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The map label for this gene is prmA

Identifier: 16272916

GI number: 16272916

Start: 1036082

End: 1036972

Strand: Direct

Name: prmA

Synonym: HI0978

Alternate gene names: 16272916

Gene position: 1036082-1036972 (Clockwise)

Preceding gene: 16272915

Following gene: 16272917

Centisome position: 56.61

GC content: 42.54

Gene sequence:

>891_bases
ATGGCTTGGATTCAAATTCGCCTGAACAGCACCAATGAAAAAGCAGAACAAATGAGCGATTTTTTAGAAGAAATCGGCTC
CGTCTCTGTAACTTTTATGGATAGTCAAGATACACCGATTTTTGAGCCTTTGCCAGGCGAAACGCGTTTATGGGGTAATA
CCGATGTTATTGCGCTATTTGATGCAGAAACAGATATGGCAGAAATTGTCCGCTTATTAAAAGAAGCGAAACACTTAGAT
AGCAATACGGCATACAAAATTGGAACAAATAGAAGATTAAAGAACTGGGAGCGTGAGTGGATGGATAACTTCCACCCAAT
GCAATTTGGTAAGCGTTTATGGATTTGTCCAAGTTGGCGTGATGTGCCTGATGAAAATGCCGTCAATGTTATGCTTGACC
CAGGTTTAGCATTTGGGACTGGCACGCATCCTACAACCGCACTATGTTTAGAATGGCTAGATGGTCTTGATTTAAAAGAT
AAAAGCGTCATCGATTTTGGTTGTGGATCTGGTATTTTAGCCATTGCAGCATTAAAACTTGGTGCGAAAAGTGCGGTGGG
AATTGACATCGATCCACAAGCCATTCTGGCTAGTCGCAATAATGCTGAGCAAAATGGCGTGACAGATCGCCTACAGCTGT
TCTTATCTGATGAAAAACCCTCTGATTTAAAAGCTGACGTCGTGGTGGCAAATATTCTTGCTGGCCCTCTCAAAGAACTT
TACCCAATCATTAGCCAACTTGTTAAGCCGAATGGCGATCTTGGTTTATCAGGCATTTTAGAAACTCAAGCTCAATCGGT
ATGCGATACCTATACGCAAACATTTGCGTTAGAGCCCGTCGCGGCGAGAGAAGAATGGTGCCGAATTACGGGTAAGCTAA
AAACGCTTTAA

Upstream 100 bases:

>100_bases
GAAATTATTTTTAAAGGTATTGAGCAATCTTATTATTACGAAGGTTACGAGAAAGAATAAAGTGCGGTAAAAATACGCAA
AATTTTGAAAGGAAAAACAA

Downstream 100 bases:

>100_bases
TTTCTTTTTGTCAATCAAAAAAAGTGTATTTTTTAAACAAATTTCACTTTGCAAAGCAAGGCAAAATGCCGTATTAATAG
CCAGCCTTGTCGGTTGTCGA

Product: ribosomal protein L11 methyltransferase

Products: NA

Alternate protein names: L11 Mtase

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MAWIQIRLNSTNEKAEQMSDFLEEIGSVSVTFMDSQDTPIFEPLPGETRLWGNTDVIALFDAETDMAEIVRLLKEAKHLD
SNTAYKIGTNRRLKNWEREWMDNFHPMQFGKRLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTALCLEWLDGLDLKD
KSVIDFGCGSGILAIAALKLGAKSAVGIDIDPQAILASRNNAEQNGVTDRLQLFLSDEKPSDLKADVVVANILAGPLKEL
YPIISQLVKPNGDLGLSGILETQAQSVCDTYTQTFALEPVAAREEWCRITGKLKTL

Sequences:

>Translated_296_residues
MAWIQIRLNSTNEKAEQMSDFLEEIGSVSVTFMDSQDTPIFEPLPGETRLWGNTDVIALFDAETDMAEIVRLLKEAKHLD
SNTAYKIGTNRRLKNWEREWMDNFHPMQFGKRLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTALCLEWLDGLDLKD
KSVIDFGCGSGILAIAALKLGAKSAVGIDIDPQAILASRNNAEQNGVTDRLQLFLSDEKPSDLKADVVVANILAGPLKEL
YPIISQLVKPNGDLGLSGILETQAQSVCDTYTQTFALEPVAAREEWCRITGKLKTL
>Mature_295_residues
AWIQIRLNSTNEKAEQMSDFLEEIGSVSVTFMDSQDTPIFEPLPGETRLWGNTDVIALFDAETDMAEIVRLLKEAKHLDS
NTAYKIGTNRRLKNWEREWMDNFHPMQFGKRLWICPSWRDVPDENAVNVMLDPGLAFGTGTHPTTALCLEWLDGLDLKDK
SVIDFGCGSGILAIAALKLGAKSAVGIDIDPQAILASRNNAEQNGVTDRLQLFLSDEKPSDLKADVVVANILAGPLKELY
PIISQLVKPNGDLGLSGILETQAQSVCDTYTQTFALEPVAAREEWCRITGKLKTL

Specific function: Methylates ribosomal protein L11

COG id: COG2264

COG function: function code J; Ribosomal protein L11 methylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. PrmA family

Homologues:

Organism=Escherichia coli, GI2367208, Length=292, Percent_Identity=69.8630136986301, Blast_Score=395, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PRMA_HAEIN (P44402)

Other databases:

- EMBL:   L42023
- PIR:   I64105
- RefSeq:   NP_439141.1
- ProteinModelPortal:   P44402
- GeneID:   949962
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0978
- NMPDR:   fig|71421.1.peg.945
- TIGR:   HI_0978
- HOGENOM:   HBG584653
- OMA:   EDQDWER
- ProtClustDB:   PRK00517
- BioCyc:   HINF71421:HI_0978-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00735
- InterPro:   IPR010456
- InterPro:   IPR004498
- TIGRFAMs:   TIGR00406

Pfam domain/function: PF06325 PrmA

EC number: 2.1.1.- [C]

Molecular weight: Translated: 32765; Mature: 32633

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAWIQIRLNSTNEKAEQMSDFLEEIGSVSVTFMDSQDTPIFEPLPGETRLWGNTDVIALF
CEEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEECCCCCEEEEE
DAETDMAEIVRLLKEAKHLDSNTAYKIGTNRRLKNWEREWMDNFHPMQFGKRLWICPSWR
ECCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCHHHCCEEEECCCCC
DVPDENAVNVMLDPGLAFGTGTHPTTALCLEWLDGLDLKDKSVIDFGCGSGILAIAALKL
CCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHH
GAKSAVGIDIDPQAILASRNNAEQNGVTDRLQLFLSDEKPSDLKADVVVANILAGPLKEL
CCCCEECCCCCCHHHEECCCCCCCCCHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHH
YPIISQLVKPNGDLGLSGILETQAQSVCDTYTQTFALEPVAAREEWCRITGKLKTL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHCCC
>Mature Secondary Structure 
AWIQIRLNSTNEKAEQMSDFLEEIGSVSVTFMDSQDTPIFEPLPGETRLWGNTDVIALF
EEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCEECCCCCEEEEE
DAETDMAEIVRLLKEAKHLDSNTAYKIGTNRRLKNWEREWMDNFHPMQFGKRLWICPSWR
ECCCCHHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHCCCCCHHHCCEEEECCCCC
DVPDENAVNVMLDPGLAFGTGTHPTTALCLEWLDGLDLKDKSVIDFGCGSGILAIAALKL
CCCCCCCEEEEECCCEEECCCCCHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHH
GAKSAVGIDIDPQAILASRNNAEQNGVTDRLQLFLSDEKPSDLKADVVVANILAGPLKEL
CCCCEECCCCCCHHHEECCCCCCCCCHHHHHHEEECCCCCCCCHHHHHHHHHHHHHHHHH
YPIISQLVKPNGDLGLSGILETQAQSVCDTYTQTFALEPVAAREEWCRITGKLKTL
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Catalyzes the methylation of ribosomal protein L11 by S-adenosyl methionine [C]

General reaction: Transferases; Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800