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The map label for this gene is hepA [H]

Identifier: 16272558

GI number: 16272558

Start: 648322

End: 651093

Strand: Direct

Name: hepA [H]

Synonym: HI0616

Alternate gene names: 16272558

Gene position: 648322-651093 (Clockwise)

Preceding gene: 16272550

Following gene: 16272559

Centisome position: 35.42

GC content: 40.91

Gene sequence:

>2772_bases
ATGCCCTTTGCTATTGGTCAGCGTTGGTTAAGTGAAAGTGAAAACGCTTTAGGATTAGGTGTTATTACCGCATTAGATCA
ACGAACTGTTACTATTTATTTCCCCGCAGCAGATGAAACACGGATATATGCTATGGCGCAAGCACCTTTAAGTCGAATTG
TATTTAGCAAAGGCGAAACATTATCCCATCAAGCTGGCTGGCAAGGCGAGATTTTAGACGTTCAAAATATGAACGGTTTG
TTGTTTTATTTAGTTAAAAATCCACAAGATGAAGATGTTATTGTGCAAGAACGTGATATTTCGCCGATTATTTCTTTTAG
TCAAGCGAAAGATCGTCTGTTTTCAGCACAAATTGATCGCAGCACTCATTTTGCATTGCGTTATCGCACGCTTTGTCATC
AGCAAGCACAATTTAAATCGCCATTGCGTGGTTTACGCGGAACGCGTGCAAGTTTAATTCCCCATCAGCTTCATATTGCA
GCTGAAGTCGGTAATCGAGTTAATCCTCGCGTGTTATTGGCGGATGAGGTTGGTTTAGGGAAAACCATTGAAGCAGGAAT
GATTTTGCAGAATCAACTTTTTGCTGAGAAAGTGCAACGTGTTCTTATTATCGTGCCAGAAACCTTGCAACATCAATGGC
TGGTGGAAATGCTTCGTCGTTTTAATTTGCATTTTGCACTTTTTGATGAAGAACGTTGCAACGATTTTGATCTTGATGCG
GTTAATCCATTCACGACTGAAAGTTTAATTATCTGTTCGCTGAATTGGTTAGAAACGCATCCAAACAGAGTAGAGCTGGT
GCTCAATGCTCAATTTGATTGCTTAATTGTGGACGAAGCCCATCATTTGGTGTGGTCTGAAACCTCGCCAAGTACTGCTT
ATTTATTAGTTGAACAGCTTGCTCGTATCATTCCATCCGTCTTGTTACTCACTGCAACTCCAGAGCAACTTGGGCAAGAA
AGTCATTTTGCTCGTTTGCGCTTACTGGATCCAGAACGTTTCTTTGATTATCAAACCTTTGTGAAAGAGCAGGAACACTA
TCAACCTGTGGTTAATGCCGTTGAATCTTTGTTGGCAAATAAGGCATTAAGTGCGGTCGAAAAAAATCATATTTCTGATT
TATTGCTTGAACAAGATGTCGAGCCACTTTTTAAAGCGATTGCATCAAATAATGATGAAGAACAACAGCGTGCCCGTCAG
GAATTGATTCAAGCCTTAATTGATCGTCACGGCACGGGGCGAATGTTATTCCGCAATACACGTCAAGGCGTGAAAGGTTT
TCCGCACCGTGTTTATCATCAAATTACACTCTCTGAAGAGAATGATAAAATTGATTGGCTGATTGACTTCCTCAAACTAC
ATCGCAATGAAAAAATCTTTGTGATTTGCCAGACGGCGGCAACTGCGATTCAGTTAGAACAAATTTTACGTGAACGTGAG
GCGATTCGCGCCGCAGTGTTTCACGAAAAAATGTCGATTATCGAACGGGATAGAGCCGCCGCTTATTTTGCGGATTTAGA
AAACGGCGCGCAGGTTTTACTGAGCTCGAGTATTGGCTCGGAAGGGCGTAATTTCCAATTCGCAGCAAATTTAGTGTTAT
TTGATTTACCGACAAATCCCGATTTATTGGAACAATGTATTGGCCGATTGGATCGTATTGGACAAAAACGTGATGTGCAA
GTTTATGTGCCTTGTGCGAAAGATTCGCCTCAAAGTCGTTTAGCACGTTGGTACAATGAGGGATTGAATGCTTTTGAACA
AACTTGTCCAATGGGAATGGCATTATTTTCTCAGTTTGCCGATGAGTTGGAAAAAGTGCGGTCAAATTCTACCGCACTTT
CAGAGAATGAATTTTCTGGATTATTAAAACAAACTAAAACCGCACGGGAAAAACTCAAGATTGAGTTAGAAAAAGGTCGT
GATCGTTTATTAGAGCTAAATTCTCATGGCGGTGAGCAAGCACAAGCATTAGCGGATCAAATTGCTGATGAAGATAATTC
GCCAGAGCTTGTGAATTTTGCTTTAAAATTATTTGATATTATTGGCGTAGAGCAAGAAGATCTTGGGGCTAATAGTATTG
TAATTAGTCCAACTGGGACAATGCTTGTGCCCGATTTTCCAGGTTTAAAAGAAGAAGGTGTGACGGTTACCTTTGATCGA
GAACTTGCCCTTGCCCGCGAAGAAATGGAGTTTCTGACTTGGGATCATCCTATGATTCGTCAAGGTATTGATCTTGTTGC
TTCGGGGGATATTGGCAAAGCCGCAATGGCATTGCTTGTAAATAAACAACTGCCAGCTGGAACCTTATTAATTGAATTGA
TTTATGTGGTGGAAAGCCAATCGCCAAAAGGGTTGCAGCTCAATCGTTTCTTGCCGCCAACGCCTATTCGTCTGCTGCTT
GATAACAAAGGAAATAACATTGGTGAGCAGGTTGCCTTTGAAACCTTGCATAGCAAATTGAAACCACTTGGTAAAAATAT
TACTAATCAAATGGTGAAAATGGCACGGAGCAACATTGAATCCTTGATCATGCGAGGTGATCAACTCGTAAAATCCTTGG
CAGAACCGATTATTGCTGAAGCTAAAAATCAAGCAGATCAACAATTAAGCGCAGAAATTAACCGTTTACAGGCTTTGCGA
GCAGTGAATAAAAATATTCGCCAAAGCGAAATTGATATTTTGGAACAACAACGAACACAATCACTTGACGAGCTTTCTAA
AGCAAATTGGCGTTTGGATTGCTTGCGTGTCATTGTGACGAACAAGGAATAA

Upstream 100 bases:

>100_bases
CCTAAAAGTGCGGTCAATTTTTTGTGAGTTTCTTTTCAAGAGTATGCAAGCTACAATACGCCCCCAAGTTTTATCAATGT
AAATCAGAAAGAGAATAATT

Downstream 100 bases:

>100_bases
AAATGGCATTGATTGAATACAATCCGCCCCTTGAACCTTATTTGGATATTATTTATCAAGATAATCATTTGTGCGTGGTA
AACAAACCGAGCGGTTTGCT

Product: ATP-dependent helicase HepA

Products: NA

Alternate protein names: ATP-dependent helicase hepA [H]

Number of amino acids: Translated: 923; Mature: 922

Protein sequence:

>923_residues
MPFAIGQRWLSESENALGLGVITALDQRTVTIYFPAADETRIYAMAQAPLSRIVFSKGETLSHQAGWQGEILDVQNMNGL
LFYLVKNPQDEDVIVQERDISPIISFSQAKDRLFSAQIDRSTHFALRYRTLCHQQAQFKSPLRGLRGTRASLIPHQLHIA
AEVGNRVNPRVLLADEVGLGKTIEAGMILQNQLFAEKVQRVLIIVPETLQHQWLVEMLRRFNLHFALFDEERCNDFDLDA
VNPFTTESLIICSLNWLETHPNRVELVLNAQFDCLIVDEAHHLVWSETSPSTAYLLVEQLARIIPSVLLLTATPEQLGQE
SHFARLRLLDPERFFDYQTFVKEQEHYQPVVNAVESLLANKALSAVEKNHISDLLLEQDVEPLFKAIASNNDEEQQRARQ
ELIQALIDRHGTGRMLFRNTRQGVKGFPHRVYHQITLSEENDKIDWLIDFLKLHRNEKIFVICQTAATAIQLEQILRERE
AIRAAVFHEKMSIIERDRAAAYFADLENGAQVLLSSSIGSEGRNFQFAANLVLFDLPTNPDLLEQCIGRLDRIGQKRDVQ
VYVPCAKDSPQSRLARWYNEGLNAFEQTCPMGMALFSQFADELEKVRSNSTALSENEFSGLLKQTKTAREKLKIELEKGR
DRLLELNSHGGEQAQALADQIADEDNSPELVNFALKLFDIIGVEQEDLGANSIVISPTGTMLVPDFPGLKEEGVTVTFDR
ELALAREEMEFLTWDHPMIRQGIDLVASGDIGKAAMALLVNKQLPAGTLLIELIYVVESQSPKGLQLNRFLPPTPIRLLL
DNKGNNIGEQVAFETLHSKLKPLGKNITNQMVKMARSNIESLIMRGDQLVKSLAEPIIAEAKNQADQQLSAEINRLQALR
AVNKNIRQSEIDILEQQRTQSLDELSKANWRLDCLRVIVTNKE

Sequences:

>Translated_923_residues
MPFAIGQRWLSESENALGLGVITALDQRTVTIYFPAADETRIYAMAQAPLSRIVFSKGETLSHQAGWQGEILDVQNMNGL
LFYLVKNPQDEDVIVQERDISPIISFSQAKDRLFSAQIDRSTHFALRYRTLCHQQAQFKSPLRGLRGTRASLIPHQLHIA
AEVGNRVNPRVLLADEVGLGKTIEAGMILQNQLFAEKVQRVLIIVPETLQHQWLVEMLRRFNLHFALFDEERCNDFDLDA
VNPFTTESLIICSLNWLETHPNRVELVLNAQFDCLIVDEAHHLVWSETSPSTAYLLVEQLARIIPSVLLLTATPEQLGQE
SHFARLRLLDPERFFDYQTFVKEQEHYQPVVNAVESLLANKALSAVEKNHISDLLLEQDVEPLFKAIASNNDEEQQRARQ
ELIQALIDRHGTGRMLFRNTRQGVKGFPHRVYHQITLSEENDKIDWLIDFLKLHRNEKIFVICQTAATAIQLEQILRERE
AIRAAVFHEKMSIIERDRAAAYFADLENGAQVLLSSSIGSEGRNFQFAANLVLFDLPTNPDLLEQCIGRLDRIGQKRDVQ
VYVPCAKDSPQSRLARWYNEGLNAFEQTCPMGMALFSQFADELEKVRSNSTALSENEFSGLLKQTKTAREKLKIELEKGR
DRLLELNSHGGEQAQALADQIADEDNSPELVNFALKLFDIIGVEQEDLGANSIVISPTGTMLVPDFPGLKEEGVTVTFDR
ELALAREEMEFLTWDHPMIRQGIDLVASGDIGKAAMALLVNKQLPAGTLLIELIYVVESQSPKGLQLNRFLPPTPIRLLL
DNKGNNIGEQVAFETLHSKLKPLGKNITNQMVKMARSNIESLIMRGDQLVKSLAEPIIAEAKNQADQQLSAEINRLQALR
AVNKNIRQSEIDILEQQRTQSLDELSKANWRLDCLRVIVTNKE
>Mature_922_residues
PFAIGQRWLSESENALGLGVITALDQRTVTIYFPAADETRIYAMAQAPLSRIVFSKGETLSHQAGWQGEILDVQNMNGLL
FYLVKNPQDEDVIVQERDISPIISFSQAKDRLFSAQIDRSTHFALRYRTLCHQQAQFKSPLRGLRGTRASLIPHQLHIAA
EVGNRVNPRVLLADEVGLGKTIEAGMILQNQLFAEKVQRVLIIVPETLQHQWLVEMLRRFNLHFALFDEERCNDFDLDAV
NPFTTESLIICSLNWLETHPNRVELVLNAQFDCLIVDEAHHLVWSETSPSTAYLLVEQLARIIPSVLLLTATPEQLGQES
HFARLRLLDPERFFDYQTFVKEQEHYQPVVNAVESLLANKALSAVEKNHISDLLLEQDVEPLFKAIASNNDEEQQRARQE
LIQALIDRHGTGRMLFRNTRQGVKGFPHRVYHQITLSEENDKIDWLIDFLKLHRNEKIFVICQTAATAIQLEQILREREA
IRAAVFHEKMSIIERDRAAAYFADLENGAQVLLSSSIGSEGRNFQFAANLVLFDLPTNPDLLEQCIGRLDRIGQKRDVQV
YVPCAKDSPQSRLARWYNEGLNAFEQTCPMGMALFSQFADELEKVRSNSTALSENEFSGLLKQTKTAREKLKIELEKGRD
RLLELNSHGGEQAQALADQIADEDNSPELVNFALKLFDIIGVEQEDLGANSIVISPTGTMLVPDFPGLKEEGVTVTFDRE
LALAREEMEFLTWDHPMIRQGIDLVASGDIGKAAMALLVNKQLPAGTLLIELIYVVESQSPKGLQLNRFLPPTPIRLLLD
NKGNNIGEQVAFETLHSKLKPLGKNITNQMVKMARSNIESLIMRGDQLVKSLAEPIIAEAKNQADQQLSAEINRLQALRA
VNKNIRQSEIDILEQQRTQSLDELSKANWRLDCLRVIVTNKE

Specific function: Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on

COG id: COG0553

COG function: function code KL; Superfamily II DNA/RNA helicases, SNF2 family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI1786245, Length=971, Percent_Identity=52.7291452111225, Blast_Score=1045, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR022737
- InterPro:   IPR000330 [H]

Pfam domain/function: PF00271 Helicase_C; PF12137 RapA_C; PF00176 SNF2_N [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 104407; Mature: 104276

Theoretical pI: Translated: 5.15; Mature: 5.15

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPFAIGQRWLSESENALGLGVITALDQRTVTIYFPAADETRIYAMAQAPLSRIVFSKGET
CCCCHHHHHHCCCCCCCEEHHEEECCCCEEEEEECCCCCCEEEEEHHHHHHHHHHCCCCC
LSHQAGWQGEILDVQNMNGLLFYLVKNPQDEDVIVQERDISPIISFSQAKDRLFSAQIDR
CCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCC
STHFALRYRTLCHQQAQFKSPLRGLRGTRASLIPHQLHIAAEVGNRVNPRVLLADEVGLG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHEEHHHHCCCCCCEEEEEECCCCC
KTIEAGMILQNQLFAEKVQRVLIIVPETLQHQWLVEMLRRFNLHFALFDEERCNDFDLDA
CCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
VNPFTTESLIICSLNWLETHPNRVELVLNAQFDCLIVDEAHHLVWSETSPSTAYLLVEQL
CCCCCCCCEEEEEEHHHHCCCCEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHHHHHH
ARIIPSVLLLTATPEQLGQESHFARLRLLDPERFFDYQTFVKEQEHYQPVVNAVESLLAN
HHHHHHHHEEECCHHHHCCCCCHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALSAVEKNHISDLLLEQDVEPLFKAIASNNDEEQQRARQELIQALIDRHGTGRMLFRNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RQGVKGFPHRVYHQITLSEENDKIDWLIDFLKLHRNEKIFVICQTAATAIQLEQILRERE
HHHCCCCCHHHEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHH
AIRAAVFHEKMSIIERDRAAAYFADLENGAQVLLSSSIGSEGRNFQFAANLVLFDLPTNP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEEEEEEEECCCCH
DLLEQCIGRLDRIGQKRDVQVYVPCAKDSPQSRLARWYNEGLNAFEQTCPMGMALFSQFA
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DELEKVRSNSTALSENEFSGLLKQTKTAREKLKIELEKGRDRLLELNSHGGEQAQALADQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHCCCCCEEEECCCCCHHHHHHHHH
IADEDNSPELVNFALKLFDIIGVEQEDLGANSIVISPTGTMLVPDFPGLKEEGVTVTFDR
HCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCEEEECCCCCEECCCCCCCCCCCEEEEECH
ELALAREEMEFLTWDHPMIRQGIDLVASGDIGKAAMALLVNKQLPAGTLLIELIYVVESQ
HHHHHHHHHHHHCCCCHHHHCCCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
SPKGLQLNRFLPPTPIRLLLDNKGNNIGEQVAFETLHSKLKPLGKNITNQMVKMARSNIE
CCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIMRGDQLVKSLAEPIIAEAKNQADQQLSAEINRLQALRAVNKNIRQSEIDILEQQRTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLDELSKANWRLDCLRVIVTNKE
HHHHHHHCCCCEEEEEEEEECCC
>Mature Secondary Structure 
PFAIGQRWLSESENALGLGVITALDQRTVTIYFPAADETRIYAMAQAPLSRIVFSKGET
CCCHHHHHHCCCCCCCEEHHEEECCCCEEEEEECCCCCCEEEEEHHHHHHHHHHCCCCC
LSHQAGWQGEILDVQNMNGLLFYLVKNPQDEDVIVQERDISPIISFSQAKDRLFSAQIDR
CCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCC
STHFALRYRTLCHQQAQFKSPLRGLRGTRASLIPHQLHIAAEVGNRVNPRVLLADEVGLG
CHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHEEHHHHCCCCCCEEEEEECCCCC
KTIEAGMILQNQLFAEKVQRVLIIVPETLQHQWLVEMLRRFNLHFALFDEERCNDFDLDA
CCCCCCHHHHHHHHHHHHHHEEEECCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCC
VNPFTTESLIICSLNWLETHPNRVELVLNAQFDCLIVDEAHHLVWSETSPSTAYLLVEQL
CCCCCCCCEEEEEEHHHHCCCCEEEEEEECCCCEEEEECCCCEEECCCCCCHHHHHHHHH
ARIIPSVLLLTATPEQLGQESHFARLRLLDPERFFDYQTFVKEQEHYQPVVNAVESLLAN
HHHHHHHHEEECCHHHHCCCCCHHEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KALSAVEKNHISDLLLEQDVEPLFKAIASNNDEEQQRARQELIQALIDRHGTGRMLFRNT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHH
RQGVKGFPHRVYHQITLSEENDKIDWLIDFLKLHRNEKIFVICQTAATAIQLEQILRERE
HHHCCCCCHHHEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHH
AIRAAVFHEKMSIIERDRAAAYFADLENGAQVLLSSSIGSEGRNFQFAANLVLFDLPTNP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCCCCEEEEEEEEEEECCCCH
DLLEQCIGRLDRIGQKRDVQVYVPCAKDSPQSRLARWYNEGLNAFEQTCPMGMALFSQFA
HHHHHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
DELEKVRSNSTALSENEFSGLLKQTKTAREKLKIELEKGRDRLLELNSHGGEQAQALADQ
HHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHEEHHHCCCCCEEEECCCCCHHHHHHHHH
IADEDNSPELVNFALKLFDIIGVEQEDLGANSIVISPTGTMLVPDFPGLKEEGVTVTFDR
HCCCCCCHHHHHHHHHHHHHHCCCHHCCCCCEEEECCCCCEECCCCCCCCCCCEEEEECH
ELALAREEMEFLTWDHPMIRQGIDLVASGDIGKAAMALLVNKQLPAGTLLIELIYVVESQ
HHHHHHHHHHHHCCCCHHHHCCCCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCC
SPKGLQLNRFLPPTPIRLLLDNKGNNIGEQVAFETLHSKLKPLGKNITNQMVKMARSNIE
CCCCEEECCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLIMRGDQLVKSLAEPIIAEAKNQADQQLSAEINRLQALRAVNKNIRQSEIDILEQQRTQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLDELSKANWRLDCLRVIVTNKE
HHHHHHHCCCCEEEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA