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The map label for this gene is ribH

Identifier: 15668478

GI number: 15668478

Start: 285552

End: 285977

Strand: Reverse

Name: ribH

Synonym: MJ0303

Alternate gene names: 15668478

Gene position: 285977-285552 (Counterclockwise)

Preceding gene: 15668479

Following gene: 15668477

Centisome position: 17.18

GC content: 38.26

Gene sequence:

>426_bases
GTGGTATTGATGGTAAATCTTGGGTTTGTTATTGCTGAGTTCAACAGAGATATAACATATATGATGGAGAAGGTTGCTGA
GGAGCATGCTGAATTTTTAGGAGCCACTGTAAAATATAAAATTGTTGTTCCGGGAGTTTTTGATATGCCTTTAGCAGTTA
AAAAGTTGTTAGAAAAGGATGATGTTGATGCAGTTGTAACAATTGGGTGTGTTATTGAGGGAGAGACAGAACATGATGAG
ATAGTTGTTCATAATGCAGCGAGAAAAATAGCAGATTTAGCTCTACAATATGATAAACCAGTAACTCTCGGAATTTCAGG
GCCAGGAATGACAAGGTTGCAGGCTCAGGAAAGAGTTGATTACGGTAAGAGGGCTGTTGAAGCGGCTGTTAAAATGGTTA
AAAGGTTGAAGGCATTAGAAGAATAG

Upstream 100 bases:

>100_bases
AAGAGAATGCATTGAGATACGTTAAATTATCTGAAACCTTAGAAAGTTATAAATAAAAATTAAACTAAATAGAAATAACA
AAAATCCTTTGAAGTAAAAG

Downstream 100 bases:

>100_bases
TGTCTTCTAAAATTATAAAAAATTTTTATGAAATTGAATGCCTTCCAAAGAAAGGTGTTCATTAGTGCCTTAGTTATTAC
AAAATGTTTTGAAAGACACT

Product: 6,7-dimethyl-8-ribityllumazine synthase

Products: NA

Alternate protein names: DMRL synthase; Lumazine synthase; Riboflavin synthase beta chain

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MVLMVNLGFVIAEFNRDITYMMEKVAEEHAEFLGATVKYKIVVPGVFDMPLAVKKLLEKDDVDAVVTIGCVIEGETEHDE
IVVHNAARKIADLALQYDKPVTLGISGPGMTRLQAQERVDYGKRAVEAAVKMVKRLKALEE

Sequences:

>Translated_141_residues
MVLMVNLGFVIAEFNRDITYMMEKVAEEHAEFLGATVKYKIVVPGVFDMPLAVKKLLEKDDVDAVVTIGCVIEGETEHDE
IVVHNAARKIADLALQYDKPVTLGISGPGMTRLQAQERVDYGKRAVEAAVKMVKRLKALEE
>Mature_141_residues
MVLMVNLGFVIAEFNRDITYMMEKVAEEHAEFLGATVKYKIVVPGVFDMPLAVKKLLEKDDVDAVVTIGCVIEGETEHDE
IVVHNAARKIADLALQYDKPVTLGISGPGMTRLQAQERVDYGKRAVEAAVKMVKRLKALEE

Specific function: Riboflavin synthase is a bifunctional enzyme complex catalyzing the formation of riboflavin from 5-amino-6-(1'-D)- ribityl-amino-2,4(1H,3H)-pyrimidinedione and L-3,4-dihydrohy-2- butanone-4-phosphate via 6,7-dimethyl-8-lumazine. The beta subunit catalyzes

COG id: COG0054

COG function: function code H; Riboflavin synthase beta-chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DMRL synthase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RISB_METJA (Q57751)

Other databases:

- EMBL:   L77117
- PIR:   H64337
- RefSeq:   NP_247276.1
- ProteinModelPortal:   Q57751
- SMR:   Q57751
- GeneID:   1451158
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0303
- NMPDR:   fig|243232.1.peg.313
- TIGR:   MJ0303
- HOGENOM:   HBG311126
- OMA:   AVIQGAT
- ProtClustDB:   PRK00061
- BioCyc:   MetaCyc:MONOMER-14604
- BioCyc:   MJAN243232:MJ_0303-MONOMER
- BRENDA:   2.5.1.9
- HAMAP:   MF_00178
- InterPro:   IPR002180
- Gene3D:   G3DSA:3.40.50.960
- PANTHER:   PTHR21058
- TIGRFAMs:   TIGR00114

Pfam domain/function: PF00885 DMRL_synthase; SSF52121 DMRL_synthase

EC number: =2.5.1.9

Molecular weight: Translated: 15646; Mature: 15646

Theoretical pI: Translated: 5.04; Mature: 5.04

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVLMVNLGFVIAEFNRDITYMMEKVAEEHAEFLGATVKYKIVVPGVFDMPLAVKKLLEKD
CEEEEECCEEEEHHCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHCCC
DVDAVVTIGCVIEGETEHDEIVVHNAARKIADLALQYDKPVTLGISGPGMTRLQAQERVD
CCCEEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
YGKRAVEAAVKMVKRLKALEE
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MVLMVNLGFVIAEFNRDITYMMEKVAEEHAEFLGATVKYKIVVPGVFDMPLAVKKLLEKD
CEEEEECCEEEEHHCCCHHHHHHHHHHHHHHHHCCEEEEEEEECCCCCCCHHHHHHHCCC
DVDAVVTIGCVIEGETEHDEIVVHNAARKIADLALQYDKPVTLGISGPGMTRLQAQERVD
CCCEEEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHH
YGKRAVEAAVKMVKRLKALEE
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087