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The map label for this gene is citT [C]

Identifier: 16272550

GI number: 16272550

Start: 638552

End: 639937

Strand: Direct

Name: citT [C]

Synonym: HI0608

Alternate gene names: 16272550

Gene position: 638552-639937 (Clockwise)

Preceding gene: 16272549

Following gene: 16272558

Centisome position: 34.89

GC content: 35.28

Gene sequence:

>1386_bases
ATGGGTGAGATGGCATCTTTAAGAAGTCATAAAAATGGCATTATTTTTATTTTAGATATTGTGCTGTTTTTTGTGTTATT
AAATGTATTACCTTTTGAACCAAAAGCTAATTCTGGTTTGGCATTATTAGCTTTTATCGCGGTGCTTTGGTTAAGTGAAG
CATTACACGTTACTATTACTGCATTATTAGTTCCACTTTTGGCTGTGGCATTGGGATTAGTTAGTACCAAACAAGCTTTA
GTTGGTTTTGCTGATCCGACAATATTTTTATTTTTTGGTGGCTTTTCCTTGGCGACGGCATTGCATATTCAAAAACTTGA
TAAATTGATTGCCAATAAGATTATGGCACTAGCACGCGGTAATTTATTTATCGCAGTTATTTATCTCTTTTTGATTACAG
CCTTTCTTTCTATGTGGATGAGTAACACGGCAACTGCTGCAATGATGTTACCCCTCGCCATGGGTATTTTAAGCCAGCTT
GATCGCGAAAAAGATCATAACACCTATGTGTTTGTGCTGTTAGGGATTGCTTACAGTGCATCAATTGGTGGTATGGGAAC
CCTTGTAGGAAGCCCACCAAATGCAATTGTAGCAAGTAATTTAAATTTAACTTTTTCTGATTGGTTATGGTATGGCTTAC
CAATAATGATTATTTTGTTGCCGTTGATGATTGGGATTCTTTATATTATTTTCAAACCAAAACTTCATCTCAATTTTGAA
CAGACCTTTGAAAATATTGAAATGAATCCTATGCGTATATTGACGTTTATTATTTTTCCAGTCATTGCTTTAACGTGGAT
ATTTAGCGGTAAAATTAATCCGTTTATTTCAGGATTACTAGGATTACAAAAAAACATTGCAAGTTTTGATAGTATCGTAG
CCTTATTGGCGGCAATTGTTATTTGTTCAACAGGCGTTGCAAGTTGGAAACAAATTCAATCAAATACCGATTGGGGCGTA
TTAATGCTTTTCGGTGGTGGATTAACATTAAGTGCGGTGTTGAAGGATTCTGGTGCAAGTAAAATTTTAGCGGATAGTAT
TGTTTTTATGATTGATGGACAACATTTCTATCTTATTGGTTTATTAGTTGCGGCGTTCATTATTTTCTTAACTGAATTTA
CTTCTAATACAGCGAGTGCGGCGTTACTTGTACCTATCTTTATTTCTATCGCTCAATCATTGGGTATGCCAGAAATTGGT
TTAGCATTAATTATTGGTATTGGTGCATCCTGTGCCTTTATGCTACCAGTAGCGACACCACCAAATGCGATTGTATTTGG
CTCTGGTCAAGTAAAACAAAGTGAAATGGTCAAAGTTGGTTTCTTACTGAATTTAGTCTGTGTTGTAGTTATTGCCACTA
TGGGTTATATGTTCTGGCTTAAATAA

Upstream 100 bases:

>100_bases
GTTGCTCTCGATCACATTTCTGAATATTGCTCGTTGCATCTTTATAACATTCATTTAACATTGAACCCTATTTAAGTGAT
AGCTCTAACGGAGGAACTTT

Downstream 100 bases:

>100_bases
TATAGAATTGTTTACTTTTAATAAATGATGATTGAAGATCATAAATTTAAACGTAAGAAGTACAATAAAGCCATTTAAAT
AAATGGGTTAAAGCAAATGA

Product: putative di- and tricarboxylate transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 461; Mature: 460

Protein sequence:

>461_residues
MGEMASLRSHKNGIIFILDIVLFFVLLNVLPFEPKANSGLALLAFIAVLWLSEALHVTITALLVPLLAVALGLVSTKQAL
VGFADPTIFLFFGGFSLATALHIQKLDKLIANKIMALARGNLFIAVIYLFLITAFLSMWMSNTATAAMMLPLAMGILSQL
DREKDHNTYVFVLLGIAYSASIGGMGTLVGSPPNAIVASNLNLTFSDWLWYGLPIMIILLPLMIGILYIIFKPKLHLNFE
QTFENIEMNPMRILTFIIFPVIALTWIFSGKINPFISGLLGLQKNIASFDSIVALLAAIVICSTGVASWKQIQSNTDWGV
LMLFGGGLTLSAVLKDSGASKILADSIVFMIDGQHFYLIGLLVAAFIIFLTEFTSNTASAALLVPIFISIAQSLGMPEIG
LALIIGIGASCAFMLPVATPPNAIVFGSGQVKQSEMVKVGFLLNLVCVVVIATMGYMFWLK

Sequences:

>Translated_461_residues
MGEMASLRSHKNGIIFILDIVLFFVLLNVLPFEPKANSGLALLAFIAVLWLSEALHVTITALLVPLLAVALGLVSTKQAL
VGFADPTIFLFFGGFSLATALHIQKLDKLIANKIMALARGNLFIAVIYLFLITAFLSMWMSNTATAAMMLPLAMGILSQL
DREKDHNTYVFVLLGIAYSASIGGMGTLVGSPPNAIVASNLNLTFSDWLWYGLPIMIILLPLMIGILYIIFKPKLHLNFE
QTFENIEMNPMRILTFIIFPVIALTWIFSGKINPFISGLLGLQKNIASFDSIVALLAAIVICSTGVASWKQIQSNTDWGV
LMLFGGGLTLSAVLKDSGASKILADSIVFMIDGQHFYLIGLLVAAFIIFLTEFTSNTASAALLVPIFISIAQSLGMPEIG
LALIIGIGASCAFMLPVATPPNAIVFGSGQVKQSEMVKVGFLLNLVCVVVIATMGYMFWLK
>Mature_460_residues
GEMASLRSHKNGIIFILDIVLFFVLLNVLPFEPKANSGLALLAFIAVLWLSEALHVTITALLVPLLAVALGLVSTKQALV
GFADPTIFLFFGGFSLATALHIQKLDKLIANKIMALARGNLFIAVIYLFLITAFLSMWMSNTATAAMMLPLAMGILSQLD
REKDHNTYVFVLLGIAYSASIGGMGTLVGSPPNAIVASNLNLTFSDWLWYGLPIMIILLPLMIGILYIIFKPKLHLNFEQ
TFENIEMNPMRILTFIIFPVIALTWIFSGKINPFISGLLGLQKNIASFDSIVALLAAIVICSTGVASWKQIQSNTDWGVL
MLFGGGLTLSAVLKDSGASKILADSIVFMIDGQHFYLIGLLVAAFIIFLTEFTSNTASAALLVPIFISIAQSLGMPEIGL
ALIIGIGASCAFMLPVATPPNAIVFGSGQVKQSEMVKVGFLLNLVCVVVIATMGYMFWLK

Specific function: Responsible For The Uptake Of Citrate In Exchange To The Efflux Of Succinate. Has A Relatively Broad Specificity For C(4)- Dicarboxylates And Tricarboxylates. [C]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily

Homologues:

Organism=Homo sapiens, GI31377715, Length=548, Percent_Identity=27.7372262773723, Blast_Score=153, Evalue=3e-37,
Organism=Homo sapiens, GI301069349, Length=496, Percent_Identity=28.2258064516129, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI58761541, Length=520, Percent_Identity=27.3076923076923, Blast_Score=146, Evalue=3e-35,
Organism=Homo sapiens, GI29171306, Length=503, Percent_Identity=26.8389662027833, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI19923838, Length=349, Percent_Identity=29.2263610315186, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI301069353, Length=356, Percent_Identity=27.247191011236, Blast_Score=110, Evalue=3e-24,
Organism=Homo sapiens, GI4506979, Length=151, Percent_Identity=38.4105960264901, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI225637552, Length=151, Percent_Identity=38.4105960264901, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI225637549, Length=151, Percent_Identity=38.4105960264901, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI301069346, Length=145, Percent_Identity=34.4827586206897, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI31795546, Length=351, Percent_Identity=23.6467236467236, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI219802232, Length=466, Percent_Identity=24.2489270386266, Blast_Score=85, Evalue=2e-16,
Organism=Escherichia coli, GI1786829, Length=410, Percent_Identity=22.6829268292683, Blast_Score=63, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI17551790, Length=506, Percent_Identity=24.1106719367589, Blast_Score=144, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI71988385, Length=485, Percent_Identity=27.6288659793814, Blast_Score=143, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI71989118, Length=504, Percent_Identity=26.3888888888889, Blast_Score=137, Evalue=9e-33,
Organism=Caenorhabditis elegans, GI32564681, Length=484, Percent_Identity=24.1735537190083, Blast_Score=132, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI32565804, Length=446, Percent_Identity=27.5784753363229, Blast_Score=131, Evalue=9e-31,
Organism=Saccharomyces cerevisiae, GI6324340, Length=477, Percent_Identity=25.1572327044025, Blast_Score=101, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6322263, Length=462, Percent_Identity=25.5411255411255, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6319885, Length=480, Percent_Identity=28.3333333333333, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI78706796, Length=472, Percent_Identity=24.7881355932203, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI78706798, Length=472, Percent_Identity=24.7881355932203, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI281366409, Length=239, Percent_Identity=26.7782426778243, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737623, Length=239, Percent_Identity=26.7782426778243, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24666468, Length=239, Percent_Identity=26.7782426778243, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45551633, Length=239, Percent_Identity=26.7782426778243, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281362114, Length=232, Percent_Identity=26.2931034482759, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281362112, Length=232, Percent_Identity=26.2931034482759, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI281362116, Length=232, Percent_Identity=26.2931034482759, Blast_Score=77, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): Y608_HAEIN (Q57486)

Other databases:

- EMBL:   L42023
- PIR:   I64080
- RefSeq:   NP_438766.1
- GeneID:   949996
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0608
- NMPDR:   fig|71421.1.peg.577
- TIGR:   HI_0608
- HOGENOM:   HBG616159
- OMA:   NRIMALA
- ProtClustDB:   CLSK870380
- BioCyc:   HINF71421:HI_0608-MONOMER
- InterPro:   IPR001898
- TIGRFAMs:   TIGR00785

Pfam domain/function: PF00939 Na_sulph_symp

EC number: NA

Molecular weight: Translated: 49763; Mature: 49631

Theoretical pI: Translated: 7.59; Mature: 7.59

Prosite motif: PS01271 NA_SULFATE

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xb6f3de0)-; HASH(0xc297cb0)-; HASH(0xce22ed8)-; HASH(0xcf9c8c8)-; HASH(0xcd09520)-; HASH(0xb03bdc4)-; HASH(0xc72b380)-; HASH(0xcc78700)-; HASH(0xc084060)-; HASH(0xbcf8850)-; HASH(0xcd49860)-; HASH(0xd047944)-; HASH(0xc60e32c)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEMASLRSHKNGIIFILDIVLFFVLLNVLPFEPKANSGLALLAFIAVLWLSEALHVTIT
CCCHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALLVPLLAVALGLVSTKQALVGFADPTIFLFFGGFSLATALHIQKLDKLIANKIMALARG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
NLFIAVIYLFLITAFLSMWMSNTATAAMMLPLAMGILSQLDREKDHNTYVFVLLGIAYSA
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHC
SIGGMGTLVGSPPNAIVASNLNLTFSDWLWYGLPIMIILLPLMIGILYIIFKPKLHLNFE
CCCCCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHH
QTFENIEMNPMRILTFIIFPVIALTWIFSGKINPFISGLLGLQKNIASFDSIVALLAAIV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ICSTGVASWKQIQSNTDWGVLMLFGGGLTLSAVLKDSGASKILADSIVFMIDGQHFYLIG
HHHCCHHHHHHHHCCCCCEEEEEECCCCEEEHHHHCCCCCHHHHHCEEEEECCCHHHHHH
LLVAAFIIFLTEFTSNTASAALLVPIFISIAQSLGMPEIGLALIIGIGASCAFMLPVATP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCC
PNAIVFGSGQVKQSEMVKVGFLLNLVCVVVIATMGYMFWLK
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH
>Mature Secondary Structure 
GEMASLRSHKNGIIFILDIVLFFVLLNVLPFEPKANSGLALLAFIAVLWLSEALHVTIT
CCHHHHHHCCCCEEEHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ALLVPLLAVALGLVSTKQALVGFADPTIFLFFGGFSLATALHIQKLDKLIANKIMALARG
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCC
NLFIAVIYLFLITAFLSMWMSNTATAAMMLPLAMGILSQLDREKDHNTYVFVLLGIAYSA
CHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHHHC
SIGGMGTLVGSPPNAIVASNLNLTFSDWLWYGLPIMIILLPLMIGILYIIFKPKLHLNFE
CCCCCCCCCCCCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCHH
QTFENIEMNPMRILTFIIFPVIALTWIFSGKINPFISGLLGLQKNIASFDSIVALLAAIV
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
ICSTGVASWKQIQSNTDWGVLMLFGGGLTLSAVLKDSGASKILADSIVFMIDGQHFYLIG
HHHCCHHHHHHHHCCCCCEEEEEECCCCEEEHHHHCCCCCHHHHHCEEEEECCCHHHHHH
LLVAAFIIFLTEFTSNTASAALLVPIFISIAQSLGMPEIGLALIIGIGASCAFMLPVATP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEEEEECCC
PNAIVFGSGQVKQSEMVKVGFLLNLVCVVVIATMGYMFWLK
CCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800