIETFLTKNVGGAPIVNDENQLISLITERDVIRALLDKIDENEVIDDYITRDVIV
ATPGERLKDVARTMVRNGFRRLPVVSEGRLVGIITSTDFIKLLGSDWAFNHMQTGNVREITNVRMEEIMKRDVITAKEGD
KLKKIAEIMVTNDIGALPVVDENLRIKGIITEKDVLKYFA

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 CBS domains

Homologues:

None

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): Y1225_METJA (Q58622)

Other databases:

- EMBL:   L77117
- PIR:   H64452
- RefSeq:   NP_248220.1
- PDB:   3KH5
- PDB:   3LFZ
- PDBsum:   3KH5
- PDBsum:   3LFZ
- ProteinModelPortal:   Q58622
- GeneID:   1452121
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_1225
- NMPDR:   fig|243232.1.peg.1257
- TIGR:   MJ1225
- HOGENOM:   HBG551233
- OMA:   KDVARTM
- ProtClustDB:   CLSK876497
- BioCyc:   MJAN243232:MJ_1225-MONOMER
- InterPro:   IPR013785
- InterPro:   IPR000644
- Gene3D:   G3DSA:3.20.20.70
- SMART:   SM00116

Pfam domain/function: PF00571 CBS

EC number: 1.1.1.205 [C]

Molecular weight: Translated: 31719; Mature: 31719

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS51371 CBS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFVRVMKIAQNKKIVTVYPTTTIRKALMTMNENKYRRLPVVNAGNNKVVGIITSMDIVDF
CEEEEEEHHCCCEEEEEECCHHHHHHHHHCCCCCEEECCEEECCCCEEEEEEECHHHHHH
MGGGSKYNLIREKHERNFLAAINEPVREIMEENVITLKENADIDEAIETFLTKNVGGAPI
HCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCE
VNDENQLISLITERDVIRALLDKIDENEVIDDYITRDVIVATPGERLKDVARTMVRNGFR
ECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCHH
RLPVVSEGRLVGIITSTDFIKLLGSDWAFNHMQTGNVREITNVRMEEIMKRDVITAKEGD
CCCEECCCCEEEEEECHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCH
KLKKIAEIMVTNDIGALPVVDENLRIKGIITEKDVLKYFA
HHHHHHHHHHCCCCCCCCEECCCEEEEEEECHHHHHHHCC
>Mature Secondary Structure
MFVRVMKIAQNKKIVTVYPTTTIRKALMTMNENKYRRLPVVNAGNNKVVGIITSMDIVDF
CEEEEEEHHCCCEEEEEECCHHHHHHHHHCCCCCEEECCEEECCCCEEEEEEECHHHHHH
MGGGSKYNLIREKHERNFLAAINEPVREIMEENVITLKENADIDEAIETFLTKNVGGAPI
HCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCCCCE
VNDENQLISLITERDVIRALLDKIDENEVIDDYITRDVIVATPGERLKDVARTMVRNGFR
ECCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCHHHHHHHHHHHHCCHH
RLPVVSEGRLVGIITSTDFIKLLGSDWAFNHMQTGNVREITNVRMEEIMKRDVITAKEGD
CCCEECCCCEEEEEECHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCH
KLKKIAEIMVTNDIGALPVVDENLRIKGIITEKDVLKYFA
HHHHHHHHHHCCCCCCCCEECCCEEEEEEECHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O; IMP; Nicotinamide adenine dinucleotide [C]

Specific reaction: H2O + IMP + Nicotinamide adenine dinucleotide --> H+ + Nicotinamide adenine dinucleotide - reduced + Xanthosine 5'-phosphate [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087