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The map label for this gene is gptB

Identifier: 16272634

GI number: 16272634

Start: 736671

End: 737138

Strand: Reverse

Name: gptB

Synonym: HI0692

Alternate gene names: 16272634

Gene position: 737138-736671 (Counterclockwise)

Preceding gene: 16272637

Following gene: 16272627

Centisome position: 40.28

GC content: 41.88

Gene sequence:

>468_bases
ATGAGCGAAAAATATGTGGTAACTTGGGATATGTTTCAAATGCATGCCCGCAGATTATCAGAACGTTTACTTCCAGCTTC
CCAATGGAAAGGTATTATTGCGGTGAGTCGCGGTGGTTTGTTTCCAGCGGCTGTATTGGCTCGTGAATTGGGTCTTCGTC
ATATTGAAACCGTTTGTATCGCAAGTTATCACGATCACAATAATCAGGGAGAACTACAAGTTCTTCATGCAGCCCAAGTG
CCAAATGGCGGCGAAGGATTTATCGTGGTAGATGATTTAGTTGATACGGGTAATACAGCGCGTGCCATTCGTCAAATGTA
CCCTAATGCAAAATTTGTCACTGTATTTGCAAAACCTGCAGGTGCGGAATTAGTGGATGATTACGTAATTGATATTCCAC
AAAATACTTGGATTGAGCAACCTTGGGATTTAGGTTTAACCTTTGTTCCACCTCTCTCTAGAAAATAA

Upstream 100 bases:

>100_bases
TTGCCCCTGATTTATTCAATAAGGCATCATACATTTGATTTACGTCTGTGAAAAATGCGGGTAGTGCATCTTTACGCAAA
ATTTAAACTAAGGTGCAATT

Downstream 100 bases:

>100_bases
TTTTTATACAAAAAAGTGCGGTTAAAATAAAAGAATTTTTAACCGCACTTTTTGTATGAGAATTAATTTATAAATTATTC
TTCATCTTCTTTTGCCCATT

Product: xanthine-guanine phosphoribosyltransferase

Products: NA

Alternate protein names: Xanthine-guanine phosphoribosyltransferase 1; XGPRT 1

Number of amino acids: Translated: 155; Mature: 154

Protein sequence:

>155_residues
MSEKYVVTWDMFQMHARRLSERLLPASQWKGIIAVSRGGLFPAAVLARELGLRHIETVCIASYHDHNNQGELQVLHAAQV
PNGGEGFIVVDDLVDTGNTARAIRQMYPNAKFVTVFAKPAGAELVDDYVIDIPQNTWIEQPWDLGLTFVPPLSRK

Sequences:

>Translated_155_residues
MSEKYVVTWDMFQMHARRLSERLLPASQWKGIIAVSRGGLFPAAVLARELGLRHIETVCIASYHDHNNQGELQVLHAAQV
PNGGEGFIVVDDLVDTGNTARAIRQMYPNAKFVTVFAKPAGAELVDDYVIDIPQNTWIEQPWDLGLTFVPPLSRK
>Mature_154_residues
SEKYVVTWDMFQMHARRLSERLLPASQWKGIIAVSRGGLFPAAVLARELGLRHIETVCIASYHDHNNQGELQVLHAAQVP
NGGEGFIVVDDLVDTGNTARAIRQMYPNAKFVTVFAKPAGAELVDDYVIDIPQNTWIEQPWDLGLTFVPPLSRK

Specific function: Acts on guanine, xanthine and to a lesser extent hypoxanthine

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily

Homologues:

Organism=Escherichia coli, GI1786433, Length=155, Percent_Identity=71.6129032258065, Blast_Score=239, Evalue=5e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): XGPT1_HAEI8 (Q4QMP2)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248365.1
- ProteinModelPortal:   Q4QMP2
- SMR:   Q4QMP2
- STRING:   Q4QMP2
- GeneID:   3430106
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0796
- eggNOG:   COG0503
- HOGENOM:   HBG503428
- PhylomeDB:   Q4QMP2
- ProtClustDB:   PRK09177
- BioCyc:   HINF281310:NTHI0796-MONOMER
- HAMAP:   MF_01903
- InterPro:   IPR000836

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.22

Molecular weight: Translated: 17325; Mature: 17194

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: BINDING 95-95 BINDING 138-138

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEKYVVTWDMFQMHARRLSERLLPASQWKGIIAVSRGGLFPAAVLARELGLRHIETVCI
CCCCEEEEHHHHHHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHCHHHHHHHEE
ASYHDHNNQGELQVLHAAQVPNGGEGFIVVDDLVDTGNTARAIRQMYPNAKFVTVFAKPA
EEECCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCC
GAELVDDYVIDIPQNTWIEQPWDLGLTFVPPLSRK
CCHHHCCEEEECCCCCCCCCCCCCCEEECCCCCCC
>Mature Secondary Structure 
SEKYVVTWDMFQMHARRLSERLLPASQWKGIIAVSRGGLFPAAVLARELGLRHIETVCI
CCCEEEEHHHHHHHHHHHHHHCCCHHHCCCEEEEECCCCCHHHHHHHHHCHHHHHHHEE
ASYHDHNNQGELQVLHAAQVPNGGEGFIVVDDLVDTGNTARAIRQMYPNAKFVTVFAKPA
EEECCCCCCCCEEEEEEECCCCCCCCEEEEECCCCCCCHHHHHHHHCCCCEEEEEEECCC
GAELVDDYVIDIPQNTWIEQPWDLGLTFVPPLSRK
CCHHHCCEEEECCCCCCCCCCCCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA