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The map label for this gene is groEL [H]

Identifier: 16272487

GI number: 16272487

Start: 565947

End: 567593

Strand: Direct

Name: groEL [H]

Synonym: HI0543

Alternate gene names: 16272487

Gene position: 565947-567593 (Clockwise)

Preceding gene: 16272486

Following gene: 16272493

Centisome position: 30.92

GC content: 41.83

Gene sequence:

>1647_bases
ATGGCAGCAAAAGACGTAAAATTTGGTAATGACGCACGCGTAAAAATGCTTAAAGGCGTGAATGTATTAGCGGATGCAGT
AAAAGTAACCCTTGGCCCGAAAGGTCGTCATGTAATTTTAGATAAATCATTTGGCGCACCAACTATCACTAAAGACGGTG
TGTCTGTTGCTCGTGAAATCGAATTAGAAGATAAATTCGAAAACATGGGGGCACAAATGGTGAAAGAAGTGGCATCTAAA
GCAAATGATGCTGCAGGTGACGGTACAACTACTGCAACTGTACTTGCGCAAGCTATCGTAAATGAAGGCTTGAAAGCAGT
AGCTGCAGGTATGAATCCAATGGATTTAAAACGTGGTATTGATAAAGCAGTAAGTGCGGTTGTTTCTGAACTTAAAAATT
TATCTAAACCTTGTGAAACAGCAAAAGAAATTGAACAAGTAGGGACTATTTCTGCAAACTCTGACAGCATTGTGGGTCAA
TTAATCTCACAAGCAATGGAAAAAGTGGGCAAGGAAGGTGTAATTACTGTTGAAGATGGTACGGGTCTTGAAGATGAATT
AGATGTGGTTGAAGGCATGCAATTCGACCGTGGTTACCTTTCTCCATATTTCATCAACAAACCAGAAACTGCAACCGTTG
AATTAGATAATCCATATCTTCTTCTTGTAGATAAAAAAATCTCTAACATTCGTGAATTACTTCCCGTGTTAGAAGGCGTT
GCGAAAGCAGGTAAACCGTTATTAATCATCGCTGAAGACGTGGAAGGCGAAGCGCTTGCAACCTTAGTGGTAAACACTAT
GCGCGGTATCGTGAAAGTTGCAGCCGTGAAAGCACCAGGTTTTGGTGATCGTCGTAAAGCGATGTTACAAGATATTGCAA
TTTTAACAGCGGGTACAGTGATTTCTGAAGAAATTGGTATGGAGCTTGAAAAAGCAACATTGGAAGATTTAGGTCAAGCA
AAACGTGTTGTTATCAATAAAGATAACACAACCATTATTGATGGTATCGGCGATGAAGCACAAATCAAAGGTCGTGTGGC
TCAAATTCGTCAGCAAATCGAAGAATCAACTTCTGACTACGACAAAGAAAAACTCCAAGAACGCGTGGCTAAATTAGCAG
GCGGTGTGGCAGTAATCAAAGTGGGCGCAGCAACTGAAGTTGAAATGAAAGAGAAAAAAGATCGTGTAGATGATGCATTA
CATGCAACTCGTGCAGCGGTTGAAGAAGGTATCGTTGCTGGTGGTGGCGTTGCATTAGTTCGCGCAGCAGCGAAAGTTGC
AGCAAGCCTAAAAGGTGACAACGAAGAACAAAATGTGGGTATCAAACTTGCATTACGTGCTATGGAAGCGCCTTTACGTC
AAATCGTCACTAACGCAGGTGAAGAAGCTTCAGTTGTGGCAAGTGCGGTTAAAAATGGCGAAGGAAACTTTGGTTATAAT
GCAGGAACAGAACAGTACGGCGATATGATCGAAATGGGTATCTTAGATCCAACTAAAGTCACTCGTTCTGCATTGCAATT
CGCAGCTTCTGTAGCAGGCTTAATGATTACCACTGAATGTATGGTAACTGATCTTCCAAAAGATGATAAAGCCGATTTAG
GTGCTGCTGGAATGGGCGGTATGGGTGGAATGGGCGGAATGATGTAA

Upstream 100 bases:

>100_bases
GGCGTGAAAAGCGAAAAAATCGATGGTGAAGAAGTGTTAATCATTTCTGAAAACGACATCCTAGCAATTGTAGAATAATT
ATTAAATAAGGGAAAAGAAA

Downstream 100 bases:

>100_bases
TTCGCTTATACGAGTAAAAAATCTATCCCAACAGAAAATTTGAGCCCTATATGACTTAGGGCTCAAATCTACTAAAATAA
GGGATATTTTTTATTACCCT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 548; Mature: 547

Protein sequence:

>548_residues
MAAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRHVILDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVSAVVSELKNLSKPCETAKEIEQVGTISANSDSIVGQ
LISQAMEKVGKEGVITVEDGTGLEDELDVVEGMQFDRGYLSPYFINKPETATVELDNPYLLLVDKKISNIRELLPVLEGV
AKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEDLGQA
KRVVINKDNTTIIDGIGDEAQIKGRVAQIRQQIEESTSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVAGGGVALVRAAAKVAASLKGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVASAVKNGEGNFGYN
AGTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKDDKADLGAAGMGGMGGMGGMM

Sequences:

>Translated_548_residues
MAAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRHVILDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASK
ANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVSAVVSELKNLSKPCETAKEIEQVGTISANSDSIVGQ
LISQAMEKVGKEGVITVEDGTGLEDELDVVEGMQFDRGYLSPYFINKPETATVELDNPYLLLVDKKISNIRELLPVLEGV
AKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEDLGQA
KRVVINKDNTTIIDGIGDEAQIKGRVAQIRQQIEESTSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDAL
HATRAAVEEGIVAGGGVALVRAAAKVAASLKGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVASAVKNGEGNFGYN
AGTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKDDKADLGAAGMGGMGGMGGMM
>Mature_547_residues
AAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRHVILDKSFGAPTITKDGVSVAREIELEDKFENMGAQMVKEVASKA
NDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGIDKAVSAVVSELKNLSKPCETAKEIEQVGTISANSDSIVGQL
ISQAMEKVGKEGVITVEDGTGLEDELDVVEGMQFDRGYLSPYFINKPETATVELDNPYLLLVDKKISNIRELLPVLEGVA
KAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTVISEEIGMELEKATLEDLGQAK
RVVINKDNTTIIDGIGDEAQIKGRVAQIRQQIEESTSDYDKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALH
ATRAAVEEGIVAGGGVALVRAAAKVAASLKGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVASAVKNGEGNFGYNA
GTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKDDKADLGAAGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=529, Percent_Identity=52.7410207939509, Blast_Score=545, Evalue=1e-155,
Organism=Homo sapiens, GI31542947, Length=529, Percent_Identity=52.7410207939509, Blast_Score=545, Evalue=1e-155,
Organism=Homo sapiens, GI5453607, Length=537, Percent_Identity=22.1601489757914, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI38455427, Length=544, Percent_Identity=19.8529411764706, Blast_Score=66, Evalue=1e-10,
Organism=Escherichia coli, GI1790586, Length=533, Percent_Identity=87.2420262664165, Blast_Score=927, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.930056710775, Blast_Score=551, Evalue=1e-157,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=51.1848341232227, Blast_Score=211, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17564182, Length=536, Percent_Identity=22.3880597014925, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=527, Percent_Identity=54.6489563567362, Blast_Score=554, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6322524, Length=162, Percent_Identity=27.1604938271605, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=53.5984848484849, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=53.5984848484849, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550936, Length=525, Percent_Identity=53.1428571428571, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550132, Length=525, Percent_Identity=53.1428571428571, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI45550935, Length=525, Percent_Identity=53.1428571428571, Blast_Score=545, Evalue=1e-155,
Organism=Drosophila melanogaster, GI17864606, Length=555, Percent_Identity=44.1441441441441, Blast_Score=463, Evalue=1e-130,
Organism=Drosophila melanogaster, GI24584129, Length=530, Percent_Identity=36.9811320754717, Blast_Score=340, Evalue=1e-93,
Organism=Drosophila melanogaster, GI19921262, Length=530, Percent_Identity=36.9811320754717, Blast_Score=340, Evalue=1e-93,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57578; Mature: 57447

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRHVILDKSFGAPTITKDGVSVAREI
CCCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVSAVVSELKNLSKPCETAKEIEQVGTISANSDSIVGQLISQAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
TGLEDELDVVEGMQFDRGYLSPYFINKPETATVELDNPYLLLVDKKISNIRELLPVLEGV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEIGMELEKATLEDLGQAKRVVINKDNTTIIDGIGDEAQIKGRVAQIRQQIEESTSDY
HHHHHCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVAGGGVALV
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAAAKVAASLKGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVASAVKNGEGNFGYN
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
AGTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKDDKADLGAAGMGG
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MGGMGGMM
CCCCCCCC
>Mature Secondary Structure 
AAKDVKFGNDARVKMLKGVNVLADAVKVTLGPKGRHVILDKSFGAPTITKDGVSVAREI
CCCCCCCCCCHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCCCCCCCCHHHHHHH
ELEDKFENMGAQMVKEVASKANDAAGDGTTTATVLAQAIVNEGLKAVAAGMNPMDLKRGI
HHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
DKAVSAVVSELKNLSKPCETAKEIEQVGTISANSDSIVGQLISQAMEKVGKEGVITVEDG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECC
TGLEDELDVVEGMQFDRGYLSPYFINKPETATVELDNPYLLLVDKKISNIRELLPVLEGV
CCCHHHHHHHHCCCCCCCCCCCEEECCCCEEEEEECCCEEEEECCHHHHHHHHHHHHHHH
AKAGKPLLIIAEDVEGEALATLVVNTMRGIVKVAAVKAPGFGDRRKAMLQDIAILTAGTV
HHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHH
ISEEIGMELEKATLEDLGQAKRVVINKDNTTIIDGIGDEAQIKGRVAQIRQQIEESTSDY
HHHHHCCHHHHHHHHHHCCCCEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHHHHHCCC
DKEKLQERVAKLAGGVAVIKVGAATEVEMKEKKDRVDDALHATRAAVEEGIVAGGGVALV
CHHHHHHHHHHHHCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RAAAKVAASLKGDNEEQNVGIKLALRAMEAPLRQIVTNAGEEASVVASAVKNGEGNFGYN
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCC
AGTEQYGDMIEMGILDPTKVTRSALQFAASVAGLMITTECMVTDLPKDDKADLGAAGMGG
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
MGGMGGMM
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA