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The map label for this gene is gch3

Identifier: 15668317

GI number: 15668317

Start: 142183

End: 142989

Strand: Reverse

Name: gch3

Synonym: MJ0145

Alternate gene names: 15668317

Gene position: 142989-142183 (Counterclockwise)

Preceding gene: 15668318

Following gene: 15668316

Centisome position: 8.59

GC content: 33.95

Gene sequence:

>807_bases
ATGATTCAAATAACAGTAATTCAGATAGATAATTACGGACCTTGGACAGTTACACCAAATCCAAGAAGAGAGAGCGATTT
ACAAGCTCTGCAGAGCAGATTATACGCTGACTTAAATTTGATGTTTGGGGCTCATAAGGGACTGGTGTTTTACACAAGAT
TTGATAATTTAATAGCTATAACAAATGGTATTGATTTAATTACACACAAAAGAATTCAGGAGAGTATAAGGAATAGATAT
CCTTTCACTGTTAGTATGGTTATTGCTTCAGCTGAAACACCTTATGAAGCTCAAAAATTAGCCACTGAAACACTTCAAGA
GTATGGAAGTGCTCAGGATGAGAATAGAAAGGAAGTTTTAGATGTTGCCAATGAATTGGTTGTTGATGGCTATGTTCAAA
TCGCTCATATAGATATAAACAACATTACTGGGACTCTTACTGACATTGTGAGTGCCTATGACACTTATTTAAATGTGAAT
AAGGTTAAATTGGCTTTAATGGAAGAGCTTTTAAAATATAACGCTCTGTTGTTTTTCATAGGTGGAGATAACTTCATGGC
TCCATCAAACGGAATGAGTGAAGAAGATTTCTTAGATATTTTCAACAGAATCAATAAAAAGTATAAGATTGAGCTAAAAG
CAGGAATTGGAATAGGAAGAACTGCTGAAGATGCCTCAAACTTAGCAGATATTGGTTTAGAAAAAATTAGAGGAAAGTTA
GTTGATAAGAATGTATGCACTTTAAAGCAGGATGACTTCTTAGAATCAAAAATGGGTATGGGAAAAATATACCATCCACA
GTTTTAG

Upstream 100 bases:

>100_bases
ACTACATAAACTTTTTAATGGATAATAATAAATAAAACCATACTGAAGTTAATTATTTACTATACTACATACTTTATAAA
TTAGTGGAAGAGATGGGAAA

Downstream 100 bases:

>100_bases
GTGATTTTATAGATGAACAAAAAAATAGAAGAATTAAATAAATTAGATAAAAAAGTTGTCTTAGCACCAATGGCAGGCAT
TACGGATGGGGATTTCTGCA

Product: GTP cyclohydrolase III

Products: NA

Alternate protein names: MjGC

Number of amino acids: Translated: 268; Mature: 268

Protein sequence:

>268_residues
MIQITVIQIDNYGPWTVTPNPRRESDLQALQSRLYADLNLMFGAHKGLVFYTRFDNLIAITNGIDLITHKRIQESIRNRY
PFTVSMVIASAETPYEAQKLATETLQEYGSAQDENRKEVLDVANELVVDGYVQIAHIDINNITGTLTDIVSAYDTYLNVN
KVKLALMEELLKYNALLFFIGGDNFMAPSNGMSEEDFLDIFNRINKKYKIELKAGIGIGRTAEDASNLADIGLEKIRGKL
VDKNVCTLKQDDFLESKMGMGKIYHPQF

Sequences:

>Translated_268_residues
MIQITVIQIDNYGPWTVTPNPRRESDLQALQSRLYADLNLMFGAHKGLVFYTRFDNLIAITNGIDLITHKRIQESIRNRY
PFTVSMVIASAETPYEAQKLATETLQEYGSAQDENRKEVLDVANELVVDGYVQIAHIDINNITGTLTDIVSAYDTYLNVN
KVKLALMEELLKYNALLFFIGGDNFMAPSNGMSEEDFLDIFNRINKKYKIELKAGIGIGRTAEDASNLADIGLEKIRGKL
VDKNVCTLKQDDFLESKMGMGKIYHPQF
>Mature_268_residues
MIQITVIQIDNYGPWTVTPNPRRESDLQALQSRLYADLNLMFGAHKGLVFYTRFDNLIAITNGIDLITHKRIQESIRNRY
PFTVSMVIASAETPYEAQKLATETLQEYGSAQDENRKEVLDVANELVVDGYVQIAHIDINNITGTLTDIVSAYDTYLNVN
KVKLALMEELLKYNALLFFIGGDNFMAPSNGMSEEDFLDIFNRINKKYKIELKAGIGIGRTAEDASNLADIGLEKIRGKL
VDKNVCTLKQDDFLESKMGMGKIYHPQF

Specific function: Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity

COG id: COG2429

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the archaeal-type GTP cyclohydrolase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH3_METJA (Q57609)

Other databases:

- EMBL:   L77117
- PIR:   B64318
- RefSeq:   NP_247113.1
- PDB:   2QV6
- PDBsum:   2QV6
- ProteinModelPortal:   Q57609
- SMR:   Q57609
- GeneID:   1450989
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0145
- NMPDR:   fig|243232.1.peg.150
- TIGR:   MJ0145
- HOGENOM:   HBG497452
- OMA:   FIGGDNF
- ProtClustDB:   PRK02240
- BioCyc:   MetaCyc:MONOMER-14598
- BioCyc:   MJAN243232:MJ_0145-MONOMER
- BRENDA:   3.5.4.29
- HAMAP:   MF_00608
- InterPro:   IPR007839
- PIRSF:   PIRSF009265
- ProDom:   PD313320

Pfam domain/function: PF05165 GGDN

EC number: =3.5.4.29

Molecular weight: Translated: 30286; Mature: 30286

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIQITVIQIDNYGPWTVTPNPRRESDLQALQSRLYADLNLMFGAHKGLVFYTRFDNLIAI
CEEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCEEEE
TNGIDLITHKRIQESIRNRYPFTVSMVIASAETPYEAQKLATETLQEYGSAQDENRKEVL
ECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHH
DVANELVVDGYVQIAHIDINNITGTLTDIVSAYDTYLNVNKVKLALMEELLKYNALLFFI
HHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEE
GGDNFMAPSNGMSEEDFLDIFNRINKKYKIELKAGIGIGRTAEDASNLADIGLEKIRGKL
CCCCEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
VDKNVCTLKQDDFLESKMGMGKIYHPQF
CCCCCCCCCCHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MIQITVIQIDNYGPWTVTPNPRRESDLQALQSRLYADLNLMFGAHKGLVFYTRFDNLIAI
CEEEEEEEECCCCCEECCCCCCCHHHHHHHHHHHHHHHHHEEECCCCEEEEEECCCEEEE
TNGIDLITHKRIQESIRNRYPFTVSMVIASAETPYEAQKLATETLQEYGSAQDENRKEVL
ECCCHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCHHHHH
DVANELVVDGYVQIAHIDINNITGTLTDIVSAYDTYLNVNKVKLALMEELLKYNALLFFI
HHHHHHHHCCEEEEEEEEECCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCEEEEEE
GGDNFMAPSNGMSEEDFLDIFNRINKKYKIELKAGIGIGRTAEDASNLADIGLEKIRGKL
CCCCEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
VDKNVCTLKQDDFLESKMGMGKIYHPQF
CCCCCCCCCCHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087; 12475257