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The map label for this gene is neuA

Identifier: 16273194

GI number: 16273194

Start: 1355984

End: 1356670

Strand: Direct

Name: neuA

Synonym: HI1279

Alternate gene names: 16273194

Gene position: 1355984-1356670 (Clockwise)

Preceding gene: 30995435

Following gene: 30995436

Centisome position: 74.09

GC content: 38.57

Gene sequence:

>687_bases
GTGAAAATAATAATGACAAGAATTGCAATTATTCCTGCGAGAGCGGGTTCTAAAGGCATTAAAGATAAAAATTTACAGCT
TGTGGGGGGCGTTTCTTTGGTGGGGCGAGCGATTTTGGCAGCGCAAGAATCGGGTATGTTTGATCAAATTGTGGTGACAT
CAGATGGCGAAAATATTTTAAAAGAAGCCACAAAATACGGCGCAAAACCAGTGGCACGCCCTGAAAGTTTGGCACAAAGT
GATACACGCACCATTGATGCTATTTTGCATTGCTTAGAAACACTTAATATTTCACAAGGCACCGCCGCACTTTTGCAACC
AACCAGCCCATTGCGTAATGCTTTAGATATTCGTAATGCAATGGAAATTTTCCTTGGCGGCAAATATAAATCCGTGGTTT
CAGCTTGCGAATGTGAGCATCATCCTTATAAATCCTTTACTTTAGAAGGCACTGAAGTTCAGCCTATTCACGAATTAACG
GATTTTGAATCCCCTCGTCAAAAATTACCGAAATCTTATCGTGCAAATGGTGCAATTTATATTAATGACATCCAAAGTCT
CTTTGAAGAAAAACGTTTTTTTATTGCGCCAATGCGTTTTTATTTAATGCCAACTTATCGTTCCATTGATATTGACTCCA
CACTTGATTTGCAATTAGCCGAAAGTTTAATTTCAAAAGAATTCTAA

Upstream 100 bases:

>100_bases
TTTCCTCTTTGTTAAACAAAAATGTGGTGCCATATTAAAGATTAGTTTTTGCTAAAACAAGGGAAAGATTCTAGAATAGT
CAGCGCTTTTATCACAGAGG

Downstream 100 bases:

>100_bases
AAAAATTGGCCGCACTTTTGATCTGCACTCCAAAAGTTGGATTAAACAACCAACTAAGGTGCAGATTTTTTATGACCAAA
TACAATTTTTTTCAAGCAAC

Product: acylneuraminate cytidylyltransferase

Products: NA

Alternate protein names: CMP-N-acetylneuraminic acid synthase; CMP-NeuNAc synthase; CMP-sialic acid synthase

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKIIMTRIAIIPARAGSKGIKDKNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENILKEATKYGAKPVARPESLAQS
DTRTIDAILHCLETLNISQGTAALLQPTSPLRNALDIRNAMEIFLGGKYKSVVSACECEHHPYKSFTLEGTEVQPIHELT
DFESPRQKLPKSYRANGAIYINDIQSLFEEKRFFIAPMRFYLMPTYRSIDIDSTLDLQLAESLISKEF

Sequences:

>Translated_228_residues
MKIIMTRIAIIPARAGSKGIKDKNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENILKEATKYGAKPVARPESLAQS
DTRTIDAILHCLETLNISQGTAALLQPTSPLRNALDIRNAMEIFLGGKYKSVVSACECEHHPYKSFTLEGTEVQPIHELT
DFESPRQKLPKSYRANGAIYINDIQSLFEEKRFFIAPMRFYLMPTYRSIDIDSTLDLQLAESLISKEF
>Mature_228_residues
MKIIMTRIAIIPARAGSKGIKDKNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENILKEATKYGAKPVARPESLAQS
DTRTIDAILHCLETLNISQGTAALLQPTSPLRNALDIRNAMEIFLGGKYKSVVSACECEHHPYKSFTLEGTEVQPIHELT
DFESPRQKLPKSYRANGAIYINDIQSLFEEKRFFIAPMRFYLMPTYRSIDIDSTLDLQLAESLISKEF

Specific function: Unknown

COG id: COG1083

COG function: function code M; CMP-N-acetylneuraminic acid synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CMP-NeuNAc synthase family

Homologues:

Organism=Homo sapiens, GI8923900, Length=225, Percent_Identity=28.8888888888889, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NEUA_HAEIN (Q57140)

Other databases:

- EMBL:   L42023
- PIR:   C64114
- RefSeq:   NP_439432.1
- ProteinModelPortal:   Q57140
- SMR:   Q57140
- GeneID:   950022
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1279
- NMPDR:   fig|71421.1.peg.1221
- TIGR:   HI_1279
- HOGENOM:   HBG656811
- OMA:   IKDKNLQ
- ProtClustDB:   CLSK789358
- BioCyc:   HINF71421:HI_1279-MONOMER
- BRENDA:   2.7.7.43
- GO:   GO:0005737
- InterPro:   IPR003329

Pfam domain/function: PF02348 CTP_transf_3

EC number: =2.7.7.43

Molecular weight: Translated: 25309; Mature: 25309

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIIMTRIAIIPARAGSKGIKDKNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENIL
CEEEEEEHHEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
KEATKYGAKPVARPESLAQSDTRTIDAILHCLETLNISQGTAALLQPTSPLRNALDIRNA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCHHHHHHHHHHHH
MEIFLGGKYKSVVSACECEHHPYKSFTLEGTEVQPIHELTDFESPRQKLPKSYRANGAIY
HHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHCCCCHHHHCCHHHCCCCCEE
INDIQSLFEEKRFFIAPMRFYLMPTYRSIDIDSTLDLQLAESLISKEF
EHHHHHHHHHHHHEEECHHHHEECCCCEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKIIMTRIAIIPARAGSKGIKDKNLQLVGGVSLVGRAILAAQESGMFDQIVVTSDGENIL
CEEEEEEHHEEECCCCCCCCCCCCEEEEECHHHHHHHHHHHHCCCCEEEEEEECCCHHHH
KEATKYGAKPVARPESLAQSDTRTIDAILHCLETLNISQGTAALLQPTSPLRNALDIRNA
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHEECCCHHHHHHHHHHHH
MEIFLGGKYKSVVSACECEHHPYKSFTLEGTEVQPIHELTDFESPRQKLPKSYRANGAIY
HHHHHCCCHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHCCCCHHHHCCHHHCCCCCEE
INDIQSLFEEKRFFIAPMRFYLMPTYRSIDIDSTLDLQLAESLISKEF
EHHHHHHHHHHHHEEECHHHHEECCCCEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800