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The map label for this gene is nrdB

Identifier: 16273547

GI number: 16273547

Start: 1726925

End: 1728055

Strand: Direct

Name: nrdB

Synonym: HI1660

Alternate gene names: 16273547

Gene position: 1726925-1728055 (Clockwise)

Preceding gene: 30995466

Following gene: 16273558

Centisome position: 94.36

GC content: 37.93

Gene sequence:

>1131_bases
ATGGCATACACCACTTTTTCCCAAAATAAAAACGATCAATTAAAAGAACCGATGTTCTTTGGTCAAAACGTTAATGTTGC
GCGTTACGATCAACAAAAATATGAGACGTTTGAGAAGCTGATTGAAAAACAACTTTCTTTTTTCTGGCGTCCAGAAGAAG
TAGATGTATCGCAAGACCGTATCGACTACGCAGCATTGCCTGAACACGAAAAACACATCTTCATCAGCAACTTAAAATAT
CAAACCTTATTGGATTCTATTCAAGGCCGTAGCCCGAACGTGGCATTATTGCCTTTAGTGTCGATTCCTGAATTAGAAAC
TTGGATTGAGACGTGGACATTCTCTGAAACCATCCACTCTCGCTCTTACACACATATTATTCGTAATATTGTGAACGATC
CTTCTATCGTATTTGATGACATCGTAACTAACGAAGAAATCATCAAACGCGCACAAGATATTTCATCTTACTACGATGAT
TTAATCCGTGATAGCCAACTTTATGGCTTATACGGCGAAGGCACTTATACCGTAGATGGCAAAGAATGCGTCGTGACTTT
ACGTAGTTTGAAAAAACAACTTTATCTTTGCCTAATGAGCGTGAATGCACTTGAAGCAATTCGTTTCTACGTTTCTTTCG
CTTGTTCATTTGCTTTTGCTGAACGTCGTTTAATGGAAGGGAATGCAAAAATTATTAAATTTATCGCACGTGATGAAGCC
TTGCATTTAACAGGTACACAGCATATTTTAAATATTATGGCTGCAGGTCAAGACGATCCTGAAATGGCAGAAATTGCGGA
AGAATGTAAACAAGAAGCCTATGATTTATTTGTTGCAGCGGCAGAACAAGAAAAAGCTTGGGCTGATTATCTATTTAAAG
ACGGTTCTATGATCGGCCTCAACAGAGATATTTTAGTTCAATACGTAGAATATATTACTAATATCCGTATGCAAGCTGTT
GGATTGCCACTACCATTCCAAACACGTTCAAATCCAATTCCTTGGATTAACGCTTGGTTAGTGTCAGATAACGTACAGGT
TGCACCACAAGAAGTAGAAGTAAGCTCTTATCTTGTCGGTCAAATTGACTCAAAAGTTGATACGAATGATTTTGACGATT
TTTCTCTCTAA

Upstream 100 bases:

>100_bases
GACATAACGAATTAGGATACTTTCCTCAGTCTTTGATAGTTTCCCCTGATAAACAGGGAAAGCTAAATAAATGATAAGTT
CTATTTAAAGGATAAATAAA

Downstream 100 bases:

>100_bases
TTAAAAACACATAAAAAACTAACCGCACTTTGGAATATTCTTTTTAAATATTTAAAGTGCGGTTAATTTTTTGTTCATTT
TAAAAGGCTTTCTAACACAG

Product: ribonucleotide-diphosphate reductase subunit beta

Products: NA

Alternate protein names: Ribonucleotide reductase small subunit

Number of amino acids: Translated: 376; Mature: 375

Protein sequence:

>376_residues
MAYTTFSQNKNDQLKEPMFFGQNVNVARYDQQKYETFEKLIEKQLSFFWRPEEVDVSQDRIDYAALPEHEKHIFISNLKY
QTLLDSIQGRSPNVALLPLVSIPELETWIETWTFSETIHSRSYTHIIRNIVNDPSIVFDDIVTNEEIIKRAQDISSYYDD
LIRDSQLYGLYGEGTYTVDGKECVVTLRSLKKQLYLCLMSVNALEAIRFYVSFACSFAFAERRLMEGNAKIIKFIARDEA
LHLTGTQHILNIMAAGQDDPEMAEIAEECKQEAYDLFVAAAEQEKAWADYLFKDGSMIGLNRDILVQYVEYITNIRMQAV
GLPLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSKVDTNDFDDFSL

Sequences:

>Translated_376_residues
MAYTTFSQNKNDQLKEPMFFGQNVNVARYDQQKYETFEKLIEKQLSFFWRPEEVDVSQDRIDYAALPEHEKHIFISNLKY
QTLLDSIQGRSPNVALLPLVSIPELETWIETWTFSETIHSRSYTHIIRNIVNDPSIVFDDIVTNEEIIKRAQDISSYYDD
LIRDSQLYGLYGEGTYTVDGKECVVTLRSLKKQLYLCLMSVNALEAIRFYVSFACSFAFAERRLMEGNAKIIKFIARDEA
LHLTGTQHILNIMAAGQDDPEMAEIAEECKQEAYDLFVAAAEQEKAWADYLFKDGSMIGLNRDILVQYVEYITNIRMQAV
GLPLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSKVDTNDFDDFSL
>Mature_375_residues
AYTTFSQNKNDQLKEPMFFGQNVNVARYDQQKYETFEKLIEKQLSFFWRPEEVDVSQDRIDYAALPEHEKHIFISNLKYQ
TLLDSIQGRSPNVALLPLVSIPELETWIETWTFSETIHSRSYTHIIRNIVNDPSIVFDDIVTNEEIIKRAQDISSYYDDL
IRDSQLYGLYGEGTYTVDGKECVVTLRSLKKQLYLCLMSVNALEAIRFYVSFACSFAFAERRLMEGNAKIIKFIARDEAL
HLTGTQHILNIMAAGQDDPEMAEIAEECKQEAYDLFVAAAEQEKAWADYLFKDGSMIGLNRDILVQYVEYITNIRMQAVG
LPLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVGQIDSKVDTNDFDDFSL

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides

COG id: COG0208

COG function: function code F; Ribonucleotide reductase, beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribonucleoside diphosphate reductase small chain family

Homologues:

Organism=Escherichia coli, GI1788567, Length=376, Percent_Identity=85.3723404255319, Blast_Score=676, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): RIR2_HAEIN (P43755)

Other databases:

- EMBL:   L42023
- PIR:   C64135
- RefSeq:   NP_439802.1
- ProteinModelPortal:   P43755
- SMR:   P43755
- GeneID:   950858
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1660
- TIGR:   HI_1660
- HOGENOM:   HBG296569
- OMA:   QHMLNLM
- ProtClustDB:   PRK09101
- BioCyc:   HINF71421:HI_1660-MONOMER
- BRENDA:   1.17.4.1
- InterPro:   IPR009078
- InterPro:   IPR012348
- InterPro:   IPR000358
- Gene3D:   G3DSA:1.10.620.20
- PANTHER:   PTHR23409

Pfam domain/function: PF00268 Ribonuc_red_sm; SSF47240 Ferritin/RR_like

EC number: =1.17.4.1

Molecular weight: Translated: 43326; Mature: 43195

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00368 RIBORED_SMALL

Important sites: ACT_SITE 123-123

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYTTFSQNKNDQLKEPMFFGQNVNVARYDQQKYETFEKLIEKQLSFFWRPEEVDVSQDR
CCEECCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
IDYAALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSIPELETWIETWTFSETIHS
CCHHCCCCCCCEEEEECCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
RSYTHIIRNIVNDPSIVFDDIVTNEEIIKRAQDISSYYDDLIRDSQLYGLYGEGTYTVDG
HHHHHHHHHHHCCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECH
KECVVTLRSLKKQLYLCLMSVNALEAIRFYVSFACSFAFAERRLMEGNAKIIKFIARDEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCE
LHLTGTQHILNIMAAGQDDPEMAEIAEECKQEAYDLFVAAAEQEKAWADYLFKDGSMIGL
EEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
NRDILVQYVEYITNIRMQAVGLPLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVG
CHHHHHHHHHHHHCCHHHEECCCCCCCCCCCCCCEEEEEEEECCCEECCHHHHHHHHHHH
QIDSKVDTNDFDDFSL
HHCCCCCCCCCCCCCC
>Mature Secondary Structure 
AYTTFSQNKNDQLKEPMFFGQNVNVARYDQQKYETFEKLIEKQLSFFWRPEEVDVSQDR
CEECCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHC
IDYAALPEHEKHIFISNLKYQTLLDSIQGRSPNVALLPLVSIPELETWIETWTFSETIHS
CCHHCCCCCCCEEEEECCHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHH
RSYTHIIRNIVNDPSIVFDDIVTNEEIIKRAQDISSYYDDLIRDSQLYGLYGEGTYTVDG
HHHHHHHHHHHCCCCEEHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEECH
KECVVTLRSLKKQLYLCLMSVNALEAIRFYVSFACSFAFAERRLMEGNAKIIKFIARDEA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCE
LHLTGTQHILNIMAAGQDDPEMAEIAEECKQEAYDLFVAAAEQEKAWADYLFKDGSMIGL
EEECCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEC
NRDILVQYVEYITNIRMQAVGLPLPFQTRSNPIPWINAWLVSDNVQVAPQEVEVSSYLVG
CHHHHHHHHHHHHCCHHHEECCCCCCCCCCCCCCEEEEEEEECCCEECCHHHHHHHHHHH
QIDSKVDTNDFDDFSL
HHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800