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The map label for this gene is dys [H]

Identifier: 15669001

GI number: 15669001

Start: 737564

End: 738676

Strand: Reverse

Name: dys [H]

Synonym: MJ0814

Alternate gene names: 15669001

Gene position: 738676-737564 (Counterclockwise)

Preceding gene: 15669002

Following gene: 15669000

Centisome position: 44.37

GC content: 33.51

Gene sequence:

>1113_bases
ATGAGAGACATAAAGGATAATCCAATAAGAAGAGGCATTGCCGAGCAAAGCGAGGCAATGCATCCCGGGTATACCAATAG
GGCGAAGCCCTATGGTTGTAAGAGAGATCCAAAGGATATCGTGCTTAAGGAGAGTGAAGATATTGAAGGGATAGCAATTG
AAGGTCCTTGGTTAGAGGATGATATAAGCTTAGAAGAAATAATTAAGAAATACTACCTAAAAATTGGGTTTCAAGCATCA
CATATTGGAAAAGCAATAAAAATCTGGAAACATATTGAAGAGAAAAGAAAAAAAGGAGATGAAATAACGGTATTTTTTGG
ATATACATCAAATATTGTATCTTCTGGATTGAGAGAGATTATAGCATACCTTGTAAAACATAAAAAGATTGATATTATCG
TTACAACAGCTGGAGGAGTTGAAGAAGATTTTATAAAATGCTTAAAGCCTTTTATATTGGGAGATTGGGAAGTAGATGGA
AAAATGTTAAGAGAGAAGGGAATAAATAGAATTGGAAACATCTTTGTCCCAAATGACAGATATATAGCGTTTGAAGAATA
TATGATGGAATTTTTTGAAGAAATTTTAAATTTACAGAGAGAGACTGGAAAAATCATTACAGCAAGTGAATTTTGCTATA
AATTAGGAGAATTTATGGATAAAAAATTAAAAAGTAAAGAAAAGGAAAAATCAATATTATATTGGGCATATAAAAACAAC
ATCCCAATATTCTGCCCAGCAATAACAGATGGTTCAATTGGAGACATGCTATATTTCTTTAAAAAGTATAATAAAGATGA
AGAGTTGAAAATAGATGTTGCCAACGATATTGTAAAGCTAAATGATATAGCCATAAACTCTAAGGAGACAGCATGTATTG
TTTTAGGTGGTTCTCTGCCAAAGCATAGCATTATAAATGCAAATCTATTTAGAGAAGGAACAGATTATGCAATATATGTC
ACCACTGCCTTGCCTTGGGATGGTTCTTTAAGCGGAGCTCCACCTGAAGAAGGTGTATCGTGGGGAAAAATTGGGGCTAA
GGCGGATTATGTTGAAATTTGGGGAGATGCAACAATAATATTCCCATTATTGGTTTATTGTGTGATGAAGTGA

Upstream 100 bases:

>100_bases
TTGGCAGAGTTATTAATTAAAAATGCAAACAATGAAGAACTAAAATTTAAAGTAAAGGGAGAAAAATTTACAATAGACAA
ATAAATCCGGTGATGATTGT

Downstream 100 bases:

>100_bases
TAGTATGCTGTATGTTGTAGGTATAGGAAGCGGTAATGAGAGGCATTTTACAAAAGAGGCTGAGGAGATTTTAAATAAAG
TGGATTTAATAGTGTGTTAT

Product: putative deoxyhypusine synthase

Products: NA

Alternate protein names: DHS [H]

Number of amino acids: Translated: 370; Mature: 370

Protein sequence:

>370_residues
MRDIKDNPIRRGIAEQSEAMHPGYTNRAKPYGCKRDPKDIVLKESEDIEGIAIEGPWLEDDISLEEIIKKYYLKIGFQAS
HIGKAIKIWKHIEEKRKKGDEITVFFGYTSNIVSSGLREIIAYLVKHKKIDIIVTTAGGVEEDFIKCLKPFILGDWEVDG
KMLREKGINRIGNIFVPNDRYIAFEEYMMEFFEEILNLQRETGKIITASEFCYKLGEFMDKKLKSKEKEKSILYWAYKNN
IPIFCPAITDGSIGDMLYFFKKYNKDEELKIDVANDIVKLNDIAINSKETACIVLGGSLPKHSIINANLFREGTDYAIYV
TTALPWDGSLSGAPPEEGVSWGKIGAKADYVEIWGDATIIFPLLVYCVMK

Sequences:

>Translated_370_residues
MRDIKDNPIRRGIAEQSEAMHPGYTNRAKPYGCKRDPKDIVLKESEDIEGIAIEGPWLEDDISLEEIIKKYYLKIGFQAS
HIGKAIKIWKHIEEKRKKGDEITVFFGYTSNIVSSGLREIIAYLVKHKKIDIIVTTAGGVEEDFIKCLKPFILGDWEVDG
KMLREKGINRIGNIFVPNDRYIAFEEYMMEFFEEILNLQRETGKIITASEFCYKLGEFMDKKLKSKEKEKSILYWAYKNN
IPIFCPAITDGSIGDMLYFFKKYNKDEELKIDVANDIVKLNDIAINSKETACIVLGGSLPKHSIINANLFREGTDYAIYV
TTALPWDGSLSGAPPEEGVSWGKIGAKADYVEIWGDATIIFPLLVYCVMK
>Mature_370_residues
MRDIKDNPIRRGIAEQSEAMHPGYTNRAKPYGCKRDPKDIVLKESEDIEGIAIEGPWLEDDISLEEIIKKYYLKIGFQAS
HIGKAIKIWKHIEEKRKKGDEITVFFGYTSNIVSSGLREIIAYLVKHKKIDIIVTTAGGVEEDFIKCLKPFILGDWEVDG
KMLREKGINRIGNIFVPNDRYIAFEEYMMEFFEEILNLQRETGKIITASEFCYKLGEFMDKKLKSKEKEKSILYWAYKNN
IPIFCPAITDGSIGDMLYFFKKYNKDEELKIDVANDIVKLNDIAINSKETACIVLGGSLPKHSIINANLFREGTDYAIYV
TTALPWDGSLSGAPPEEGVSWGKIGAKADYVEIWGDATIIFPLLVYCVMK

Specific function: Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine

COG id: COG1899

COG function: function code O; Deoxyhypusine synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the deoxyhypusine synthase family [H]

Homologues:

Organism=Homo sapiens, GI4503325, Length=345, Percent_Identity=43.4782608695652, Blast_Score=276, Evalue=2e-74,
Organism=Homo sapiens, GI7108338, Length=308, Percent_Identity=38.6363636363636, Blast_Score=208, Evalue=5e-54,
Organism=Homo sapiens, GI7108340, Length=308, Percent_Identity=36.3636363636364, Blast_Score=188, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17536927, Length=325, Percent_Identity=44.3076923076923, Blast_Score=283, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6321859, Length=320, Percent_Identity=45.3125, Blast_Score=278, Evalue=1e-75,
Organism=Drosophila melanogaster, GI45550569, Length=348, Percent_Identity=42.5287356321839, Blast_Score=289, Evalue=3e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002773
- InterPro:   IPR022899 [H]

Pfam domain/function: PF01916 DS [H]

EC number: =2.5.1.46 [H]

Molecular weight: Translated: 42160; Mature: 42160

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: PS00228 TUBULIN_B_AUTOREG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDIKDNPIRRGIAEQSEAMHPGYTNRAKPYGCKRDPKDIVLKESEDIEGIAIEGPWLED
CCCCCCCHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEECCCCCCEEEEECCCCCC
DISLEEIIKKYYLKIGFQASHIGKAIKIWKHIEEKRKKGDEITVFFGYTSNIVSSGLREI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHH
IAYLVKHKKIDIIVTTAGGVEEDFIKCLKPFILGDWEVDGKMLREKGINRIGNIFVPNDR
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHCCEEECCCC
YIAFEEYMMEFFEEILNLQRETGKIITASEFCYKLGEFMDKKLKSKEKEKSILYWAYKNN
EEEHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
IPIFCPAITDGSIGDMLYFFKKYNKDEELKIDVANDIVKLNDIAINSKETACIVLGGSLP
CCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEHHHCEEEEEEEEECCCCCEEEEECCCCC
KHSIINANLFREGTDYAIYVTTALPWDGSLSGAPPEEGVSWGKIGAKADYVEIWGDATII
CCCEEECHHHCCCCCEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCCCEEEEECCHHHH
FPLLVYCVMK
HHHHHHHHCC
>Mature Secondary Structure
MRDIKDNPIRRGIAEQSEAMHPGYTNRAKPYGCKRDPKDIVLKESEDIEGIAIEGPWLED
CCCCCCCHHHHCHHHHHHCCCCCCCCCCCCCCCCCCCHHEEEECCCCCCEEEEECCCCCC
DISLEEIIKKYYLKIGFQASHIGKAIKIWKHIEEKRKKGDEITVFFGYTSNIVSSGLREI
CCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHH
IAYLVKHKKIDIIVTTAGGVEEDFIKCLKPFILGDWEVDGKMLREKGINRIGNIFVPNDR
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHCHHHHCCEEECCCC
YIAFEEYMMEFFEEILNLQRETGKIITASEFCYKLGEFMDKKLKSKEKEKSILYWAYKNN
EEEHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
IPIFCPAITDGSIGDMLYFFKKYNKDEELKIDVANDIVKLNDIAINSKETACIVLGGSLP
CCEEEECCCCCCHHHHHHHHHHCCCCCEEEEEHHHCEEEEEEEEECCCCCEEEEECCCCC
KHSIINANLFREGTDYAIYVTTALPWDGSLSGAPPEEGVSWGKIGAKADYVEIWGDATII
CCCEEECHHHCCCCCEEEEEEEECCCCCCCCCCCCHHCCCCCCCCCCCCEEEEECCHHHH
FPLLVYCVMK
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]