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The map label for this gene is hisE

Identifier: 15668477

GI number: 15668477

Start: 285147

End: 285434

Strand: Reverse

Name: hisE

Synonym: MJ0302

Alternate gene names: 15668477

Gene position: 285434-285147 (Counterclockwise)

Preceding gene: 15668478

Following gene: 15668476

Centisome position: 17.14

GC content: 29.17

Gene sequence:

>288_bases
ATGATTTTAGAGGAAGTTTATGAAATTATAAAACAAAGAATAAAAGAAAAGCCAGAAGGTTCTTATGTGGCAAAACTAAC
AACCGATGATAAAAAAACGGCAATAAACAAAATCTGTGAGAAAATTGGGGAGGAATCTACTGAATTAATTTTAGCAGCTA
AGGATGACAAGAAAGATGAGATTATTTATGAGGCTGCTGATTTAATATTCCATACTATGGTATTATTGGCTTATAAGAAC
ATAGAGTTTGAAGAATTATTAAAGGAATTTGAAAGAAGAAAGAAATGA

Upstream 100 bases:

>100_bases
AAAAATTTTTATGAAATTGAATGCCTTCCAAAGAAAGGTGTTCATTAGTGCCTTAGTTATTACAAAATGTTTTGAAAGAC
ACTATGGATAAGGGATATCT

Downstream 100 bases:

>100_bases
TACAATCTTTTTTTATTTTTAAAACTGAATCATCAATATAGCAGGAGGATGTTAATGAACATTGGAAAAGTTGATAACAT
AAAGATTTATACCTTAGCTG

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 95; Mature: 95

Protein sequence:

>95_residues
MILEEVYEIIKQRIKEKPEGSYVAKLTTDDKKTAINKICEKIGEESTELILAAKDDKKDEIIYEAADLIFHTMVLLAYKN
IEFEELLKEFERRKK

Sequences:

>Translated_95_residues
MILEEVYEIIKQRIKEKPEGSYVAKLTTDDKKTAINKICEKIGEESTELILAAKDDKKDEIIYEAADLIFHTMVLLAYKN
IEFEELLKEFERRKK
>Mature_95_residues
MILEEVYEIIKQRIKEKPEGSYVAKLTTDDKKTAINKICEKIGEESTELILAAKDDKKDEIIYEAADLIFHTMVLLAYKN
IEFEELLKEFERRKK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_METJA (Q57750)

Other databases:

- EMBL:   L77117
- PIR:   G64337
- RefSeq:   NP_247275.1
- ProteinModelPortal:   Q57750
- SMR:   Q57750
- GeneID:   1451157
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0302
- NMPDR:   fig|243232.1.peg.312
- TIGR:   MJ0302
- HOGENOM:   HBG646527
- OMA:   INKICEK
- ProtClustDB:   PRK00400
- BioCyc:   MJAN243232:MJ_0302-MONOMER
- BRENDA:   3.6.1.31
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 11181; Mature: 11181

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MILEEVYEIIKQRIKEKPEGSYVAKLTTDDKKTAINKICEKIGEESTELILAAKDDKKDE
CCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHEEEECCCCCHHH
IIYEAADLIFHTMVLLAYKNIEFEELLKEFERRKK
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MILEEVYEIIKQRIKEKPEGSYVAKLTTDDKKTAINKICEKIGEESTELILAAKDDKKDE
CCHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCHHEEEECCCCCHHH
IIYEAADLIFHTMVLLAYKNIEFEELLKEFERRKK
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087