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The map label for this gene is parC

Identifier: 16273429

GI number: 16273429

Start: 1600254

End: 1602497

Strand: Direct

Name: parC

Synonym: HI1529

Alternate gene names: 16273429

Gene position: 1600254-1602497 (Clockwise)

Preceding gene: 16273428

Following gene: 16273430

Centisome position: 87.44

GC content: 40.29

Gene sequence:

>2244_bases
ATGACAAATATCAACTATGAAGGCATTGAGCAAATGCCTCTACGCACCTTCACTGAAAAGGCTTATCTCAACTATTCTAT
GTATGTCATCATGGATCGTGCGTTGCCTTTTATCGGTGATGGTTTAAAACCCGTTCAACGTCGTATTGTATATGCGATGT
CTGAACTTGGCTTAAATGCCACGGCAAAATACAAAAAATCTGCTCGTACCGTCGGTGATGTACTCGGTAAATTCCATCCA
CATGGTGACAGTGCTTGTTATGAAGCTATGGTGTTAATGGCACAACCCTTCTCTTATCGTTATCCACTTGTAGATGGTCA
AGGTAACTGGGGGGCACCAGATGATCCAAAATCCTTCGCAGCCATGCGTTATACGGAATCTCGCCTATCTAAAATCTCTG
AAATCTTGTTGAATGAACTCGGACAAGGAACAGTAGATTATCAACCAAACTTTGATGGAACCTTGGCTGAACCACAATAT
TTACCTGCTCGTTTACCGCATATTTTATTGAACGGCACAACAGGTATTGCGGTGGGGATGGCCACAGATATTCCACCACA
CAATATTAACGAAATTGCTGATGCGGCAGTAATGTTGCTAGATAATCCTAAAGCGGGATTAGATGATGTACTTGAAATTG
TTCAAGGCCCAGATTTTCCAACAGAAGCGGAAATTATTTCGCCAAAATCAGAAATTCGTAAAATTTATGAGCAAGGTCGT
GGCTCAATAAAAATGCGTGCAACTTGGAAAAAAGAAGACGGTGAAATTATTATTTCAGCGCTTCCACATCAATCTTCGCC
ATCCAAAGTCATTGCACAAATAGCCGAACAAATGACGGCAAAAAAACTGCCAATGCTAGAAGATATTCGAGATGAAGCCG
ATCACGAAAATCCAATTCGCATTGTGCTAGTTCCTCGCTCAAATCGCGTCGATACTGATGCCTTAATGGCACATTTATTT
GCGACCACAGATCTTGAAAAAAGCTACCGTGTAAATATGAATATGATCGGGCTTGATCATAAACCAGCGGTAAAAGGCTT
ATTAGAAATCTTAAATGAATGGCTTGACTTCCGTCGCACAACGGTCACTCGTCGCCTTCAATATCGCCTAGATAAAGTGC
TCTCTCGCTTGCATATTTTAGAAGGCTTGATGATAGCCTTTTTAAATATTGATGAAGTTATCGAAATTATACGCCACGAA
GATGATCCAAAAGCAGAGCTTATGGCACGCTTTAATTTAAGCGATGAACAAGCCGATGCCATTTTAAATTTACGCTTACG
TCATTTAGCGAAATTAGAAGAAAACCAACTCAAAGCAGAACAAGATGAACTTGAAAAAGAGCGGTTAAATTTAGAAGCAA
TTTTAGGATCAGAACGCCGTTTGAATACGCTTATCAAAAAAGAAATTCAAGAAGATGCGAAAAAATATGCCAATCCACGT
ATGTCTCAACTGGTCGAACGTGAAGAAGCCAAAATGATCTCTGAAAGTGATATGACACCAGCAGAACCAGTTACTGTCAT
CTTATCAGAAATGGGCTGGGTACGTTGTGCAAAAGGACACGATATTGATCCTAAATCATTAAGCTACAAAGCTGGTGATA
GCTATCTAGCTCACGCTTGTGGCAAAAGTAATCAAGCCGTTGTATTCATTGATAGCACGGGGCGGAGTTATGCACTCGAT
CCGCTTTCCTTGCCTTCCGCTCGCTCCCAAGGCGAACCACTTACAGGTAAACTCAATTTACCCACTGGTGCGACCATTGA
ATATGTTGTAATGGCCAGCGAACAGCAAGAATTATTGATGGCTTCTGATGCAGGATATGGTTTTATTTGTAAATTTGAAG
ATTTAATTGCACGTAACAAGGCTGGAAAAGCCTTGATTTCTTTACCAGAAAATGCCAAAGTGTTGAAGCCTAAAACATTG
ATAAATTCTACCGCACTTGTTGTCGCAATCACATCAGCAGGCAGAATGTTGATTTTTCCAGCACAGGATTTACCGGTATT
ATCAAAAGGTAAAGGCAATAAAATGATCACTATTCCCGCAGCGAATGCAAAAGATCGTAGCGAACTATTGACAAAATTAT
TGCTTATTTCAGATCAAGCAAGTCTTGAATTTTATTCTGGAAAACGAAAAATTGTATTAAAACCAGAAGATCTGCAAAAG
TTCCGCGCAGAACGAGGCAGAAAAGGTTCGACATTACCACGTGGATTACATACCAATCTTGAAATTATGGTAATCGAGCC
GTAA

Upstream 100 bases:

>100_bases
AGCGAAAGGCGATCAGGTTGATTTATCTGTTTAGACTAAATTAATCTCAGCAAATCCGAATTTTAATAAATTAAGAATAT
ATCAATTAACAGAAACAAAA

Downstream 100 bases:

>100_bases
CACAACACATCACTTAAACATAACATAGGGAGATCCAATTTATGAGCTATACTTTTAGCACGTATGAAACCCTTGCATTA
GCAAGCTTAGTTTTGCTATT

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A

Number of amino acids: Translated: 747; Mature: 746

Protein sequence:

>747_residues
MTNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKYKKSARTVGDVLGKFHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKISEILLNELGQGTVDYQPNFDGTLAEPQY
LPARLPHILLNGTTGIAVGMATDIPPHNINEIADAAVMLLDNPKAGLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGR
GSIKMRATWKKEDGEIIISALPHQSSPSKVIAQIAEQMTAKKLPMLEDIRDEADHENPIRIVLVPRSNRVDTDALMAHLF
ATTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLDFRRTTVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHE
DDPKAELMARFNLSDEQADAILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYANPR
MSQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHACGKSNQAVVFIDSTGRSYALD
PLSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLMASDAGYGFICKFEDLIARNKAGKALISLPENAKVLKPKTL
INSTALVVAITSAGRMLIFPAQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQK
FRAERGRKGSTLPRGLHTNLEIMVIEP

Sequences:

>Translated_747_residues
MTNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKYKKSARTVGDVLGKFHP
HGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKISEILLNELGQGTVDYQPNFDGTLAEPQY
LPARLPHILLNGTTGIAVGMATDIPPHNINEIADAAVMLLDNPKAGLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGR
GSIKMRATWKKEDGEIIISALPHQSSPSKVIAQIAEQMTAKKLPMLEDIRDEADHENPIRIVLVPRSNRVDTDALMAHLF
ATTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLDFRRTTVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHE
DDPKAELMARFNLSDEQADAILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYANPR
MSQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHACGKSNQAVVFIDSTGRSYALD
PLSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLMASDAGYGFICKFEDLIARNKAGKALISLPENAKVLKPKTL
INSTALVVAITSAGRMLIFPAQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQK
FRAERGRKGSTLPRGLHTNLEIMVIEP
>Mature_746_residues
TNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNATAKYKKSARTVGDVLGKFHPH
GDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFAAMRYTESRLSKISEILLNELGQGTVDYQPNFDGTLAEPQYL
PARLPHILLNGTTGIAVGMATDIPPHNINEIADAAVMLLDNPKAGLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGRG
SIKMRATWKKEDGEIIISALPHQSSPSKVIAQIAEQMTAKKLPMLEDIRDEADHENPIRIVLVPRSNRVDTDALMAHLFA
TTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLDFRRTTVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHED
DPKAELMARFNLSDEQADAILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYANPRM
SQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHACGKSNQAVVFIDSTGRSYALDP
LSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLMASDAGYGFICKFEDLIARNKAGKALISLPENAKVLKPKTLI
NSTALVVAITSAGRMLIFPAQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQKF
RAERGRKGSTLPRGLHTNLEIMVIEP

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family

Homologues:

Organism=Homo sapiens, GI19913406, Length=336, Percent_Identity=24.1071428571429, Blast_Score=67, Evalue=9e-11,
Organism=Escherichia coli, GI1789396, Length=728, Percent_Identity=71.4285714285714, Blast_Score=1100, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=730, Percent_Identity=33.6986301369863, Blast_Score=369, Evalue=1e-103,
Organism=Caenorhabditis elegans, GI212645845, Length=246, Percent_Identity=25.2032520325203, Blast_Score=69, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324241, Length=383, Percent_Identity=25.065274151436, Blast_Score=72, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PARC_HAEIN (P43702)

Other databases:

- EMBL:   L42023
- PIR:   F64127
- RefSeq:   NP_439678.1
- ProteinModelPortal:   P43702
- SMR:   P43702
- GeneID:   950391
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1529
- NMPDR:   fig|71421.1.peg.1456
- TIGR:   HI_1529
- HOGENOM:   HBG635183
- OMA:   ILAITNE
- ProtClustDB:   PRK05561
- BioCyc:   HINF71421:HI_1529-MONOMER
- DrugBank:   DB00537
- DrugBank:   DB00467
- DrugBank:   DB01044
- DrugBank:   DB01155
- DrugBank:   DB00365
- DrugBank:   DB01137
- DrugBank:   DB00978
- DrugBank:   DB00218
- DrugBank:   DB01059
- DrugBank:   DB01165
- DrugBank:   DB00487
- DrugBank:   DB01208
- DrugBank:   DB01405
- DrugBank:   DB00685
- GO:   GO:0005694
- InterPro:   IPR020899
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742
- Gene3D:   G3DSA:3.30.1360.40
- Gene3D:   G3DSA:3.90.199.10
- Gene3D:   G3DSA:1.10.268.10
- SMART:   SM00434
- TIGRFAMs:   TIGR01062

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV; SSF56719 Topo_IIA_cen

EC number: 5.99.1.-

Molecular weight: Translated: 83368; Mature: 83237

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: ACT_SITE 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNA
CCCCCCCCCHHCCHHHHHHHHHHCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCC
TAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLSKISEILLNELGQGTVDYQPNFDGTLAEPQYLPARLPHILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEE
ATDIPPHNINEIADAAVMLLDNPKAGLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGR
ECCCCCCCHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHCCC
GSIKMRATWKKEDGEIIISALPHQSSPSKVIAQIAEQMTAKKLPMLEDIRDEADHENPIR
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEE
IVLVPRSNRVDTDALMAHLFATTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLDFRRT
EEEEECCCCCCHHHHHHHHHHHCCCCCCEEECEEEEECCCCHHHHHHHHHHHHHHHHHHH
TVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHEDDPKAELMARFNLSDEQADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHEECCCCHHHHHH
ILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYANPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCHH
MSQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHAC
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHC
GKSNQAVVFIDSTGRSYALDPLSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLM
CCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCHHHEE
ASDAGYGFICKFEDLIARNKAGKALISLPENAKVLKPKTLINSTALVVAITSAGRMLIFP
ECCCCCEEEEEHHHHHHCCCCCCEEEECCCCCCEECCHHHHCCCEEEEEEECCCEEEEEC
AQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQK
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHH
FRAERGRKGSTLPRGLHTNLEIMVIEP
HHHHCCCCCCCCCCCCCCCEEEEEECC
>Mature Secondary Structure 
TNINYEGIEQMPLRTFTEKAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNA
CCCCCCCCHHCCHHHHHHHHHHCEEEEEEEECCCHHHCCCHHHHHHHHHHHHHHCCCCC
TAKYKKSARTVGDVLGKFHPHGDSACYEAMVLMAQPFSYRYPLVDGQGNWGAPDDPKSFA
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCEECCCCCCCCCCCCHHHH
AMRYTESRLSKISEILLNELGQGTVDYQPNFDGTLAEPQYLPARLPHILLNGTTGIAVGM
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCCCEEEEE
ATDIPPHNINEIADAAVMLLDNPKAGLDDVLEIVQGPDFPTEAEIISPKSEIRKIYEQGR
ECCCCCCCHHHHHHHEEEEECCCCCCHHHHHHHHCCCCCCCCCCEECCHHHHHHHHHCCC
GSIKMRATWKKEDGEIIISALPHQSSPSKVIAQIAEQMTAKKLPMLEDIRDEADHENPIR
CCEEEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCEE
IVLVPRSNRVDTDALMAHLFATTDLEKSYRVNMNMIGLDHKPAVKGLLEILNEWLDFRRT
EEEEECCCCCCHHHHHHHHHHHCCCCCCEEECEEEEECCCCHHHHHHHHHHHHHHHHHHH
TVTRRLQYRLDKVLSRLHILEGLMIAFLNIDEVIEIIRHEDDPKAELMARFNLSDEQADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCHHHHHEECCCCHHHHHH
ILNLRLRHLAKLEENQLKAEQDELEKERLNLEAILGSERRLNTLIKKEIQEDAKKYANPR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCHH
MSQLVEREEAKMISESDMTPAEPVTVILSEMGWVRCAKGHDIDPKSLSYKAGDSYLAHAC
HHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEECCCCCCCCCCCCCCCCCHHHHHHC
GKSNQAVVFIDSTGRSYALDPLSLPSARSQGEPLTGKLNLPTGATIEYVVMASEQQELLM
CCCCCEEEEEECCCCEEECCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEEECCCHHHEE
ASDAGYGFICKFEDLIARNKAGKALISLPENAKVLKPKTLINSTALVVAITSAGRMLIFP
ECCCCCEEEEEHHHHHHCCCCCCEEEECCCCCCEECCHHHHCCCEEEEEEECCCEEEEEC
AQDLPVLSKGKGNKMITIPAANAKDRSELLTKLLLISDQASLEFYSGKRKIVLKPEDLQK
CCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEECCCEEEEECCHHHHH
FRAERGRKGSTLPRGLHTNLEIMVIEP
HHHHCCCCCCCCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800