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The map label for this gene is hisG

Identifier: 16272416

GI number: 16272416

Start: 490631

End: 491542

Strand: Direct

Name: hisG

Synonym: HI0468

Alternate gene names: 16272416

Gene position: 490631-491542 (Clockwise)

Preceding gene: 16272413

Following gene: 16272417

Centisome position: 26.81

GC content: 39.8

Gene sequence:

>912_bases
ATGACAAACACAACAATGCAACCAAACCGCCTTCGTATTGCTTTGCAAAAAAAAGGGCGTTTAAGCCAAGATTGTGCCAT
ATTACTTAAACAATGTGGCGTGAAAATTAATTGGAATGAACAACGTTTAATCGCTTATGCGGAAAATTTGCCGATTGAAA
TTCTTCGCGTACGTGATGATGATATTCCTGGATTGATTTTTGATGGCGTAGTGGATCTTGGGATTATTGGCGAAAATGTG
TTAGAAGAGGAAGAGCTTGGTCGCCGTGCAGCAAATGAAACAGTTACATACAAAAAACTTCGCCAACTTGATTTTGGTGA
TTGTCGTCTATCACTTGCGGTTGATCGCGATTGTCATTATGAGAATGTGAAAGATCTTGCTAATAGGCGTATTGCAACTT
CTTACCCGCATTTGCTCAAACGTTATATGAATGAGAATGGGGTGTCGTTTAAAAGTTGTTTATTAAATGGTTCAGTAGAA
GTCGCACCTAGTGCGGGTATTGCTTATGCGATTTGCGATTTAGTATCATCAGGGGCAACGCTTGAAGCAAATGGCTTAAA
AGAAGTGGACGTGATTTATCGTTCTAAAGCTTGTTTAATTCAGCGTGCTGAACCGCTTGAATCAACTAAACAAGCTCTTG
TGGATAAACTACTCACTCGTATTCAAGGTGTGCAGCAGGCAGCAGAAAGTAAATATATTATGCTCCACGCTCCGAAAGAA
AAACTTGAAAAAATCACCGCGCTTTTACCTGGCGTTGAAAATCCGACCATTTTACCATTAGCCAGTGATACAACTCGGGT
AGCAATGCACGTAGTGAGCCAAGAAAATTTATTTTGGGAAACAATGGAACAGTTAAAAGAGGCAGGAGCTAGTTCAATTT
TAGTGTTACCAATTGAGAAGATGATGGAGTAA

Upstream 100 bases:

>100_bases
CCGAGTGTAATAAAAATCAGTGTAAAAGCAATAAATACCCCTCGGAAGGCAATTTTCGAGGGGTTTTCTTTTATCTCAAC
TTTAAAATAGGAAAAACATT

Downstream 100 bases:

>100_bases
ATGTAGTGCGAGCTTTGACTCGCCATTTAAATAATCAATATCTCAAAATGCTGGGTTATCATCCATTTTACGGATACAAA
GGAAAATAAACAATGCAAAC

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTNTTMQPNRLRIALQKKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDDDIPGLIFDGVVDLGIIGENV
LEEEELGRRAANETVTYKKLRQLDFGDCRLSLAVDRDCHYENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVE
VAPSAGIAYAICDLVSSGATLEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKE
KLEKITALLPGVENPTILPLASDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEKMME

Sequences:

>Translated_303_residues
MTNTTMQPNRLRIALQKKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDDDIPGLIFDGVVDLGIIGENV
LEEEELGRRAANETVTYKKLRQLDFGDCRLSLAVDRDCHYENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVE
VAPSAGIAYAICDLVSSGATLEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKE
KLEKITALLPGVENPTILPLASDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEKMME
>Mature_302_residues
TNTTMQPNRLRIALQKKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDDDIPGLIFDGVVDLGIIGENVL
EEEELGRRAANETVTYKKLRQLDFGDCRLSLAVDRDCHYENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVEV
APSAGIAYAICDLVSSGATLEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKEK
LEKITALLPGVENPTILPLASDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=303, Percent_Identity=71.2871287128713, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6320896, Length=296, Percent_Identity=28.7162162162162, Blast_Score=119, Evalue=5e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_HAEI8 (Q4QN75)

Other databases:

- EMBL:   CP000057
- RefSeq:   YP_248182.1
- HSSP:   P60757
- ProteinModelPortal:   Q4QN75
- SMR:   Q4QN75
- STRING:   Q4QN75
- GeneID:   3429909
- GenomeReviews:   CP000057_GR
- KEGG:   hit:NTHI0599
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- PhylomeDB:   Q4QN75
- ProtClustDB:   PRK00489
- BioCyc:   HINF281310:NTHI0599-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 33822; Mature: 33690

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNTTMQPNRLRIALQKKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDD
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEECCCCCEEEEEECCCCEEEEEECCC
DIPGLIFDGVVDLGIIGENVLEEEELGRRAANETVTYKKLRQLDFGDCRLSLAVDRDCHY
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEECCCCCH
ENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVEVAPSAGIAYAICDLVSSGAT
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHCCCE
LEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKE
EECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
KLEKITALLPGVENPTILPLASDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEK
HHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHH
MME
HCC
>Mature Secondary Structure 
TNTTMQPNRLRIALQKKGRLSQDCAILLKQCGVKINWNEQRLIAYAENLPIEILRVRDD
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEECCCCCEEEEEECCCCEEEEEECCC
DIPGLIFDGVVDLGIIGENVLEEEELGRRAANETVTYKKLRQLDFGDCRLSLAVDRDCHY
CCCCHHHHHHHHHHHHCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCEEEEEEECCCCCH
ENVKDLANRRIATSYPHLLKRYMNENGVSFKSCLLNGSVEVAPSAGIAYAICDLVSSGAT
HHHHHHHCCCCCCHHHHHHHHHHCCCCCCHHHHHCCCCEEECCCCCHHHHHHHHHHCCCE
LEANGLKEVDVIYRSKACLIQRAEPLESTKQALVDKLLTRIQGVQQAAESKYIMLHAPKE
EECCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHH
KLEKITALLPGVENPTILPLASDTTRVAMHVVSQENLFWETMEQLKEAGASSILVLPIEK
HHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHCCHHHHHHHHHHHHCCCCCEEEEEHHH
MME
HCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA