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The map label for this gene is lolE

Identifier: 16273448

GI number: 16273448

Start: 1619170

End: 1620420

Strand: Reverse

Name: lolE

Synonym: HI1548

Alternate gene names: 16273448

Gene position: 1620420-1619170 (Counterclockwise)

Preceding gene: 16273449

Following gene: 16273447

Centisome position: 88.54

GC content: 37.97

Gene sequence:

>1251_bases
ATGAATACGCCTTTTTTTATTAGCTGGCGTTATCAACGTGGCAAACAAAAAAATCCTTTAGTCGCGTTAATTGCAAAATT
TTCTGCAATTGGTATTGCATTGGGTGTTGCAGTTTTAATTGTTGGTTTAAGTGCGATGAATGGTTTTGAGCGTGAGCTTA
ATCAACGAATTCTTGCAGTGGTTCCCCATGCAGAGATTTTATCTGCACCCAATGCGACGGAACCAACCATTCACCATTGG
CAAAATTTAGAAAAACGCCTACAACAAAATCCACAAATTAAAGGAATCTCTCCTTTTGTTAGCTTTACGGCATTGGTAGA
AAATGGCTCAAAATTGAAAGTTGTTCAGGTCAAAGGTGTTGAAAAACAAGCAGAAGATAAGGTAAGTTCAATTGGCAATT
TTGTACAAGAGCAAGGTTGGAACAAATTTGAGAAAGAAGGCGGATTGGTCTTGGGATCGGGTATCGCTAAAGAACTTGAT
GTAAAAGTAGGGGATTGGATTACCTTGCTTATTTCTCAGCAAAACGGCGATGAACAATTTGCTCAACCAACTCGTGAGCC
AGTGCAAGTTACCTCTATTTTACGCTTAGATGGTCAGCTTGATTATAGTTATGCCTTATTGCCGCTTGCTCAAGCACAAA
CCTTTTTGACTTATCAACCTGATCAAATTACAGGTGTTGAATTGAAATTAGATGATCCTTTTTCTGCGAGAAATCTGGAT
TTATCAATGCTTAATGATTATCCGCAGATGCTATATATGCAAAATTGGATTAGTAAATTTGGTTATATGTATCGCGATAT
TCAGCTTATTAGAACCGTAATGTATATCGCAATGGTGCTTGTGATCGGTGTTGCGTGTTTTAATATTGTTTCTACGCTGA
TTATGGCAGTAAAAGATAAGCAAGGCGATATTGCCATTATGCGCACGCTTGGGGCGAATAATGCGTTTATCAAACGTATT
TTTATTTGGTATGGCTTACAGGCAGGAATGAAAGGTTGCTTAATTGGAATTGTGTTAGGCATTATACTTGCATTAAATCT
TACAACCTTTATTCAAGGTATTGAGTGGGTTATCGGTAAGAAATTATTATCGGGCGATGTGTATTTTGTGGATTTCTTGC
CAAGCGAGTTGCATTGGTTGGATGTTTTGATGGTTTTAGTTGCAGCACTTGCATTGAGTTTAATGGCAAGCCTTTATCCA
GCAAGCCGAGCTGCTAAATTACAACCTGCACAAGTATTAAGTAGCCATTAA

Upstream 100 bases:

>100_bases
AAAATATTGCTTTTTTATTAGTCACTCACGATATGGGGCTTGCGGAAAAATTATCACGCCGTTTAGTGATGCAAGATGGT
CTTTTGAAGGAAGGTGCATA

Downstream 100 bases:

>100_bases
TTTCGAGAGTACAGCACAAAAGTGCGGTATTTTTTTATCTTTTATTTACTTAATTATTTCGTTTTATTCAGCTTGCAAGA
GAGTTGTAAAGATAGTTTAA

Product: outer membrane-specific lipoprotein transporter subunit LolE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MNTPFFISWRYQRGKQKNPLVALIAKFSAIGIALGVAVLIVGLSAMNGFERELNQRILAVVPHAEILSAPNATEPTIHHW
QNLEKRLQQNPQIKGISPFVSFTALVENGSKLKVVQVKGVEKQAEDKVSSIGNFVQEQGWNKFEKEGGLVLGSGIAKELD
VKVGDWITLLISQQNGDEQFAQPTREPVQVTSILRLDGQLDYSYALLPLAQAQTFLTYQPDQITGVELKLDDPFSARNLD
LSMLNDYPQMLYMQNWISKFGYMYRDIQLIRTVMYIAMVLVIGVACFNIVSTLIMAVKDKQGDIAIMRTLGANNAFIKRI
FIWYGLQAGMKGCLIGIVLGIILALNLTTFIQGIEWVIGKKLLSGDVYFVDFLPSELHWLDVLMVLVAALALSLMASLYP
ASRAAKLQPAQVLSSH

Sequences:

>Translated_416_residues
MNTPFFISWRYQRGKQKNPLVALIAKFSAIGIALGVAVLIVGLSAMNGFERELNQRILAVVPHAEILSAPNATEPTIHHW
QNLEKRLQQNPQIKGISPFVSFTALVENGSKLKVVQVKGVEKQAEDKVSSIGNFVQEQGWNKFEKEGGLVLGSGIAKELD
VKVGDWITLLISQQNGDEQFAQPTREPVQVTSILRLDGQLDYSYALLPLAQAQTFLTYQPDQITGVELKLDDPFSARNLD
LSMLNDYPQMLYMQNWISKFGYMYRDIQLIRTVMYIAMVLVIGVACFNIVSTLIMAVKDKQGDIAIMRTLGANNAFIKRI
FIWYGLQAGMKGCLIGIVLGIILALNLTTFIQGIEWVIGKKLLSGDVYFVDFLPSELHWLDVLMVLVAALALSLMASLYP
ASRAAKLQPAQVLSSH
>Mature_416_residues
MNTPFFISWRYQRGKQKNPLVALIAKFSAIGIALGVAVLIVGLSAMNGFERELNQRILAVVPHAEILSAPNATEPTIHHW
QNLEKRLQQNPQIKGISPFVSFTALVENGSKLKVVQVKGVEKQAEDKVSSIGNFVQEQGWNKFEKEGGLVLGSGIAKELD
VKVGDWITLLISQQNGDEQFAQPTREPVQVTSILRLDGQLDYSYALLPLAQAQTFLTYQPDQITGVELKLDDPFSARNLD
LSMLNDYPQMLYMQNWISKFGYMYRDIQLIRTVMYIAMVLVIGVACFNIVSTLIMAVKDKQGDIAIMRTLGANNAFIKRI
FIWYGLQAGMKGCLIGIVLGIILALNLTTFIQGIEWVIGKKLLSGDVYFVDFLPSELHWLDVLMVLVAALALSLMASLYP
ASRAAKLQPAQVLSSH

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily

Homologues:

Organism=Escherichia coli, GI1787362, Length=417, Percent_Identity=51.3189448441247, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1787360, Length=413, Percent_Identity=28.5714285714286, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): LOLE_HAEIN (P44250)

Other databases:

- EMBL:   L42023
- PIR:   H64035
- RefSeq:   NP_439697.1
- GeneID:   950412
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1548
- NMPDR:   fig|71421.1.peg.1475
- TIGR:   HI_1548
- HOGENOM:   HBG675801
- OMA:   ANNAFIK
- ProtClustDB:   PRK11146
- BioCyc:   HINF71421:HI_1548-MONOMER
- GO:   GO:0006810
- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926
- TIGRFAMs:   TIGR02212
- TIGRFAMs:   TIGR02213

Pfam domain/function: PF02687 FtsX

EC number: NA

Molecular weight: Translated: 46230; Mature: 46230

Theoretical pI: Translated: 8.57; Mature: 8.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe5b6410)-; HASH(0xe279078)-; HASH(0xe4f5adc)-; HASH(0xd93a7d0)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTPFFISWRYQRGKQKNPLVALIAKFSAIGIALGVAVLIVGLSAMNGFERELNQRILAV
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEE
VPHAEILSAPNATEPTIHHWQNLEKRLQQNPQIKGISPFVSFTALVENGSKLKVVQVKGV
ECCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCC
EKQAEDKVSSIGNFVQEQGWNKFEKEGGLVLGSGIAKELDVKVGDWITLLISQQNGDEQF
CHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEECCCCHHHCCCCCCEEEEEEECCCCCHHH
AQPTREPVQVTSILRLDGQLDYSYALLPLAQAQTFLTYQPDQITGVELKLDDPFSARNLD
HCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCEEEEEEEECCCCCCCCCC
LSMLNDYPQMLYMQNWISKFGYMYRDIQLIRTVMYIAMVLVIGVACFNIVSTLIMAVKDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGDIAIMRTLGANNAFIKRIFIWYGLQAGMKGCLIGIVLGIILALNLTTFIQGIEWVIGK
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLSGDVYFVDFLPSELHWLDVLMVLVAALALSLMASLYPASRAAKLQPAQVLSSH
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCH
>Mature Secondary Structure
MNTPFFISWRYQRGKQKNPLVALIAKFSAIGIALGVAVLIVGLSAMNGFERELNQRILAV
CCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCEEE
VPHAEILSAPNATEPTIHHWQNLEKRLQQNPQIKGISPFVSFTALVENGSKLKVVQVKGV
ECCHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCCEEEEEEECCC
EKQAEDKVSSIGNFVQEQGWNKFEKEGGLVLGSGIAKELDVKVGDWITLLISQQNGDEQF
CHHHHHHHHHHHHHHHHCCCCHHHHCCCEEEECCCCHHHCCCCCCEEEEEEECCCCCHHH
AQPTREPVQVTSILRLDGQLDYSYALLPLAQAQTFLTYQPDQITGVELKLDDPFSARNLD
HCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCEEEEECCCCEEEEEEEECCCCCCCCCC
LSMLNDYPQMLYMQNWISKFGYMYRDIQLIRTVMYIAMVLVIGVACFNIVSTLIMAVKDK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
QGDIAIMRTLGANNAFIKRIFIWYGLQAGMKGCLIGIVLGIILALNLTTFIQGIEWVIGK
CCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLLSGDVYFVDFLPSELHWLDVLMVLVAALALSLMASLYPASRAAKLQPAQVLSSH
HHHCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800