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The map label for this gene is moeA [C]

Identifier: 15669076

GI number: 15669076

Start: 816340

End: 818202

Strand: Reverse

Name: moeA [C]

Synonym: MJ0886

Alternate gene names: 15669076

Gene position: 818202-816340 (Counterclockwise)

Preceding gene: 15669077

Following gene: 15669075

Centisome position: 49.14

GC content: 31.99

Gene sequence:

>1863_bases
ATGACAAGATATTTAACATTACACAGCATTGAAGAAGCAAAATCCATAATAAATGAGAGTTTAAAAAAATTAAAAAATGA
AGTTGAAGAGGTTGATTTATTTAACGCCATTGGAAGAGTTTTGGCTGAAGATGTATTTTCTAATATAGATATCCCACCTT
ATGATAGGGCAAAGATGGATGGTTATGCAGTTAAAGCAGAAGATACCTATGAAGCAGATGAAGACAATCCAGTAGAGTTA
AAGGTTATTGGTTCTTTAAAAGCTGGGGAGATTAAAGACTTAGAAATAAATAATGGAGAATGTGTAGAGATAGCTACGGG
AGCAATAATTCCAAAAGGAGCTAATGCCGTTGTTATGGTTGAATACACTGAAAGAGATAATGATAGAGTTAAGATATACA
GGGCAGTCCCCCCAATGGAAAACATCCAATTCACTGGTTCAGATATAATGGCTGGAGAGCTTGTTTTAAGAAAAAATACT
AAATTAACCCCAAGAGATATTGGGGTTTTAGCTGCTATTGGTAAAAGCAAAGTTAAAGTTTATAAAAAACTAAAATTTGG
AATAATATCAACTGGAAATGAGATTATAAGCCCAAATGAGCAGTTAGAGTTTGGAAAAATCTACGATATAAATTCTTATA
CATTAGTATCTTACATAAAAACTCTTGGCTATGATTTTGAATTCTTTGGAATAGCCAAAGATGATAAAGAAGAATTAAAA
GAAAAGATTAAAAAAGCTCTAAAATGTGATATAATCTTATTAAGTGGGGGAACTTCTGCAGGTGTCGGGGATTTAACTGA
AACAGCTATAAAAGAGCTTGGTGGGAAAATTTTAGTTCATGGAATAAAGATAAAGCCAGGAAAACCAACTATAATTGGGA
AAATTGATAATAAGTTAATTGTCGGATTGCCTGGCTATCCGACCTCATGCCTAACTATATTCGATGTCCTATTTGGAGAC
GAAAAGAATGTTGTAAAGGCAAAATTCCCAGTGAGATATATTTCAGCAAAGGGGAGGGTGGAATATCTACCAGTTATATT
AGTTAAGCATAAGAATGGATTCTCAGCTTATCCAATAACTAAAGGAAGCGGAGCTATAACCTCTTTATCAGAGGCAGATG
GGTATATAATTATTGATGAAAATAAAGAGATTTTAGAGAATGAAGATGTAGAAGTTCATCTATTTGGAGATGTTAAAGTT
GGATTAAATATTATTGGCAGTCATTGTATTGGTGTAGATATAATCTTAAAAGAGGCAAAGTTATTAGCAAAAACTATAAA
TGTTGGTTCTTTAGGTGGAGTATTATCAATAAAAAGAGGAGAGGCAGATATTGCCGGAATTCATTTGTTGGATGAAAAAA
CCAACACCTACAACATCCCTTTCTTAGAGAAGTATAAAGTTAAAGATGCTGTATTAGTTAGAGGATATATTAGGGAGCAA
GGATTTATGTTTAGGAAAGAATTAGGCTTTAAATCTATAGAGGAGATTATAGAACATATTTATAAATTAGAGTTTATAAA
TAGAAATAAAGGTTCTGGAACAAGAATATTGTTTGATAAGTTTTTGAAAGATTATAATATAAATCCAAAAGAGATTAAAG
GCTACAACATAGAGGCAAAGACACATTCAGCAGTTGCTACAGCTATAGCAATGAAAAAGGCAGATATTGGTTTAGGCATA
AGGACAGTTGCAGAACAATATAATTTAGCTTTTATTCCATTGGCTAATGAACATTATGACTTCTTAATTAGAAAGGAGAG
ATTTAACGATGAGGATGTTCAAAACTTTATTAAAGCTTTAAAAACTGCCAAATTACCATTTAAAAAGCCAGATAACTGTG
GAGAAATTATATGGGGAGGATAA

Upstream 100 bases:

>100_bases
GAAATGATACATATACAAAAAATTATCTAAAAAGCTTAGGAATTGATGTAGAGCCAAAGCATTCATCAGCTGGAAGATTT
GTGGTAAAGAGGAGATAAAT

Downstream 100 bases:

>100_bases
AAATAAATTATTTAAACTATTGTCCCCAAAATTAACTATTGGGGATGAGTATGGGAAAAATAAAAATTGATGCTCTAATA
GACAACACATACAAAACTAT

Product: putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 620; Mature: 619

Protein sequence:

>620_residues
MTRYLTLHSIEEAKSIINESLKKLKNEVEEVDLFNAIGRVLAEDVFSNIDIPPYDRAKMDGYAVKAEDTYEADEDNPVEL
KVIGSLKAGEIKDLEINNGECVEIATGAIIPKGANAVVMVEYTERDNDRVKIYRAVPPMENIQFTGSDIMAGELVLRKNT
KLTPRDIGVLAAIGKSKVKVYKKLKFGIISTGNEIISPNEQLEFGKIYDINSYTLVSYIKTLGYDFEFFGIAKDDKEELK
EKIKKALKCDIILLSGGTSAGVGDLTETAIKELGGKILVHGIKIKPGKPTIIGKIDNKLIVGLPGYPTSCLTIFDVLFGD
EKNVVKAKFPVRYISAKGRVEYLPVILVKHKNGFSAYPITKGSGAITSLSEADGYIIIDENKEILENEDVEVHLFGDVKV
GLNIIGSHCIGVDIILKEAKLLAKTINVGSLGGVLSIKRGEADIAGIHLLDEKTNTYNIPFLEKYKVKDAVLVRGYIREQ
GFMFRKELGFKSIEEIIEHIYKLEFINRNKGSGTRILFDKFLKDYNINPKEIKGYNIEAKTHSAVATAIAMKKADIGLGI
RTVAEQYNLAFIPLANEHYDFLIRKERFNDEDVQNFIKALKTAKLPFKKPDNCGEIIWGG

Sequences:

>Translated_620_residues
MTRYLTLHSIEEAKSIINESLKKLKNEVEEVDLFNAIGRVLAEDVFSNIDIPPYDRAKMDGYAVKAEDTYEADEDNPVEL
KVIGSLKAGEIKDLEINNGECVEIATGAIIPKGANAVVMVEYTERDNDRVKIYRAVPPMENIQFTGSDIMAGELVLRKNT
KLTPRDIGVLAAIGKSKVKVYKKLKFGIISTGNEIISPNEQLEFGKIYDINSYTLVSYIKTLGYDFEFFGIAKDDKEELK
EKIKKALKCDIILLSGGTSAGVGDLTETAIKELGGKILVHGIKIKPGKPTIIGKIDNKLIVGLPGYPTSCLTIFDVLFGD
EKNVVKAKFPVRYISAKGRVEYLPVILVKHKNGFSAYPITKGSGAITSLSEADGYIIIDENKEILENEDVEVHLFGDVKV
GLNIIGSHCIGVDIILKEAKLLAKTINVGSLGGVLSIKRGEADIAGIHLLDEKTNTYNIPFLEKYKVKDAVLVRGYIREQ
GFMFRKELGFKSIEEIIEHIYKLEFINRNKGSGTRILFDKFLKDYNINPKEIKGYNIEAKTHSAVATAIAMKKADIGLGI
RTVAEQYNLAFIPLANEHYDFLIRKERFNDEDVQNFIKALKTAKLPFKKPDNCGEIIWGG
>Mature_619_residues
TRYLTLHSIEEAKSIINESLKKLKNEVEEVDLFNAIGRVLAEDVFSNIDIPPYDRAKMDGYAVKAEDTYEADEDNPVELK
VIGSLKAGEIKDLEINNGECVEIATGAIIPKGANAVVMVEYTERDNDRVKIYRAVPPMENIQFTGSDIMAGELVLRKNTK
LTPRDIGVLAAIGKSKVKVYKKLKFGIISTGNEIISPNEQLEFGKIYDINSYTLVSYIKTLGYDFEFFGIAKDDKEELKE
KIKKALKCDIILLSGGTSAGVGDLTETAIKELGGKILVHGIKIKPGKPTIIGKIDNKLIVGLPGYPTSCLTIFDVLFGDE
KNVVKAKFPVRYISAKGRVEYLPVILVKHKNGFSAYPITKGSGAITSLSEADGYIIIDENKEILENEDVEVHLFGDVKVG
LNIIGSHCIGVDIILKEAKLLAKTINVGSLGGVLSIKRGEADIAGIHLLDEKTNTYNIPFLEKYKVKDAVLVRGYIREQG
FMFRKELGFKSIEEIIEHIYKLEFINRNKGSGTRILFDKFLKDYNINPKEIKGYNIEAKTHSAVATAIAMKKADIGLGIR
TVAEQYNLAFIPLANEHYDFLIRKERFNDEDVQNFIKALKTAKLPFKKPDNCGEIIWGG

Specific function: Involved In The Biosynthesis Of A Demolybdo-Cofactor (Molybdopterin), Necessary For Molybdo-Enzymes. Seems To Be Involved In A Step Of Activation Of Molybdenum In The Form Of Thiomolybdenum. [C]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family

Homologues:

Organism=Homo sapiens, GI10880983, Length=415, Percent_Identity=30.8433734939759, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI66932975, Length=415, Percent_Identity=30.8433734939759, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1787049, Length=385, Percent_Identity=32.987012987013, Blast_Score=194, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25147659, Length=326, Percent_Identity=34.0490797546012, Blast_Score=163, Evalue=3e-40,
Organism=Caenorhabditis elegans, GI17562606, Length=268, Percent_Identity=27.9850746268657, Blast_Score=91, Evalue=3e-18,
Organism=Drosophila melanogaster, GI17136978, Length=359, Percent_Identity=27.0194986072423, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24638841, Length=359, Percent_Identity=27.0194986072423, Blast_Score=110, Evalue=2e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y886_METJA (Q58296)

Other databases:

- EMBL:   L77117
- PIR:   F64410
- RefSeq:   NP_247881.1
- ProteinModelPortal:   Q58296
- SMR:   Q58296
- GeneID:   1451775
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0886
- NMPDR:   fig|243232.1.peg.918
- TIGR:   MJ0886
- HOGENOM:   HBG731522
- OMA:   TSCLTIF
- ProtClustDB:   PRK14498
- BioCyc:   MJAN243232:MJ_0886-MONOMER
- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453
- Gene3D:   G3DSA:3.40.980.10
- SMART:   SM00852
- TIGRFAMs:   TIGR00177

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N; SSF53218 MoCF_biosynth; SSF63867 MoeA_C; SSF63882 MoeA_N

EC number: NA

Molecular weight: Translated: 68898; Mature: 68766

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRYLTLHSIEEAKSIINESLKKLKNEVEEVDLFNAIGRVLAEDVFSNIDIPPYDRAKMD
CCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GYAVKAEDTYEADEDNPVELKVIGSLKAGEIKDLEINNGECVEIATGAIIPKGANAVVMV
CEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCEEEEECCEEEECCCCEEEEE
EYTERDNDRVKIYRAVPPMENIQFTGSDIMAGELVLRKNTKLTPRDIGVLAAIGKSKVKV
EEECCCCCEEEEEECCCCCCCEEECCCCEEECEEEEECCCCCCHHHCCEEEECCCHHHHH
YKKLKFGIISTGNEIISPNEQLEFGKIYDINSYTLVSYIKTLGYDFEFFGIAKDDKEELK
HHHHEEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCEEEEEECCCCHHHHH
EKIKKALKCDIILLSGGTSAGVGDLTETAIKELGGKILVHGIKIKPGKPTIIGKIDNKLI
HHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCEEE
VGLPGYPTSCLTIFDVLFGDEKNVVKAKFPVRYISAKGRVEYLPVILVKHKNGFSAYPIT
EECCCCCHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCEEEEEEEEEEECCCCEECCEE
KGSGAITSLSEADGYIIIDENKEILENEDVEVHLFGDVKVGLNIIGSHCIGVDIILKEAK
CCCCCEEECCCCCCEEEECCCHHHHCCCCEEEEEEECEEECHHHHCCHHCCHHHHHHHHH
LLAKTINVGSLGGVLSIKRGEADIAGIHLLDEKTNTYNIPFLEKYKVKDAVLVRGYIREQ
HHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCEECCCCCEECCCCHHHHHHHHHHHC
GFMFRKELGFKSIEEIIEHIYKLEFINRNKGSGTRILFDKFLKDYNINPKEIKGYNIEAK
CCHHHHHCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHCCCCHHHCCCEEEECC
THSAVATAIAMKKADIGLGIRTVAEQYNLAFIPLANEHYDFLIRKERFNDEDVQNFIKAL
CHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHH
KTAKLPFKKPDNCGEIIWGG
HHCCCCCCCCCCCCCCEECC
>Mature Secondary Structure 
TRYLTLHSIEEAKSIINESLKKLKNEVEEVDLFNAIGRVLAEDVFSNIDIPPYDRAKMD
CEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
GYAVKAEDTYEADEDNPVELKVIGSLKAGEIKDLEINNGECVEIATGAIIPKGANAVVMV
CEEEECCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCCCEEEEECCEEEECCCCEEEEE
EYTERDNDRVKIYRAVPPMENIQFTGSDIMAGELVLRKNTKLTPRDIGVLAAIGKSKVKV
EEECCCCCEEEEEECCCCCCCEEECCCCEEECEEEEECCCCCCHHHCCEEEECCCHHHHH
YKKLKFGIISTGNEIISPNEQLEFGKIYDINSYTLVSYIKTLGYDFEFFGIAKDDKEELK
HHHHEEEEEECCCCCCCCCCCCCCCEEEECCCHHHHHHHHHHCCCEEEEEECCCCHHHHH
EKIKKALKCDIILLSGGTSAGVGDLTETAIKELGGKILVHGIKIKPGKPTIIGKIDNKLI
HHHHHHHEEEEEEEECCCCCCCCHHHHHHHHHCCCEEEEEEEEECCCCCEEEEECCCEEE
VGLPGYPTSCLTIFDVLFGDEKNVVKAKFPVRYISAKGRVEYLPVILVKHKNGFSAYPIT
EECCCCCHHHHHHHHHHHCCCCCEEEEECCEEEEECCCCEEEEEEEEEEECCCCEECCEE
KGSGAITSLSEADGYIIIDENKEILENEDVEVHLFGDVKVGLNIIGSHCIGVDIILKEAK
CCCCCEEECCCCCCEEEECCCHHHHCCCCEEEEEEECEEECHHHHCCHHCCHHHHHHHHH
LLAKTINVGSLGGVLSIKRGEADIAGIHLLDEKTNTYNIPFLEKYKVKDAVLVRGYIREQ
HHHHHCCCCCCCCEEEEECCCCCEEEEEEEECCCCEECCCCCEECCCCHHHHHHHHHHHC
GFMFRKELGFKSIEEIIEHIYKLEFINRNKGSGTRILFDKFLKDYNINPKEIKGYNIEAK
CCHHHHHCCHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHCCCCHHHCCCEEEECC
THSAVATAIAMKKADIGLGIRTVAEQYNLAFIPLANEHYDFLIRKERFNDEDVQNFIKAL
CHHHHHHHHHHHHCCCCCCHHHHHHHCCEEEEEECCCCCEEEEEECCCCHHHHHHHHHHH
KTAKLPFKKPDNCGEIIWGG
HHCCCCCCCCCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087