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The map label for this gene is hemA

Identifier: 15668315

GI number: 15668315

Start: 140219

End: 141397

Strand: Direct

Name: hemA

Synonym: MJ0143

Alternate gene names: 15668315

Gene position: 140219-141397 (Clockwise)

Preceding gene: 15668314

Following gene: 15668322

Centisome position: 8.42

GC content: 30.28

Gene sequence:

>1179_bases
ATGATAATACTAAAAGCTGATTATAAAAAATACAACGTCTCTGAATTAGAAAAGCTCAGAATGGATGAAGAAAAATTTTA
TGAGACATTTGATAATGCCATATTATTACAAACATGCAACAGAGTTGAGATAATCTTTGATGCAGATAGCTTAGAAGAAA
TTAAAGGAATCGAAAATATAGATTTAGAAAAATTTGATATTCTATTTGGAGATAAAGCAATAGAACATCTTTTTAGAGTT
GCATGTGGTTTAGAGTCCATGATTGTTGGAGAAGACCAAATACTTGGGCAGTTAAAAAATGCCTATCTAAAAGCAAAAGA
AAAAGGCAGAATATCCAAAAAATTGGAGAAAATTATTTTAAAGGCAATACATACTGGACAAAGGGCAAGAGTAGAGACAA
AGATAAATGAGGGCGGGGTTTCAATTGGCTCTGCGGCAGTTGAATTGGCAGAAAAAATTTTTGGATTAGAAGGGAAAAAT
GTCTTATTAATTGGAGCTGGAGAGATGGCAAATTTAGTTATAAAGGCATTGAAGGAAAAAAACATTAAAGCAATTATCGT
AGCAAATAGGACTTATGAAAAAGCTGAAAAATTAGCTAAAGAACTTGGAGGAATGGCTATAAAGTTTGATAAATTGGAAG
AGGCTTTAAGATATGCCGATATAGTTATATCAGCAACAGGGGCTCCACATCCAATTTTAAATAAGGAGAGGTTAAAAAAT
GCTGGAAAGACAATTATTATAGATATTGCCAATCCAAGAGACACAACTGATGACATTAGAGAACTGCCAGATATTTTTTT
ATTCACAATTGATGATTTAAGATTAGTGGCTGAAGAAAATTTAAAGAAGAGAAAAGAAGAAATCCCAAAGGTTGAGATGA
TTATTTGTGAAGAATTAGAGAGGTTAAAAGAATTTCTTGATAAAATGAGATTTGAAACAGCAATAAAAGAACTTGGGCAA
TATATTGAAAATGTGAGAAAGAAGGAGGTTGAAAAAGCAAAAAAGATATTGAAGAATAAAAATAAGCCAGTTGAGGAAGT
TTTAGAAGATTTTTCAAAGGCATTGTGTAAGAGAATAATTTACGATATAATAAAGATATTTGAGAATGTGGAAGATAAAG
AAGTTTTTGAGTGTTTAGCCAAAGAATTTAAAAAACTTGGCAATAAAAATAAAAATTAA

Upstream 100 bases:

>100_bases
ATAAAAAAGGAAGAGGCTGAATATTTACTTCACAAAGGGCATATATTCTTAAATAAAACTAAAAAATACTTAATATCAAA
AAATATACTAAAGGGAGAGA

Downstream 100 bases:

>100_bases
ATATTCTCTTTATTTAACTCTTTTATCCATTCAACATTACCTTTTAAAATAGTCCTTGCAACAGATACAAAATCAGAGTA
TTTTAACATTTCCTTAGCTT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MIILKADYKKYNVSELEKLRMDEEKFYETFDNAILLQTCNRVEIIFDADSLEEIKGIENIDLEKFDILFGDKAIEHLFRV
ACGLESMIVGEDQILGQLKNAYLKAKEKGRISKKLEKIILKAIHTGQRARVETKINEGGVSIGSAAVELAEKIFGLEGKN
VLLIGAGEMANLVIKALKEKNIKAIIVANRTYEKAEKLAKELGGMAIKFDKLEEALRYADIVISATGAPHPILNKERLKN
AGKTIIIDIANPRDTTDDIRELPDIFLFTIDDLRLVAEENLKKRKEEIPKVEMIICEELERLKEFLDKMRFETAIKELGQ
YIENVRKKEVEKAKKILKNKNKPVEEVLEDFSKALCKRIIYDIIKIFENVEDKEVFECLAKEFKKLGNKNKN

Sequences:

>Translated_392_residues
MIILKADYKKYNVSELEKLRMDEEKFYETFDNAILLQTCNRVEIIFDADSLEEIKGIENIDLEKFDILFGDKAIEHLFRV
ACGLESMIVGEDQILGQLKNAYLKAKEKGRISKKLEKIILKAIHTGQRARVETKINEGGVSIGSAAVELAEKIFGLEGKN
VLLIGAGEMANLVIKALKEKNIKAIIVANRTYEKAEKLAKELGGMAIKFDKLEEALRYADIVISATGAPHPILNKERLKN
AGKTIIIDIANPRDTTDDIRELPDIFLFTIDDLRLVAEENLKKRKEEIPKVEMIICEELERLKEFLDKMRFETAIKELGQ
YIENVRKKEVEKAKKILKNKNKPVEEVLEDFSKALCKRIIYDIIKIFENVEDKEVFECLAKEFKKLGNKNKN
>Mature_392_residues
MIILKADYKKYNVSELEKLRMDEEKFYETFDNAILLQTCNRVEIIFDADSLEEIKGIENIDLEKFDILFGDKAIEHLFRV
ACGLESMIVGEDQILGQLKNAYLKAKEKGRISKKLEKIILKAIHTGQRARVETKINEGGVSIGSAAVELAEKIFGLEGKN
VLLIGAGEMANLVIKALKEKNIKAIIVANRTYEKAEKLAKELGGMAIKFDKLEEALRYADIVISATGAPHPILNKERLKN
AGKTIIIDIANPRDTTDDIRELPDIFLFTIDDLRLVAEENLKKRKEEIPKVEMIICEELERLKEFLDKMRFETAIKELGQ
YIENVRKKEVEKAKKILKNKNKPVEEVLEDFSKALCKRIIYDIIKIFENVEDKEVFECLAKEFKKLGNKNKN

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=400, Percent_Identity=32.5, Blast_Score=187, Evalue=9e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_METJA (Q60172)

Other databases:

- EMBL:   L77117
- PIR:   H64317
- RefSeq:   NP_247111.1
- ProteinModelPortal:   Q60172
- SMR:   Q60172
- GeneID:   1450987
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0143
- NMPDR:   fig|243232.1.peg.148
- TIGR:   MJ0143
- HOGENOM:   HBG732626
- OMA:   IVANRTY
- ProtClustDB:   PRK00045
- BioCyc:   MJAN243232:MJ_0143-MONOMER
- BRENDA:   1.2.1.70
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR003462
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR13812
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 44847; Mature: 44847

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 39-39 BINDING 86-86 BINDING 97-97

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILKADYKKYNVSELEKLRMDEEKFYETFDNAILLQTCNRVEIIFDADSLEEIKGIENI
CEEEECCCCCCCHHHHHHHHCCHHHHHHHHCCCCEEECCCCEEEEECCCHHHHHCCCCCC
DLEKFDILFGDKAIEHLFRVACGLESMIVGEDQILGQLKNAYLKAKEKGRISKKLEKIIL
CCHHHHHHCCCHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAIHTGQRARVETKINEGGVSIGSAAVELAEKIFGLEGKNVLLIGAGEMANLVIKALKEK
HHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHC
NIKAIIVANRTYEKAEKLAKELGGMAIKFDKLEEALRYADIVISATGAPHPILNKERLKN
CCEEEEEECCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHC
AGKTIIIDIANPRDTTDDIRELPDIFLFTIDDLRLVAEENLKKRKEEIPKVEMIICEELE
CCCEEEEECCCCCCCHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RLKEFLDKMRFETAIKELGQYIENVRKKEVEKAKKILKNKNKPVEEVLEDFSKALCKRII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YDIIKIFENVEDKEVFECLAKEFKKLGNKNKN
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MIILKADYKKYNVSELEKLRMDEEKFYETFDNAILLQTCNRVEIIFDADSLEEIKGIENI
CEEEECCCCCCCHHHHHHHHCCHHHHHHHHCCCCEEECCCCEEEEECCCHHHHHCCCCCC
DLEKFDILFGDKAIEHLFRVACGLESMIVGEDQILGQLKNAYLKAKEKGRISKKLEKIIL
CCHHHHHHCCCHHHHHHHHHHHCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KAIHTGQRARVETKINEGGVSIGSAAVELAEKIFGLEGKNVLLIGAGEMANLVIKALKEK
HHHHCCCHHEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHHHHC
NIKAIIVANRTYEKAEKLAKELGGMAIKFDKLEEALRYADIVISATGAPHPILNKERLKN
CCEEEEEECCCHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHEECCCCCCCCCCHHHHHC
AGKTIIIDIANPRDTTDDIRELPDIFLFTIDDLRLVAEENLKKRKEEIPKVEMIICEELE
CCCEEEEECCCCCCCHHHHHHCCHHEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
RLKEFLDKMRFETAIKELGQYIENVRKKEVEKAKKILKNKNKPVEEVLEDFSKALCKRII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
YDIIKIFENVEDKEVFECLAKEFKKLGNKNKN
HHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087