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The map label for this gene is accC

Identifier: 16272909

GI number: 16272909

Start: 1028779

End: 1030125

Strand: Direct

Name: accC

Synonym: HI0972

Alternate gene names: 16272909

Gene position: 1028779-1030125 (Clockwise)

Preceding gene: 16272908

Following gene: 16272910

Centisome position: 56.21

GC content: 41.57

Gene sequence:

>1347_bases
ATGTTAGAAAAAGTTGTGATTGCTAACCGCGGTGAAATTGCACTACGCATTTTACGTGCTTGTAAAGAATTAGGTATTAA
AACTGTGGCGGTTCACTCCACTGCTGATCGTGATTTAAAACACGTTTTACTCGCTGATGAAACCATTTGTATCGGTCCAG
CACCTTCCGCAAAAAGTTATTTAAATATTCCAGCTATCATTGCTGCCGCCGAAGTAACAGGTGCGGATGCAATTCATCCT
GGATACGGTTTCTTATCTGAAAACGCTGACTTTGCTGAACAAGTTGAACGTTCAGGTTTCACTTTCATCGGCCCAACAGC
AGATGTTATTCGTTTAATGGGCGATAAAGTTTCAGCTATTAAAGCGATGAAAAAAGCAGGCGTGCCTTGTGTACCAGGTT
CGGATGGCCCTGTAAGTAATGATATTGCTAAAAATAAAGAAATCGCCAAACGTATTGGTTATCCAATCATCATCAAAGCA
TCAGGCGGCGGCGGTGGCCGAGGAATGCGTGTTGTTCGTAGCGAAGACGCATTAGAAGAATCTATTGCGATGACCAAAGC
AGAAGCGAAAGCCGCATTCAACAATGATATGGTTTATATGGAAAAATACTTAGAAAATCCACGTCACGTGGAAATTCAAG
TATTAGCAGATACCCATGGAAATGCGGTTTATTTGGCTGAACGTGACTGCTCAATGCAGCGTCGTCACCAAAAAGTTGTG
GAAGAAGCACCAGCTCCAGGTATTACAGAAGAAGTTCGCCGCGATATTGGCTCTCGCTGTGCAAATGCTTGTGTAGAAAT
CGGCTATCGCGGAGCGGGAACCTTTGAATTCTTATATGAAAATGGCGAATTCTACTTTATTGAAATGAATACCCGTATCC
AAGTAGAACACCCAGTAACAGAAATGATTACAGGTGTAGATTTAGTGAAAGAGCAATTGCGTATTGCAGCAGGCTTGCCA
ATTTCCTTTAAACAAGAGGACATTAAAGTTAAAGGCCATGCAATGGAATGCCGTATTAACGCAGAAGATCCCAAAACATT
CTTACCGTCTCCGGGCAAAGTAAATCACTTACATTCGCCTGGCGGTTTGGGCGTTCGTTGGGATTCTCATGTTTATGGTG
GCTATACTGTGCCTCCACATTACGACTCCATGATCGCAAAACTTATCACTTACGGCGATACACGTGAAGTGGCAATCCGT
CGTATGCAAAATGCCTTATCTGAAACAATTATTGATGGTATCAAAACCAATATCCCACTTCATGAATTAATTCTTGAAGA
TGAAAATTTCCAAAAAGGCGGAACAAACATCCATTATTTGGAGAAAAAATTAGGTATGAATGAATAA

Upstream 100 bases:

>100_bases
GATATAAATTGAAATCTGTTCACGCCAAATTTTATAGGGAGAACAATATTTCAAGAGCCTACATAAAAATTCACGTCTAT
CTGACTAAACGGACTCTTTT

Downstream 100 bases:

>100_bases
TTAAAATTTTAAACAGCTAACAGATGTTAGCTATTCTCTTATTGATTTTATAGACTTTTATTATAAAAAAAGATTTCATA
GAGAATTAATTGAGACAACT

Product: acetyl-CoA carboxylase biotin carboxylase subunit

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPAPSAKSYLNIPAIIAAAEVTGADAIHP
GYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAIKAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKA
SGGGGGRGMRVVRSEDALEESIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLP
ISFKQEDIKVKGHAMECRINAEDPKTFLPSPGKVNHLHSPGGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIR
RMQNALSETIIDGIKTNIPLHELILEDENFQKGGTNIHYLEKKLGMNE

Sequences:

>Translated_448_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPAPSAKSYLNIPAIIAAAEVTGADAIHP
GYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAIKAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKA
SGGGGGRGMRVVRSEDALEESIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLP
ISFKQEDIKVKGHAMECRINAEDPKTFLPSPGKVNHLHSPGGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIR
RMQNALSETIIDGIKTNIPLHELILEDENFQKGGTNIHYLEKKLGMNE
>Mature_448_residues
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPAPSAKSYLNIPAIIAAAEVTGADAIHP
GYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAIKAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKA
SGGGGGRGMRVVRSEDALEESIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVTEMITGVDLVKEQLRIAAGLP
ISFKQEDIKVKGHAMECRINAEDPKTFLPSPGKVNHLHSPGGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIR
RMQNALSETIIDGIKTNIPLHELILEDENFQKGGTNIHYLEKKLGMNE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain

Homologues:

Organism=Homo sapiens, GI116805327, Length=440, Percent_Identity=50.9090909090909, Blast_Score=430, Evalue=1e-120,
Organism=Homo sapiens, GI189095269, Length=443, Percent_Identity=48.7584650112867, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI65506442, Length=443, Percent_Identity=48.7584650112867, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI295821183, Length=443, Percent_Identity=48.7584650112867, Blast_Score=422, Evalue=1e-118,
Organism=Homo sapiens, GI106049528, Length=449, Percent_Identity=45.8797327394209, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049295, Length=449, Percent_Identity=45.8797327394209, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI106049292, Length=449, Percent_Identity=45.8797327394209, Blast_Score=385, Evalue=1e-107,
Organism=Homo sapiens, GI38679977, Length=510, Percent_Identity=30.5882352941176, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679967, Length=510, Percent_Identity=30.5882352941176, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=30.5882352941176, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=30.5882352941176, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI38679960, Length=510, Percent_Identity=30.5882352941176, Blast_Score=241, Evalue=1e-63,
Organism=Homo sapiens, GI134142062, Length=513, Percent_Identity=31.3840155945419, Blast_Score=234, Evalue=1e-61,
Organism=Escherichia coli, GI1789654, Length=448, Percent_Identity=82.1428571428571, Blast_Score=750, Evalue=0.0,
Organism=Escherichia coli, GI1786216, Length=240, Percent_Identity=24.1666666666667, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17567343, Length=443, Percent_Identity=47.4040632054176, Blast_Score=412, Evalue=1e-115,
Organism=Caenorhabditis elegans, GI71987519, Length=442, Percent_Identity=47.737556561086, Blast_Score=395, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17562816, Length=448, Percent_Identity=45.3125, Blast_Score=365, Evalue=1e-101,
Organism=Caenorhabditis elegans, GI133931226, Length=496, Percent_Identity=29.8387096774194, Blast_Score=202, Evalue=4e-52,
Organism=Caenorhabditis elegans, GI71997163, Length=517, Percent_Identity=27.852998065764, Blast_Score=201, Evalue=8e-52,
Organism=Caenorhabditis elegans, GI71997168, Length=517, Percent_Identity=27.852998065764, Blast_Score=201, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=42.6636568848758, Blast_Score=362, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6319695, Length=439, Percent_Identity=46.9248291571754, Blast_Score=358, Evalue=1e-99,
Organism=Saccharomyces cerevisiae, GI6321376, Length=439, Percent_Identity=47.380410022779, Blast_Score=350, Evalue=3e-97,
Organism=Saccharomyces cerevisiae, GI6324343, Length=516, Percent_Identity=31.5891472868217, Blast_Score=236, Evalue=5e-63,
Organism=Saccharomyces cerevisiae, GI6323863, Length=458, Percent_Identity=33.1877729257642, Blast_Score=226, Evalue=4e-60,
Organism=Drosophila melanogaster, GI24651757, Length=447, Percent_Identity=45.413870246085, Blast_Score=397, Evalue=1e-111,
Organism=Drosophila melanogaster, GI281363050, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652224, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652222, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652220, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652218, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652212, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652210, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652214, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI19921944, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24652216, Length=448, Percent_Identity=47.3214285714286, Blast_Score=386, Evalue=1e-107,
Organism=Drosophila melanogaster, GI24651759, Length=408, Percent_Identity=45.343137254902, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI24586458, Length=505, Percent_Identity=30.0990099009901, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI161076407, Length=505, Percent_Identity=30.0990099009901, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI24586460, Length=505, Percent_Identity=30.0990099009901, Blast_Score=219, Evalue=4e-57,
Organism=Drosophila melanogaster, GI161076409, Length=505, Percent_Identity=30.0990099009901, Blast_Score=219, Evalue=4e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACCC_HAEIN (P43873)

Other databases:

- EMBL:   L42023
- PIR:   F64105
- RefSeq:   NP_439133.1
- ProteinModelPortal:   P43873
- SMR:   P43873
- GeneID:   949398
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0972
- NMPDR:   fig|71421.1.peg.938
- TIGR:   HI_0972
- HOGENOM:   HBG535236
- OMA:   ESIAMTK
- ProtClustDB:   PRK08591
- BioCyc:   HINF71421:HI_0972-MONOMER
- BRENDA:   6.3.4.14
- BRENDA:   6.4.1.2
- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054
- Gene3D:   G3DSA:3.30.1490.20
- Gene3D:   G3DSA:3.30.470.20
- Gene3D:   G3DSA:3.40.50.20
- SMART:   SM00878
- TIGRFAMs:   TIGR00514

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2; SSF52440 PreATP-grasp-like; SSF51246 Rudmnt_hyb_motif

EC number: =6.3.4.14; =6.4.1.2

Molecular weight: Translated: 49109; Mature: 49109

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS50975 ATP_GRASP; PS50979 BC; PS00866 CPSASE_1; PS00867 CPSASE_2

Important sites: ACT_SITE 292-292 BINDING 116-116 BINDING 201-201 BINDING 236-236

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPAPSAKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHEEECCEEEECCCCCCCCC
LNIPAIIAAAEVTGADAIHPGYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAI
CCCCHHEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCHHHHHHHHCCHHHHH
KAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKASGGGGGRGMRVVRSEDALEE
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHH
SIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLVKEQLRIAAGLPISFKQEDIKVKGHAMECRINAEDPKTFLPSPGKVNHLHSP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEECCCCCCCCCCCCCCCCCCCCC
GGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIRRMQNALSETIIDGIKTNIPL
CCCCEEECCEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
HELILEDENFQKGGTNIHYLEKKLGMNE
HHHHCCCCCCCCCCCCCEEHHHHCCCCC
>Mature Secondary Structure
MLEKVVIANRGEIALRILRACKELGIKTVAVHSTADRDLKHVLLADETICIGPAPSAKSY
CCCEEEEECCCHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHEEECCEEEECCCCCCCCC
LNIPAIIAAAEVTGADAIHPGYGFLSENADFAEQVERSGFTFIGPTADVIRLMGDKVSAI
CCCCHHEEEEHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCHHHHHHHHCCHHHHH
KAMKKAGVPCVPGSDGPVSNDIAKNKEIAKRIGYPIIIKASGGGGGRGMRVVRSEDALEE
HHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEEECHHHHHH
SIAMTKAEAKAAFNNDMVYMEKYLENPRHVEIQVLADTHGNAVYLAERDCSMQRRHQKVV
HHHHHHHHHHHHHCCCHHHHHHHHCCCCEEEEEEEEECCCCEEEEECCCCHHHHHHHHHH
EEAPAPGITEEVRRDIGSRCANACVEIGYRGAGTFEFLYENGEFYFIEMNTRIQVEHPVT
HHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEEECCEEEECCCHH
EMITGVDLVKEQLRIAAGLPISFKQEDIKVKGHAMECRINAEDPKTFLPSPGKVNHLHSP
HHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECEEEEEEECCCCCCCCCCCCCCCCCCCCC
GGLGVRWDSHVYGGYTVPPHYDSMIAKLITYGDTREVAIRRMQNALSETIIDGIKTNIPL
CCCCEEECCEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCH
HELILEDENFQKGGTNIHYLEKKLGMNE
HHHHCCCCCCCCCCCCCEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800