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The map label for this gene is glpA

Identifier: 16272627

GI number: 16272627

Start: 728088

End: 729779

Strand: Reverse

Name: glpA

Synonym: HI0685

Alternate gene names: 16272627

Gene position: 729779-728088 (Counterclockwise)

Preceding gene: 16272634

Following gene: 16272626

Centisome position: 39.88

GC content: 44.09

Gene sequence:

>1692_bases
ATGGGATTATCGCCTAGTATCTATAAAGATGTTGGAGATCTTTCGTCACTTAGCACTGATGTGATCATTATCGGTGGTGG
CGCAACAGGAGCAGGTATTGCGCGCGATTGCGCACTTCGTGGCATTGATTGTATTTTATTGGAACGTCGAGATATTGCGA
CAGGAGCCACAGGACGTAACCACGGATTATTACACAGTGGTGCACGTTACGCCGTGAACGACCAAGAATCTGCTGAAGAA
TGTATTAAAGAAAACCGCATTTTGCGCAAAATTGCGCGTCATTGCGTAGATGAAACGGAAGGCTTATTTATCACTTTGCC
TGAAGATTCGCTCGACTATCAAAAAACCTTCCTTGAGAGCTGTGCAAAATCTGGAATTGATGCACAAGCCATTGATCCTG
AACTAGCTAAAATTATGGAGCCTTCTGTAAACCCAGATTTAGTGGGTGCTGTTGTTGTGCCAGATGGTTCTATTGACCCA
TTCCGTTTAACCGCCTCTAATATGATGGACGCCACAGAAAACGGCGCAAAAATGTTCACTTATTGCGAAGTAAAAAATTT
GATTCGTGAAGGTGGAAAAGTGATTGGCGTGAATGCGTACGATCACAAAAATCGCAGAGAACGCCAATTTTTTGCACCGC
TTGTTGTAAATGCTGGTGGTATTTGGGGACAAGGGATTGCGGAATATGCCGATCTCAAAATTAAAATGTTCCCTGCAAAA
GGCGCATTACTCGTAATGGGTCATCGCATTAATAAACTTGTAATTAACCGCTGCCGTAAACCTGCTGATGCGGATATTCT
CGTCCCTGGCGATACAATTTGTGTGATCGGAACAACATCTAGCCGCATTCCTTATGATCAAATTGATAATATGGAAGTAA
CACCAGAGGAAGTGGATATTCTTTTCCGTGAAGGTGAAAAACTCGCACCTAGCTTGCGTCATACTCGCGTATTACGTGCT
TATGCTGGGGTGCGTCCATTAGTTGCAAGCGATGATGATCCATCAGGTCGAAATGTGAGTCGTGGTATCGTGCTACTTGA
CCACGCAGAACGTGATGGCTTAGATGGCTTTATTACTATCACTGGCGGTAAGTTAATGACTTATCGTTTAATGGCTGAAT
GGGCGACTGACCTTGTTTGTAAAAAACTCAATAAAACGGCACGTTGTGTGACTGCAGAGCAACCTTTGCCAGGCTCTACT
GAAAGTCGTCAAGAGACCAATCAAAAAGTCATTTCATTACCAAGTACTATTCGTTATTCTGCCGTATATCGTCACGGTTC
ACGGGCTACTCGTTTGCTTGAAAAAGAACGTTTAGATCGTTCAATGGTTTGCGAATGTGAAGCGGTAACAGCGGGGGAAG
TTCGTTACGCTGTTGATGAACTGGATGTAAATAATCTCGTCGATTTACGTCGTCGTTCCCGAGTTGGAATGGGAACTTGT
CAAGCTGAACTCTGTGCTTGTCGTGCTGCAGGACTAATGAATCGTTTTGAAGTGGCAACACCACGTCAATCAACCACTCA
ACTTTCCGCCTTTATGGAAGAACGCTGGCGTGGTATTGAACCGATTGCTTGGGGGGAAGCTATTCGCGAAGCCGAATTTA
CCTCTTGGATGTATGCTAGTGTATTAGGTTTAAATGATGTGAAACCGCTTGATGAACAAGCACAACAAGGGACGGATAGC
AATGAATTTTGA

Upstream 100 bases:

>100_bases
CTTTTACACTCAAAATGTTGTTAATTTTGGCCGCACTTCCCTACAATGATTACACTTTTTATATTATTTTTTCTTACATT
TTGGGAATCGGGGGTAAACA

Downstream 100 bases:

>100_bases
TGTAGCCATTATTGGCGGTGGTTTGGCGGGTTTAACCTGTGCCATCGCCCTTCAACAACGCGGTAAACGTTGCGTGATTA
TCAACAACGGTCAAGCAGCC

Product: sn-glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase

Number of amino acids: Translated: 563; Mature: 562

Protein sequence:

>563_residues
MGLSPSIYKDVGDLSSLSTDVIIIGGGATGAGIARDCALRGIDCILLERRDIATGATGRNHGLLHSGARYAVNDQESAEE
CIKENRILRKIARHCVDETEGLFITLPEDSLDYQKTFLESCAKSGIDAQAIDPELAKIMEPSVNPDLVGAVVVPDGSIDP
FRLTASNMMDATENGAKMFTYCEVKNLIREGGKVIGVNAYDHKNRRERQFFAPLVVNAGGIWGQGIAEYADLKIKMFPAK
GALLVMGHRINKLVINRCRKPADADILVPGDTICVIGTTSSRIPYDQIDNMEVTPEEVDILFREGEKLAPSLRHTRVLRA
YAGVRPLVASDDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDLVCKKLNKTARCVTAEQPLPGST
ESRQETNQKVISLPSTIRYSAVYRHGSRATRLLEKERLDRSMVCECEAVTAGEVRYAVDELDVNNLVDLRRRSRVGMGTC
QAELCACRAAGLMNRFEVATPRQSTTQLSAFMEERWRGIEPIAWGEAIREAEFTSWMYASVLGLNDVKPLDEQAQQGTDS
NEF

Sequences:

>Translated_563_residues
MGLSPSIYKDVGDLSSLSTDVIIIGGGATGAGIARDCALRGIDCILLERRDIATGATGRNHGLLHSGARYAVNDQESAEE
CIKENRILRKIARHCVDETEGLFITLPEDSLDYQKTFLESCAKSGIDAQAIDPELAKIMEPSVNPDLVGAVVVPDGSIDP
FRLTASNMMDATENGAKMFTYCEVKNLIREGGKVIGVNAYDHKNRRERQFFAPLVVNAGGIWGQGIAEYADLKIKMFPAK
GALLVMGHRINKLVINRCRKPADADILVPGDTICVIGTTSSRIPYDQIDNMEVTPEEVDILFREGEKLAPSLRHTRVLRA
YAGVRPLVASDDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDLVCKKLNKTARCVTAEQPLPGST
ESRQETNQKVISLPSTIRYSAVYRHGSRATRLLEKERLDRSMVCECEAVTAGEVRYAVDELDVNNLVDLRRRSRVGMGTC
QAELCACRAAGLMNRFEVATPRQSTTQLSAFMEERWRGIEPIAWGEAIREAEFTSWMYASVLGLNDVKPLDEQAQQGTDS
NEF
>Mature_562_residues
GLSPSIYKDVGDLSSLSTDVIIIGGGATGAGIARDCALRGIDCILLERRDIATGATGRNHGLLHSGARYAVNDQESAEEC
IKENRILRKIARHCVDETEGLFITLPEDSLDYQKTFLESCAKSGIDAQAIDPELAKIMEPSVNPDLVGAVVVPDGSIDPF
RLTASNMMDATENGAKMFTYCEVKNLIREGGKVIGVNAYDHKNRRERQFFAPLVVNAGGIWGQGIAEYADLKIKMFPAKG
ALLVMGHRINKLVINRCRKPADADILVPGDTICVIGTTSSRIPYDQIDNMEVTPEEVDILFREGEKLAPSLRHTRVLRAY
AGVRPLVASDDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDLVCKKLNKTARCVTAEQPLPGSTE
SRQETNQKVISLPSTIRYSAVYRHGSRATRLLEKERLDRSMVCECEAVTAGEVRYAVDELDVNNLVDLRRRSRVGMGTCQ
AELCACRAAGLMNRFEVATPRQSTTQLSAFMEERWRGIEPIAWGEAIREAEFTSWMYASVLGLNDVKPLDEQAQQGTDSN
EF

Specific function: Conversion Of Glycerol 3-Phosphate To Dihydroxyacetone. Uses Fumarate Or Nitrate As Electron Acceptor. [C]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family

Homologues:

Organism=Homo sapiens, GI285002233, Length=524, Percent_Identity=26.3358778625954, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI285002231, Length=524, Percent_Identity=26.3358778625954, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI197927446, Length=287, Percent_Identity=25.0871080139373, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI21361378, Length=287, Percent_Identity=25.0871080139373, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788574, Length=529, Percent_Identity=70.5103969754253, Blast_Score=748, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17509253, Length=412, Percent_Identity=28.3980582524272, Blast_Score=86, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI115534726, Length=411, Percent_Identity=26.0340632603406, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI161077125, Length=409, Percent_Identity=27.6283618581907, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24653942, Length=409, Percent_Identity=27.6283618581907, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI24653944, Length=409, Percent_Identity=27.6283618581907, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI20130025, Length=409, Percent_Identity=27.6283618581907, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI20130091, Length=243, Percent_Identity=30.8641975308642, Blast_Score=89, Evalue=7e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLPA_HAEIN (P43799)

Other databases:

- EMBL:   L42023
- PIR:   E64086
- RefSeq:   NP_438845.1
- ProteinModelPortal:   P43799
- SMR:   P43799
- GeneID:   949605
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0685
- NMPDR:   fig|71421.1.peg.655
- TIGR:   HI_0685
- HOGENOM:   HBG720894
- OMA:   KTFLESC
- ProtClustDB:   PRK11101
- BioCyc:   HINF71421:HI_0685-MONOMER
- BRENDA:   1.1.99.5
- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447
- PRINTS:   PR01001
- TIGRFAMs:   TIGR03377

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD

EC number: =1.1.5.3

Molecular weight: Translated: 61920; Mature: 61789

Theoretical pI: Translated: 5.35; Mature: 5.35

Prosite motif: PS00977 FAD_G3PDH_1; PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLSPSIYKDVGDLSSLSTDVIIIGGGATGAGIARDCALRGIDCILLERRDIATGATGRN
CCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCC
HGLLHSGARYAVNDQESAEECIKENRILRKIARHCVDETEGLFITLPEDSLDYQKTFLES
CCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
CAKSGIDAQAIDPELAKIMEPSVNPDLVGAVVVPDGSIDPFRLTASNMMDATENGAKMFT
HHHCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEHHHHHHCCCCCCEEEE
YCEVKNLIREGGKVIGVNAYDHKNRRERQFFAPLVVNAGGIWGQGIAEYADLKIKMFPAK
HHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCEEEECCCCCCCCHHHHHCEEEEEECCC
GALLVMGHRINKLVINRCRKPADADILVPGDTICVIGTTSSRIPYDQIDNMEVTPEEVDI
CEEEEECCHHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHCCCCCCCHHHHHH
LFREGEKLAPSLRHTRVLRAYAGVRPLVASDDDPSGRNVSRGIVLLDHAERDGLDGFITI
HHHCCCHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEE
TGGKLMTYRLMAEWATDLVCKKLNKTARCVTAEQPLPGSTESRQETNQKVISLPSTIRYS
ECCCEEHHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCHHHHHHHHEEECCCHHHHH
AVYRHGSRATRLLEKERLDRSMVCECEAVTAGEVRYAVDELDVNNLVDLRRRSRVGMGTC
HHHHCCHHHHHHHHHHHCCHHHEEEECCCCCCCEEEHHHHCCHHHHHHHHHHHCCCCCHH
QAELCACRAAGLMNRFEVATPRQSTTQLSAFMEERWRGIEPIAWGEAIREAEFTSWMYAS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VLGLNDVKPLDEQAQQGTDSNEF
HHCCCCCCCCHHHHHCCCCCCCC
>Mature Secondary Structure 
GLSPSIYKDVGDLSSLSTDVIIIGGGATGAGIARDCALRGIDCILLERRDIATGATGRN
CCCCHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCC
HGLLHSGARYAVNDQESAEECIKENRILRKIARHCVDETEGLFITLPEDSLDYQKTFLES
CCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCCHHHHHHHHH
CAKSGIDAQAIDPELAKIMEPSVNPDLVGAVVVPDGSIDPFRLTASNMMDATENGAKMFT
HHHCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCCCCCCEEEEHHHHHHCCCCCCEEEE
YCEVKNLIREGGKVIGVNAYDHKNRRERQFFAPLVVNAGGIWGQGIAEYADLKIKMFPAK
HHHHHHHHHCCCEEEEEECCCCCCCHHHHHHCCEEEECCCCCCCCHHHHHCEEEEEECCC
GALLVMGHRINKLVINRCRKPADADILVPGDTICVIGTTSSRIPYDQIDNMEVTPEEVDI
CEEEEECCHHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHCCCCCCCHHHHHH
LFREGEKLAPSLRHTRVLRAYAGVRPLVASDDDPSGRNVSRGIVLLDHAERDGLDGFITI
HHHCCCHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEE
TGGKLMTYRLMAEWATDLVCKKLNKTARCVTAEQPLPGSTESRQETNQKVISLPSTIRYS
ECCCEEHHHHHHHHHHHHHHHHHCCHHEEEECCCCCCCCCCHHHHHHHHEEECCCHHHHH
AVYRHGSRATRLLEKERLDRSMVCECEAVTAGEVRYAVDELDVNNLVDLRRRSRVGMGTC
HHHHCCHHHHHHHHHHHCCHHHEEEECCCCCCCEEEHHHHCCHHHHHHHHHHHCCCCCHH
QAELCACRAAGLMNRFEVATPRQSTTQLSAFMEERWRGIEPIAWGEAIREAEFTSWMYAS
HHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
VLGLNDVKPLDEQAQQGTDSNEF
HHCCCCCCCCHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800