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The map label for this gene is clpB

Identifier: 16272799

GI number: 16272799

Start: 906976

End: 909546

Strand: Direct

Name: clpB

Synonym: HI0859

Alternate gene names: 16272799

Gene position: 906976-909546 (Clockwise)

Preceding gene: 16272798

Following gene: 161350023

Centisome position: 49.56

GC content: 41.15

Gene sequence:

>2571_bases
ATGAACATTGAAAAATTTACGACAAAATTCCAAGAAGCGTTAAGCGAACGACAATCACTTGCTATCGGAAAAGACAATCA
ATTTATTGAACCTGTGCATTTATTGACCGCACTTTTAAATCAACAGGGCGGCTCTATTGCGCCAATTTTGACAGCAAGTG
GCGTAAATGTGGCTTTATTGCGTAATGAATTAAAGACAGAACTAAATAAATTGCCGCAAGTGATTGGCAATGGCGGTGAT
GTACAACTTTCACGCCAGCTTATTAATCTACTTAATTTATGCGATAAATTCGCACAGCAAAACCAAGATAAATTTATTTC
GAGCGAATTGTTTTTGTTTGCAGCTTTAGAAGAACGAGGAACGATCAGCGATATTTTGAAAAAGTGCGGTGCGAAAAAAG
AACAAATTTCGCAAGCTATTCAGCACATTAGAGGGGGACAAAACGTGAACGATCAAAATGCAGAAGAAAGCAGACAAGCG
CTTGAAAAATATACGATTGATTTAACCGCTCGTGCAGAAAGTGGCAAACTTGATCCTGTAATTGGGCGTGATGAAGAAAT
TCGTCGAGCCATTCAAGTATTACAACGTCGTACCAAAAATAACCCTGTGTTAATTGGTGAACCAGGTGTAGGGAAAACGG
CGATTGTCGAAGGCTTGGCACAGCGCATCGTAAACGGCGAAGTGCCAGAAGGTTTGAAAAATAAACGTGTGCTTTCATTA
GATATGGGGGCGTTGATTGCTGGTGCGAAATATCGTGGTGAATTTGAAGAACGTTTAAAAGCAGTACTCAATGAACTTTC
GAAAGAAGAAGGTCGCGTTATCCTCTTTATTGACGAAATTCATACTATGGTCGGCGCGGGTAAAACCGATGGTGCGATGG
ATGCGGGTAATTTGTTAAAACCAAGTTTGGCACGAGGCGAATTACATTGCGTGGGTGCAACTACTTTAGATGAATATCGT
CAATATATCGAAAAAGATGCCGCACTTGAACGCCGTTTCCAAAAAGTCTTTGTGGACGAACCAAGTGTAGAAGATACCAT
TGCGATCTTACGTGGTTTGAAAGAACGTTATGAAATTCATCATCACGTGGATATTACTGACCCAGCAATTGTCGCTGCAG
CAACGCTTTCACATCGTTATATTTCCGATCGTCAGTTACCAGATAAAGCCATTGATTTGATCGATGAAGCAGCGTCTAGC
ATTCGTATGGAAATAGATTCTAAACCTGAACCGCTTGATCGTCTTGAACGTCGTATTATCCAATTAAAATTGGAACAACA
AGCGTTACAAAAAGAAGAAGACGAAGCAAGTCGCAAACGTTTAGAAATGTTAGAGAAAGAATTGGCTGAAAAAGAACGTG
AATACGCCGAACTTGAAGAAGTATGGAAATCTGAAAAAGCAACGCTTTCTGGCTCTCAACATATTAAACAAGAGTTAGAT
ACTGCAAAAACCGAACTAGAACAAGCTCGTCGCGCGGGTGATTTAGCGAAAATGTCTGAGTTGCAATATGGCCGCATCCC
TGATCTTGAAAAGCAACTTGAGCAAGCTGAAACCAGCGAAGGAAAAGAAATGACGCTTTTACGCTATCGCGTCACAGATG
AAGAAATCGCAGAAGTGCTTTCTAAAGCCACAGGCATTCCTGTATCAAAAATGATGGAAGGCGAGAAAGAAAAACTCTTG
CGTATGGAAGATGAACTACATAAACGAGTGATTGGTCAAGAAGAAGCGGTTGATGCGGTAGCAAACGCGATTCGTCGTAG
TCGTGCAGGTCTTTCCGATCCTAATCGCCCAATTGGTTCTTTCTTGTTCCTAGGGCCAACAGGTGTTGGGAAAACAGAGC
TTTGCAAAACTTTGGCTAAATTCTTGTTTGATAGTGAAGATGCGATGGTGCGTATTGATATGTCAGAGTTTATGGAAAAA
CACAGTGTTTCTCGTTTAGTTGGTGCGCCTCCAGGCTATGTCGGCTATGAAGAAGGCGGTTATTTAACTGAAGCTGTTCG
TCGTCGTCCATATTCAGTGATCTTATTAGATGAAGTTGAAAAAGCACACGCAGATGTATTCAATATCTTATTACAAGTGT
TGGATGATGGTCGTTTAACTGATGGTCAAGGTCGTACTGTGGACTTCCGTAACACTGTGGTTATTATGACCTCTAACTTG
GGTTCTGATTTAATCCAAGGTAATAAAGACGAAAGCTATAGCGAAATGAAAGCCTTAGTGATGTCAGTGGTAAGCCAACA
TTTCCGCCCAGAATTCATCAACCGTATTGACGAAACCGTGGTATTCCATCCACTTGGTAAAGAAAATATCCGTGCGATTG
CAAGTATCCAATTAGAACGCTTAGCAAAACGTATGGAAACTCGTGGATACGAATTGGTGTTTACCGATGCTTTATTAGAC
TTCATTGGCGAAGTGGGATACGACCCAATTTATGGTGCACGTCCATTGAAACGTGCTATTCAACAAGAAATTGAAAACAG
CTTGGCACAACAAATTCTATCTGGTGCGTTATTACCTGGTAAGGTTGTTACCATTGATTATGCCAACGCAGAAGTTCAAG
CGAGACAATAG

Upstream 100 bases:

>100_bases
ATAAAATCAAAATATTTCATTTTTTCTCTTGAAATTTATTCAACCGAGCTTACTTAGTTTATGCAAATGGCGAAAGCCGA
AATCAAATTGAGGAAAGTGT

Downstream 100 bases:

>100_bases
GTATTAAAAAAGTGCGGTAAATTTACCGCACTTTTCTTATGAACCTAAACGCTGACGTACAATTTCAAATAAACATACCC
CTGTTGCGACAGATACATTT

Product: ATP-dependent Clp protease ATPase subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 856; Mature: 856

Protein sequence:

>856_residues
MNIEKFTTKFQEALSERQSLAIGKDNQFIEPVHLLTALLNQQGGSIAPILTASGVNVALLRNELKTELNKLPQVIGNGGD
VQLSRQLINLLNLCDKFAQQNQDKFISSELFLFAALEERGTISDILKKCGAKKEQISQAIQHIRGGQNVNDQNAEESRQA
LEKYTIDLTARAESGKLDPVIGRDEEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSL
DMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLARGELHCVGATTLDEYR
QYIEKDAALERRFQKVFVDEPSVEDTIAILRGLKERYEIHHHVDITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASS
IRMEIDSKPEPLDRLERRIIQLKLEQQALQKEEDEASRKRLEMLEKELAEKEREYAELEEVWKSEKATLSGSQHIKQELD
TAKTELEQARRAGDLAKMSELQYGRIPDLEKQLEQAETSEGKEMTLLRYRVTDEEIAEVLSKATGIPVSKMMEGEKEKLL
RMEDELHKRVIGQEEAVDAVANAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLAKFLFDSEDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHADVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQGNKDESYSEMKALVMSVVSQHFRPEFINRIDETVVFHPLGKENIRAIASIQLERLAKRMETRGYELVFTDALLD
FIGEVGYDPIYGARPLKRAIQQEIENSLAQQILSGALLPGKVVTIDYANAEVQARQ

Sequences:

>Translated_856_residues
MNIEKFTTKFQEALSERQSLAIGKDNQFIEPVHLLTALLNQQGGSIAPILTASGVNVALLRNELKTELNKLPQVIGNGGD
VQLSRQLINLLNLCDKFAQQNQDKFISSELFLFAALEERGTISDILKKCGAKKEQISQAIQHIRGGQNVNDQNAEESRQA
LEKYTIDLTARAESGKLDPVIGRDEEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSL
DMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLARGELHCVGATTLDEYR
QYIEKDAALERRFQKVFVDEPSVEDTIAILRGLKERYEIHHHVDITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASS
IRMEIDSKPEPLDRLERRIIQLKLEQQALQKEEDEASRKRLEMLEKELAEKEREYAELEEVWKSEKATLSGSQHIKQELD
TAKTELEQARRAGDLAKMSELQYGRIPDLEKQLEQAETSEGKEMTLLRYRVTDEEIAEVLSKATGIPVSKMMEGEKEKLL
RMEDELHKRVIGQEEAVDAVANAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLAKFLFDSEDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHADVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQGNKDESYSEMKALVMSVVSQHFRPEFINRIDETVVFHPLGKENIRAIASIQLERLAKRMETRGYELVFTDALLD
FIGEVGYDPIYGARPLKRAIQQEIENSLAQQILSGALLPGKVVTIDYANAEVQARQ
>Mature_856_residues
MNIEKFTTKFQEALSERQSLAIGKDNQFIEPVHLLTALLNQQGGSIAPILTASGVNVALLRNELKTELNKLPQVIGNGGD
VQLSRQLINLLNLCDKFAQQNQDKFISSELFLFAALEERGTISDILKKCGAKKEQISQAIQHIRGGQNVNDQNAEESRQA
LEKYTIDLTARAESGKLDPVIGRDEEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSL
DMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLKPSLARGELHCVGATTLDEYR
QYIEKDAALERRFQKVFVDEPSVEDTIAILRGLKERYEIHHHVDITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASS
IRMEIDSKPEPLDRLERRIIQLKLEQQALQKEEDEASRKRLEMLEKELAEKEREYAELEEVWKSEKATLSGSQHIKQELD
TAKTELEQARRAGDLAKMSELQYGRIPDLEKQLEQAETSEGKEMTLLRYRVTDEEIAEVLSKATGIPVSKMMEGEKEKLL
RMEDELHKRVIGQEEAVDAVANAIRRSRAGLSDPNRPIGSFLFLGPTGVGKTELCKTLAKFLFDSEDAMVRIDMSEFMEK
HSVSRLVGAPPGYVGYEEGGYLTEAVRRRPYSVILLDEVEKAHADVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
GSDLIQGNKDESYSEMKALVMSVVSQHFRPEFINRIDETVVFHPLGKENIRAIASIQLERLAKRMETRGYELVFTDALLD
FIGEVGYDPIYGARPLKRAIQQEIENSLAQQILSGALLPGKVVTIDYANAEVQARQ

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family

Homologues:

Organism=Homo sapiens, GI13540606, Length=353, Percent_Identity=36.8271954674221, Blast_Score=208, Evalue=2e-53,
Organism=Escherichia coli, GI1788943, Length=857, Percent_Identity=77.4795799299883, Blast_Score=1368, Evalue=0.0,
Organism=Escherichia coli, GI1787109, Length=398, Percent_Identity=40.9547738693467, Blast_Score=275, Evalue=1e-74,
Organism=Saccharomyces cerevisiae, GI6320464, Length=701, Percent_Identity=53.922967189729, Blast_Score=771, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323002, Length=858, Percent_Identity=43.1235431235431, Blast_Score=680, Evalue=0.0,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): CLPB_HAEIN (P44403)

Other databases:

- EMBL:   L42023
- PIR:   F64098
- RefSeq:   NP_439019.1
- ProteinModelPortal:   P44403
- GeneID:   949871
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0859
- NMPDR:   fig|71421.1.peg.827
- TIGR:   HI_0859
- HOGENOM:   HBG413133
- OMA:   HISNALN
- ProtClustDB:   CLSK870580
- BioCyc:   HINF71421:HI_0859-MONOMER
- GO:   GO:0005737
- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR017730
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- Gene3D:   G3DSA:1.10.1780.10
- PRINTS:   PR00300
- SMART:   SM00382
- TIGRFAMs:   TIGR03346

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small

EC number: NA

Molecular weight: Translated: 95839; Mature: 95839

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: PS00870 CLPAB_1; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIEKFTTKFQEALSERQSLAIGKDNQFIEPVHLLTALLNQQGGSIAPILTASGVNVALL
CCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
RNELKTELNKLPQVIGNGGDVQLSRQLINLLNLCDKFAQQNQDKFISSELFLFAALEERG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
TISDILKKCGAKKEQISQAIQHIRGGQNVNDQNAEESRQALEKYTIDLTARAESGKLDPV
CHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCC
IGRDEEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLK
CHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCC
PSLARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVDEPSVEDTIAILRGLKERYEIH
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HHVDITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASSIRMEIDSKPEPLDRLERRII
HCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
QLKLEQQALQKEEDEASRKRLEMLEKELAEKEREYAELEEVWKSEKATLSGSQHIKQELD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TAKTELEQARRAGDLAKMSELQYGRIPDLEKQLEQAETSEGKEMTLLRYRVTDEEIAEVL
HHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHH
SKATGIPVSKMMEGEKEKLLRMEDELHKRVIGQEEAVDAVANAIRRSRAGLSDPNRPIGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKTLAKFLFDSEDAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSVILLDEVEKAHADVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSDLIQGNKDESYSEMKALVMSVVSQHFRPEFINRIDETVVFHPLGKENIRAIASIQLER
CHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHH
LAKRMETRGYELVFTDALLDFIGEVGYDPIYGARPLKRAIQQEIENSLAQQILSGALLPG
HHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
KVVTIDYANAEVQARQ
EEEEEEECCCCCCCCC
>Mature Secondary Structure
MNIEKFTTKFQEALSERQSLAIGKDNQFIEPVHLLTALLNQQGGSIAPILTASGVNVALL
CCHHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHH
RNELKTELNKLPQVIGNGGDVQLSRQLINLLNLCDKFAQQNQDKFISSELFLFAALEERG
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
TISDILKKCGAKKEQISQAIQHIRGGQNVNDQNAEESRQALEKYTIDLTARAESGKLDPV
CHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHEEEEECCCCCCCCC
IGRDEEIRRAIQVLQRRTKNNPVLIGEPGVGKTAIVEGLAQRIVNGEVPEGLKNKRVLSL
CCCCHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
DMGALIAGAKYRGEFEERLKAVLNELSKEEGRVILFIDEIHTMVGAGKTDGAMDAGNLLK
CHHHHHHCCHHCCCHHHHHHHHHHHHHHCCCCEEEEHHHHHHHHCCCCCCCCCCCCCCCC
PSLARGELHCVGATTLDEYRQYIEKDAALERRFQKVFVDEPSVEDTIAILRGLKERYEIH
CCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
HHVDITDPAIVAAATLSHRYISDRQLPDKAIDLIDEAASSIRMEIDSKPEPLDRLERRII
HCCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
QLKLEQQALQKEEDEASRKRLEMLEKELAEKEREYAELEEVWKSEKATLSGSQHIKQELD
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
TAKTELEQARRAGDLAKMSELQYGRIPDLEKQLEQAETSEGKEMTLLRYRVTDEEIAEVL
HHHHHHHHHHHHCCHHHHHHCCCCCCCCHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHH
SKATGIPVSKMMEGEKEKLLRMEDELHKRVIGQEEAVDAVANAIRRSRAGLSDPNRPIGS
HHHCCCCHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCC
FLFLGPTGVGKTELCKTLAKFLFDSEDAMVRIDMSEFMEKHSVSRLVGAPPGYVGYEEGG
EEEECCCCCCHHHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHHHHHCCCCCCCCCCCCC
YLTEAVRRRPYSVILLDEVEKAHADVFNILLQVLDDGRLTDGQGRTVDFRNTVVIMTSNL
HHHHHHHHCCCEEEEHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCEEEEEECCC
GSDLIQGNKDESYSEMKALVMSVVSQHFRPEFINRIDETVVFHPLGKENIRAIASIQLER
CHHHHCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHEEECCCCHHHHHHHHHHHHHH
LAKRMETRGYELVFTDALLDFIGEVGYDPIYGARPLKRAIQQEIENSLAQQILSGALLPG
HHHHHHHCCCEEEEHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCC
KVVTIDYANAEVQARQ
EEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800