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The map label for this gene is moeA

Identifier: 16273355

GI number: 16273355

Start: 1534766

End: 1535980

Strand: Direct

Name: moeA

Synonym: HI1448

Alternate gene names: 16273355

Gene position: 1534766-1535980 (Clockwise)

Preceding gene: 16273351

Following gene: 16273356

Centisome position: 83.86

GC content: 40.25

Gene sequence:

>1215_bases
ATGCTTACATTGGATCAAGCTCGCTCGAAAATGCTTGAACAGCTTCCCTTCCCGACTCAAACTGAATACCTAAATTTACA
AGAAGCCGCCAATCGAATTTGTGCAGAAGATATTATTTCGCCTATCAATGTTCCCTCTTTCGATAACTCAGCAATGGATG
GTTATGCTGTACGTTTATCGGATTTACAACAATCTTTAACCCTTTCAGTGGCAGGGAAATCTTTTGCAGGTAATCCATTC
CAAGAGGAATGGCCATCAAAAAGTGCGGTCAGAATTATGACTGGTGCGATGATTCCTGAAGGCACAGATGCAGTGATAAT
GCAAGAGCAAGTAACACTCAATGAAGACGGCACCATCACTTTTAGTGAATTACCTAAGCCGAATCAAAACATCCGTCGTA
TTGGTGAAGATGTAAAAAAAGGGGATGTCGTATTAGAACAAGGCGCACAGCTCACCCCAGTTTCCTTGCCATTATTGGCC
TCTCTAGGCATTGCAGAAGTAAAATGCTATCGTCAATTAAAAGTCGGTGTACTCTCAACTGGCGATGAACTTGTGGAAGT
GGGCAAACCATTACAAAGCGGACAAATCTATGACACTAACCGTTTCACCGTAAAATTACTGCTAGAAAAACTACACTGTG
AAGTCATTGATTTAGGACTATTACCTGATAACGAAGCTGAATTTGAAAAAGCATTTATTGCCGCACAAAGCCAAGCCGAT
TTAGTGATTACTAGTGGCGGTGTTTCCGTTGGTGAAGCGGATTTCACTAAAGCGGTATTGGAAAAAGTAGGTCAAGTAAA
TTTCTGGAAAATTGCAATCAAACCGGGCAAACCATTCGCTTTTGGTAAATTAGAAAATGCTTGGTTCTGTGGTTTACCCG
GCAATCCTGTTTCTGCATTAGTAACATTTTATCAACTTGTTCAGCCATTAATCGCTAAACTTCAAGGCCAAAAACAATGG
AAAAAACCACCGCACTTTTCAGCCATTGCTACAATGAATTTGAAAAAAGCAGTGGGACGTTTAGACTTCCAACGGGGTTT
TTATTACATCAATGAACAAGGCCAAATTGAAGTGCAATCAGTAGGTTTCCAAGGTTCTCATCTCTTTAGTGCTTTTGTAA
AAAGCAATTGTTTTATCGTTTTAGAACAAGAACGTGGCAATGTCTCTGCGGGCGAAACAGTGACAATTGAGCCTTTCAAT
CATTTATTAGGATAA

Upstream 100 bases:

>100_bases
AAAGGATAATAGGATGGTAAAATGAGAAAAATTGCAAATTTGAATGAATTAGGCTTTAGATATAGAATAGCTGACAAATT
TTATCAAATAAGGATTTTCT

Downstream 100 bases:

>100_bases
AAAATGATCGAACTTAGTCACGAAGAAGAATTGCGTTATAACCGTCAAATTATTCTTAAGAGCGTAGATTTTGACGGGCA
AGAAAAACTTAAAGCAAGCA

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MLTLDQARSKMLEQLPFPTQTEYLNLQEAANRICAEDIISPINVPSFDNSAMDGYAVRLSDLQQSLTLSVAGKSFAGNPF
QEEWPSKSAVRIMTGAMIPEGTDAVIMQEQVTLNEDGTITFSELPKPNQNIRRIGEDVKKGDVVLEQGAQLTPVSLPLLA
SLGIAEVKCYRQLKVGVLSTGDELVEVGKPLQSGQIYDTNRFTVKLLLEKLHCEVIDLGLLPDNEAEFEKAFIAAQSQAD
LVITSGGVSVGEADFTKAVLEKVGQVNFWKIAIKPGKPFAFGKLENAWFCGLPGNPVSALVTFYQLVQPLIAKLQGQKQW
KKPPHFSAIATMNLKKAVGRLDFQRGFYYINEQGQIEVQSVGFQGSHLFSAFVKSNCFIVLEQERGNVSAGETVTIEPFN
HLLG

Sequences:

>Translated_404_residues
MLTLDQARSKMLEQLPFPTQTEYLNLQEAANRICAEDIISPINVPSFDNSAMDGYAVRLSDLQQSLTLSVAGKSFAGNPF
QEEWPSKSAVRIMTGAMIPEGTDAVIMQEQVTLNEDGTITFSELPKPNQNIRRIGEDVKKGDVVLEQGAQLTPVSLPLLA
SLGIAEVKCYRQLKVGVLSTGDELVEVGKPLQSGQIYDTNRFTVKLLLEKLHCEVIDLGLLPDNEAEFEKAFIAAQSQAD
LVITSGGVSVGEADFTKAVLEKVGQVNFWKIAIKPGKPFAFGKLENAWFCGLPGNPVSALVTFYQLVQPLIAKLQGQKQW
KKPPHFSAIATMNLKKAVGRLDFQRGFYYINEQGQIEVQSVGFQGSHLFSAFVKSNCFIVLEQERGNVSAGETVTIEPFN
HLLG
>Mature_404_residues
MLTLDQARSKMLEQLPFPTQTEYLNLQEAANRICAEDIISPINVPSFDNSAMDGYAVRLSDLQQSLTLSVAGKSFAGNPF
QEEWPSKSAVRIMTGAMIPEGTDAVIMQEQVTLNEDGTITFSELPKPNQNIRRIGEDVKKGDVVLEQGAQLTPVSLPLLA
SLGIAEVKCYRQLKVGVLSTGDELVEVGKPLQSGQIYDTNRFTVKLLLEKLHCEVIDLGLLPDNEAEFEKAFIAAQSQAD
LVITSGGVSVGEADFTKAVLEKVGQVNFWKIAIKPGKPFAFGKLENAWFCGLPGNPVSALVTFYQLVQPLIAKLQGQKQW
KKPPHFSAIATMNLKKAVGRLDFQRGFYYINEQGQIEVQSVGFQGSHLFSAFVKSNCFIVLEQERGNVSAGETVTIEPFN
HLLG

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family

Homologues:

Organism=Homo sapiens, GI66932975, Length=396, Percent_Identity=34.0909090909091, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI10880983, Length=396, Percent_Identity=34.0909090909091, Blast_Score=189, Evalue=3e-48,
Organism=Escherichia coli, GI1787049, Length=404, Percent_Identity=56.4356435643564, Blast_Score=454, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI25147659, Length=334, Percent_Identity=32.6347305389222, Blast_Score=149, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562606, Length=328, Percent_Identity=30.1829268292683, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136978, Length=375, Percent_Identity=29.6, Blast_Score=134, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24638841, Length=375, Percent_Identity=29.6, Blast_Score=134, Evalue=2e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOEA_HAEIN (P45210)

Other databases:

- EMBL:   L42023
- PIR:   B64124
- RefSeq:   NP_439600.1
- ProteinModelPortal:   P45210
- SMR:   P45210
- GeneID:   950719
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1448
- NMPDR:   fig|71421.1.peg.1382
- TIGR:   HI_1448
- HOGENOM:   HBG731522
- OMA:   DVTFWKI
- ProtClustDB:   CLSK870206
- BioCyc:   HINF71421:HI_1448-MONOMER
- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453
- Gene3D:   G3DSA:3.40.980.10
- SMART:   SM00852
- TIGRFAMs:   TIGR00177

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N; SSF53218 MoCF_biosynth; SSF63867 MoeA_C; SSF63882 MoeA_N

EC number: NA

Molecular weight: Translated: 44310; Mature: 44310

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTLDQARSKMLEQLPFPTQTEYLNLQEAANRICAEDIISPINVPSFDNSAMDGYAVRLS
CCCHHHHHHHHHHHCCCCCCHHEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHH
DLQQSLTLSVAGKSFAGNPFQEEWPSKSAVRIMTGAMIPEGTDAVIMQEQVTLNEDGTIT
HHHHHEEEEECCCCCCCCCCHHHCCCCCCEEEEECCCCCCCCCEEEEEEEEEECCCCCEE
FSELPKPNQNIRRIGEDVKKGDVVLEQGAQLTPVSLPLLASLGIAEVKCYRQLKVGVLST
ECCCCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHEEECC
GDELVEVGKPLQSGQIYDTNRFTVKLLLEKLHCEVIDLGLLPDNEAEFEKAFIAAQSQAD
CHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCCC
LVITSGGVSVGEADFTKAVLEKVGQVNFWKIAIKPGKPFAFGKLENAWFCGLPGNPVSAL
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCEEECCCCCHHHHH
VTFYQLVQPLIAKLQGQKQWKKPPHFSAIATMNLKKAVGRLDFQRGFYYINEQGQIEVQS
HHHHHHHHHHHHHHCCCHHCCCCCCCHHEEHHHHHHHHHHHHHHCCEEEECCCCCEEEEE
VGFQGSHLFSAFVKSNCFIVLEQERGNVSAGETVTIEPFNHLLG
ECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCHHHHCC
>Mature Secondary Structure
MLTLDQARSKMLEQLPFPTQTEYLNLQEAANRICAEDIISPINVPSFDNSAMDGYAVRLS
CCCHHHHHHHHHHHCCCCCCHHEEEHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEHH
DLQQSLTLSVAGKSFAGNPFQEEWPSKSAVRIMTGAMIPEGTDAVIMQEQVTLNEDGTIT
HHHHHEEEEECCCCCCCCCCHHHCCCCCCEEEEECCCCCCCCCEEEEEEEEEECCCCCEE
FSELPKPNQNIRRIGEDVKKGDVVLEQGAQLTPVSLPLLASLGIAEVKCYRQLKVGVLST
ECCCCCCCHHHHHHHHHHHHCCEEECCCCCCCCCCHHHHHHCCHHHHHHHHHHHHEEECC
GDELVEVGKPLQSGQIYDTNRFTVKLLLEKLHCEVIDLGLLPDNEAEFEKAFIAAQSQAD
CHHHHHHCCCCCCCEEEECCCHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHHHCCCCCC
LVITSGGVSVGEADFTKAVLEKVGQVNFWKIAIKPGKPFAFGKLENAWFCGLPGNPVSAL
EEEECCCCCCCCHHHHHHHHHHHCCCEEEEEEEECCCCEEEECCCCCEEECCCCCHHHHH
VTFYQLVQPLIAKLQGQKQWKKPPHFSAIATMNLKKAVGRLDFQRGFYYINEQGQIEVQS
HHHHHHHHHHHHHHCCCHHCCCCCCCHHEEHHHHHHHHHHHHHHCCEEEECCCCCEEEEE
VGFQGSHLFSAFVKSNCFIVLEQERGNVSAGETVTIEPFNHLLG
ECCCCHHHHHHHHHCCCEEEEEECCCCCCCCCEEEECCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800