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The map label for this gene is tyrP

Identifier: 16272472

GI number: 16272472

Start: 550936

End: 552156

Strand: Reverse

Name: tyrP

Synonym: HI0528

Alternate gene names: 16272472

Gene position: 552156-550936 (Counterclockwise)

Preceding gene: 30995383

Following gene: 16272470

Centisome position: 30.17

GC content: 41.44

Gene sequence:

>1221_bases
ATGCTAAAAAACAAAACTTTTGGGAGTGCGCTGATTATTGCAGGCACAACCATTGGAGCAGGTATGCTTGCTATGCCGCT
TACATCAGCAGGTATGGGCTTTGGTTATACCCTGTTATTGCTCGTTGGCTTGTGGGCTTTGTTGGTTTACAGCGGATTGT
TGTTTGTAGAAGTGTATCAAACAGCGGATCAGTTGGATGATGGTGTCGCCACGCTCGCTGAAAAATATTTTGGGGTTCCT
GGGCGAATTTTCGCAACGTTGAGTTTGTTAGTTTTACTTTATGCACTTTCAGCCGCTTATATTACTGGTGGTGGATCTTT
ACTTTCAGGCTTGCCAACTGCGTTTGGAATGGAAGCGATGTCGCTTAAAACGGCGATTATTATCTTTACGGTGGTATTAG
GTTCTTTCGTGGTTGTAGGAACGAAAGGCGTGGATGGCTTAACTCGCGTGTTATTTATTGGTAAGTTAATCGCCTTTGCT
TTTGTGCTGTTTATGATGCTTCCAAAAGTAGCAACAGATAATTTAATGGCATTGCCTTTGGATTATGCTTTTGTGGTTTC
TGCGGCACCAATATTTTTAACTTCTTTCGGTTTCCACGTTATTATGGCGAGTGTGAATAGCTACTTAGGTGGAAGTGTTG
ATAAATTTCGTCGTGCCATTTTGATTGGTACTGCGATTCCATTAGCCGCTTACCTTGTATGGCAGTTAGCAACTCATGGT
GTATTAAGTCAAAGTGAATTTGTGCGTATTTTACAAGCTGACCCAACGCTAAATGGCTTAGTGAATGCAACGCGTGAAAT
TACAGGTTCTCATTTTATGGGAGAGGTTGTGCGTGTGTTCTCATCACTTGCACTGATCACTTCTTTCTTAGGCGTAATGC
TTGGTGTATTTGAGGGATTGGGGGATTTATTCAAGCGTTATCATTTGCCAAATAATCGCTTTGTATTAACCATTGCCGCA
TTTTTACCGCCACTTGTATTTGCATTGTTTTATCCTGAAGGATTTATTACTGCATTAAGTTACGCTGGTTTGTTGTGTGC
GTTCTATTGCTTAATTTTACCAATTAGCTTGGCATGGCGTACACGTATTGAAAATCCAACATTGCCATATCGAGTCGCTG
GCGGTAATTTTGCTTTGGTGCTTGCGTTATTAATTGGCGTCGTGATTATGCTCATTCCATTTTTAATTCAATGGGGATAT
TTACCAGTGGTGGCGGGGTAA

Upstream 100 bases:

>100_bases
AGGCAATGATTCTTATCTTTCTGTTTGCCGTTTACACTATAAAGAAAAGTGCGGTCAAATTTAAATTAGTTTTTAAACAC
AACATTATAAGGACAATTTT

Downstream 100 bases:

>100_bases
TGTGAAGAAAAGTAACTCAATGTAGTTCTTTTTATAGATAAAAGTGCGGTGAAAAATTTCGTTTTTTGATAATAAAAATA
AGCTCAAAATTAACCGCACT

Product: tyrosine-specific transport protein

Products: Proton [Cytoplasm]; L-tyrosine [Cytoplasm] [C]

Alternate protein names: Tyrosine permease 2

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQTADQLDDGVATLAEKYFGVP
GRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMEAMSLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFA
FVLFMMLPKVATDNLMALPLDYAFVVSAAPIFLTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGLGDLFKRYHLPNNRFVLTIAA
FLPPLVFALFYPEGFITALSYAGLLCAFYCLILPISLAWRTRIENPTLPYRVAGGNFALVLALLIGVVIMLIPFLIQWGY
LPVVAG

Sequences:

>Translated_406_residues
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQTADQLDDGVATLAEKYFGVP
GRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMEAMSLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFA
FVLFMMLPKVATDNLMALPLDYAFVVSAAPIFLTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGLGDLFKRYHLPNNRFVLTIAA
FLPPLVFALFYPEGFITALSYAGLLCAFYCLILPISLAWRTRIENPTLPYRVAGGNFALVLALLIGVVIMLIPFLIQWGY
LPVVAG
>Mature_406_residues
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQTADQLDDGVATLAEKYFGVP
GRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMEAMSLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFA
FVLFMMLPKVATDNLMALPLDYAFVVSAAPIFLTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGLGDLFKRYHLPNNRFVLTIAA
FLPPLVFALFYPEGFITALSYAGLLCAFYCLILPISLAWRTRIENPTLPYRVAGGNFALVLALLIGVVIMLIPFLIQWGY
LPVVAG

Specific function: Involved in transporting tyrosine across the cytoplasmic membrane

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. Mtr/TnaB/TyrP permease subfamily

Homologues:

Organism=Escherichia coli, GI1788218, Length=403, Percent_Identity=46.6501240694789, Blast_Score=333, Evalue=2e-92,
Organism=Escherichia coli, GI1790145, Length=402, Percent_Identity=29.1044776119403, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1789552, Length=389, Percent_Identity=28.7917737789203, Blast_Score=140, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TYRPB_HAEIN (P44747)

Other databases:

- EMBL:   L42023
- PIR:   F64074
- RefSeq:   NP_438686.1
- GeneID:   949591
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0528
- NMPDR:   fig|71421.1.peg.499
- TIGR:   HI_0528
- HOGENOM:   HBG482321
- OMA:   KNKTFGS
- ProtClustDB:   CLSK870223
- BioCyc:   HINF71421:HI_0528-MONOMER
- InterPro:   IPR002091
- InterPro:   IPR013061
- InterPro:   IPR013059
- InterPro:   IPR018227
- PRINTS:   PR00166
- TIGRFAMs:   TIGR00837

Pfam domain/function: PF03222 Trp_Tyr_perm

EC number: NA

Molecular weight: Translated: 43477; Mature: 43477

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00594 AROMATIC_AA_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xd25b43c)-; HASH(0xd1c1224)-; HASH(0xcc04fe8)-; HASH(0xd23016c)-; HASH(0xd1c120c)-; HASH(0xd20cfac)-; HASH(0xc8bb894)-; HASH(0xd19d650)-; HASH(0xceac168)-; HASH(0xb01158c)-; HASH(0xb9eb8dc)-;

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQ
CCCCCCCCCEEEEECCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TADQLDDGVATLAEKYFGVPGRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMEAM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHCHHHH
SLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFAFVLFMMLPKVATDNLMALPL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
DYAFVVSAAPIFLTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLFKRYHLPNNRFVLTIAAFLPPLVFALFYPEGFITALSYAGLLCAFYCLILPISLAWR
HHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRIENPTLPYRVAGGNFALVLALLIGVVIMLIPFLIQWGYLPVVAG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH
>Mature Secondary Structure
MLKNKTFGSALIIAGTTIGAGMLAMPLTSAGMGFGYTLLLLVGLWALLVYSGLLFVEVYQ
CCCCCCCCCEEEEECCHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TADQLDDGVATLAEKYFGVPGRIFATLSLLVLLYALSAAYITGGGSLLSGLPTAFGMEAM
HHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHCHHHH
SLKTAIIIFTVVLGSFVVVGTKGVDGLTRVLFIGKLIAFAFVLFMMLPKVATDNLMALPL
HHHHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCC
DYAFVVSAAPIFLTSFGFHVIMASVNSYLGGSVDKFRRAILIGTAIPLAAYLVWQLATHG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
VLSQSEFVRILQADPTLNGLVNATREITGSHFMGEVVRVFSSLALITSFLGVMLGVFEGL
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GDLFKRYHLPNNRFVLTIAAFLPPLVFALFYPEGFITALSYAGLLCAFYCLILPISLAWR
HHHHHHHCCCCCCEEEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
TRIENPTLPYRVAGGNFALVLALLIGVVIMLIPFLIQWGYLPVVAG
HCCCCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-tyrosine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800