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The map label for this gene is accB

Identifier: 16272908

GI number: 16272908

Start: 1028137

End: 1028604

Strand: Direct

Name: accB

Synonym: HI0971

Alternate gene names: 16272908

Gene position: 1028137-1028604 (Clockwise)

Preceding gene: 16272907

Following gene: 16272909

Centisome position: 56.18

GC content: 46.37

Gene sequence:

>468_bases
ATGGACATTCGTAAAATTAAAAAATTAATCGAATTAGTAGAAGAATCGGGCATTACTGAATTAGAAGTGCAAGAAGAAGA
GGGTACAGTACGTATTAGCCGTGCTGCACCAGTAATTGCTCCAGCAGCCGTTCAATATGCTGCAGCACCAGTAGTAGCAC
CGACTCCTGCCGCTGCACCAGCTCAAGTTCCAGCAGCTGCGACAACCGCACCAGCCGCATCGGATGAGTTATCAGGCCAT
CTTGTACGTTCTCCAATGGTGGGAACGTTCTATCGCAGCCCAAGCCCAGAAGCAAAAGCATTCGTTGAAGTGGGGCAGTC
TGTGAAAGTTGGCGATGCGCTTTGTATCGTTGAAGCAATGAAAATGATGAACCGCATTGAAGCGGACAAAGCTGGCGTAG
TAAAAGCAATTCTTATCAACGACGGTAACGCCGTTGAATTTGACGAACCATTAATCGTTATTGAATAA

Upstream 100 bases:

>100_bases
AAATTAAGGTAATCTTTGCAACACAAAAGTAAGTTTATTCATAACCGCACTTTTTCCTTTAAAAGTGCGGTTAAAATTTC
AATCTTTTTAGGAAGAACGT

Downstream 100 bases:

>100_bases
TTTCCAATATTTTTGTCGGGCGGACTTTAGTCCGTATTTCATATACAAACAATTAGAGCGAATTTATCGTAGGCGATATA
AATTGAAATCTGTTCACGCC

Product: acetyl-CoA carboxylase biotin carboxyl carrier protein subunit

Products: Malonyl-CoA; malonyl-CoA; phosphate; ADP [C]

Alternate protein names: BCCP

Number of amino acids: Translated: 155; Mature: 155

Protein sequence:

>155_residues
MDIRKIKKLIELVEESGITELEVQEEEGTVRISRAAPVIAPAAVQYAAAPVVAPTPAAAPAQVPAAATTAPAASDELSGH
LVRSPMVGTFYRSPSPEAKAFVEVGQSVKVGDALCIVEAMKMMNRIEADKAGVVKAILINDGNAVEFDEPLIVIE

Sequences:

>Translated_155_residues
MDIRKIKKLIELVEESGITELEVQEEEGTVRISRAAPVIAPAAVQYAAAPVVAPTPAAAPAQVPAAATTAPAASDELSGH
LVRSPMVGTFYRSPSPEAKAFVEVGQSVKVGDALCIVEAMKMMNRIEADKAGVVKAILINDGNAVEFDEPLIVIE
>Mature_155_residues
MDIRKIKKLIELVEESGITELEVQEEEGTVRISRAAPVIAPAAVQYAAAPVVAPTPAAAPAQVPAAATTAPAASDELSGH
LVRSPMVGTFYRSPSPEAKAFVEVGQSVKVGDALCIVEAMKMMNRIEADKAGVVKAILINDGNAVEFDEPLIVIE

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA

COG id: COG0511

COG function: function code I; Biotin carboxyl carrier protein

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain

Homologues:

Organism=Escherichia coli, GI1789653, Length=159, Percent_Identity=69.811320754717, Blast_Score=204, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BCCP_HAEIN (P43874)

Other databases:

- EMBL:   L42023
- PIR:   E64105
- RefSeq:   NP_439132.1
- ProteinModelPortal:   P43874
- SMR:   P43874
- GeneID:   949974
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0971
- NMPDR:   fig|71421.1.peg.937
- TIGR:   HI_0971
- HOGENOM:   HBG745267
- OMA:   KMMNRIE
- ProtClustDB:   PRK06302
- BioCyc:   HINF71421:HI_0971-MONOMER
- InterPro:   IPR001249
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR011053
- PRINTS:   PR01071
- TIGRFAMs:   TIGR00531

Pfam domain/function: PF00364 Biotin_lipoyl; SSF51230 Hybrid_motif

EC number: NA

Molecular weight: Translated: 16247; Mature: 16247

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: PS00188 BIOTIN; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIRKIKKLIELVEESGITELEVQEEEGTVRISRAAPVIAPAAVQYAAAPVVAPTPAAAP
CCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHCCCCCCCCCCCCC
AQVPAAATTAPAASDELSGHLVRSPMVGTFYRSPSPEAKAFVEVGQSVKVGDALCIVEAM
CCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHH
KMMNRIEADKAGVVKAILINDGNAVEFDEPLIVIE
HHHHHHCCCCCCEEEEEEEECCCEEEECCCEEEEC
>Mature Secondary Structure
MDIRKIKKLIELVEESGITELEVQEEEGTVRISRAAPVIAPAAVQYAAAPVVAPTPAAAP
CCHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCCCCCHHHHHHHCCCCCCCCCCCCC
AQVPAAATTAPAASDELSGHLVRSPMVGTFYRSPSPEAKAFVEVGQSVKVGDALCIVEAM
CCCCCCCCCCCCCCCCCCCEEECCCCCEEEECCCCCHHHHHHHCCCCCCCCHHHHHHHHH
KMMNRIEADKAGVVKAILINDGNAVEFDEPLIVIE
HHHHHHCCCCCCEEEEEEEECCCEEEECCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Acetyl-CoA; HCO3-; Proton; acetyl-CoA; ATP [C]

Specific reaction: acetyl-CoA = malonyl-CoA HCO3- + Proton + acetyl-CoA + ATP = malonyl-CoA + phosphate + ADP [C]

General reaction: Ligases; Forming Carbon-Carbon Bonds; acetyl-CoA carboxylase Reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800; 10675023