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The map label for this gene is hpt

Identifier: 16273078

GI number: 16273078

Start: 1221027

End: 1221566

Strand: Direct

Name: hpt

Synonym: HI1153

Alternate gene names: 16273078

Gene position: 1221027-1221566 (Clockwise)

Preceding gene: 16273077

Following gene: 16273079

Centisome position: 66.72

GC content: 37.96

Gene sequence:

>540_bases
ATGAAAAAACACCACGTAGATGTTTTAATTTCAGAGAACGATGTTCATGCTCGTATTGCTGAATTAGGTGCTCAAATTAC
AAAATTTTATCAAGAAAAACAGATCGATAACCTTGTTGTCGTAGGGCTTTTACGTGGTTCCTTTATGTTTATGGCGGATA
TCGTTCGTCAGATAAATTTACCTGTGGAAATTGAATTTATGACCACTTCAAGTTATGGCACTGGTATGACCACGAATCAC
GACGTTCGTATTACCAAAGATTTGGACGGCGATATAAAAGGTAAACACGTTTTAATTGTGGAAGATATTATTGATACGGG
CTATACGTTGGAAAAAGTGCGTGATATTTTGAATTTACGTGAGCCTGCGAGCCTTACAATTTGTACGTTACTTGATAAAC
CCTCTCGTCGCGAAGTGGAAGTGCCTGTTGAATGGGTTGGTTTTGAAATTCCTGATGAATTTGTTGTGGGGTATGGTATC
GATTACGCGCAACGCCATCGTAATTTAGGCTATATCGGTAAAGTTGTTTTAGAAGAATAA

Upstream 100 bases:

>100_bases
AAATTCGTTAGGGTTCAAAAAGGCTGAAGGTTTAAACTTCAGCCTTTTTTTTGTAAAATAGCAAACGATTTTATCCCCTG
TCATTTCATAAGGAAACACA

Downstream 100 bases:

>100_bases
TTTGATTTTATTGAAAAGTGCGGTTGAAATTTTAAATGAATTTTTAGCCGCACTTTTTTATATTATTTCATTGCTATTTT
CTCGATCACTTGCTAAATCT

Product: hypoxanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: HPRT

Number of amino acids: Translated: 179; Mature: 179

Protein sequence:

>179_residues
MKKHHVDVLISENDVHARIAELGAQITKFYQEKQIDNLVVVGLLRGSFMFMADIVRQINLPVEIEFMTTSSYGTGMTTNH
DVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLREPASLTICTLLDKPSRREVEVPVEWVGFEIPDEFVVGYGI
DYAQRHRNLGYIGKVVLEE

Sequences:

>Translated_179_residues
MKKHHVDVLISENDVHARIAELGAQITKFYQEKQIDNLVVVGLLRGSFMFMADIVRQINLPVEIEFMTTSSYGTGMTTNH
DVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLREPASLTICTLLDKPSRREVEVPVEWVGFEIPDEFVVGYGI
DYAQRHRNLGYIGKVVLEE
>Mature_179_residues
MKKHHVDVLISENDVHARIAELGAQITKFYQEKQIDNLVVVGLLRGSFMFMADIVRQINLPVEIEFMTTSSYGTGMTTNH
DVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLREPASLTICTLLDKPSRREVEVPVEWVGFEIPDEFVVGYGI
DYAQRHRNLGYIGKVVLEE

Specific function: This enzyme acts exclusively on hypoxanthine; it does not act on guanine

COG id: COG0634

COG function: function code F; Hypoxanthine-guanine phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4504483, Length=145, Percent_Identity=34.4827586206897, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI9910262, Length=174, Percent_Identity=29.3103448275862, Blast_Score=77, Evalue=1e-14,
Organism=Escherichia coli, GI87081689, Length=175, Percent_Identity=69.1428571428571, Blast_Score=249, Evalue=8e-68,
Organism=Caenorhabditis elegans, GI17510817, Length=173, Percent_Identity=36.9942196531792, Blast_Score=94, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HPRT_HAEIN (P45078)

Other databases:

- EMBL:   L42023
- PIR:   D64168
- RefSeq:   NP_439311.1
- ProteinModelPortal:   P45078
- SMR:   P45078
- GeneID:   950117
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1153
- NMPDR:   fig|71421.1.peg.1106
- TIGR:   HI_1153
- HOGENOM:   HBG536385
- OMA:   INAHYAD
- ProtClustDB:   CLSK869975
- BioCyc:   HINF71421:HI_1153-MONOMER
- BRENDA:   2.4.2.8
- GO:   GO:0005737
- InterPro:   IPR005904
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01203

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.8

Molecular weight: Translated: 20371; Mature: 20371

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKHHVDVLISENDVHARIAELGAQITKFYQEKQIDNLVVVGLLRGSFMFMADIVRQINL
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHCCC
PVEIEFMTTSSYGTGMTTNHDVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLR
CEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHCCC
EPASLTICTLLDKPSRREVEVPVEWVGFEIPDEFVVGYGIDYAQRHRNLGYIGKVVLEE
CCCCEEEEEECCCCCCCEEECCCEEECEECCCCEEEECCCCHHHHCCCCCCEEEEEECC
>Mature Secondary Structure
MKKHHVDVLISENDVHARIAELGAQITKFYQEKQIDNLVVVGLLRGSFMFMADIVRQINL
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEHHCCHHHHHHHHHHCCC
PVEIEFMTTSSYGTGMTTNHDVRITKDLDGDIKGKHVLIVEDIIDTGYTLEKVRDILNLR
CEEEEEEEECCCCCCCCCCCCEEEEECCCCCCCCCEEEEEEHHHCCCCCHHHHHHHHCCC
EPASLTICTLLDKPSRREVEVPVEWVGFEIPDEFVVGYGIDYAQRHRNLGYIGKVVLEE
CCCCEEEEEECCCCCCCEEECCCEEECEECCCCEEEECCCCHHHHCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800