Click here to switch to the map view.

The map label for this gene is hisD [H]

Identifier: 16272417

GI number: 16272417

Start: 491635

End: 492918

Strand: Direct

Name: hisD [H]

Synonym: HI0469

Alternate gene names: 16272417

Gene position: 491635-492918 (Clockwise)

Preceding gene: 16272416

Following gene: 16272418

Centisome position: 26.86

GC content: 42.21

Gene sequence:

>1284_bases
ATGCAAACAATTATTTGGAATCATTTATCAGAAACTGAAAAACGCAAAGTCATTATGCGTCCAGTCCAACAAAATGGGAA
AAACATTCAGCAGGCAGTTAATGCCATTCGTGAAAATGTGGCATACAATGGCGATCGGGCATTATTTGAACTCTGTGAAA
AATTTGATGGCGTGAAGTTAGATAAACTCATTGTTTCGGCAGATGAAATTCAAGCGGCAAGTAGTCGGATTTCTGTAAAA
CTTCGCAATGCGATTGAGCAAGCCAAAACGAACATTGAAGCCTTTCACAAAGCACAGCAAAATCAGGAAATTGACCTAGA
GATCCAAGAAGGCGTGCGTTGCCAAGTTGTGACTCGTCCAATTTCTTGTGTAGGGCTTTATATTCCGGGTGGTTCAGCAC
CGTTGTTTTCCACCGTATTGATGTTAGCTATTCCTGCTAAAATTGCAGGTTGTAAAAAAATCGTGCTTTGTTCACCGCCA
CCGATCTCAGATGAAATTCTCTACACTGCTCATCTTTGCGGTGTGGAAACTATCTACGCTATAGGTGGTGCTCAAGCAGT
TTTTGCGATGGCTCAAGGCACGGAAAGCGTGGCGAAAGTAGATAAAATTTTCGGACCTGGAAACGCATTTGTGACAGAAG
CAAAACGTCAGGTAGCACAAAATAGTACGGCGATTGATATGCCTGCGGGACCTTCAGAAGTGTTAGTAATTGCAGATGAA
TCGGCAGATCCTGAATTTGTGGCAAGCGATTTACTCTCTCAAGCGGAACATGGGGCAGATAGCCAAGTGATTTTGGTGGC
GACCTGTGAAACTCTGGCAAAAGAGACCGCACTTGCGATTGAACGCCAACTTGCTCTATTACCTCGTGCTGAAACCGTTC
GAAAAGCGTTAAACCACAGCCGTATTTTTATAGCAGAAAGCCTTGAACAAGCGGTAGAAATTAGCAATGAATATGCCCCT
GAACATTTAATTGTGCAAACAAAAAACGCCCGTAAATTATTACCATATTTAGATAACGCAGGCTCAATTTTCTTAGGTGC
ATATTCGCCTGAAAGTATGGGCGATTATGCCAGTGGCACAAACCACGTTTTGCCTACTTATGGTTACACCAAAACTTATT
CTAGTCTAGGATTAGCTGATTTTAGTAAGCGAATGACAGTACAAGAACTCACACCAAAAGGTTTTAAAAACCTTGCTGAA
ACGGTGGAAGTGATGGCAGAAGCTGAGCAATTGGCAGCACATAAAATGGCAGTAAGTGTAAGATTGGCGAAACTCAATAT
CTAA

Upstream 100 bases:

>100_bases
TGGAGTAAATGTAGTGCGAGCTTTGACTCGCCATTTAAATAATCAATATCTCAAAATGCTGGGTTATCATCCATTTTACG
GATACAAAGGAAAATAAACA

Downstream 100 bases:

>100_bases
GATATTAATTATAGATCTAAGCACGACACGTAAGCAGTCAAATTTTCATACAACAATACGAAATATGTATGAATGATTAC
AATTCGCACATTTTACAATG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MQTIIWNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVKLDKLIVSADEIQAASSRISVK
LRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTRPISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPP
PISDEILYTAHLCGVETIYAIGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQNSTAIDMPAGPSEVLVIADE
SADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETVRKALNHSRIFIAESLEQAVEISNEYAP
EHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAE
TVEVMAEAEQLAAHKMAVSVRLAKLNI

Sequences:

>Translated_427_residues
MQTIIWNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVKLDKLIVSADEIQAASSRISVK
LRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTRPISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPP
PISDEILYTAHLCGVETIYAIGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQNSTAIDMPAGPSEVLVIADE
SADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETVRKALNHSRIFIAESLEQAVEISNEYAP
EHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAE
TVEVMAEAEQLAAHKMAVSVRLAKLNI
>Mature_427_residues
MQTIIWNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVKLDKLIVSADEIQAASSRISVK
LRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTRPISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPP
PISDEILYTAHLCGVETIYAIGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQNSTAIDMPAGPSEVLVIADE
SADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETVRKALNHSRIFIAESLEQAVEISNEYAP
EHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYASGTNHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAE
TVEVMAEAEQLAAHKMAVSVRLAKLNI

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=428, Percent_Identity=63.5514018691589, Blast_Score=552, Evalue=1e-158,
Organism=Saccharomyces cerevisiae, GI6319819, Length=425, Percent_Identity=50.3529411764706, Blast_Score=397, Evalue=1e-111,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46340; Mature: 46340

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTIIWNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVKL
CCEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
DKLIVSADEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTRP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEECC
ISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPPPISDEILYTAHLCGVETIYA
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCHHHHHH
IGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQNSTAIDMPAGPSEVLVIADE
HCCHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEEECC
SADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETVRKALNHS
CCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
RIFIAESLEQAVEISNEYAPEHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYASGT
EEEHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
NHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAETVEVMAEAEQLAAHKMAVSV
CCCCCCCCCHHHHHHCCHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
RLAKLNI
EEEEECC
>Mature Secondary Structure
MQTIIWNHLSETEKRKVIMRPVQQNGKNIQQAVNAIRENVAYNGDRALFELCEKFDGVKL
CCEEECCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCH
DKLIVSADEIQAASSRISVKLRNAIEQAKTNIEAFHKAQQNQEIDLEIQEGVRCQVVTRP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCEEEEEECC
ISCVGLYIPGGSAPLFSTVLMLAIPAKIAGCKKIVLCSPPPISDEILYTAHLCGVETIYA
EEEEEEEECCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHHHHHHCHHHHHH
IGGAQAVFAMAQGTESVAKVDKIFGPGNAFVTEAKRQVAQNSTAIDMPAGPSEVLVIADE
HCCHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEECCCCCCCEEEEECC
SADPEFVASDLLSQAEHGADSQVILVATCETLAKETALAIERQLALLPRAETVRKALNHS
CCCHHHHHHHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCC
RIFIAESLEQAVEISNEYAPEHLIVQTKNARKLLPYLDNAGSIFLGAYSPESMGDYASGT
EEEHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
NHVLPTYGYTKTYSSLGLADFSKRMTVQELTPKGFKNLAETVEVMAEAEQLAAHKMAVSV
CCCCCCCCCHHHHHHCCHHHHHHCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEE
RLAKLNI
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA