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The map label for this gene is cofC

Identifier: 15669077

GI number: 15669077

Start: 818205

End: 818879

Strand: Reverse

Name: cofC

Synonym: MJ0887

Alternate gene names: 15669077

Gene position: 818879-818205 (Counterclockwise)

Preceding gene: 15669078

Following gene: 15669076

Centisome position: 49.18

GC content: 28.0

Gene sequence:

>675_bases
ATGAATTGTGGGATAAAAATGAAAGTTATAATCCCTGTATCACCAATAAACTCACTAAAAACCAGATTATCAGAATTTTT
AAGTGGTGAGGAGAGGAAAAACCTATTATTAAATATGCTTAAAGATATTATTAAAGCTTTAGATGGTTTAGATATTGTTA
TAGTTAGCAGAGATGAGGAAATTTTGGATTTTGCTAAAAATGAATTAAAGGCAGAAACTATTAAAGAAAAATATAAAGGA
TTAAACAATGCAATAAAACAGGCATTTGAGGAAATTGAAGATAAAGAAGTTATCATTATTCCAGCAGACATCCCATTAAT
TAAGAAAAAGCATATTGAGGATATCTTAAAACTTTCTAAGAATTATGATTTAATTATAGCTCCATCAAGAGGAGGGGGAA
CTAACTTATTATATTTAAAATCTAAAGATTTAATTGAGATAAAATACGAGGGCTTTAGTTTTTTAAAACATTTAGAAGAG
GCAAAAAAGAGAAATTTAAGATATTACATTTACGATTCCTTTTTAATCTCTGTTGATATAAACACACCAGAAGATTTGGG
AGAGATATTCATCCATGGAAATGATACATATACAAAAAATTATCTAAAAAGCTTAGGAATTGATGTAGAGCCAAAGCATT
CATCAGCTGGAAGATTTGTGGTAAAGAGGAGATAA

Upstream 100 bases:

>100_bases
AGAATAGCAAATGAAAGGAATATAGATAAATTATACCCCGGACATGGAGAAATTGGAGATAGGATGGCTTTTAGCTATGC
AAAACTTTTTATATAAATAA

Downstream 100 bases:

>100_bases
ATATGACAAGATATTTAACATTACACAGCATTGAAGAAGCAAAATCCATAATAAATGAGAGTTTAAAAAAATTAAAAAAT
GAAGTTGAAGAGGTTGATTT

Product: hypothetical protein

Products: NA

Alternate protein names: LP guanylyltransferase

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MNCGIKMKVIIPVSPINSLKTRLSEFLSGEERKNLLLNMLKDIIKALDGLDIVIVSRDEEILDFAKNELKAETIKEKYKG
LNNAIKQAFEEIEDKEVIIIPADIPLIKKKHIEDILKLSKNYDLIIAPSRGGGTNLLYLKSKDLIEIKYEGFSFLKHLEE
AKKRNLRYYIYDSFLISVDINTPEDLGEIFIHGNDTYTKNYLKSLGIDVEPKHSSAGRFVVKRR

Sequences:

>Translated_224_residues
MNCGIKMKVIIPVSPINSLKTRLSEFLSGEERKNLLLNMLKDIIKALDGLDIVIVSRDEEILDFAKNELKAETIKEKYKG
LNNAIKQAFEEIEDKEVIIIPADIPLIKKKHIEDILKLSKNYDLIIAPSRGGGTNLLYLKSKDLIEIKYEGFSFLKHLEE
AKKRNLRYYIYDSFLISVDINTPEDLGEIFIHGNDTYTKNYLKSLGIDVEPKHSSAGRFVVKRR
>Mature_224_residues
MNCGIKMKVIIPVSPINSLKTRLSEFLSGEERKNLLLNMLKDIIKALDGLDIVIVSRDEEILDFAKNELKAETIKEKYKG
LNNAIKQAFEEIEDKEVIIIPADIPLIKKKHIEDILKLSKNYDLIIAPSRGGGTNLLYLKSKDLIEIKYEGFSFLKHLEE
AKKRNLRYYIYDSFLISVDINTPEDLGEIFIHGNDTYTKNYLKSLGIDVEPKHSSAGRFVVKRR

Specific function: Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor. Is able to ut

COG id: COG1920

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CofC family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COFC_METJA (Q58297)

Other databases:

- EMBL:   L77117
- PIR:   G64410
- RefSeq:   NP_247882.1
- ProteinModelPortal:   Q58297
- SMR:   Q58297
- GeneID:   1451776
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0887
- NMPDR:   fig|243232.1.peg.919
- TIGR:   MJ0887
- HOGENOM:   HBG699055
- OMA:   IVMADLP
- ProtClustDB:   CLSK876373
- BioCyc:   MetaCyc:MONOMER-14615
- BioCyc:   MJAN243232:MJ_0887-MONOMER
- HAMAP:   MF_02114
- InterPro:   IPR002835
- TIGRFAMs:   TIGR03552

Pfam domain/function: PF01983 DUF121

EC number: =2.7.7.68

Molecular weight: Translated: 25683; Mature: 25683

Theoretical pI: Translated: 8.81; Mature: 8.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNCGIKMKVIIPVSPINSLKTRLSEFLSGEERKNLLLNMLKDIIKALDGLDIVIVSRDEE
CCCCEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHH
ILDFAKNELKAETIKEKYKGLNNAIKQAFEEIEDKEVIIIPADIPLIKKKHIEDILKLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCC
NYDLIIAPSRGGGTNLLYLKSKDLIEIKYEGFSFLKHLEEAKKRNLRYYIYDSFLISVDI
CCCEEEEECCCCCCEEEEEECCCEEEEEECHHHHHHHHHHHHHCCCEEEEEEEEEEEEEC
NTPEDLGEIFIHGNDTYTKNYLKSLGIDVEPKHSSAGRFVVKRR
CCCHHCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCEEEECC
>Mature Secondary Structure
MNCGIKMKVIIPVSPINSLKTRLSEFLSGEERKNLLLNMLKDIIKALDGLDIVIVSRDEE
CCCCEEEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCHH
ILDFAKNELKAETIKEKYKGLNNAIKQAFEEIEDKEVIIIPADIPLIKKKHIEDILKLSK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHCC
NYDLIIAPSRGGGTNLLYLKSKDLIEIKYEGFSFLKHLEEAKKRNLRYYIYDSFLISVDI
CCCEEEEECCCCCCEEEEEECCCEEEEEECHHHHHHHHHHHHHCCCEEEEEEEEEEEEEC
NTPEDLGEIFIHGNDTYTKNYLKSLGIDVEPKHSSAGRFVVKRR
CCCHHCCEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087