Click here to switch to the map view.

The map label for this gene is gcp

Identifier: 16272474

GI number: 16272474

Start: 552783

End: 553811

Strand: Reverse

Name: gcp

Synonym: HI0530

Alternate gene names: 16272474

Gene position: 553811-552783 (Counterclockwise)

Preceding gene: 16272478

Following gene: 30995383

Centisome position: 30.26

GC content: 42.37

Gene sequence:

>1029_bases
ATGAAAATCTTAGGCATTGAAACTTCCTGTGATGAAACGGGCGTGGCGATTTATGATGAAGAAAAAGGATTAATTGCTAA
TCAACTTTATACTCAAATTGCCCTGCATGCAGATTATGGTGGTGTGGTTCCTGAATTAGCATCACGTGATCATATTCGGA
AAACAGCACCTCTTATTAAAGCGGCATTAGAGGAAGCCAATTTAACCGCGAGCGATATTGATGGTATTGCTTATACGAGT
GGCCCTGGGCTTGTTGGCGCATTGCTTGTCGGTGCTACGATTGCACGTTCTTTAGCCTATGCTTGGAATGTTCCTGCGAT
TGGTGTTCATCATATGGAAGGGCATTTACTTGCGCCAATGCTTGATGACAATTCACCGCACTTTCCTTTTGTTGCTCTGT
TGGTATCGGGTGGCCACACTCAATTAGTGCGTGTCGATGGTGTAGGAAAATATGAAGTGATAGGAGAATCTATTGATGAT
GCTGCTGGCGAAGCCTTTGATAAAACAGCAAAATTACTTGGACTAGATTATCCAGGTGGCGCGGCACTTTCTCGTTTAGC
GGAAAAAGGTACGCCAAATCGTTTCACATTTCCACGTCCAATGACAGATCGTGCAGGCCTTGATTTTAGTTTTTCTGGTT
TAAAAACATTTGCCGCAAATACAGTTAATCAAGCAATTAAAAACGAGGGCGAACTGATAGAGCAAACTAAAGCAGATATT
GCTTATGCTTTCCAAGATGCGGTGGTGGATACTCTTGCCATTAAATGTAAGCGTGCATTGAAAGAAACAGGCTATAAACG
TTTAGTGATTGCGGGAGGGGTGAGCGCAAATAAAAAACTCCGAGAAACGCTTGCGCACTTAATGCAAAATTTAGGTGGCG
AAGTGTTTTATCCTCAACCTCAATTTTGTACAGATAATGGTGCGATGATTGCTTACACAGGTTTTTTACGTTTAAAACAA
GGTCAGCATAGCGATCTGGCTATTGATGTTAAACCTCGTTGGGCAATGGCGGAATTACCGGCAATTTAG

Upstream 100 bases:

>100_bases
AGAATGCCAATTCACCTTAATATTTGTGGTTTCAACTGGTTAAAACCGCTTAAACAGGGTAAAATCGCGCAACATTTTAG
GTAATAAATTAAGAAAATCA

Downstream 100 bases:

>100_bases
GAGAAAAAATGGCGAAACTCTACTTCTATTACTCCACAATGAACGCTGGAAAATCAACGACGTTGCTACAATCTTCCTAT
AACTATCGTGAGCGTGATAT

Product: putative DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 342; Mature: 342

Protein sequence:

>342_residues
MKILGIETSCDETGVAIYDEEKGLIANQLYTQIALHADYGGVVPELASRDHIRKTAPLIKAALEEANLTASDIDGIAYTS
GPGLVGALLVGATIARSLAYAWNVPAIGVHHMEGHLLAPMLDDNSPHFPFVALLVSGGHTQLVRVDGVGKYEVIGESIDD
AAGEAFDKTAKLLGLDYPGGAALSRLAEKGTPNRFTFPRPMTDRAGLDFSFSGLKTFAANTVNQAIKNEGELIEQTKADI
AYAFQDAVVDTLAIKCKRALKETGYKRLVIAGGVSANKKLRETLAHLMQNLGGEVFYPQPQFCTDNGAMIAYTGFLRLKQ
GQHSDLAIDVKPRWAMAELPAI

Sequences:

>Translated_342_residues
MKILGIETSCDETGVAIYDEEKGLIANQLYTQIALHADYGGVVPELASRDHIRKTAPLIKAALEEANLTASDIDGIAYTS
GPGLVGALLVGATIARSLAYAWNVPAIGVHHMEGHLLAPMLDDNSPHFPFVALLVSGGHTQLVRVDGVGKYEVIGESIDD
AAGEAFDKTAKLLGLDYPGGAALSRLAEKGTPNRFTFPRPMTDRAGLDFSFSGLKTFAANTVNQAIKNEGELIEQTKADI
AYAFQDAVVDTLAIKCKRALKETGYKRLVIAGGVSANKKLRETLAHLMQNLGGEVFYPQPQFCTDNGAMIAYTGFLRLKQ
GQHSDLAIDVKPRWAMAELPAI
>Mature_342_residues
MKILGIETSCDETGVAIYDEEKGLIANQLYTQIALHADYGGVVPELASRDHIRKTAPLIKAALEEANLTASDIDGIAYTS
GPGLVGALLVGATIARSLAYAWNVPAIGVHHMEGHLLAPMLDDNSPHFPFVALLVSGGHTQLVRVDGVGKYEVIGESIDD
AAGEAFDKTAKLLGLDYPGGAALSRLAEKGTPNRFTFPRPMTDRAGLDFSFSGLKTFAANTVNQAIKNEGELIEQTKADI
AYAFQDAVVDTLAIKCKRALKETGYKRLVIAGGVSANKKLRETLAHLMQNLGGEVFYPQPQFCTDNGAMIAYTGFLRLKQ
GQHSDLAIDVKPRWAMAELPAI

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=337, Percent_Identity=34.7181008902077, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI8923380, Length=327, Percent_Identity=33.0275229357798, Blast_Score=161, Evalue=8e-40,
Organism=Escherichia coli, GI1789445, Length=341, Percent_Identity=73.900293255132, Blast_Score=532, Evalue=1e-152,
Organism=Caenorhabditis elegans, GI17557464, Length=330, Percent_Identity=32.7272727272727, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71995670, Length=332, Percent_Identity=33.433734939759, Blast_Score=148, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6320099, Length=376, Percent_Identity=35.6382978723404, Blast_Score=187, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6322891, Length=349, Percent_Identity=30.3724928366762, Blast_Score=132, Evalue=7e-32,
Organism=Drosophila melanogaster, GI20129063, Length=349, Percent_Identity=33.810888252149, Blast_Score=191, Evalue=5e-49,
Organism=Drosophila melanogaster, GI21357207, Length=327, Percent_Identity=33.3333333333333, Blast_Score=167, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_HAEIN (P43764)

Other databases:

- EMBL:   L42023
- PIR:   H64074
- RefSeq:   NP_438688.1
- ProteinModelPortal:   P43764
- SMR:   P43764
- MEROPS:   M22.001
- GeneID:   950725
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0530
- NMPDR:   fig|71421.1.peg.501
- TIGR:   HI_0530
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   HINF71421:HI_0530-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 36652; Mature: 36652

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILGIETSCDETGVAIYDEEKGLIANQLYTQIALHADYGGVVPELASRDHIRKTAPLIK
CEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
AALEEANLTASDIDGIAYTSGPGLVGALLVGATIARSLAYAWNVPAIGVHHMEGHLLAPM
HHHHHCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEE
LDDNSPHFPFVALLVSGGHTQLVRVDGVGKYEVIGESIDDAAGEAFDKTAKLLGLDYPGG
ECCCCCCCCEEEEEEECCCEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCH
AALSRLAEKGTPNRFTFPRPMTDRAGLDFSFSGLKTFAANTVNQAIKNEGELIEQTKADI
HHHHHHHHCCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AYAFQDAVVDTLAIKCKRALKETGYKRLVIAGGVSANKKLRETLAHLMQNLGGEVFYPQP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEECCCC
QFCTDNGAMIAYTGFLRLKQGQHSDLAIDVKPRWAMAELPAI
CCCCCCCCEEEEEEEEEECCCCCCCEEEEECCCCHHHCCCCC
>Mature Secondary Structure
MKILGIETSCDETGVAIYDEEKGLIANQLYTQIALHADYGGVVPELASRDHIRKTAPLIK
CEEEECCCCCCCCCEEEEECCCCHHHHHHHHHHEEECCCCCCCHHHHCHHHHHHHHHHHH
AALEEANLTASDIDGIAYTSGPGLVGALLVGATIARSLAYAWNVPAIGVHHMEGHLLAPM
HHHHHCCCCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCEEEEEE
LDDNSPHFPFVALLVSGGHTQLVRVDGVGKYEVIGESIDDAAGEAFDKTAKLLGLDYPGG
ECCCCCCCCEEEEEEECCCEEEEEECCCCCEEECCCCHHHHHHHHHHHHHHHHCCCCCCH
AALSRLAEKGTPNRFTFPRPMTDRAGLDFSFSGLKTFAANTVNQAIKNEGELIEQTKADI
HHHHHHHHCCCCCCEECCCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCCHHHHHHHHHHH
AYAFQDAVVDTLAIKCKRALKETGYKRLVIAGGVSANKKLRETLAHLMQNLGGEVFYPQP
HHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCEECCCC
QFCTDNGAMIAYTGFLRLKQGQHSDLAIDVKPRWAMAELPAI
CCCCCCCCEEEEEEEEEECCCCCCCEEEEECCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800