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The map label for this gene is licA [H]

Identifier: 16273437

GI number: 16273437

Start: 1608780

End: 1609583

Strand: Direct

Name: licA [H]

Synonym: HI1537

Alternate gene names: 16273437

Gene position: 1608780-1609583 (Clockwise)

Preceding gene: 16273436

Following gene: 16273438

Centisome position: 87.9

GC content: 33.46

Gene sequence:

>804_bases
ATGACCAATCAAAATGTTCTACTTAATATTTCTGGAGTTAAGTTTGTATTACGGATCCCTAATGCCGTAAATTTATCACT
TATAAATCGAGAATATGAGGCATTCAATAATGCACAGGCATATCGTGCTGGCTTGAATGTAGAAACTCCCGTATTAGATG
CCAAAAGTGGCGTAAAACTGACTCGTTATTTAGAAAATAGTAATACGTTAAGCCAGATACAATTAAACGAACAAAGTTGT
TTGTCTCAAGTTGTGAATAATTTATATCGTTTACACAATAGTGAATTTGTTTTTCGTAATGTATTTAGCGTATTCGATGA
GTTTCGCCAATATTTTTCATTGCTAGAAAACAAATCCGCTTTTTATCAAGCTGATTCGAGAATGGATAAACTTTCAGCTG
TATTTTGGCAATTTGAAGAAATCAATAAAGAGGTAATTTTACGTCCGTGCCACAATGATTTAGTCCCTGAAAATATGTTA
TTACAAGATGATCGGCTATTTTTTATCGATTGGGAATATTCGGGCTTAAATGATCCGCTATTTGATATAGCTACTATCAT
TGAGGAAGCTCATTTATCGAAAGAAGCTGCTGATTTTCTATTAGAAACCTATTGCAATCAGACAAATAAATATCACAAGA
CAGAATTTCAAATCGCTCACAAACGGTTAAAAATCCATCGTTTTTGCCAAAATGTATTGTGGTTTTTATGGACAAAAGTA
AAAGAAGAACACGGCGAGAATTTTGGCGATTATGCGTTAAAACGCTTAGACGCAGCATTTAAACTGTTAGAGGAATTGCC
ATAA

Upstream 100 bases:

>100_bases
AATCAATCAAATTGTAGGATTTGTTAAAACTTGCTACAAGCCTGAGGAAGTATTTCATTTTCTTCATCAGCATTCCATTC
CTTTTTCCTCCATTGGAGGA

Downstream 100 bases:

>100_bases
TGCGTGGCTATCTCTTTGGCATACTGTCCGCTGTATTTTGGGCATTATCTGGACTGTTGTATAATGAATTGCCATTAAGT
GAATATACTGCGTTAGGGAA

Product: lic-1 operon protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 266

Protein sequence:

>267_residues
MTNQNVLLNISGVKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSNTLSQIQLNEQSC
LSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAFYQADSRMDKLSAVFWQFEEINKEVILRPCHNDLVPENML
LQDDRLFFIDWEYSGLNDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKV
KEEHGENFGDYALKRLDAAFKLLEELP

Sequences:

>Translated_267_residues
MTNQNVLLNISGVKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSNTLSQIQLNEQSC
LSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAFYQADSRMDKLSAVFWQFEEINKEVILRPCHNDLVPENML
LQDDRLFFIDWEYSGLNDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKV
KEEHGENFGDYALKRLDAAFKLLEELP
>Mature_266_residues
TNQNVLLNISGVKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKLTRYLENSNTLSQIQLNEQSCL
SQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSAFYQADSRMDKLSAVFWQFEEINKEVILRPCHNDLVPENMLL
QDDRLFFIDWEYSGLNDPLFDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKVK
EEHGENFGDYALKRLDAAFKLLEELP

Specific function: Mediates phase variation of the LOS 6A2 and 12D9 epitopes. Phase variation of H.influenza LOS epitopes expressed by licA is determined by a translational switch [H]

COG id: COG0510

COG function: function code M; Predicted choline kinase involved in LPS biosynthesis

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S49 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002573
- InterPro:   IPR011009 [H]

Pfam domain/function: PF01633 Choline_kinase [H]

EC number: NA

Molecular weight: Translated: 31395; Mature: 31264

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNQNVLLNISGVKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKL
CCCCCEEEEECCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHH
TRYLENSNTLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSA
HHHHCCCCCHHHEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
FYQADSRMDKLSAVFWQFEEINKEVILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPL
HHHHHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCCCCCEECCCCEEEEEEECCCCCCHH
FDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEEHGENFGDYALKRLDAAFKLLEELP
HHHHCCCHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TNQNVLLNISGVKFVLRIPNAVNLSLINREYEAFNNAQAYRAGLNVETPVLDAKSGVKL
CCCCEEEEECCEEEEEECCCCCCHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCCCCCHH
TRYLENSNTLSQIQLNEQSCLSQVVNNLYRLHNSEFVFRNVFSVFDEFRQYFSLLENKSA
HHHHCCCCCHHHEEECHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCHH
FYQADSRMDKLSAVFWQFEEINKEVILRPCHNDLVPENMLLQDDRLFFIDWEYSGLNDPL
HHHHHHHHHHHHHHHHHHHHHCHHHEEECCCCCCCCCCCEECCCCEEEEEEECCCCCCHH
FDIATIIEEAHLSKEAADFLLETYCNQTNKYHKTEFQIAHKRLKIHRFCQNVLWFLWTKV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KEEHGENFGDYALKRLDAAFKLLEELP
HHHHCCCHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2479481; 8861214 [H]