Click here to switch to the map view.

The map label for this gene is hmd

Identifier: 15668966

GI number: 15668966

Start: 707015

End: 708091

Strand: Direct

Name: hmd

Synonym: MJ0784

Alternate gene names: 15668966

Gene position: 707015-708091 (Clockwise)

Preceding gene: 15668965

Following gene: 15668967

Centisome position: 42.46

GC content: 38.81

Gene sequence:

>1077_bases
ATGAAAATAGCAATCTTAGGAGCTGGATGTTACAGAACCCACGCAGCAGCAGGAATAACCAATTTTATGAGAGCTTGTGA
AGTTGCTAAAGAAGTAGGAAAACCAGAAATTGCTTTAACACACTCTTCTATAACCTATGGAGCTGAGCTTTTACACTTAG
TTCCTGATGTTAAAGAAGTTATTGTTTCAGACCCATGCTTTGCTGAAGAACCAGGATTAGTTGTTATTGATGAATTTGAC
CCAAAAGAAGTCATGGAAGCTCACTTATCTGGAAACCCAGAGAGCATAATGCCAAAGATTAGAGAAGTTGTTAAGGCAAA
GGCAAAAGAGTTGCCAAAACCACCAAAGGCATGTATCCACTTAGTCCATCCAGAGGATGTTGGTTTAAAAGTAACATCAG
ATGATAGAGAGGCAGTTGAGGGAGCAGATATTGTAATTACATGGTTACCAAAAGGAAACAAACAGCCAGACATTATTAAG
AAATTTGCAGATGCAATTCCAGAAGGAGCTATTGTAACCCACGCATGTACAATCCCAACAACAAAGTTTGCTAAAATCTT
TAAAGACTTGGGAAGAGAGGATTTAAACATCACCTCATACCACCCCGGATGTGTTCCAGAGATGAAGGGACAAGTTTATA
TCGCAGAAGGTTATGCAAGTGAAGAGGCAGTTAATAAATTATATGAAATAGGTAAAATTGCAAGAGGAAAAGCATTTAAA
ATGCCAGCTAACTTGATTGGTCCTGTCTGTGATATGTGTTCAGCAGTTACAGCAACAGTTTATGCTGGTTTATTAGCATA
CAGAGATGCAGTTACAAAGATCTTAGGAGCTCCAGCTGACTTCGCTCAGATGATGGCTGATGAAGCTTTAACACAAATTC
ACAACTTAATGAAGGAGAAGGGAATAGCAAACATGGAGGAGGCGTTAGACCCAGCTGCTTTATTGGGAACCGCTGATAGT
ATGTGCTTTGGTCCATTGGCAGAGATCTTACCAACTGCTTTAAAGGTCTTAGAAAAACACAAAGTAGTTGAAGAAGAAGG
AAAAACAAAATGTGAAATAATGTCTCAAAAGGAATAA

Upstream 100 bases:

>100_bases
GCTATTTACTACTTAGAACCAAATAGATAATTTTATATATTACCAAACATAACAATAATATTACCAAAGTCACTCACAAT
ATTAACAAAAAGGTGAGAGG

Downstream 100 bases:

>100_bases
ATAAAGGGATAGGTAAAATTTAAATCAAAATAAATTGTAATTTAACTTAATTTCTAATTTTTTATTTTTTATAAGATAAT
TTTTCATTTTTTCTATAAAA

Product: H(2)-dependent methylenetetrahydromethanopterin dehydrogenase

Products: NA

Alternate protein names: H(2)-dependent methylene-H(4)MPT dehydrogenase; H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase; N(5),N(10)-methenyltetrahydromethanopterin hydrogenase

Number of amino acids: Translated: 358; Mature: 358

Protein sequence:

>358_residues
MKIAILGAGCYRTHAAAGITNFMRACEVAKEVGKPEIALTHSSITYGAELLHLVPDVKEVIVSDPCFAEEPGLVVIDEFD
PKEVMEAHLSGNPESIMPKIREVVKAKAKELPKPPKACIHLVHPEDVGLKVTSDDREAVEGADIVITWLPKGNKQPDIIK
KFADAIPEGAIVTHACTIPTTKFAKIFKDLGREDLNITSYHPGCVPEMKGQVYIAEGYASEEAVNKLYEIGKIARGKAFK
MPANLIGPVCDMCSAVTATVYAGLLAYRDAVTKILGAPADFAQMMADEALTQIHNLMKEKGIANMEEALDPAALLGTADS
MCFGPLAEILPTALKVLEKHKVVEEEGKTKCEIMSQKE

Sequences:

>Translated_358_residues
MKIAILGAGCYRTHAAAGITNFMRACEVAKEVGKPEIALTHSSITYGAELLHLVPDVKEVIVSDPCFAEEPGLVVIDEFD
PKEVMEAHLSGNPESIMPKIREVVKAKAKELPKPPKACIHLVHPEDVGLKVTSDDREAVEGADIVITWLPKGNKQPDIIK
KFADAIPEGAIVTHACTIPTTKFAKIFKDLGREDLNITSYHPGCVPEMKGQVYIAEGYASEEAVNKLYEIGKIARGKAFK
MPANLIGPVCDMCSAVTATVYAGLLAYRDAVTKILGAPADFAQMMADEALTQIHNLMKEKGIANMEEALDPAALLGTADS
MCFGPLAEILPTALKVLEKHKVVEEEGKTKCEIMSQKE
>Mature_358_residues
MKIAILGAGCYRTHAAAGITNFMRACEVAKEVGKPEIALTHSSITYGAELLHLVPDVKEVIVSDPCFAEEPGLVVIDEFD
PKEVMEAHLSGNPESIMPKIREVVKAKAKELPKPPKACIHLVHPEDVGLKVTSDDREAVEGADIVITWLPKGNKQPDIIK
KFADAIPEGAIVTHACTIPTTKFAKIFKDLGREDLNITSYHPGCVPEMKGQVYIAEGYASEEAVNKLYEIGKIARGKAFK
MPANLIGPVCDMCSAVTATVYAGLLAYRDAVTKILGAPADFAQMMADEALTQIHNLMKEKGIANMEEALDPAALLGTADS
MCFGPLAEILPTALKVLEKHKVVEEEGKTKCEIMSQKE

Specific function: Catalyzes the reversible reduction of methenyl- H(4)MPT(+) to methylene-H(4)MPT

COG id: COG4074

COG function: function code C; H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMD family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HMD_METJA (Q58194)

Other databases:

- EMBL:   L77117
- PIR:   H64397
- RefSeq:   NP_247770.1
- PDB:   2B0J
- PDB:   3DAF
- PDB:   3DAG
- PDB:   3F46
- PDB:   3F47
- PDB:   3H65
- PDBsum:   2B0J
- PDBsum:   3DAF
- PDBsum:   3DAG
- PDBsum:   3F46
- PDBsum:   3F47
- PDBsum:   3H65
- ProteinModelPortal:   Q58194
- SMR:   Q58194
- GeneID:   1451662
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0784
- NMPDR:   fig|243232.1.peg.807
- TIGR:   MJ0784
- HOGENOM:   HBG540926
- OMA:   THACTIP
- ProtClustDB:   PRK00961
- BioCyc:   MJAN243232:MJ_0784-MONOMER
- BRENDA:   1.12.98.2
- GO:   GO:0005488
- HAMAP:   MF_01090
- InterPro:   IPR008927
- InterPro:   IPR004889
- InterPro:   IPR010062
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01723

Pfam domain/function: PF03201 HMD; SSF48179 6DGDH_C_like

EC number: =1.12.98.2

Molecular weight: Translated: 38689; Mature: 38689

Theoretical pI: Translated: 5.32; Mature: 5.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIAILGAGCYRTHAAAGITNFMRACEVAKEVGKPEIALTHSSITYGAELLHLVPDVKEV
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
IVSDPCFAEEPGLVVIDEFDPKEVMEAHLSGNPESIMPKIREVVKAKAKELPKPPKACIH
HHCCCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHEE
LVHPEDVGLKVTSDDREAVEGADIVITWLPKGNKQPDIIKKFADAIPEGAIVTHACTIPT
EECCCCCCEEEECCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCH
TKFAKIFKDLGREDLNITSYHPGCVPEMKGQVYIAEGYASEEAVNKLYEIGKIARGKAFK
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCC
MPANLIGPVCDMCSAVTATVYAGLLAYRDAVTKILGAPADFAQMMADEALTQIHNLMKEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GIANMEEALDPAALLGTADSMCFGPLAEILPTALKVLEKHKVVEEEGKTKCEIMSQKE
CCCCHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC
>Mature Secondary Structure
MKIAILGAGCYRTHAAAGITNFMRACEVAKEVGKPEIALTHSSITYGAELLHLVPDVKEV
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHH
IVSDPCFAEEPGLVVIDEFDPKEVMEAHLSGNPESIMPKIREVVKAKAKELPKPPKACIH
HHCCCCCCCCCCEEEEECCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHEE
LVHPEDVGLKVTSDDREAVEGADIVITWLPKGNKQPDIIKKFADAIPEGAIVTHACTIPT
EECCCCCCEEEECCCHHHHCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCH
TKFAKIFKDLGREDLNITSYHPGCVPEMKGQVYIAEGYASEEAVNKLYEIGKIARGKAFK
HHHHHHHHHHCCCCCCEECCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHCCCCCC
MPANLIGPVCDMCSAVTATVYAGLLAYRDAVTKILGAPADFAQMMADEALTQIHNLMKEK
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHC
GIANMEEALDPAALLGTADSMCFGPLAEILPTALKVLEKHKVVEEEGKTKCEIMSQKE
CCCCHHHHCCHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087