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The map label for this gene is pth

Identifier: 15668222

GI number: 15668222

Start: 52347

End: 52694

Strand: Direct

Name: pth

Synonym: MJ0051

Alternate gene names: 15668222

Gene position: 52347-52694 (Clockwise)

Preceding gene: 15668218

Following gene: 15668230

Centisome position: 3.14

GC content: 37.07

Gene sequence:

>348_bases
ATGAAGATGGTTGTAGTAATAAGGAACGATTTAGGTATGGGAAAGGGAAAGATGGTAGCTCAGGGAGGACATGCAATAAT
AGAGGCTTTCTTAGATGCTAAAAGGAAAAATCCAAGGGCTGTTGATGAATGGTTGAGAGAAGGACAGAAAAAGGTAGTGG
TTAAAGTAAATTCTGAAAAAGAGTTGATAGATATTTACAACAAAGCAAGAAGTGAAGGATTGCCGTGCTCAATCATTAGA
GATGCAGGACATACACAATTAGAGCCAGGAACTTTGACAGCTGTAGCCATAGGCCCTGAGAAAGATGAGAAAATAGATAA
AATAACAGGACATTTAAAACTTTTATAA

Upstream 100 bases:

>100_bases
TTTTTAGTTGATAAACATCATGATTAAATTTATAAGTATTTAATGCGTTCTTAGGTATAAATATAATACAATATACTAAA
CATTTATTTGAGGTTTAATT

Downstream 100 bases:

>100_bases
ATTTAAATTTTTTATTTATCTACTGCATGCTTAAACGCTTTAAAGCCACCTATTAATCTTTTAACTTTAAAACCCAATAG
TTGTAAAATTAAAGCCATTG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 115; Mature: 115

Protein sequence:

>115_residues
MKMVVVIRNDLGMGKGKMVAQGGHAIIEAFLDAKRKNPRAVDEWLREGQKKVVVKVNSEKELIDIYNKARSEGLPCSIIR
DAGHTQLEPGTLTAVAIGPEKDEKIDKITGHLKLL

Sequences:

>Translated_115_residues
MKMVVVIRNDLGMGKGKMVAQGGHAIIEAFLDAKRKNPRAVDEWLREGQKKVVVKVNSEKELIDIYNKARSEGLPCSIIR
DAGHTQLEPGTLTAVAIGPEKDEKIDKITGHLKLL
>Mature_115_residues
MKMVVVIRNDLGMGKGKMVAQGGHAIIEAFLDAKRKNPRAVDEWLREGQKKVVVKVNSEKELIDIYNKARSEGLPCSIIR
DAGHTQLEPGTLTAVAIGPEKDEKIDKITGHLKLL

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG1990

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH2 family

Homologues:

Organism=Homo sapiens, GI7706351, Length=113, Percent_Identity=49.5575221238938, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17558188, Length=116, Percent_Identity=38.7931034482759, Blast_Score=75, Evalue=6e-15,
Organism=Saccharomyces cerevisiae, GI6319414, Length=120, Percent_Identity=39.1666666666667, Blast_Score=88, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281376919, Length=115, Percent_Identity=46.9565217391304, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24644665, Length=115, Percent_Identity=46.9565217391304, Blast_Score=107, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24646438, Length=118, Percent_Identity=38.135593220339, Blast_Score=89, Evalue=5e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_METJA (Q60363)

Other databases:

- EMBL:   L77117
- PIR:   C64306
- RefSeq:   NP_247015.1
- PDB:   2ZV3
- PDBsum:   2ZV3
- ProteinModelPortal:   Q60363
- SMR:   Q60363
- GeneID:   1450890
- GenomeReviews:   L77117_GR
- KEGG:   mja:MJ_0051
- NMPDR:   fig|243232.1.peg.52
- TIGR:   MJ0051
- HOGENOM:   HBG526257
- OMA:   IQRRNPE
- ProtClustDB:   PRK04322
- BioCyc:   MJAN243232:MJ_0051-MONOMER
- BRENDA:   3.1.1.29
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00628
- InterPro:   IPR002833
- TIGRFAMs:   TIGR00283

Pfam domain/function: PF01981 PTH2

EC number: =3.1.1.29

Molecular weight: Translated: 12670; Mature: 12670

Theoretical pI: Translated: 9.93; Mature: 9.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKMVVVIRNDLGMGKGKMVAQGGHAIIEAFLDAKRKNPRAVDEWLREGQKKVVVKVNSEK
CEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCH
ELIDIYNKARSEGLPCSIIRDAGHTQLEPGTLTAVAIGPEKDEKIDKITGHLKLL
HHHHHHHHHHCCCCCEEEEECCCCCEECCCCEEEEEECCCCCHHHHHHHCEEECC
>Mature Secondary Structure
MKMVVVIRNDLGMGKGKMVAQGGHAIIEAFLDAKRKNPRAVDEWLREGQKKVVVKVNSEK
CEEEEEEECCCCCCCCCEEECCCHHHHHHHHHHCCCCCCHHHHHHHCCCEEEEEEECCCH
ELIDIYNKARSEGLPCSIIRDAGHTQLEPGTLTAVAIGPEKDEKIDKITGHLKLL
HHHHHHHHHHCCCCCEEEEECCCCCEECCCCEEEEEECCCCCHHHHHHHCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087