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The map label for this gene is hisB

Identifier: 15668879

GI number: 15668879

Start: 623406

End: 623999

Strand: Direct

Name: hisB

Synonym: MJ0698

Alternate gene names: 15668879

Gene position: 623406-623999 (Clockwise)

Preceding gene: 15668878

Following gene: 15668881

Centisome position: 37.44

GC content: 35.19

Gene sequence:

>594_bases
ATGTTTGGTGGGAATATGAGGATTTTTGAAGTAATGAGGGAAACAAAAGAGACTAATATTTACCTAAAAATAAACATTGA
TGGAACTGGAAAATATAAAATAGACACGGGTATTCCATTTTTTGACCATTTGTTGGCATCTTTTGCTAAACATGGATGTT
TTGATTTGATTGTTAAGGCAAGAGGGGATTTGGAGATAGATGACCACCACACTGTTGAAGATGTTGGAATTTGCTTAGGT
TTAGCCTTAAATCAGATTGAAAAGAGGAATATTTTTAGATTCGGCTGGGCTATAATTCCAATGGACGATGCAAGGGCTAC
TGTAGCGATAGATTTAAGTGGAAGGAGTTATTGTGTAGGAAATTATGAGCCAAAAAGAGAGTTTGTTGGAGACTTAGCAA
CTGAGAATATAAATCACTTTTTTGAGTCAGTTGCAAGTTATGGAATGCTAAATATCCATTATGAAGTTATTGGAAAGAAT
GAGCATCACAAGGCAGAGGCTTTGTTTAAGGCTTTTGGAGTAGCTTTAGATTTAGCTACAAAAATTGATGAAAGGAAGGG
AGTTATAAGCACTAAGGGAGAGGTTAAGCTATAA

Upstream 100 bases:

>100_bases
GTCTCCTCCTATGGTTGGAGAAAGACCACATATTATGTTTGTTGGAGTTTGGGAAGGATAAAGCTTTTTTAGATAAATTT
AAAATTATTTTTTAGTAAAA

Downstream 100 bases:

>100_bases
AAATTCTTTTTTATCATCTCTAAAAAAATATTTTTAAATCTCTAAAAGAATGTAATTTTAATTATTCAACAAATTTTAAC
CTTATCTATTTGAATATTCT

Product: imidazoleglycerol-phosphate dehydratase

Products: NA

Alternate protein names: IGPD

Number of amino acids: Translated: 197; Mature: 197

Protein sequence:

>197_residues
MFGGNMRIFEVMRETKETNIYLKINIDGTGKYKIDTGIPFFDHLLASFAKHGCFDLIVKARGDLEIDDHHTVEDVGICLG
LALNQIEKRNIFRFGWAIIPMDDARATVAIDLSGRSYCVGNYEPKREFVGDLATENINHFFESVASYGMLNIHYEVIGKN
EHHKAEALFKAFGVALDLATKIDERKGVISTKGEVKL

Sequences:

>Translated_197_residues
MFGGNMRIFEVMRETKETNIYLKINIDGTGKYKIDTGIPFFDHLLASFAKHGCFDLIVKARGDLEIDDHHTVEDVGICLG
LALNQIEKRNIFRFGWAIIPMDDARATVAIDLSGRSYCVGNYEPKREFVGDLATENINHFFESVASYGMLNIHYEVIGKN
EHHKAEALFKAFGVALDLATKIDERKGVISTKGEVKL
>Mature_197_residues
MFGGNMRIFEVMRETKETNIYLKINIDGTGKYKIDTGIPFFDHLLASFAKHGCFDLIVKARGDLEIDDHHTVEDVGICLG
LALNQIEKRNIFRFGWAIIPMDDARATVAIDLSGRSYCVGNYEPKREFVGDLATENINHFFESVASYGMLNIHYEVIGKN
EHHKAEALFKAFGVALDLATKIDERKGVISTKGEVKL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the imidazoleglycerol-phosphate dehydratase family

Homologues:

Organism=Escherichia coli, GI87082027, Length=189, Percent_Identity=45.5026455026455, Blast_Score=155, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6324776, Length=163, Percent_Identity=44.7852760736196, Blast_Score=136, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS7_METJA (Q58109)

Other databases:

- EMBL:   L77117
- PIR:   B64387
- RefSeq:   NP_247682.1
- ProteinModelPortal:   Q58109
- SMR:   Q58109
- GeneID:   1451565
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0698
- NMPDR:   fig|243232.1.peg.719
- TIGR:   MJ0698
- HOGENOM:   HBG289010
- OMA:   FGWAIIP
- ProtClustDB:   PRK00951
- BioCyc:   MJAN243232:MJ_0698-MONOMER
- BRENDA:   4.2.1.19
- GO:   GO:0005737
- HAMAP:   MF_00076
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR020568

Pfam domain/function: PF00475 IGPD; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =4.2.1.19

Molecular weight: Translated: 22159; Mature: 22159

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS00954 IGP_DEHYDRATASE_1; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGGNMRIFEVMRETKETNIYLKINIDGTGKYKIDTGIPFFDHLLASFAKHGCFDLIVKA
CCCCCHHHHHHHHHHHHCEEEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCEEEEEEC
RGDLEIDDHHTVEDVGICLGLALNQIEKRNIFRFGWAIIPMDDARATVAIDLSGRSYCVG
CCCEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECEEEEEECCCCEEEEEEECCCEEEEC
NYEPKREFVGDLATENINHFFESVASYGMLNIHYEVIGKNEHHKAEALFKAFGVALDLAT
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
KIDERKGVISTKGEVKL
HHHHHCCEECCCCCCCC
>Mature Secondary Structure
MFGGNMRIFEVMRETKETNIYLKINIDGTGKYKIDTGIPFFDHLLASFAKHGCFDLIVKA
CCCCCHHHHHHHHHHHHCEEEEEEEECCCCCEEECCCCCHHHHHHHHHHHCCCEEEEEEC
RGDLEIDDHHTVEDVGICLGLALNQIEKRNIFRFGWAIIPMDDARATVAIDLSGRSYCVG
CCCEEECCCCCHHHHHHHHHHHHHHHHHCCEEEECEEEEEECCCCEEEEEEECCCEEEEC
NYEPKREFVGDLATENINHFFESVASYGMLNIHYEVIGKNEHHKAEALFKAFGVALDLAT
CCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHH
KIDERKGVISTKGEVKL
HHHHHCCEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087