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The map label for this gene is kdtA

Identifier: 16272595

GI number: 16272595

Start: 696057

End: 697340

Strand: Reverse

Name: kdtA

Synonym: HI0652

Alternate gene names: 16272595

Gene position: 697340-696057 (Counterclockwise)

Preceding gene: 16272597

Following gene: 16272594

Centisome position: 38.1

GC content: 39.95

Gene sequence:

>1284_bases
ATGTGGCGTTTTTTTTATACCAGCTTGCTTTTAATTTGCCAGCCGTTGATATTGTGTTTTATTGGCTTGCTCAGTGTTAA
ATCTCCACGTTATCGTCAGCGTTTGGCTGAACGTTATGGTTTTTATGGCAATGCGTCTTGCCCACCACCACAAGGGATCT
TTATCCACGCAGCCTCCGTAGGGGAAGTGATTGCTGCGACACCGCTGGTTCGTCAATTGCAACAAGATTATCCACATTTA
TCCATTACTTTTACGACTTTTACGCCCACAGGTTCAGAGCGCGTCAAAGCCACTTTTGGAGATAGTGTTTTTCATTATTA
TCTCCCCCTTGATTTACCTTTTTCGATCCATCGTTTTATTAATTTTGTACAACCTAAATTATGTATCGTGATGGAAACAG
AACTTTGGCCTAATCTTATTCATCAATTATTTTTACGCAATATTCCATTTGTTATCGCTAATGCACGTTTATCTGCGCGT
TCTGCGCATCGTTACGGAAAAATAAAAGCGCACTTACAAACAATGTGGTCACAAATTAGCTTGATTGCAGCGCAGGATAA
CATTAGTGGAAAACGCTATGCCACTTTGGGCTATCCAAAGGAAAAATTGAATATCACGGGCAATATTAAATATGATCTCA
ATACGAATGATGAACTATTACGTAAAATTGATTCATTGCGCACCCTTTGGAAACAAGATCGCCCAATATGGATTGCTGCC
AGCACGCATAATGGAGAAGATGAAATCATTTTAAAATCTCACCGCGCTTTGTTAGCAAAATACCCAAATTTATTGTTATT
GCTCGTTCCTCGCCATCCAGAGCGTTTTAATGTGGTGGCTGATTTACTTAAAAAGGAAAAATTTCAATTTATTCGTCGCT
CCACAAATGAATTACCAAATGAAAATACCCAAGTGATTTTGGGCGATAGTATGGGCGAATTGATGTTGATGTATGGCATT
TCCGATATTGCTTTTGTGGGTGGAAGCCTTGTGAAACACGGGGGGCATAATCCTTTAGAACCTCTTGCATTTAAAATGCC
AGTGATTACTGGCAAGCATACTTTCAATTTTCCCGAGATATTTCGAATGCTGGTAGAAGTGCAAGGTGTGTTGGAAGTTA
ATTCAACCGCAGATGCCTTAGAACGCGCCGTAGAAGCCTTATTAAACTCAAAAGAATCCCGCGAACGTTTAGGTAATGCT
GGCTATGAAGTGCTGATGGAAAACCGAGGGGCATTACAGCGTTTGTTAGATTTATTAAAACCTTATTTGGAGCGCAATGT
ATGA

Upstream 100 bases:

>100_bases
TCATTTTTTATAATCATTGCAACGCTAATTGTAGGCATATTTTCAATCCTTTTTTTGCTATACTAGCCGAAATTTTTTTA
AGTATAACCGAATTTCATTT

Downstream 100 bases:

>100_bases
CGAGCGTGATTTATCCTGGTACTTTTGATCCGATTACGAACGGTCATTTAGACATTATTGAAAGAAGTGCGGTAATTTTT
CCTCGTGTTTTAGTGGCGGT

Product: 3-deoxy-D-manno-octulosonic-acid transferase

Products: NA

Alternate protein names: KDO transferase

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MWRFFYTSLLLICQPLILCFIGLLSVKSPRYRQRLAERYGFYGNASCPPPQGIFIHAASVGEVIAATPLVRQLQQDYPHL
SITFTTFTPTGSERVKATFGDSVFHYYLPLDLPFSIHRFINFVQPKLCIVMETELWPNLIHQLFLRNIPFVIANARLSAR
SAHRYGKIKAHLQTMWSQISLIAAQDNISGKRYATLGYPKEKLNITGNIKYDLNTNDELLRKIDSLRTLWKQDRPIWIAA
STHNGEDEIILKSHRALLAKYPNLLLLLVPRHPERFNVVADLLKKEKFQFIRRSTNELPNENTQVILGDSMGELMLMYGI
SDIAFVGGSLVKHGGHNPLEPLAFKMPVITGKHTFNFPEIFRMLVEVQGVLEVNSTADALERAVEALLNSKESRERLGNA
GYEVLMENRGALQRLLDLLKPYLERNV

Sequences:

>Translated_427_residues
MWRFFYTSLLLICQPLILCFIGLLSVKSPRYRQRLAERYGFYGNASCPPPQGIFIHAASVGEVIAATPLVRQLQQDYPHL
SITFTTFTPTGSERVKATFGDSVFHYYLPLDLPFSIHRFINFVQPKLCIVMETELWPNLIHQLFLRNIPFVIANARLSAR
SAHRYGKIKAHLQTMWSQISLIAAQDNISGKRYATLGYPKEKLNITGNIKYDLNTNDELLRKIDSLRTLWKQDRPIWIAA
STHNGEDEIILKSHRALLAKYPNLLLLLVPRHPERFNVVADLLKKEKFQFIRRSTNELPNENTQVILGDSMGELMLMYGI
SDIAFVGGSLVKHGGHNPLEPLAFKMPVITGKHTFNFPEIFRMLVEVQGVLEVNSTADALERAVEALLNSKESRERLGNA
GYEVLMENRGALQRLLDLLKPYLERNV
>Mature_427_residues
MWRFFYTSLLLICQPLILCFIGLLSVKSPRYRQRLAERYGFYGNASCPPPQGIFIHAASVGEVIAATPLVRQLQQDYPHL
SITFTTFTPTGSERVKATFGDSVFHYYLPLDLPFSIHRFINFVQPKLCIVMETELWPNLIHQLFLRNIPFVIANARLSAR
SAHRYGKIKAHLQTMWSQISLIAAQDNISGKRYATLGYPKEKLNITGNIKYDLNTNDELLRKIDSLRTLWKQDRPIWIAA
STHNGEDEIILKSHRALLAKYPNLLLLLVPRHPERFNVVADLLKKEKFQFIRRSTNELPNENTQVILGDSMGELMLMYGI
SDIAFVGGSLVKHGGHNPLEPLAFKMPVITGKHTFNFPEIFRMLVEVQGVLEVNSTADALERAVEALLNSKESRERLGNA
GYEVLMENRGALQRLLDLLKPYLERNV

Specific function: Essential step in lipopolysaccharides biosynthesis. Acts at transfer of 3-deoxy-D-mono octulonic acid (KDO) from CMP-KDO to a tetraacyldisaccharide 1,4'-bisphosphate precursor of lipid A (lipid IVA). Transfers a single molecule of KDO to lipid IVA

COG id: COG1519

COG function: function code M; 3-deoxy-D-manno-octulosonic-acid transferase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential)

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycosyltransferase 1 family

Homologues:

Organism=Escherichia coli, GI1790064, Length=423, Percent_Identity=50.5910165484634, Blast_Score=434, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KDTA_HAEIN (P44806)

Other databases:

- EMBL:   AJ277814
- EMBL:   AJ277815
- EMBL:   L42023
- PIR:   F64084
- RefSeq:   NP_438812.1
- ProteinModelPortal:   P44806
- GeneID:   949683
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0652
- NMPDR:   fig|71421.1.peg.622
- TIGR:   HI_0652
- HOGENOM:   HBG664037
- OMA:   HPQRFDE
- ProtClustDB:   PRK05749
- BioCyc:   HINF71421:HI_0652-MONOMER
- InterPro:   IPR001296
- InterPro:   IPR007507

Pfam domain/function: PF00534 Glycos_transf_1; PF04413 Glycos_transf_N

EC number: 2.-.-.-

Molecular weight: Translated: 48743; Mature: 48743

Theoretical pI: Translated: 9.65; Mature: 9.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd403ac4)-;

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWRFFYTSLLLICQPLILCFIGLLSVKSPRYRQRLAERYGFYGNASCPPPQGIFIHAASV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCH
GEVIAATPLVRQLQQDYPHLSITFTTFTPTGSERVKATFGDSVFHYYLPLDLPFSIHRFI
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCHHHHHHH
NFVQPKLCIVMETELWPNLIHQLFLRNIPFVIANARLSARSAHRYGKIKAHLQTMWSQIS
HHCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHE
LIAAQDNISGKRYATLGYPKEKLNITGNIKYDLNTNDELLRKIDSLRTLWKQDRPIWIAA
EEEECCCCCCCEEEECCCCHHHEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEE
STHNGEDEIILKSHRALLAKYPNLLLLLVPRHPERFNVVADLLKKEKFQFIRRSTNELPN
ECCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
ENTQVILGDSMGELMLMYGISDIAFVGGSLVKHGGHNPLEPLAFKMPVITGKHTFNFPEI
CCCEEEECCCHHHHHHHHCCHHHHHHCCHHHHCCCCCCCCCHHEECCEEECCCCCCHHHH
FRMLVEVQGVLEVNSTADALERAVEALLNSKESRERLGNAGYEVLMENRGALQRLLDLLK
HHHHHHHHHHHEECCHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCHHHHHHHHHHHH
PYLERNV
HHHHCCH
>Mature Secondary Structure
MWRFFYTSLLLICQPLILCFIGLLSVKSPRYRQRLAERYGFYGNASCPPPQGIFIHAASV
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCH
GEVIAATPLVRQLQQDYPHLSITFTTFTPTGSERVKATFGDSVFHYYLPLDLPFSIHRFI
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEECCCCEEEEEECCCCCHHHHHHH
NFVQPKLCIVMETELWPNLIHQLFLRNIPFVIANARLSARSAHRYGKIKAHLQTMWSQIS
HHCCCCEEEEEEHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHE
LIAAQDNISGKRYATLGYPKEKLNITGNIKYDLNTNDELLRKIDSLRTLWKQDRPIWIAA
EEEECCCCCCCEEEECCCCHHHEEEEEEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEE
STHNGEDEIILKSHRALLAKYPNLLLLLVPRHPERFNVVADLLKKEKFQFIRRSTNELPN
ECCCCCCCEEEHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCCC
ENTQVILGDSMGELMLMYGISDIAFVGGSLVKHGGHNPLEPLAFKMPVITGKHTFNFPEI
CCCEEEECCCHHHHHHHHCCHHHHHHCCHHHHCCCCCCCCCHHEECCEEECCCCCCHHHH
FRMLVEVQGVLEVNSTADALERAVEALLNSKESRERLGNAGYEVLMENRGALQRLLDLLK
HHHHHHHHHHHEECCHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHCHHHHHHHHHHHH
PYLERNV
HHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10952982; 7542800