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The map label for this gene is cofG [H]

Identifier: 15668622

GI number: 15668622

Start: 399492

End: 400577

Strand: Direct

Name: cofG [H]

Synonym: MJ0446

Alternate gene names: 15668622

Gene position: 399492-400577 (Clockwise)

Preceding gene: 15668617

Following gene: 15668624

Centisome position: 23.99

GC content: 33.15

Gene sequence:

>1086_bases
GTGGATAGGATGATAAGTAGAGAGGAGGCAATTAATTTCCTTAACTCAACGTCTTCTAAGGATATATTAGATAAATTAGC
TCAAATCAATAATACATTTAAGAGAGAATATATAACTTACTCAAAAAACGTCTTTATACCTTTATCAAAGTGGTGCAGAA
ATAAGTGCGGATACTGCATCTTTAGAGAAGATAAGCCAAGTTTAATGAAGCCGAATGAAGTTAAAGAGATTTTATTAAAG
GGAGATAGATTAGGATGTAGAGAGGCGTTATTTACATTTGGGGAACACGTAGATGAAAATAAAGAGATTAAAGAACAATT
AAAATCAATGGGTTATGATAATATATTAGAATATCTCTACGATTTAGAGGAATGGACATTGAATAACACTTCTCTCCTTC
CACATACAAATTGTGGAATCTTAAATTATGATGAGTTAAAGATGCTTAAAGATGTCAATGCATCTATGGGTTTGATGTTG
GAAAATGCTTCAGAGAGGTTAATGAATACAATTGCCCACAAACACAGCCCTGGAAAGCATCCAAAGTTAAGGATAGAGAT
GATTGAAAATGCTGGAAAGTTAAAGATTCCATTCACAACTGGTTTATTAATTGGTATTGGAGAGACAAATGAGGAAATTG
TTGATTCACTATTTAAAATAAAAGAAATTCATGAAAAGTATGGGCATATACAGGAAGTTATAATCCAAAACTTTAGAGCT
AAGAAAGGCATTCCAATGGAGAATTTTAAAGAGCCATCACCAATAAAGATGTTAAAGGTTATTATTTTAGCAAAGTTGAT
TTTAGATGATATTTCAATCCAAATTCCTCCAAATTTAAATAGAGAGACGGGGCAGTTGTTTTTATTGGCAGGGGTTGATG
ATTGGGGAGGAGTTTCTCCACTAACAAGGGACTACGTTAATCCAGAGGCAGAGTGGCCAGAAATAAAGGAGTTGAGGGAA
TGGACTGAGGAGTTAGGGTTAAAGTTAAAGATGAGATTGCCAGTTTATGATAAATACATAAGTGAAGAGTGGTTAAGTGA
AAAAGTTTATAATAAGATTATTGAGATGGGATGGTTAAAGGAATAG

Upstream 100 bases:

>100_bases
TGTCTATGGGTTTGTAATATCTACTTTATATACTCTCACTATATATATGTGTTGATTGACAATAAAATTTAGTGTTATTT
AAATTTCTTCAATATTAAAG

Downstream 100 bases:

>100_bases
CGTCCTCTATTATTGATATCTGCTTTTTTAAGATATTCTCATATCTATTTTTTAATATTTGTAGGGCCTTATAGGCAGAT
TTTCCATCTAAATATACAAC

Product: FO synthase subunit 1

Products: NA

Alternate protein names: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase subunit 1 [H]

Number of amino acids: Translated: 361; Mature: 361

Protein sequence:

>361_residues
MDRMISREEAINFLNSTSSKDILDKLAQINNTFKREYITYSKNVFIPLSKWCRNKCGYCIFREDKPSLMKPNEVKEILLK
GDRLGCREALFTFGEHVDENKEIKEQLKSMGYDNILEYLYDLEEWTLNNTSLLPHTNCGILNYDELKMLKDVNASMGLML
ENASERLMNTIAHKHSPGKHPKLRIEMIENAGKLKIPFTTGLLIGIGETNEEIVDSLFKIKEIHEKYGHIQEVIIQNFRA
KKGIPMENFKEPSPIKMLKVIILAKLILDDISIQIPPNLNRETGQLFLLAGVDDWGGVSPLTRDYVNPEAEWPEIKELRE
WTEELGLKLKMRLPVYDKYISEEWLSEKVYNKIIEMGWLKE

Sequences:

>Translated_361_residues
MDRMISREEAINFLNSTSSKDILDKLAQINNTFKREYITYSKNVFIPLSKWCRNKCGYCIFREDKPSLMKPNEVKEILLK
GDRLGCREALFTFGEHVDENKEIKEQLKSMGYDNILEYLYDLEEWTLNNTSLLPHTNCGILNYDELKMLKDVNASMGLML
ENASERLMNTIAHKHSPGKHPKLRIEMIENAGKLKIPFTTGLLIGIGETNEEIVDSLFKIKEIHEKYGHIQEVIIQNFRA
KKGIPMENFKEPSPIKMLKVIILAKLILDDISIQIPPNLNRETGQLFLLAGVDDWGGVSPLTRDYVNPEAEWPEIKELRE
WTEELGLKLKMRLPVYDKYISEEWLSEKVYNKIIEMGWLKE
>Mature_361_residues
MDRMISREEAINFLNSTSSKDILDKLAQINNTFKREYITYSKNVFIPLSKWCRNKCGYCIFREDKPSLMKPNEVKEILLK
GDRLGCREALFTFGEHVDENKEIKEQLKSMGYDNILEYLYDLEEWTLNNTSLLPHTNCGILNYDELKMLKDVNASMGLML
ENASERLMNTIAHKHSPGKHPKLRIEMIENAGKLKIPFTTGLLIGIGETNEEIVDSLFKIKEIHEKYGHIQEVIIQNFRA
KKGIPMENFKEPSPIKMLKVIILAKLILDDISIQIPPNLNRETGQLFLLAGVDDWGGVSPLTRDYVNPEAEWPEIKELRE
WTEELGLKLKMRLPVYDKYISEEWLSEKVYNKIIEMGWLKE

Specific function: Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) [H]

COG id: COG1060

COG function: function code HR; Thiamine biosynthesis enzyme ThiH and related uncharacterized enzymes

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. CofG family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR010722
- InterPro:   IPR006638
- InterPro:   IPR019939
- InterPro:   IPR007197 [H]

Pfam domain/function: PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 41985; Mature: 41985

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDRMISREEAINFLNSTSSKDILDKLAQINNTFKREYITYSKNVFIPLSKWCRNKCGYCI
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCEEEEHHHHHCCCCCEEE
FREDKPSLMKPNEVKEILLKGDRLGCREALFTFGEHVDENKEIKEQLKSMGYDNILEYLY
EECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHH
DLEEWTLNNTSLLPHTNCGILNYDELKMLKDVNASMGLMLENASERLMNTIAHKHSPGKH
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PKLRIEMIENAGKLKIPFTTGLLIGIGETNEEIVDSLFKIKEIHEKYGHIQEVIIQNFRA
CCEEEEEECCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKGIPMENFKEPSPIKMLKVIILAKLILDDISIQIPPNLNRETGQLFLLAGVDDWGGVSP
CCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCEEEEECCCCCCCCCC
LTRDYVNPEAEWPEIKELREWTEELGLKLKMRLPVYDKYISEEWLSEKVYNKIIEMGWLK
HHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
E
C
>Mature Secondary Structure
MDRMISREEAINFLNSTSSKDILDKLAQINNTFKREYITYSKNVFIPLSKWCRNKCGYCI
CCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHEECCCEEEEHHHHHCCCCCEEE
FREDKPSLMKPNEVKEILLKGDRLGCREALFTFGEHVDENKEIKEQLKSMGYDNILEYLY
EECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHH
DLEEWTLNNTSLLPHTNCGILNYDELKMLKDVNASMGLMLENASERLMNTIAHKHSPGKH
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
PKLRIEMIENAGKLKIPFTTGLLIGIGETNEEIVDSLFKIKEIHEKYGHIQEVIIQNFRA
CCEEEEEECCCCCEEEEEECCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KKGIPMENFKEPSPIKMLKVIILAKLILDDISIQIPPNLNRETGQLFLLAGVDDWGGVSP
CCCCCHHHCCCCCHHHHHHHHHHHHHHHHHCEEECCCCCCCCCCCEEEEECCCCCCCCCC
LTRDYVNPEAEWPEIKELREWTEELGLKLKMRLPVYDKYISEEWLSEKVYNKIIEMGWLK
HHHHHCCCCCCCCHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
E
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]