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The map label for this gene is purE

Identifier: 16273505

GI number: 16273505

Start: 1682965

End: 1683459

Strand: Direct

Name: purE

Synonym: HI1615

Alternate gene names: 16273505

Gene position: 1682965-1683459 (Clockwise)

Preceding gene: 16273503

Following gene: 16273506

Centisome position: 91.96

GC content: 44.85

Gene sequence:

>495_bases
ATGTCAAAAACTGCACAAATTGCCGTTGTAATGGGTTCCAAAAGCGATTGGGCTACTATGCAAGAGGCAACTCAGATTTT
AGATGAATTAAACGTGCCTTATCATGTGGAAGTCGTCTCGGCTCATCGTACGCCTGATAAACTTTTTGAATTTGCTGAAA
ATGCACAAAAAAATGGCTATAAAGTAATTATTGCTGGTGCAGGGGGGGCGGCACATTTACCCGGTATGATCGCAGCGAAA
ACACTTGTGCCAGTGCTGGGGGTGCCAGTAAAAAGTTCTATGTTAAGTGGTGTGGATAGCCTTTATTCAATTGTGCAAAT
GCCAAAAGGGATTCCTGTCGGAACATTAGCGATTGGCCCTGCGGGTGCGGCAAATGCTGGGTTGTTAGCAGCCCAAATTC
TAGCAGGTTGGGATGATGCGTTATTCACTCGCCTACAAGCATTCCGCGAAAATCAAACCAATATGGTATTGGACAATCCT
GATCCACGCACATAA

Upstream 100 bases:

>100_bases
TGGTATTTTCCTATAAAAGCCATTTAGCAAACGTTTGCCTGATATATGTAAGATGTGCTATTCTACGCCACGTTTTTAAT
TAGAAAATTGAGAAAATAGC

Downstream 100 bases:

>100_bases
AAACATCTTTAGATCTGACCGCACTTTTAAAGTGCGGTTGTTTTTTTCGTAAATTTAACGAGAAATATTATGCAAAACTC
CACCTTATACCCAACGGTTT

Product: phosphoribosylaminoimidazole carboxylase catalytic subunit

Products: NA

Alternate protein names: N5-CAIR mutase; 5-(carboxyamino)imidazole ribonucleotide mutase

Number of amino acids: Translated: 164; Mature: 163

Protein sequence:

>164_residues
MSKTAQIAVVMGSKSDWATMQEATQILDELNVPYHVEVVSAHRTPDKLFEFAENAQKNGYKVIIAGAGGAAHLPGMIAAK
TLVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQILAGWDDALFTRLQAFRENQTNMVLDNP
DPRT

Sequences:

>Translated_164_residues
MSKTAQIAVVMGSKSDWATMQEATQILDELNVPYHVEVVSAHRTPDKLFEFAENAQKNGYKVIIAGAGGAAHLPGMIAAK
TLVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQILAGWDDALFTRLQAFRENQTNMVLDNP
DPRT
>Mature_163_residues
SKTAQIAVVMGSKSDWATMQEATQILDELNVPYHVEVVSAHRTPDKLFEFAENAQKNGYKVIIAGAGGAAHLPGMIAAKT
LVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGPAGAANAGLLAAQILAGWDDALFTRLQAFRENQTNMVLDNPD
PRT

Specific function: Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)

COG id: COG0041

COG function: function code F; Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the AIR carboxylase family

Homologues:

Organism=Escherichia coli, GI1786734, Length=159, Percent_Identity=77.9874213836478, Blast_Score=216, Evalue=6e-58,
Organism=Saccharomyces cerevisiae, GI6324702, Length=151, Percent_Identity=51.6556291390728, Blast_Score=158, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURE_HAEIN (P43849)

Other databases:

- EMBL:   L42023
- EMBL:   Z33502
- PIR:   G64132
- PIR:   S54434
- RefSeq:   NP_439757.1
- ProteinModelPortal:   P43849
- SMR:   P43849
- GeneID:   949616
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1615
- NMPDR:   fig|71421.1.peg.1531
- TIGR:   HI_1615
- HOGENOM:   HBG301965
- OMA:   GVVMGSS
- ProtClustDB:   CLSK870172
- BioCyc:   HINF71421:HI_1615-MONOMER
- BRENDA:   4.1.1.21
- InterPro:   IPR000031
- Gene3D:   G3DSA:3.40.50.7700
- PANTHER:   PTHR23046
- TIGRFAMs:   TIGR01162

Pfam domain/function: PF00731 AIRC; SSF52255 AIR_carboxyl

EC number: =5.4.99.18

Molecular weight: Translated: 17269; Mature: 17138

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: BINDING 13-13 BINDING 16-16 BINDING 43-43

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKTAQIAVVMGSKSDWATMQEATQILDELNVPYHVEVVSAHRTPDKLFEFAENAQKNGY
CCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCC
KVIIAGAGGAAHLPGMIAAKTLVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGP
EEEEEECCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
AGAANAGLLAAQILAGWDDALFTRLQAFRENQTNMVLDNPDPRT
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCC
>Mature Secondary Structure 
SKTAQIAVVMGSKSDWATMQEATQILDELNVPYHVEVVSAHRTPDKLFEFAENAQKNGY
CCCEEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHCCCCC
KVIIAGAGGAAHLPGMIAAKTLVPVLGVPVKSSMLSGVDSLYSIVQMPKGIPVGTLAIGP
EEEEEECCCCHHCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECC
AGAANAGLLAAQILAGWDDALFTRLQAFRENQTNMVLDNPDPRT
CCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 7997179