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The map label for this gene is serB

Identifier: 16272967

GI number: 16272967

Start: 1098172

End: 1099116

Strand: Direct

Name: serB

Synonym: HI1033

Alternate gene names: 16272967

Gene position: 1098172-1099116 (Clockwise)

Preceding gene: 16272966

Following gene: 16272968

Centisome position: 60.0

GC content: 38.31

Gene sequence:

>945_bases
ATGCAAATTCAATGTTTCGAAAGTATTACACAAAAATACCCACAATTTCCTACCGCACTTTTGGCTAATGAGGAACCTAT
ACAGAACGGAGAGCCTTTTATCTTATACGGCACAAAGTTGGACATAACTAAGCTAGAAAAATTTCAACAAAAGTGCGGTC
AAAATTTTCAGATTTTTGATGTTTGGATGGTAGCGAAAAATATTATCGTCTTATTGAAAGGTCAGTGGTTTTCTGATTTC
ATTAAATTTACTCACGATGTTGAAGTGGATATTGCTAAATTAGATTTCAGCCCTAAATTGTCTCAAGCAGGGTTGTTGGT
GATGGATATGGATTCTACCGCTATTCAAATTGAGTGTATTGATGAAATTGCGAAATTAGCGGGTGTTGGCGAACTTGTTT
CTGCGATTACGGAAAGTGCAATGAGGGGGGAATTAGATTTCGAGCAAAGTTTGCGTTGTCGAGTGGGTACATTAAAAGGT
GCGCCAGAAAGTATCTTACAGCAAGTTAGAGAGAATTTACCGCTAATGTCTGGATTAGTTGAAACGATCCAAACCTTACA
AAAATATGGCTGGAAAACTGCAATTGCTTCAGGCGGATTTACTTATTTTGCGGATTATTTGAAAGCCTTATTACAGCTTG
ATTTTGCGGCATCAAATCAATTTGATATTGAAGATGGAAAACTCACTGGCTTAGTTAAAGGCGATGTGGTTGATGCCCAA
TACAAAGCTAAAACATTACAACATTTGTTAGAGGAATACGGTATTGATTCACGACATTCTATTGCTATTGGCGATGGGGC
AAATGACTTGGCAATGATGAATGTGGCAGGGCTAGGTGTTGCGTTCCACGCTAAACCTAAAGTGCAACCACAAGCGCAAA
TTGTGGTAAACTTCGCCGACTTAACCGCACTTTTATGCCTTTTAAGTGCTAATGATCGAATTTAA

Upstream 100 bases:

>100_bases
TTCTATGTTATTAAAAGTAATCATACATAATAAAATCTTCTTAATTATTTGTTACCATTAGTTAGAGTAATTCAATTTTT
TAGCAACTTACAGGATTTTT

Downstream 100 bases:

>100_bases
TAAAACGGGAGAAGACTATGCCATCTTTTGATATTGTTTCTGAAATTACTTTACACGAAGTCCGTAATGCAGTGGAAAAT
GCCAACCGTGTGCTTAGCAC

Product: phosphoserine phosphatase

Products: NA

Alternate protein names: PSP; PSPase; O-phosphoserine phosphohydrolase

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MQIQCFESITQKYPQFPTALLANEEPIQNGEPFILYGTKLDITKLEKFQQKCGQNFQIFDVWMVAKNIIVLLKGQWFSDF
IKFTHDVEVDIAKLDFSPKLSQAGLLVMDMDSTAIQIECIDEIAKLAGVGELVSAITESAMRGELDFEQSLRCRVGTLKG
APESILQQVRENLPLMSGLVETIQTLQKYGWKTAIASGGFTYFADYLKALLQLDFAASNQFDIEDGKLTGLVKGDVVDAQ
YKAKTLQHLLEEYGIDSRHSIAIGDGANDLAMMNVAGLGVAFHAKPKVQPQAQIVVNFADLTALLCLLSANDRI

Sequences:

>Translated_314_residues
MQIQCFESITQKYPQFPTALLANEEPIQNGEPFILYGTKLDITKLEKFQQKCGQNFQIFDVWMVAKNIIVLLKGQWFSDF
IKFTHDVEVDIAKLDFSPKLSQAGLLVMDMDSTAIQIECIDEIAKLAGVGELVSAITESAMRGELDFEQSLRCRVGTLKG
APESILQQVRENLPLMSGLVETIQTLQKYGWKTAIASGGFTYFADYLKALLQLDFAASNQFDIEDGKLTGLVKGDVVDAQ
YKAKTLQHLLEEYGIDSRHSIAIGDGANDLAMMNVAGLGVAFHAKPKVQPQAQIVVNFADLTALLCLLSANDRI
>Mature_314_residues
MQIQCFESITQKYPQFPTALLANEEPIQNGEPFILYGTKLDITKLEKFQQKCGQNFQIFDVWMVAKNIIVLLKGQWFSDF
IKFTHDVEVDIAKLDFSPKLSQAGLLVMDMDSTAIQIECIDEIAKLAGVGELVSAITESAMRGELDFEQSLRCRVGTLKG
APESILQQVRENLPLMSGLVETIQTLQKYGWKTAIASGGFTYFADYLKALLQLDFAASNQFDIEDGKLTGLVKGDVVDAQ
YKAKTLQHLLEEYGIDSRHSIAIGDGANDLAMMNVAGLGVAFHAKPKVQPQAQIVVNFADLTALLCLLSANDRI

Specific function: Unknown

COG id: COG0560

COG function: function code E; Phosphoserine phosphatase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serB family

Homologues:

Organism=Homo sapiens, GI46249388, Length=175, Percent_Identity=29.7142857142857, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790849, Length=303, Percent_Identity=51.8151815181518, Blast_Score=310, Evalue=6e-86,
Organism=Saccharomyces cerevisiae, GI6321647, Length=238, Percent_Identity=40.7563025210084, Blast_Score=157, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SERB_HAEIN (P44997)

Other databases:

- EMBL:   L42023
- PIR:   I64108
- RefSeq:   NP_439193.1
- ProteinModelPortal:   P44997
- SMR:   P44997
- GeneID:   949401
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI1033
- NMPDR:   fig|71421.1.peg.995
- TIGR:   HI_1033
- HOGENOM:   HBG645339
- OMA:   DYQVVRL
- ProtClustDB:   PRK11133
- BioCyc:   HINF71421:HI_1033-MONOMER
- BRENDA:   3.1.3.3
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR006383
- InterPro:   IPR023190
- InterPro:   IPR004469
- Gene3D:   G3DSA:3.40.50.1000
- Gene3D:   G3DSA:1.10.150.210
- TIGRFAMs:   TIGR01488
- TIGRFAMs:   TIGR00338

Pfam domain/function: PF00702 Hydrolase; SSF56784 SSF56784

EC number: =3.1.3.3

Molecular weight: Translated: 34720; Mature: 34720

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: NA

Important sites: ACT_SITE 109-109 ACT_SITE 111-111 BINDING 118-118 BINDING 154-154 BINDING 242-242 BINDING 268-268

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQIQCFESITQKYPQFPTALLANEEPIQNGEPFILYGTKLDITKLEKFQQKCGQNFQIFD
CCCHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEH
VWMVAKNIIVLLKGQWFSDFIKFTHDVEVDIAKLDFSPKLSQAGLLVMDMDSTAIQIECI
HHHHHHCEEEEEECCHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEHHH
DEIAKLAGVGELVSAITESAMRGELDFEQSLRCRVGTLKGAPESILQQVRENLPLMSGLV
HHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCHHHHHHHHHHCCCHHHHHH
ETIQTLQKYGWKTAIASGGFTYFADYLKALLQLDFAASNQFDIEDGKLTGLVKGDVVDAQ
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEECHH
YKAKTLQHLLEEYGIDSRHSIAIGDGANDLAMMNVAGLGVAFHAKPKVQPQAQIVVNFAD
HHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHCCCEEEECCCCCCCCCEEEEEHHH
LTALLCLLSANDRI
HHHHHHHHHCCCCC
>Mature Secondary Structure
MQIQCFESITQKYPQFPTALLANEEPIQNGEPFILYGTKLDITKLEKFQQKCGQNFQIFD
CCCHHHHHHHHHCCCCCHHHHCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCEEEH
VWMVAKNIIVLLKGQWFSDFIKFTHDVEVDIAKLDFSPKLSQAGLLVMDMDSTAIQIECI
HHHHHHCEEEEEECCHHHHHHHHHCCCEEEEEEECCCCCCCCCCEEEEECCCCEEEEHHH
DEIAKLAGVGELVSAITESAMRGELDFEQSLRCRVGTLKGAPESILQQVRENLPLMSGLV
HHHHHHHCHHHHHHHHHHHHHCCCCCHHHHHHEEECCCCCCHHHHHHHHHHCCCHHHHHH
ETIQTLQKYGWKTAIASGGFTYFADYLKALLQLDFAASNQFDIEDGKLTGLVKGDVVDAQ
HHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCEECHH
YKAKTLQHLLEEYGIDSRHSIAIGDGANDLAMMNVAGLGVAFHAKPKVQPQAQIVVNFAD
HHHHHHHHHHHHHCCCCCCEEEECCCCCCEEEEEHHCCCEEEECCCCCCCCCEEEEEHHH
LTALLCLLSANDRI
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800