Click here to switch to the map view.

The map label for this gene is serA

Identifier: 16272413

GI number: 16272413

Start: 487192

End: 488424

Strand: Direct

Name: serA

Synonym: HI0465

Alternate gene names: 16272413

Gene position: 487192-488424 (Clockwise)

Preceding gene: 16272412

Following gene: 16272416

Centisome position: 26.62

GC content: 41.44

Gene sequence:

>1233_bases
ATGACAAACAAAGTCTCTCTAGACAAATCAAAAATCAAATTTGTATTGTTTGAAGGTGTGCATCAAAGCGCACTTGATAC
GCTCCATGCGGCAGGCTATACCAATATTGATTACTATAAAAAAGCACTAGATGGCGATGAATTAAAAGAAGCCATTAAAG
ATGTACACTTTATCGGCTTGCGTTCTCGCACCCATTTAACGGCAGAAATGATTGAGGCCGCACCCAAATTAATCGCTGTG
GGATGTTTCTGTATTGGCACCAACCAAGTGGATTTAAATGCAGCAAAAGCGCGTGGAATTCCTGTATTTAATGCCCCATT
CTCAAACACTCGCTCCGTCGCAGAACTTGTATTAGGCGAGATTTTATTACTTATGCGCAATGTGCCACAGGCTAATGCCG
AAGTACATCGTGGTGTCTGGAATAAATCCGCGACTGGCTCTCATGAAGTGCGGGGGAAAAAATTAGGCATTATTGGTTAC
GGTCACATTGGTTCACAATTAAGTATTATTGCTGAATCATTAGGGATGGATGTGTATTTCTACGATATTGAAAACAAACT
TCCACTCGGTAATGCCAAACAGGTTCGTAGCCTTGAAGAATTACTCAGTTCTTGCGATGTGGTTTCATTACATGTGCCAG
AACTGCCATCTACCAAAAACTTAATGAACGTAGCACGTATCGCACAATTAAAACAAGGGGCAATTTTGATCAATGCTGCG
CGTGGCACAGTGGTAGATATTGACGCTCTCGCTCAAGCCTTAAAAGATGGGAAACTTCAGGGTGCCGCAATTGATGTATT
CCCCGTTGAGCCCGCTTCAATTAATGAAGAATTTATCTCGCCGTTACGTGAATTTGATAATGTGATTTTAACGCCACATA
TCGGCGGCTCAACAGCGGAAGCACAAGAAAATATCGGTTTTGAAGTGGCAGGCAAATTTGTCAAATATTCAGACAACGGA
TCAACCCTTTCTTCGGTAAACTTCCCAGAGGTCTCTTTACCAGAACACGAGGGAACAAAACGCTTATTGCATATTCACGA
AAATCGTCCTGGTATATTGAACAAACTGAACCAAATTTTCGTCGAAGCTAACCTCAATATTGCAGCGCAATATTTACAAA
CTGACCCGAAAATTGGTTATGTTGTCGTAGATGTAGAAACGAATGATGCATCGCCATTACTGACGAAATTGAAGGAAATA
GATGGCACAATTCGTGCTCGTGTACTATACTAA

Upstream 100 bases:

>100_bases
GGATATTCGCGTTACGTGGTGCAGATGTTGTGATCGTCGGGACGCCTGAGGGTGCCAAAGTTATTGACTAATTCATAATA
AAAATCATAAGGAAGCAAAC

Downstream 100 bases:

>100_bases
ATAGAAAAAAGATCAGGTTAATGCCTGATCTTTTTTTGCTTTCTTATTCAGTAATCGAATAAGGTAACTGCACTCGCTCT
AACAATATTTCACTATTCAG

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MTNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGLRSRTHLTAEMIEAAPKLIAV
GCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQANAEVHRGVWNKSATGSHEVRGKKLGIIGY
GHIGSQLSIIAESLGMDVYFYDIENKLPLGNAKQVRSLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAA
RGTVVDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAEAQENIGFEVAGKFVKYSDNG
STLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEI
DGTIRARVLY

Sequences:

>Translated_410_residues
MTNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGLRSRTHLTAEMIEAAPKLIAV
GCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQANAEVHRGVWNKSATGSHEVRGKKLGIIGY
GHIGSQLSIIAESLGMDVYFYDIENKLPLGNAKQVRSLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAA
RGTVVDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAEAQENIGFEVAGKFVKYSDNG
STLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEI
DGTIRARVLY
>Mature_409_residues
TNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGLRSRTHLTAEMIEAAPKLIAVG
CFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGEILLLMRNVPQANAEVHRGVWNKSATGSHEVRGKKLGIIGYG
HIGSQLSIIAESLGMDVYFYDIENKLPLGNAKQVRSLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAAR
GTVVDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAEAQENIGFEVAGKFVKYSDNGS
TLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIFVEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEID
GTIRARVLY

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain

Homologues:

Organism=Homo sapiens, GI23308577, Length=290, Percent_Identity=40, Blast_Score=193, Evalue=2e-49,
Organism=Homo sapiens, GI61743967, Length=238, Percent_Identity=34.8739495798319, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI4557497, Length=238, Percent_Identity=34.8739495798319, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI145580578, Length=249, Percent_Identity=35.7429718875502, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI4557499, Length=249, Percent_Identity=35.7429718875502, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI145580575, Length=249, Percent_Identity=35.7429718875502, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI6912396, Length=275, Percent_Identity=27.6363636363636, Blast_Score=102, Evalue=8e-22,
Organism=Escherichia coli, GI1789279, Length=409, Percent_Identity=70.9046454767726, Blast_Score=589, Evalue=1e-169,
Organism=Escherichia coli, GI87082289, Length=253, Percent_Identity=33.201581027668, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1787645, Length=232, Percent_Identity=30.6034482758621, Blast_Score=105, Evalue=8e-24,
Organism=Escherichia coli, GI1788660, Length=337, Percent_Identity=28.486646884273, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI87081824, Length=161, Percent_Identity=34.1614906832298, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17532191, Length=322, Percent_Identity=35.7142857142857, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI25147481, Length=245, Percent_Identity=28.9795918367347, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320925, Length=414, Percent_Identity=48.5507246376812, Blast_Score=392, Evalue=1e-110,
Organism=Saccharomyces cerevisiae, GI6322116, Length=414, Percent_Identity=47.8260869565217, Blast_Score=382, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324055, Length=245, Percent_Identity=30.2040816326531, Blast_Score=107, Evalue=4e-24,
Organism=Saccharomyces cerevisiae, GI6324964, Length=263, Percent_Identity=30.0380228136882, Blast_Score=104, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6325144, Length=155, Percent_Identity=32.258064516129, Blast_Score=77, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6324980, Length=116, Percent_Identity=33.6206896551724, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6321253, Length=162, Percent_Identity=27.1604938271605, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI19921140, Length=321, Percent_Identity=32.0872274143302, Blast_Score=159, Evalue=3e-39,
Organism=Drosophila melanogaster, GI28574286, Length=267, Percent_Identity=29.9625468164794, Blast_Score=119, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24646446, Length=220, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24646448, Length=220, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24646452, Length=220, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24646450, Length=220, Percent_Identity=36.3636363636364, Blast_Score=118, Evalue=8e-27,
Organism=Drosophila melanogaster, GI62472511, Length=220, Percent_Identity=36.3636363636364, Blast_Score=116, Evalue=2e-26,
Organism=Drosophila melanogaster, GI28571528, Length=302, Percent_Identity=28.476821192053, Blast_Score=105, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24585514, Length=271, Percent_Identity=27.6752767527675, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574282, Length=271, Percent_Identity=27.6752767527675, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI28574284, Length=271, Percent_Identity=27.6752767527675, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45551003, Length=271, Percent_Identity=27.6752767527675, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI45552429, Length=271, Percent_Identity=27.6752767527675, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24585516, Length=297, Percent_Identity=25.2525252525253, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): SERA_HAEIN (P43885)

Other databases:

- EMBL:   L42023
- PIR:   C64070
- RefSeq:   NP_438626.1
- ProteinModelPortal:   P43885
- SMR:   P43885
- GeneID:   950636
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0465
- NMPDR:   fig|71421.1.peg.439
- TIGR:   HI_0465
- HOGENOM:   HBG731446
- OMA:   RGGWLKS
- ProtClustDB:   PRK11790
- BioCyc:   HINF71421:HI_0465-MONOMER
- BRENDA:   1.1.1.95
- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- ProDom:   PD147088

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT

EC number: =1.1.1.95

Molecular weight: Translated: 44666; Mature: 44535

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1; PS00670 D_2_HYDROXYACID_DH_2; PS00671 D_2_HYDROXYACID_DH_3

Important sites: ACT_SITE 241-241 ACT_SITE 270-270 ACT_SITE 293-293 BINDING 182-182 BINDING 265-265

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGL
CCCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHEEEC
RSRTHLTAEMIEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGE
CCCHHHHHHHHHHCCCEEEEEEEEEECCEEECCHHHHCCCEEECCCCCCHHHHHHHHHHH
ILLLMRNVPQANAEVHRGVWNKSATGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMDVYF
HHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCEEEE
YDIENKLPLGNAKQVRSLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAA
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEC
RGTVVDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAE
CCCEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCH
AQENIGFEVAGKFVKYSDNGSTLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIF
HHHCCCCEEECEEEEECCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHEE
VEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEIDGTIRARVLY
EECCCCCEEHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCEEEEEEC
>Mature Secondary Structure 
TNKVSLDKSKIKFVLFEGVHQSALDTLHAAGYTNIDYYKKALDGDELKEAIKDVHFIGL
CCCCCCCHHHEEEEEECCHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHHHEEEC
RSRTHLTAEMIEAAPKLIAVGCFCIGTNQVDLNAAKARGIPVFNAPFSNTRSVAELVLGE
CCCHHHHHHHHHHCCCEEEEEEEEEECCEEECCHHHHCCCEEECCCCCCHHHHHHHHHHH
ILLLMRNVPQANAEVHRGVWNKSATGSHEVRGKKLGIIGYGHIGSQLSIIAESLGMDVYF
HHHHHHCCCCCCHHHHHCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHCCEEEE
YDIENKLPLGNAKQVRSLEELLSSCDVVSLHVPELPSTKNLMNVARIAQLKQGAILINAA
EECCCCCCCCCHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCEEEEEEC
RGTVVDIDALAQALKDGKLQGAAIDVFPVEPASINEEFISPLREFDNVILTPHIGGSTAE
CCCEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCEEEECCCCCCCCH
AQENIGFEVAGKFVKYSDNGSTLSSVNFPEVSLPEHEGTKRLLHIHENRPGILNKLNQIF
HHHCCCCEEECEEEEECCCCCEEECCCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHEE
VEANLNIAAQYLQTDPKIGYVVVDVETNDASPLLTKLKEIDGTIRARVLY
EECCCCCEEHHHHCCCCCEEEEEEEECCCCCHHHHHHHHCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800