Click here to switch to the map view.

The map label for this gene is pepE [H]

Identifier: 30995387

GI number: 30995387

Start: 608461

End: 609117

Strand: Reverse

Name: pepE [H]

Synonym: HI0587

Alternate gene names: 30995387

Gene position: 609117-608461 (Counterclockwise)

Preceding gene: 16272534

Following gene: 16272530

Centisome position: 33.28

GC content: 38.2

Gene sequence:

>657_bases
ATGAAAAATATGTTACTGCTCAGTAGCTCAAAATACAAGAACACAGGTTATCTTGAACACACCATACCTTGGTTACAAAA
TTTCTTGGCTGATTATCGTGGTAAAACAATTGCTTTTGTACCTTATGCTGGGGTGAGCCGCACTTTTGATGAATATGAAA
AAACTGTGCAAAATGCACTTTCTGATTTAGGGATGAATATTGTTTCCGTTCATCGTGGCAAACAGCATCGAGATATTATT
GAACAAGCAGATGTCATCGCTATTGGCGGCGGGAATACATTTTGTTTGTTAAAACAGCTTTATGAACACAATTTGATTGA
TATCATTCGTGAAAAAGTAAATAACGGTACGCCTTATTTTGGTTGGAGTGCTGGGGCCAATGTAGCTGGCTCATCTATTA
TGACAACTAATGATATGCCGATTACTTATCCTCCTTCATTTCAAGCATTACAGCTTTTTCCTCATCAAATTAATCCGCAC
TTTATTTCAGGTAAAATGCAAGGCCACAATGGTGAAAGCCGAGAAGAACGTTTGGCAGAATTTTTACTCGTTAATCCAAC
CGCACTTGTATATGCATTACCTGAAGGTTCTGCGCTTCATATACAAAATGGAATGGGCAACCGTATTGGGCGAAAATCCT
ATTTTGTGCTTCAGTGA

Upstream 100 bases:

>100_bases
TTTTTGATATTCGTCAAACAATTATAATTTTTCGTTGAAAATTAACCTTTTCTAAGCGTAATATTGGTATTGCTAAATGC
CCCTAAAAAGGATTATAAAT

Downstream 100 bases:

>100_bases
AAATATGGAATGTGGCACATTTGATATCAATACAACTTTTTCTTATTAACTTAAAGGGAACATATAATGGAATTATTTAA
ATCCATCGTTGCAGTGATTG

Product: peptidase E

Products: NA

Alternate protein names: Alpha-aspartyl dipeptidase; Asp-specific dipeptidase; Dipeptidase E [H]

Number of amino acids: Translated: 218; Mature: 218

Protein sequence:

>218_residues
MKNMLLLSSSKYKNTGYLEHTIPWLQNFLADYRGKTIAFVPYAGVSRTFDEYEKTVQNALSDLGMNIVSVHRGKQHRDII
EQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNGTPYFGWSAGANVAGSSIMTTNDMPITYPPSFQALQLFPHQINPH
FISGKMQGHNGESREERLAEFLLVNPTALVYALPEGSALHIQNGMGNRIGRKSYFVLQ

Sequences:

>Translated_218_residues
MKNMLLLSSSKYKNTGYLEHTIPWLQNFLADYRGKTIAFVPYAGVSRTFDEYEKTVQNALSDLGMNIVSVHRGKQHRDII
EQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNGTPYFGWSAGANVAGSSIMTTNDMPITYPPSFQALQLFPHQINPH
FISGKMQGHNGESREERLAEFLLVNPTALVYALPEGSALHIQNGMGNRIGRKSYFVLQ
>Mature_218_residues
MKNMLLLSSSKYKNTGYLEHTIPWLQNFLADYRGKTIAFVPYAGVSRTFDEYEKTVQNALSDLGMNIVSVHRGKQHRDII
EQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNGTPYFGWSAGANVAGSSIMTTNDMPITYPPSFQALQLFPHQINPH
FISGKMQGHNGESREERLAEFLLVNPTALVYALPEGSALHIQNGMGNRIGRKSYFVLQ

Specific function: Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids [H]

COG id: COG3340

COG function: function code E; Peptidase E

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S51 family [H]

Homologues:

Organism=Escherichia coli, GI1790452, Length=215, Percent_Identity=41.3953488372093, Blast_Score=179, Evalue=2e-46,
Organism=Drosophila melanogaster, GI24641669, Length=189, Percent_Identity=46.031746031746, Blast_Score=159, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005320
- InterPro:   IPR023172 [H]

Pfam domain/function: PF03575 Peptidase_S51 [H]

EC number: =3.4.13.21 [H]

Molecular weight: Translated: 24420; Mature: 24420

Theoretical pI: Translated: 8.42; Mature: 8.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNMLLLSSSKYKNTGYLEHTIPWLQNFLADYRGKTIAFVPYAGVSRTFDEYEKTVQNAL
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHH
SDLGMNIVSVHRGKQHRDIIEQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNGTPYF
HHCCCCEEEHHCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCC
GWSAGANVAGSSIMTTNDMPITYPPSFQALQLFPHQINPHFISGKMQGHNGESREERLAE
CCCCCCCCCCCEEEEECCCCEECCCCCHHHHHCCCCCCCEEEECEECCCCCCHHHHHHHH
FLLVNPTALVYALPEGSALHIQNGMGNRIGRKSYFVLQ
HHEECCCEEEEECCCCCEEEEECCCCCCCCCCEEEEEC
>Mature Secondary Structure
MKNMLLLSSSKYKNTGYLEHTIPWLQNFLADYRGKTIAFVPYAGVSRTFDEYEKTVQNAL
CCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHH
SDLGMNIVSVHRGKQHRDIIEQADVIAIGGGNTFCLLKQLYEHNLIDIIREKVNNGTPYF
HHCCCCEEEHHCCCHHHHHHHHCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHCCCCCCC
GWSAGANVAGSSIMTTNDMPITYPPSFQALQLFPHQINPHFISGKMQGHNGESREERLAE
CCCCCCCCCCCEEEEECCCCEECCCCCHHHHHCCCCCCCEEEECEECCCCCCHHHHHHHH
FLLVNPTALVYALPEGSALHIQNGMGNRIGRKSYFVLQ
HHEECCCEEEEECCCCCEEEEECCCCCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA