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The map label for this gene is moaA [H]

Identifier: 16273563

GI number: 16273563

Start: 1744224

End: 1745237

Strand: Reverse

Name: moaA [H]

Synonym: HI1676

Alternate gene names: 16273563

Gene position: 1745237-1744224 (Counterclockwise)

Preceding gene: 16273567

Following gene: 16273562

Centisome position: 95.36

GC content: 38.26

Gene sequence:

>1014_bases
ATGCAATCCATTCCTATTAAAAACGTAGGAGAGTCTCGCTTAGTCGATCCTTTCCAACGTCAATATTACTATCTACGGCT
GTCGATTACCGATCAGTGTAATTTTCGTTGTACTTATTGTTTACCTGATGGTTATCAACCCGAAGCTAACAAACCAAGTT
TCTTAACTTTAAAAGAAATTACCCATCTTGCTCAAGCCTTTGCTGAAATGGGCACAGAGAAAATCCGTTTAACGGGTGGC
GAACCGACTTTACGCAAAGATTTTATTTCTATTGCTGAAAGCATTACTAACATTGATGGCATTCGTCAATTAGCCGTCAC
GACAAACGGCTATCGCATGGCAAAAGATGTGGCTGATTGGAAGAAAGCAGGGATTACGTCTATTAACGTCAGTGTTGATA
GTCTTGATCCCAAAATGTTCCATCAAATTACAGGTATCAATAAATTTGATGACGTGATGCGTGGTATCGATCGTGCATTT
GAAGTGGGCTACAACAAAGTTAAAGTCAATTCAGTTTTAATGAAAAATCTGAATGATAAAGAATTTGAACAATTTCTCGC
TTGGGTTAAAGATCGCCCAATTCAAATGCGCTTTATCGAACTCATGCAAACGGGCGAAATGGATAGTTTCTTTGATAAAT
TCCATCTTTCTGGACAAGTCTTAGCGGATAAATTGTTGAAAAATGGTTGGACATTACAACACAAATCCCATACTGATGGT
CCTGCTAAAGTATTCACGCATCCTGATTATGCAGGCGAAATTGGTTTAATTATGCCTTATGAAAAGAATTTTTGCGCAAG
TTGCAATCGTTTAAGAGTGTCAGCAAAAGGTAAACTTCATCTTTGTTTATTTGGCGAAGAAGGCATTGAATTACGTGATT
TATTGCAGTCGCACGAACAGCAAGGTATTTTACAGGCTCGTATTTTTGCCGCACTTCAAGGCAAACGTGAACATCATTAT
TTGCATATCGGCGATACTGGTGTAAGAAATCATTTAGCTTCTATTGGTGGCTAA

Upstream 100 bases:

>100_bases
CTAAGTTTCATAGAAATACGGTGGCAAGCCAATAACGCGCTACGTTATTCAGGGATACGCTGGAAACGGTTTATCCTCTC
CGTATTTAGAAAGGTGTAAA

Downstream 100 bases:

>100_bases
AAAGCAAAGTGAGATGAATGGTAATATTCATCTGCTTCCTTTTGTCGCTTATTTAAAACATTCAATATTTTAACCGCACT
TTTATTATATTATGACTACA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEITHLAQAFAEMGTEKIRLTGG
EPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADWKKAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAF
EVGYNKVKVNSVLMKNLNDKEFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
PAKVFTHPDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQQGILQARIFAALQGKREHHY
LHIGDTGVRNHLASIGG

Sequences:

>Translated_337_residues
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEITHLAQAFAEMGTEKIRLTGG
EPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADWKKAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAF
EVGYNKVKVNSVLMKNLNDKEFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
PAKVFTHPDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQQGILQARIFAALQGKREHHY
LHIGDTGVRNHLASIGG
>Mature_337_residues
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEITHLAQAFAEMGTEKIRLTGG
EPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADWKKAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAF
EVGYNKVKVNSVLMKNLNDKEFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
PAKVFTHPDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQQGILQARIFAALQGKREHHY
LHIGDTGVRNHLASIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=38.5321100917431, Blast_Score=231, Evalue=9e-61,
Organism=Homo sapiens, GI22027536, Length=327, Percent_Identity=38.5321100917431, Blast_Score=230, Evalue=1e-60,
Organism=Escherichia coli, GI1786999, Length=327, Percent_Identity=61.7737003058104, Blast_Score=439, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI32566331, Length=311, Percent_Identity=36.0128617363344, Blast_Score=207, Evalue=8e-54,
Organism=Caenorhabditis elegans, GI32566329, Length=311, Percent_Identity=36.0128617363344, Blast_Score=207, Evalue=9e-54,
Organism=Caenorhabditis elegans, GI17561210, Length=312, Percent_Identity=35.8974358974359, Blast_Score=204, Evalue=7e-53,
Organism=Drosophila melanogaster, GI28574490, Length=332, Percent_Identity=36.7469879518072, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI28574488, Length=339, Percent_Identity=35.9882005899705, Blast_Score=213, Evalue=1e-55,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 38305; Mature: 38305

Theoretical pI: Translated: 8.15; Mature: 8.15

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEI
CCCCCCCCCCCCCCCCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHHH
THLAQAFAEMGTEKIRLTGGEPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADW
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHH
KKAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAFEVGYNKVKVNSVLMKNLNDK
HHCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCHH
EFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCC
PAKVFTHPDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQ
CCEEEECCCCCCCEEEEECCCCCHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
QGILQARIFAALQGKREHHYLHIGDTGVRNHLASIGG
CCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCC
>Mature Secondary Structure
MQSIPIKNVGESRLVDPFQRQYYYLRLSITDQCNFRCTYCLPDGYQPEANKPSFLTLKEI
CCCCCCCCCCCCCCCCHHHCCEEEEEEEEECCCCCEEEEECCCCCCCCCCCCCEEEHHHH
THLAQAFAEMGTEKIRLTGGEPTLRKDFISIAESITNIDGIRQLAVTTNGYRMAKDVADW
HHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHH
KKAGITSINVSVDSLDPKMFHQITGINKFDDVMRGIDRAFEVGYNKVKVNSVLMKNLNDK
HHCCCEEEEEECCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEHHHHHHHCCCHH
EFEQFLAWVKDRPIQMRFIELMQTGEMDSFFDKFHLSGQVLADKLLKNGWTLQHKSHTDG
HHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHCCCEEEECCCCCC
PAKVFTHPDYAGEIGLIMPYEKNFCASCNRLRVSAKGKLHLCLFGEEGIELRDLLQSHEQ
CCEEEECCCCCCCEEEEECCCCCHHCCCCEEEEECCCCEEEEEECCCCCHHHHHHHHHHH
QGILQARIFAALQGKREHHYLHIGDTGVRNHLASIGG
CCHHHHHHHHHHCCCCCCEEEEECCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA