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The map label for this gene is tmk

Identifier: 15668468

GI number: 15668468

Start: 275599

End: 276165

Strand: Direct

Name: tmk

Synonym: MJ0293

Alternate gene names: 15668468

Gene position: 275599-276165 (Clockwise)

Preceding gene: 15668466

Following gene: 15668471

Centisome position: 16.55

GC content: 27.69

Gene sequence:

>567_bases
TTGGTGGATAACATGTTTATTGTGTTTGAGGGTATAGATGGTAGTGGAAAAACTACACAATCAAAGCTTTTAGCTAAAAA
AATGGATGCATTTTGGACTTATGAGCCATCAAATAGCTTAGTAGGGAAAATAATAAGAGAAATTTTATCTGGAAAAACAG
AAGTGGATAATAAAACCTTAGCTTTGTTATTTGCGGCTGATAGAATAGAGCATACAAAATTAATAAAAGAAGAATTAAAA
AAGAGAGACGTTGTTTGTGATAGATATCTATACTCATCTATTGCCTATCAAAGTGTTGCAGGAGTTGATGAGAATTTTAT
AAAATCAATAAACAGATATGCTCTAAAGCCAGATATTGTTTTTTTATTAATTGTTGATATTGAGACAGCATTAAAGAGGG
TTAAAACAAAAGACATATTTGAAAAAAAAGATTTTTTAAAAAAAGTTCAGGATAAATATTTAGAGTTAGCTGAAGAATAT
AATTTTATAGTTATTGACACAACAAAAAAGTCAGTAGAAGAGGTTCATAATGAGATTATAGGTTATTTAAAAAACATACC
TCATTAA

Upstream 100 bases:

>100_bases
CCCTATTGGGATACCCGAGCGAGGTTGCCAAGACAACCTCACTTTAATAAAGATTTGAGAGCATATCAATAGGAGCAAAA
CCCTTGGATGTATAACTTTT

Downstream 100 bases:

>100_bases
TTGTATAGAGACTATCAAGTTAAGTTTTTATTAAATATTGATAAAAAAATAATAAAATATGAGGCTCATGATAGAAGTTA
TAAAGGAGAAAATCGTAGAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MVDNMFIVFEGIDGSGKTTQSKLLAKKMDAFWTYEPSNSLVGKIIREILSGKTEVDNKTLALLFAADRIEHTKLIKEELK
KRDVVCDRYLYSSIAYQSVAGVDENFIKSINRYALKPDIVFLLIVDIETALKRVKTKDIFEKKDFLKKVQDKYLELAEEY
NFIVIDTTKKSVEEVHNEIIGYLKNIPH

Sequences:

>Translated_188_residues
MVDNMFIVFEGIDGSGKTTQSKLLAKKMDAFWTYEPSNSLVGKIIREILSGKTEVDNKTLALLFAADRIEHTKLIKEELK
KRDVVCDRYLYSSIAYQSVAGVDENFIKSINRYALKPDIVFLLIVDIETALKRVKTKDIFEKKDFLKKVQDKYLELAEEY
NFIVIDTTKKSVEEVHNEIIGYLKNIPH
>Mature_188_residues
MVDNMFIVFEGIDGSGKTTQSKLLAKKMDAFWTYEPSNSLVGKIIREILSGKTEVDNKTLALLFAADRIEHTKLIKEELK
KRDVVCDRYLYSSIAYQSVAGVDENFIKSINRYALKPDIVFLLIVDIETALKRVKTKDIFEKKDFLKKVQDKYLELAEEY
NFIVIDTTKKSVEEVHNEIIGYLKNIPH

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Homo sapiens, GI42544174, Length=190, Percent_Identity=30.5263157894737, Blast_Score=80, Evalue=1e-15,
Organism=Escherichia coli, GI1787340, Length=187, Percent_Identity=28.8770053475936, Blast_Score=66, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17535647, Length=146, Percent_Identity=35.6164383561644, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6322517, Length=186, Percent_Identity=28.494623655914, Blast_Score=73, Evalue=3e-14,
Organism=Drosophila melanogaster, GI28573735, Length=185, Percent_Identity=29.7297297297297, Blast_Score=88, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_METJA (Q57741)

Other databases:

- EMBL:   L77117
- PIR:   F64336
- RefSeq:   NP_247266.1
- ProteinModelPortal:   Q57741
- SMR:   Q57741
- GeneID:   1451148
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0293
- NMPDR:   fig|243232.1.peg.303
- TIGR:   MJ0293
- HOGENOM:   HBG626009
- OMA:   SSLAYQW
- ProtClustDB:   PRK13975
- BioCyc:   MJAN243232:MJ_0293-MONOMER
- BRENDA:   2.7.4.9
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 21687; Mature: 21687

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVDNMFIVFEGIDGSGKTTQSKLLAKKMDAFWTYEPSNSLVGKIIREILSGKTEVDNKTL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCCCCCCE
ALLFAADRIEHTKLIKEELKKRDVVCDRYLYSSIAYQSVAGVDENFIKSINRYALKPDIV
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FLLIVDIETALKRVKTKDIFEKKDFLKKVQDKYLELAEEYNFIVIDTTKKSVEEVHNEII
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
GYLKNIPH
HHHHCCCC
>Mature Secondary Structure
MVDNMFIVFEGIDGSGKTTQSKLLAKKMDAFWTYEPSNSLVGKIIREILSGKTEVDNKTL
CCCCEEEEEECCCCCCCHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHHCCCCCCCCCCE
ALLFAADRIEHTKLIKEELKKRDVVCDRYLYSSIAYQSVAGVDENFIKSINRYALKPDIV
EEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCEE
FLLIVDIETALKRVKTKDIFEKKDFLKKVQDKYLELAEEYNFIVIDTTKKSVEEVHNEII
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCHHHHHHHHHHHH
GYLKNIPH
HHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087