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The map label for this gene is moeB

Identifier: 16273356

GI number: 16273356

Start: 1535984

End: 1536715

Strand: Direct

Name: moeB

Synonym: HI1449

Alternate gene names: 16273356

Gene position: 1535984-1536715 (Clockwise)

Preceding gene: 16273355

Following gene: 16273357

Centisome position: 83.93

GC content: 40.57

Gene sequence:

>732_bases
ATGATCGAACTTAGTCACGAAGAAGAATTGCGTTATAACCGTCAAATTATTCTTAAGAGCGTAGATTTTGACGGGCAAGA
AAAACTTAAAGCAAGCAAAATGCTGATCGTTGGGCTTGGTGGCTTAGGCTGTGCAGCCAGCCAATATCTCGCAGCAGCAG
GTGTTGGAAATTTAACGCTGTTGGATTTCGATACAGTTTCTCTTTCGAATCTTCAACGCCAAGTCTTGCACTGCGATGCT
CGCTTGAATATGCCAAAAGTGGAATCCGCTAAAATTGCACTGGAACAAATCAATCCACATATAAACATAGAGACGATTAA
TGCGAAGTTAGACGAAGAAAAACTCGCAGAAATCATTCCGCACTTTGATATTGTTTTAGATTGTACAGACAATGTGGAAA
TCCGTAATCAATTGGATCGCCAATGTAATCATATGAAAGTCCCTCTTATTTCTGGCGCAGCGATTCGGATGGAAGGTCAG
GTTTCCGTTTTCACTTATGAACCAAATACGCCTACTTATCGTGATCTCAGCAAATTATTTAGACAAAATGTATTAAGCTG
TGTGGAAGCTGGCGTGCTTGCACCAATCGTCGGTATTGTGGGCTGCATTCAAGCCTTAGAAGCAATTAAAGTGCGGTTAA
AAATCGGTAAGAATTTGTGTGGCCGCCTATTGATGATTGACGGTTTTTCGATGAATATCCGAGAAATTAAACTTCCAACC
AATATGGAATAA

Upstream 100 bases:

>100_bases
AAAAAGCAATTGTTTTATCGTTTTAGAACAAGAACGTGGCAATGTCTCTGCGGGCGAAACAGTGACAATTGAGCCTTTCA
ATCATTTATTAGGATAAAAA

Downstream 100 bases:

>100_bases
AACGCTTCAAAAGAGAAAAAAATTTAACCGCACTTTTATGAACCATAACCTTTACGACAAAACACTATGACAACAGAAAT
TAAAAAACTTGATCCCGATA

Product: molybdopterin biosynthesis protein MoeB

Products: NA

Alternate protein names: MoaD protein adenylase; Molybdopterin-converting factor subunit 1 adenylase

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MIELSHEEELRYNRQIILKSVDFDGQEKLKASKMLIVGLGGLGCAASQYLAAAGVGNLTLLDFDTVSLSNLQRQVLHCDA
RLNMPKVESAKIALEQINPHINIETINAKLDEEKLAEIIPHFDIVLDCTDNVEIRNQLDRQCNHMKVPLISGAAIRMEGQ
VSVFTYEPNTPTYRDLSKLFRQNVLSCVEAGVLAPIVGIVGCIQALEAIKVRLKIGKNLCGRLLMIDGFSMNIREIKLPT
NME

Sequences:

>Translated_243_residues
MIELSHEEELRYNRQIILKSVDFDGQEKLKASKMLIVGLGGLGCAASQYLAAAGVGNLTLLDFDTVSLSNLQRQVLHCDA
RLNMPKVESAKIALEQINPHINIETINAKLDEEKLAEIIPHFDIVLDCTDNVEIRNQLDRQCNHMKVPLISGAAIRMEGQ
VSVFTYEPNTPTYRDLSKLFRQNVLSCVEAGVLAPIVGIVGCIQALEAIKVRLKIGKNLCGRLLMIDGFSMNIREIKLPT
NME
>Mature_243_residues
MIELSHEEELRYNRQIILKSVDFDGQEKLKASKMLIVGLGGLGCAASQYLAAAGVGNLTLLDFDTVSLSNLQRQVLHCDA
RLNMPKVESAKIALEQINPHINIETINAKLDEEKLAEIIPHFDIVLDCTDNVEIRNQLDRQCNHMKVPLISGAAIRMEGQ
VSVFTYEPNTPTYRDLSKLFRQNVLSCVEAGVLAPIVGIVGCIQALEAIKVRLKIGKNLCGRLLMIDGFSMNIREIKLPT
NME

Specific function: Catalyzes the adenylation by ATP of the carboxyl group of the C-terminal glycine of sulfur carrier protein moaD

COG id: COG0476

COG function: function code H; Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hesA/moeB/thiF family

Homologues:

Organism=Homo sapiens, GI7657339, Length=231, Percent_Identity=39.8268398268398, Blast_Score=157, Evalue=9e-39,
Organism=Homo sapiens, GI23510338, Length=162, Percent_Identity=30.8641975308642, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI23510340, Length=162, Percent_Identity=30.8641975308642, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI4885649, Length=138, Percent_Identity=31.1594202898551, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI38045948, Length=163, Percent_Identity=30.0613496932515, Blast_Score=65, Evalue=7e-11,
Organism=Escherichia coli, GI1787048, Length=241, Percent_Identity=63.9004149377593, Blast_Score=319, Evalue=1e-88,
Organism=Escherichia coli, GI87082356, Length=235, Percent_Identity=40.4255319148936, Blast_Score=155, Evalue=3e-39,
Organism=Escherichia coli, GI1789177, Length=139, Percent_Identity=28.0575539568345, Blast_Score=69, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17540406, Length=237, Percent_Identity=38.3966244725738, Blast_Score=181, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI193203301, Length=139, Percent_Identity=34.5323741007194, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321903, Length=241, Percent_Identity=37.344398340249, Blast_Score=156, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6322639, Length=165, Percent_Identity=31.5151515151515, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320598, Length=137, Percent_Identity=27.007299270073, Blast_Score=62, Evalue=8e-11,
Organism=Drosophila melanogaster, GI24582879, Length=238, Percent_Identity=46.6386554621849, Blast_Score=208, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24660640, Length=139, Percent_Identity=33.0935251798561, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573937, Length=161, Percent_Identity=30.4347826086957, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOEB_HAEIN (P45211)

Other databases:

- EMBL:   L42023
- PIR:   C64124
- RefSeq:   NP_439601.1
- ProteinModelPortal:   P45211
- SMR:   P45211
- GeneID:   950565
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1449
- NMPDR:   fig|71421.1.peg.1383
- TIGR:   HI_1449
- HOGENOM:   HBG535305
- OMA:   SASDGIC
- ProtClustDB:   PRK05690
- BioCyc:   HINF71421:HI_1449-MONOMER
- InterPro:   IPR007901
- InterPro:   IPR009036
- InterPro:   IPR012730
- InterPro:   IPR016040
- InterPro:   IPR000594
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR02355

Pfam domain/function: PF05237 MoeZ_MoeB; PF00899 ThiF; SSF69572 MoeB

EC number: NA

Molecular weight: Translated: 26997; Mature: 26997

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: NA

Important sites: BINDING 41-41 BINDING 62-62 BINDING 86-86

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELSHEEELRYNRQIILKSVDFDGQEKLKASKMLIVGLGGLGCAASQYLAAAGVGNLTL
CCCCCCHHHHHHCCEEEEEECCCCCHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCCEEE
LDFDTVSLSNLQRQVLHCDARLNMPKVESAKIALEQINPHINIETINAKLDEEKLAEIIP
EEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCC
HFDIVLDCTDNVEIRNQLDRQCNHMKVPLISGAAIRMEGQVSVFTYEPNTPTYRDLSKLF
CCEEEEECCCCCHHHHHHHHHHCCEECEEECCCEEEEECEEEEEEECCCCCCHHHHHHHH
RQNVLSCVEAGVLAPIVGIVGCIQALEAIKVRLKIGKNLCGRLLMIDGFSMNIREIKLPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCEEEEEECCCCCEEEEECCC
NME
CCC
>Mature Secondary Structure
MIELSHEEELRYNRQIILKSVDFDGQEKLKASKMLIVGLGGLGCAASQYLAAAGVGNLTL
CCCCCCHHHHHHCCEEEEEECCCCCHHHHHHCEEEEEECCCCHHHHHHHHHHCCCCCEEE
LDFDTVSLSNLQRQVLHCDARLNMPKVESAKIALEQINPHINIETINAKLDEEKLAEIIP
EEECCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHCC
HFDIVLDCTDNVEIRNQLDRQCNHMKVPLISGAAIRMEGQVSVFTYEPNTPTYRDLSKLF
CCEEEEECCCCCHHHHHHHHHHCCEECEEECCCEEEEECEEEEEEECCCCCCHHHHHHHH
RQNVLSCVEAGVLAPIVGIVGCIQALEAIKVRLKIGKNLCGRLLMIDGFSMNIREIKLPT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHCEEEEEECCCCCEEEEECCC
NME
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800