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The map label for this gene is coaBC [C]

Identifier: 15668911

GI number: 15668911

Start: 663044

End: 663604

Strand: Reverse

Name: coaBC [C]

Synonym: MJ0730

Alternate gene names: 15668911

Gene position: 663604-663044 (Counterclockwise)

Preceding gene: 15668912

Following gene: 15668909

Centisome position: 39.86

GC content: 33.87

Gene sequence:

>561_bases
ATGCTAAAAATTGCATGGGGAATAACCGGATGTGGAGATAAACTGCCAGAAGTTGTTGAAATAATGAAAAAGCTAAAAAA
TAAATATAATTTGGATGTAGATATCTATCTCTCAAAAAATGCAAAGATTGTTGTAAAGTGGTATAAACTCTGGCAGGTTT
TGGAGGATGAGTTTTATGATTTAAGGGTTGAGGTTAATGCAAACGCTCCATTCTTAGTTGGGAAGTTGCAAACTGGAAAA
TATGATTTGTTTTTAGTAGCTCCAGCAACGGCAAACACAACTGCAAAAATAGCTTATGGTATTGCCGATACTTTAATAAC
TAATTCAGTTGCTCAAGCAATGAAGGCAAAAGTACCAGTTTATATCTTTCCACCAGATAACAAAAAAGGAACTGTAGAGA
CAATTCTGCCAGGGAATAAGAAATTAACCCTATATATGAGAGATGTTGATGTTGAAAATGTTGAGAGACTTAGAAGAATG
GAGGGAATTGAGGTTTTAGATAAACCAGAAGATATAGAGAAGGTTATTTTAAAGCACATAGAGGTGAAAAAACAGCAATA
A

Upstream 100 bases:

>100_bases
GAGTTGAGGAGGATGAGGAGGGATTGAGAGTTTTAAGAAAGACACTTAATAGATTTTATGAGGTTTTAAAAGAAAAGAGG
GGGTTATAAAGAGGGGTAGT

Downstream 100 bases:

>100_bases
GCTATCTATTTTTATAATATTTTAGCAAATCAAACACACTTAAAGTTCCAACAACCTCATCTCTATCATTAATAACAGGG
TAGGCAATGTCTTCGTTTTT

Product: DNA/pantothenate metabolism flavoprotein-like protein

Products: N-(R)-4-Phosphopantothenoyl)-L-cysteine; CMP; H+; Diphosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 186; Mature: 186

Protein sequence:

>186_residues
MLKIAWGITGCGDKLPEVVEIMKKLKNKYNLDVDIYLSKNAKIVVKWYKLWQVLEDEFYDLRVEVNANAPFLVGKLQTGK
YDLFLVAPATANTTAKIAYGIADTLITNSVAQAMKAKVPVYIFPPDNKKGTVETILPGNKKLTLYMRDVDVENVERLRRM
EGIEVLDKPEDIEKVILKHIEVKKQQ

Sequences:

>Translated_186_residues
MLKIAWGITGCGDKLPEVVEIMKKLKNKYNLDVDIYLSKNAKIVVKWYKLWQVLEDEFYDLRVEVNANAPFLVGKLQTGK
YDLFLVAPATANTTAKIAYGIADTLITNSVAQAMKAKVPVYIFPPDNKKGTVETILPGNKKLTLYMRDVDVENVERLRRM
EGIEVLDKPEDIEKVILKHIEVKKQQ
>Mature_186_residues
MLKIAWGITGCGDKLPEVVEIMKKLKNKYNLDVDIYLSKNAKIVVKWYKLWQVLEDEFYDLRVEVNANAPFLVGKLQTGK
YDLFLVAPATANTTAKIAYGIADTLITNSVAQAMKAKVPVYIFPPDNKKGTVETILPGNKKLTLYMRDVDVENVERLRRM
EGIEVLDKPEDIEKVILKHIEVKKQQ

Specific function: Catalyzes Two Steps In The Biosynthesis Of Coenzyme A. In The First Step Cysteine Is Conjugated To 4'-Phosphopantothenate To Form 4-Phosphopantothenoylcysteine, In The Latter Compound Is Decarboxylated To Form 4'-Phosphopantotheine. [C]

COG id: COG1036

COG function: function code C; Archaeal flavoproteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: To M.jannaschii MJ0208

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y730_METJA (Q58140)

Other databases:

- EMBL:   L77117
- PIR:   B64391
- RefSeq:   NP_247715.1
- ProteinModelPortal:   Q58140
- SMR:   Q58140
- GeneID:   1451607
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0730
- NMPDR:   fig|243232.1.peg.752
- TIGR:   MJ0730
- HOGENOM:   HBG509222
- OMA:   AWGITGC
- ProtClustDB:   CLSK862704
- BioCyc:   MJAN243232:MJ_0730-MONOMER
- InterPro:   IPR014072
- InterPro:   IPR003382
- Gene3D:   G3DSA:3.40.50.1950
- TIGRFAMs:   TIGR02699

Pfam domain/function: PF02441 Flavoprotein; SSF52507 Flavoprotein

EC number: 4.1.1.36; 6.3.2.5 [C]

Molecular weight: Translated: 21182; Mature: 21182

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKIAWGITGCGDKLPEVVEIMKKLKNKYNLDVDIYLSKNAKIVVKWYKLWQVLEDEFYD
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHCCCEE
LRVEVNANAPFLVGKLQTGKYDLFLVAPATANTTAKIAYGIADTLITNSVAQAMKAKVPV
EEEEECCCCCEEEEEECCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCE
YIFPPDNKKGTVETILPGNKKLTLYMRDVDVENVERLRRMEGIEVLDKPEDIEKVILKHI
EEECCCCCCCCEEEECCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
EVKKQQ
HHCCCC
>Mature Secondary Structure
MLKIAWGITGCGDKLPEVVEIMKKLKNKYNLDVDIYLSKNAKIVVKWYKLWQVLEDEFYD
CEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCEEEEHHHHHHHHHHCCCEE
LRVEVNANAPFLVGKLQTGKYDLFLVAPATANTTAKIAYGIADTLITNSVAQAMKAKVPV
EEEEECCCCCEEEEEECCCCEEEEEEECCCCCCCEEEEHHHHHHHHHHHHHHHHHHCCCE
YIFPPDNKKGTVETILPGNKKLTLYMRDVDVENVERLRRMEGIEVLDKPEDIEKVILKHI
EEECCCCCCCCEEEECCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
EVKKQQ
HHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-4'-Phosphopantothenate; CTP; L-Cysteine [C]

Specific reaction: D-4'-Phosphopantothenate + CTP + L-Cysteine --> N-((R)-4-Phosphopantothenoyl)-L-cysteine + CMP + H+ + Diphosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087