Click here to switch to the map view.

The map label for this gene is sucD

Identifier: 16273117

GI number: 16273117

Start: 1263290

End: 1264171

Strand: Direct

Name: sucD

Synonym: HI1197

Alternate gene names: 16273117

Gene position: 1263290-1264171 (Clockwise)

Preceding gene: 16273116

Following gene: 16273118

Centisome position: 69.03

GC content: 41.27

Gene sequence:

>882_bases
ATGGCGATTTTAATTGATAAAAATACCAAAGTGATTTGCCAAGGTTTTACTGGTGGACAAGGGACTTTTCATTCTGAACA
AGCATTGGCCTACGGAACGCAATTAGTTGGTGGCGTATCGCCAAATAAAGGTGGAACCACTCATCTTGGTTTACCTGTAT
TTAATACAGTTCGTGAAGCTGTCGAAAATACGGGGGTAACAGCGACAGTCATTTATGTGCCAGCATCATTTTGTAAAGAT
GCCATAATTGAAGCTATTGATGCAGGGATTCAGTTAATTGTCTGTATTACTGAGGGTATTCCTACATTGGATATGCTTAA
AGTGAAACAGAAATTAAATGAAACGGGCGTAGTAATGATTGGGCCAAATTGCCCAGGTGTGATTACGCCTGATGAATGTA
AAATCGGCATTATGCCCGCTCACATACATAAAAAAGGTAAAGTGGGGATTGTTTCTCGTTCTGGAACTTTAACTTATGAA
GCGGTAAAACAAACTACAGATGAAGGCTTTGGACAATCGACTTGTGTGGGTATCGGGGGAGATCCTATTCCAGGTTCTAG
TTTTATTGATATTCTTGAAAGATTTCAACAAGATCCCGAAACAGAAGCCATTGTGATGATTGGCGAGATTGGCGGCTCTG
CAGAGGAAGAAGCAGCAATCTTCATTAAAGATAATGTCACTAAACCAGTGGTTGCGTATATTGCGGGTATCACTGCGCCA
AAAGGAAAACGGATGGGGCATGCGGGAGCCATTATTAGCGGCGGAAAAGGTACTGCAGTAGAAAAAATTGCAGCGTTAGA
AGCCGCTGGTGTGACCTGTGTAAAAAGCCTCGCTGAAATTGGTGAAGCCTTGAGAAAGCTATTAAAATCATCTAAAAATT
AA

Upstream 100 bases:

>100_bases
GTCGCCAAATTTTAGCGGAAAGCGACGTTAATATTCTTACCGCACAGAGTTTACAACAAGCCGCAGAATTAGCCGTGAAT
GCAGCAAAAGGAGAACACTA

Downstream 100 bases:

>100_bases
CCGCACTTTAGTTTTCTAAAGCGTAGATTGGCTTTCTACGCCTTTATTTTTATATGCTCGCCATTATAAAGTGAGCACAA
AATTGCTATAATCAGCGCAC

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha

Number of amino acids: Translated: 293; Mature: 292

Protein sequence:

>293_residues
MAILIDKNTKVICQGFTGGQGTFHSEQALAYGTQLVGGVSPNKGGTTHLGLPVFNTVREAVENTGVTATVIYVPASFCKD
AIIEAIDAGIQLIVCITEGIPTLDMLKVKQKLNETGVVMIGPNCPGVITPDECKIGIMPAHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSSFIDILERFQQDPETEAIVMIGEIGGSAEEEAAIFIKDNVTKPVVAYIAGITAP
KGKRMGHAGAIISGGKGTAVEKIAALEAAGVTCVKSLAEIGEALRKLLKSSKN

Sequences:

>Translated_293_residues
MAILIDKNTKVICQGFTGGQGTFHSEQALAYGTQLVGGVSPNKGGTTHLGLPVFNTVREAVENTGVTATVIYVPASFCKD
AIIEAIDAGIQLIVCITEGIPTLDMLKVKQKLNETGVVMIGPNCPGVITPDECKIGIMPAHIHKKGKVGIVSRSGTLTYE
AVKQTTDEGFGQSTCVGIGGDPIPGSSFIDILERFQQDPETEAIVMIGEIGGSAEEEAAIFIKDNVTKPVVAYIAGITAP
KGKRMGHAGAIISGGKGTAVEKIAALEAAGVTCVKSLAEIGEALRKLLKSSKN
>Mature_292_residues
AILIDKNTKVICQGFTGGQGTFHSEQALAYGTQLVGGVSPNKGGTTHLGLPVFNTVREAVENTGVTATVIYVPASFCKDA
IIEAIDAGIQLIVCITEGIPTLDMLKVKQKLNETGVVMIGPNCPGVITPDECKIGIMPAHIHKKGKVGIVSRSGTLTYEA
VKQTTDEGFGQSTCVGIGGDPIPGSSFIDILERFQQDPETEAIVMIGEIGGSAEEEAAIFIKDNVTKPVVAYIAGITAPK
GKRMGHAGAIISGGKGTAVEKIAALEAAGVTCVKSLAEIGEALRKLLKSSKN

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family

Homologues:

Organism=Homo sapiens, GI109452591, Length=295, Percent_Identity=65.4237288135593, Blast_Score=327, Evalue=8e-90,
Organism=Homo sapiens, GI38569423, Length=263, Percent_Identity=33.8403041825095, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI38569421, Length=263, Percent_Identity=33.8403041825095, Blast_Score=116, Evalue=2e-26,
Organism=Escherichia coli, GI1786949, Length=289, Percent_Identity=83.3910034602076, Blast_Score=487, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17550194, Length=285, Percent_Identity=63.1578947368421, Blast_Score=343, Evalue=9e-95,
Organism=Caenorhabditis elegans, GI17553126, Length=291, Percent_Identity=62.1993127147766, Blast_Score=335, Evalue=2e-92,
Organism=Caenorhabditis elegans, GI17557344, Length=256, Percent_Identity=29.6875, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17551266, Length=257, Percent_Identity=30.7392996108949, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324716, Length=291, Percent_Identity=51.5463917525773, Blast_Score=276, Evalue=2e-75,
Organism=Drosophila melanogaster, GI21356559, Length=285, Percent_Identity=60.7017543859649, Blast_Score=335, Evalue=2e-92,
Organism=Drosophila melanogaster, GI28574296, Length=290, Percent_Identity=62.4137931034483, Blast_Score=326, Evalue=1e-89,
Organism=Drosophila melanogaster, GI281363477, Length=257, Percent_Identity=30.3501945525292, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363475, Length=257, Percent_Identity=30.3501945525292, Blast_Score=108, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363473, Length=257, Percent_Identity=30.3501945525292, Blast_Score=108, Evalue=3e-24,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SUCD_HAEIN (P45102)

Other databases:

- EMBL:   L42023
- PIR:   D64189
- RefSeq:   NP_439353.1
- ProteinModelPortal:   P45102
- SMR:   P45102
- GeneID:   950515
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1197
- NMPDR:   fig|71421.1.peg.1144
- TIGR:   HI_1197
- HOGENOM:   HBG615372
- OMA:   ADAICEA
- ProtClustDB:   CLSK808494
- BioCyc:   HINF71421:HI_1197-MONOMER
- BRENDA:   6.2.1.5
- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102
- Gene3D:   G3DSA:3.40.50.720
- Gene3D:   G3DSA:3.40.50.261
- PIRSF:   PIRSF001553
- PRINTS:   PR01798
- SMART:   SM00881
- TIGRFAMs:   TIGR01019

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA; SSF52210 CoA_ligase

EC number: =6.2.1.5

Molecular weight: Translated: 30390; Mature: 30258

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS01216 SUCCINYL_COA_LIG_1; PS00399 SUCCINYL_COA_LIG_2

Important sites: ACT_SITE 247-247

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAILIDKNTKVICQGFTGGQGTFHSEQALAYGTQLVGGVSPNKGGTTHLGLPVFNTVREA
CEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
VENTGVTATVIYVPASFCKDAIIEAIDAGIQLIVCITEGIPTLDMLKVKQKLNETGVVMI
HHCCCCEEEEEEECHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGVITPDECKIGIMPAHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEEEHHCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSSFIDILERFQQDPETEAIVMIGEIGGSAEEEAAIFIKDNVTKPVVAYIAGITAP
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHCCCC
KGKRMGHAGAIISGGKGTAVEKIAALEAAGVTCVKSLAEIGEALRKLLKSSKN
CCCCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AILIDKNTKVICQGFTGGQGTFHSEQALAYGTQLVGGVSPNKGGTTHLGLPVFNTVREA
EEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEECCHHHHHHHHH
VENTGVTATVIYVPASFCKDAIIEAIDAGIQLIVCITEGIPTLDMLKVKQKLNETGVVMI
HHCCCCEEEEEEECHHHHHHHHHHHHHCCEEEEEEEECCCCHHHHHHHHHHHCCCCEEEE
GPNCPGVITPDECKIGIMPAHIHKKGKVGIVSRSGTLTYEAVKQTTDEGFGQSTCVGIGG
CCCCCCCCCCCCCEEEEEEHHCCCCCCEEEEECCCCEEHHHHHHHHHCCCCCCEEEECCC
DPIPGSSFIDILERFQQDPETEAIVMIGEIGGSAEEEAAIFIKDNVTKPVVAYIAGITAP
CCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEEEEECCCCHHHHHHHHHCCCC
KGKRMGHAGAIISGGKGTAVEKIAALEAAGVTCVKSLAEIGEALRKLLKSSKN
CCCCCCCCCCEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800