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The map label for this gene is gltS

Identifier: 16273430

GI number: 16273430

Start: 1602539

End: 1603753

Strand: Direct

Name: gltS

Synonym: HI1530

Alternate gene names: 16273430

Gene position: 1602539-1603753 (Clockwise)

Preceding gene: 16273429

Following gene: 16273432

Centisome position: 87.56

GC content: 37.94

Gene sequence:

>1215_bases
ATGAGCTATACTTTTAGCACGTATGAAACCCTTGCATTAGCAAGCTTAGTTTTGCTATTGGGCTATTTTTTGGTTAAACG
CATTAATGTATTAAAAACATTTAACATTCCAGAGCCAGTTGTTGGTGGCTTTATTGTTGCCATTGGTCTTTTAATTTGGC
ACAAAATTGATGGAACATCCTTTAACTTCGATAAAAATCTACAAACCACAATGATGTTAGTGTTTTTTACTTCTATCGGT
TTAAGTGCCAACTTTTCCCGTCTAATTAAAGGTGGAAAGCCACTCGTTGTATTTCTATTCATTGCTGCATTATTAATCTT
CGGACAAAACGTTATTGGCATTGCAAGTTCAATGGCATTAGGAATCCATCCCGCTTATGGCTTACTTGCAGGTTCAGTAA
CCTTAACAGGTGGTCACGGCACTGGAGCTGCTTGGGCGGATACATTTGCACATCAATTTAATCTACAAGGTGCAACTGAA
ATTGCCATTGCCTGTGCAACTTTCGGTTTAGTATTCGGTGGTATCATCGGTGGTCCTGTCGCTCGTTTCTTATTAAATCG
CCAAAAACAAGGCGAAAATCCTGAAAATGATGAAGTTGATGACATTCAAGAAGCATTTGAACACCCAACTTATAAACGTA
AAATTACTGCACGTTCATTAATTGAAACAATTGCAATGATTTCAGTATGTTTATTAATTGGTCAATATTTAGATGTACAA
ACAAAAGGTACTGCACTCCAATTACCAACTTTCGTATGGTGTTTATTCACTGGTGTTATTGTCCGCAATATTTTAACCAA
CATTTTCCGTTTCCAAGTAGCAGAATCCGCTATTGACGTATTAGGTAGCGTAGGCTTATCCATCTTTTTAGCAATTGCTT
TAATGTCATTAAGACTTTGGGAACTTGCAGGTTTAGCAATTGACGTATTAATTGTTCTTGCTATTCAAGTAGCATTTATG
GCTGCCTTTGCAATTTTCATTACTTATCGAGCAATGGGTAAAGATTACGATGCCGTCGTATTAAGTGCTGGACACTGTGG
TTTTGGTTTAGGCGCAACCCCAACAGCAATCGCAAATATGCAAGCTGTCACCAGCCGTTTTGGGCCATCGCACAAAGCAT
TTTTAATCGTTCCAATGGTCGGTGCATTCTTTATCGACTTAATCAACGCTGCGCTATTAAAAGTTTCATTTGCAGTTGTA
AATATACTCGCGTAA

Upstream 100 bases:

>100_bases
GTTCGACATTACCACGTGGATTACATACCAATCTTGAAATTATGGTAATCGAGCCGTAACACAACACATCACTTAAACAT
AACATAGGGAGATCCAATTT

Downstream 100 bases:

>100_bases
AGTGCGGTTGAAATTGACAATGTTTTAGAGAAATGCCTTTATCTTGAATTGATAAAGGCATTTATTTCAATATAATCAAT
TATTTCAGCTGCAATATCAA

Product: glutamate permease

Products: Na (I) [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate permease

Number of amino acids: Translated: 404; Mature: 403

Protein sequence:

>404_residues
MSYTFSTYETLALASLVLLLGYFLVKRINVLKTFNIPEPVVGGFIVAIGLLIWHKIDGTSFNFDKNLQTTMMLVFFTSIG
LSANFSRLIKGGKPLVVFLFIAALLIFGQNVIGIASSMALGIHPAYGLLAGSVTLTGGHGTGAAWADTFAHQFNLQGATE
IAIACATFGLVFGGIIGGPVARFLLNRQKQGENPENDEVDDIQEAFEHPTYKRKITARSLIETIAMISVCLLIGQYLDVQ
TKGTALQLPTFVWCLFTGVIVRNILTNIFRFQVAESAIDVLGSVGLSIFLAIALMSLRLWELAGLAIDVLIVLAIQVAFM
AAFAIFITYRAMGKDYDAVVLSAGHCGFGLGATPTAIANMQAVTSRFGPSHKAFLIVPMVGAFFIDLINAALLKVSFAVV
NILA

Sequences:

>Translated_404_residues
MSYTFSTYETLALASLVLLLGYFLVKRINVLKTFNIPEPVVGGFIVAIGLLIWHKIDGTSFNFDKNLQTTMMLVFFTSIG
LSANFSRLIKGGKPLVVFLFIAALLIFGQNVIGIASSMALGIHPAYGLLAGSVTLTGGHGTGAAWADTFAHQFNLQGATE
IAIACATFGLVFGGIIGGPVARFLLNRQKQGENPENDEVDDIQEAFEHPTYKRKITARSLIETIAMISVCLLIGQYLDVQ
TKGTALQLPTFVWCLFTGVIVRNILTNIFRFQVAESAIDVLGSVGLSIFLAIALMSLRLWELAGLAIDVLIVLAIQVAFM
AAFAIFITYRAMGKDYDAVVLSAGHCGFGLGATPTAIANMQAVTSRFGPSHKAFLIVPMVGAFFIDLINAALLKVSFAVV
NILA
>Mature_403_residues
SYTFSTYETLALASLVLLLGYFLVKRINVLKTFNIPEPVVGGFIVAIGLLIWHKIDGTSFNFDKNLQTTMMLVFFTSIGL
SANFSRLIKGGKPLVVFLFIAALLIFGQNVIGIASSMALGIHPAYGLLAGSVTLTGGHGTGAAWADTFAHQFNLQGATEI
AIACATFGLVFGGIIGGPVARFLLNRQKQGENPENDEVDDIQEAFEHPTYKRKITARSLIETIAMISVCLLIGQYLDVQT
KGTALQLPTFVWCLFTGVIVRNILTNIFRFQVAESAIDVLGSVGLSIFLAIALMSLRLWELAGLAIDVLIVLAIQVAFMA
AFAIFITYRAMGKDYDAVVLSAGHCGFGLGATPTAIANMQAVTSRFGPSHKAFLIVPMVGAFFIDLINAALLKVSFAVVN
ILA

Specific function: Catalyzes the sodium-dependent uptake of extracellular glutamate

COG id: COG0786

COG function: function code E; Na+/glutamate symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gltS symporter family

Homologues:

Organism=Escherichia coli, GI1790085, Length=375, Percent_Identity=54.1333333333333, Blast_Score=363, Evalue=1e-101,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLTS_HAEIN (P45240)

Other databases:

- EMBL:   L42023
- PIR:   G64127
- RefSeq:   NP_439679.1
- GeneID:   950392
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1530
- NMPDR:   fig|71421.1.peg.1457
- TIGR:   HI_1530
- HOGENOM:   HBG644193
- OMA:   LAFADIM
- ProtClustDB:   CLSK892416
- BioCyc:   HINF71421:HI_1530-MONOMER
- InterPro:   IPR004445
- TIGRFAMs:   TIGR00210

Pfam domain/function: PF03616 Glt_symporter

EC number: NA

Molecular weight: Translated: 43372; Mature: 43241

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00134 TRYPSIN_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc936c2c)-; HASH(0xeb254b4)-; HASH(0xb09b47c)-; HASH(0xe318a00)-; HASH(0xd0a20c0)-; HASH(0xe3ddfb0)-; HASH(0xe853d34)-; HASH(0xe4751d8)-; HASH(0xea6e534)-; HASH(0xeb64274)-; HASH(0xe3a33b0)-; HASH(0xe6c2fa4)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYTFSTYETLALASLVLLLGYFLVKRINVLKTFNIPEPVVGGFIVAIGLLIWHKIDGTS
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
FNFDKNLQTTMMLVFFTSIGLSANFSRLIKGGKPLVVFLFIAALLIFGQNVIGIASSMAL
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
GIHPAYGLLAGSVTLTGGHGTGAAWADTFAHQFNLQGATEIAIACATFGLVFGGIIGGPV
CCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARFLLNRQKQGENPENDEVDDIQEAFEHPTYKRKITARSLIETIAMISVCLLIGQYLDVQ
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TKGTALQLPTFVWCLFTGVIVRNILTNIFRFQVAESAIDVLGSVGLSIFLAIALMSLRLW
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELAGLAIDVLIVLAIQVAFMAAFAIFITYRAMGKDYDAVVLSAGHCGFGLGATPTAIANM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHH
QAVTSRFGPSHKAFLIVPMVGAFFIDLINAALLKVSFAVVNILA
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
SYTFSTYETLALASLVLLLGYFLVKRINVLKTFNIPEPVVGGFIVAIGLLIWHKIDGTS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCC
FNFDKNLQTTMMLVFFTSIGLSANFSRLIKGGKPLVVFLFIAALLIFGQNVIGIASSMAL
CCCCCCHHHHHHHHHHHHHCCCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHH
GIHPAYGLLAGSVTLTGGHGTGAAWADTFAHQFNLQGATEIAIACATFGLVFGGIIGGPV
CCCCHHHHHCCCEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHH
ARFLLNRQKQGENPENDEVDDIQEAFEHPTYKRKITARSLIETIAMISVCLLIGQYLDVQ
HHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
TKGTALQLPTFVWCLFTGVIVRNILTNIFRFQVAESAIDVLGSVGLSIFLAIALMSLRLW
CCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ELAGLAIDVLIVLAIQVAFMAAFAIFITYRAMGKDYDAVVLSAGHCGFGLGATPTAIANM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHHHHH
QAVTSRFGPSHKAFLIVPMVGAFFIDLINAALLKVSFAVVNILA
HHHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + L-glutamate [Periplasm] = Na (I) [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800