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The map label for this gene is pheA

Identifier: 16273071

GI number: 16273071

Start: 1214369

End: 1215526

Strand: Direct

Name: pheA

Synonym: HI1145

Alternate gene names: 16273071

Gene position: 1214369-1215526 (Clockwise)

Preceding gene: 16273070

Following gene: 16273077

Centisome position: 66.35

GC content: 34.2

Gene sequence:

>1158_bases
ATGGCATTAGAATTATCTGACATTCGCCAACAAATTACGCAAATAGATCGTAGTTTATTAAAATTACTTTCTGAGCGTCA
TCGTTTAGCTTTCGATGTAGTGAGAAGTAAAGAGATCTCGCAAAAATCTTTACGTGATGTAGAGCGAGAACAGCAACTTT
TACAAGAACTAGTGCAATTTGCAGAAAATGAAAATTATCAGCTTGAAGCACAATATATCACTTCAATTTTCCAAAAAATC
ATTGAAGACTCGGTATTGACCCAGCAAGTCTATTTGCAAAATAAACTTAATGAACAACGTAATCAAAATTTACATATCGC
TTTTTTAGGTAAACGTGGTTCTTATTCTAATTTAGCTGCACGTAATTATGCTGCTCGTTATCAAAAACAATTTGTAGAAC
TAGGATGTCAGTCTTTTGAGCAAGTATTTGAAAAAGTTCAGACTGGAGAAGCTGACTTTGGTGTGTTACCTTTAGAAAAT
ACAACATCGGGTGCAATTAATGAAGTTTATGATTTACTTCAGCATACTGATTTATCATTAGTGGGAGAGTTGGCATATCC
AATCAAACATTGCGTACTTGTCAATGATAAGACAGATTTGAACCAAATTGATACGTTGTATAGTCATCCTCAAGTGATTC
AACAATGTAGTCAATTTATTCATAGCCTTGATCGCGTGCATATTGAATATTGCGAAAGTAGTTCACACGCAATGCAATTA
GTCGCAAGTTTGAATAAACCTAATATTGCAGCATTGGGCAATGAAGACGGTGGAAAATTGTATGGACTTAGTGTATTAAA
AACTAATATTGCTAATCAAGAGAACAATATTACGCGTTTTATTGTGGTGGCTAAAGAGCCTCGCGAAGTTTCATCACAGA
TTCCCACAAAGACCTTATTATTAATGACAACTTCACAGCAAGCTGGTGCGTTAGTGGATGCTTTATTGGTGTTTAAAAAG
CATCAAATCAATATGACAAAACTGGAATCTAGACCGATTTATGGTAAGCCTTGGGAAGAAATGTTTTATCTAGAAATTGA
AGCAAATATTCATCATCCAGATACAAAACAGGCTTTGGAAGAACTAAAAAATTATAGTAATTACTTAAAGATTTTAGGCT
GTTATCCTAGTGAAATTGTAAAGCCTGTGAGCGTGTAA

Upstream 100 bases:

>100_bases
TTCTGGTGGGAAGTATAGCTTTTTTGTTTCATCTCGTGCTTAAATAGCGAATGTACTAAAAGTGCGGTCAATTTCGTGGG
ATTTTTTATAAGGAAGCATT

Downstream 100 bases:

>100_bases
AAAAAGTGCGGTCAATAAAAATAATGTTTTTATGACCGCACTTTTTATATTTTTTTGTTCCGTTCTAAAGATTTATGTTG
AATTTTCACCGTTTTTCCTT

Product: chorismate mutase/prephenate dehydratase

Products: NA

Alternate protein names: Chorismate mutase; CM; Prephenate dehydratase; PDT

Number of amino acids: Translated: 385; Mature: 384

Protein sequence:

>385_residues
MALELSDIRQQITQIDRSLLKLLSERHRLAFDVVRSKEISQKSLRDVEREQQLLQELVQFAENENYQLEAQYITSIFQKI
IEDSVLTQQVYLQNKLNEQRNQNLHIAFLGKRGSYSNLAARNYAARYQKQFVELGCQSFEQVFEKVQTGEADFGVLPLEN
TTSGAINEVYDLLQHTDLSLVGELAYPIKHCVLVNDKTDLNQIDTLYSHPQVIQQCSQFIHSLDRVHIEYCESSSHAMQL
VASLNKPNIAALGNEDGGKLYGLSVLKTNIANQENNITRFIVVAKEPREVSSQIPTKTLLLMTTSQQAGALVDALLVFKK
HQINMTKLESRPIYGKPWEEMFYLEIEANIHHPDTKQALEELKNYSNYLKILGCYPSEIVKPVSV

Sequences:

>Translated_385_residues
MALELSDIRQQITQIDRSLLKLLSERHRLAFDVVRSKEISQKSLRDVEREQQLLQELVQFAENENYQLEAQYITSIFQKI
IEDSVLTQQVYLQNKLNEQRNQNLHIAFLGKRGSYSNLAARNYAARYQKQFVELGCQSFEQVFEKVQTGEADFGVLPLEN
TTSGAINEVYDLLQHTDLSLVGELAYPIKHCVLVNDKTDLNQIDTLYSHPQVIQQCSQFIHSLDRVHIEYCESSSHAMQL
VASLNKPNIAALGNEDGGKLYGLSVLKTNIANQENNITRFIVVAKEPREVSSQIPTKTLLLMTTSQQAGALVDALLVFKK
HQINMTKLESRPIYGKPWEEMFYLEIEANIHHPDTKQALEELKNYSNYLKILGCYPSEIVKPVSV
>Mature_384_residues
ALELSDIRQQITQIDRSLLKLLSERHRLAFDVVRSKEISQKSLRDVEREQQLLQELVQFAENENYQLEAQYITSIFQKII
EDSVLTQQVYLQNKLNEQRNQNLHIAFLGKRGSYSNLAARNYAARYQKQFVELGCQSFEQVFEKVQTGEADFGVLPLENT
TSGAINEVYDLLQHTDLSLVGELAYPIKHCVLVNDKTDLNQIDTLYSHPQVIQQCSQFIHSLDRVHIEYCESSSHAMQLV
ASLNKPNIAALGNEDGGKLYGLSVLKTNIANQENNITRFIVVAKEPREVSSQIPTKTLLLMTTSQQAGALVDALLVFKKH
QINMTKLESRPIYGKPWEEMFYLEIEANIHHPDTKQALEELKNYSNYLKILGCYPSEIVKPVSV

Specific function: L-phenylalanine biosynthesis. [C]

COG id: COG0077

COG function: function code E; Prephenate dehydratase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 prephenate dehydratase domain

Homologues:

Organism=Escherichia coli, GI1788951, Length=376, Percent_Identity=54.2553191489362, Blast_Score=427, Evalue=1e-121,
Organism=Saccharomyces cerevisiae, GI6324013, Length=326, Percent_Identity=24.8466257668712, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PHEA_HAEIN (P43900)

Other databases:

- EMBL:   L42023
- PIR:   B64186
- RefSeq:   NP_439303.1
- ProteinModelPortal:   P43900
- GeneID:   950108
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1145
- TIGR:   HI_1145
- HOGENOM:   HBG693866
- OMA:   LESRPIY
- ProtClustDB:   CLSK869985
- BioCyc:   HINF71421:HI_1145-MONOMER
- BRENDA:   4.2.1.51
- BRENDA:   5.4.99.5
- GO:   GO:0005737
- InterPro:   IPR008242
- InterPro:   IPR002701
- InterPro:   IPR020822
- InterPro:   IPR010952
- InterPro:   IPR001086
- InterPro:   IPR018528
- Gene3D:   G3DSA:1.20.59.10
- PIRSF:   PIRSF001500
- SMART:   SM00830
- TIGRFAMs:   TIGR01797

Pfam domain/function: PF01817 CM_2; PF00800 PDT; SSF48600 Chorismate_mut

EC number: =5.4.99.5; =4.2.1.51

Molecular weight: Translated: 44002; Mature: 43870

Theoretical pI: Translated: 5.98; Mature: 5.98

Prosite motif: PS51168 CHORISMATE_MUT_2; PS00857 PREPHENATE_DEHYDR_1; PS00858 PREPHENATE_DEHYDR_2; PS51171 PREPHENATE_DEHYDR_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALELSDIRQQITQIDRSLLKLLSERHRLAFDVVRSKEISQKSLRDVEREQQLLQELVQF
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AENENYQLEAQYITSIFQKIIEDSVLTQQVYLQNKLNEQRNQNLHIAFLGKRGSYSNLAA
HCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHH
RNYAARYQKQFVELGCQSFEQVFEKVQTGEADFGVLPLENTTSGAINEVYDLLQHTDLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCHHH
VGELAYPIKHCVLVNDKTDLNQIDTLYSHPQVIQQCSQFIHSLDRVHIEYCESSSHAMQL
HHHHHHHHHHEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VASLNKPNIAALGNEDGGKLYGLSVLKTNIANQENNITRFIVVAKEPREVSSQIPTKTLL
HHHCCCCCEEEECCCCCCEEEEHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCEEEE
LMTTSQQAGALVDALLVFKKHQINMTKLESRPIYGKPWEEMFYLEIEANIHHPDTKQALE
EEECCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHEEEEEEECCCCCCCHHHHHH
ELKNYSNYLKILGCYPSEIVKPVSV
HHHHHHHHHHHHCCCHHHHCCCCCC
>Mature Secondary Structure 
ALELSDIRQQITQIDRSLLKLLSERHRLAFDVVRSKEISQKSLRDVEREQQLLQELVQF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AENENYQLEAQYITSIFQKIIEDSVLTQQVYLQNKLNEQRNQNLHIAFLGKRGSYSNLAA
HCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHH
RNYAARYQKQFVELGCQSFEQVFEKVQTGEADFGVLPLENTTSGAINEVYDLLQHTDLSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCHHHHHHHHHHHHCCHHH
VGELAYPIKHCVLVNDKTDLNQIDTLYSHPQVIQQCSQFIHSLDRVHIEYCESSSHAMQL
HHHHHHHHHHEEEECCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
VASLNKPNIAALGNEDGGKLYGLSVLKTNIANQENNITRFIVVAKEPREVSSQIPTKTLL
HHHCCCCCEEEECCCCCCEEEEHHHHHHHHCCCCCCCEEEEEEECCCHHHHHHCCCEEEE
LMTTSQQAGALVDALLVFKKHQINMTKLESRPIYGKPWEEMFYLEIEANIHHPDTKQALE
EEECCCHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCHHHEEEEEEECCCCCCCHHHHHH
ELKNYSNYLKILGCYPSEIVKPVSV
HHHHHHHHHHHHCCCHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800