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The map label for this gene is lon

Identifier: 16272410

GI number: 16272410

Start: 482692

End: 485103

Strand: Direct

Name: lon

Synonym: HI0462

Alternate gene names: 16272410

Gene position: 482692-485103 (Clockwise)

Preceding gene: 16272408

Following gene: 16272411

Centisome position: 26.37

GC content: 40.17

Gene sequence:

>2412_bases
ATGGCGAAGAATACCCAACGTACAATGCCCGTATTGCCATTACGCGATGTTGTCGTTTTTCCTTATATGGTGATGCCACT
TTTTGTAGGGCGCGCAAAATCAATTAATGCCCTTGAAGAAGCGATGAACGATGACAAACAGATTCTTTTGGTATCCCAAA
GAGAAGCTGATTTGGAAGAACCTACCCCTGAAGATTTATTTGATGTGGGTACCATTGCTAACATTATTCAGTTATTAAAA
TTACCTGATGACACAGTAAAAGTGCTAGTTGAAGGTCAAAATCGCGCGAAAATTAACAGTCTTGAAGACGGCGAAAAGTG
CTTTTCCGCCCAAATTACCCCTATCGAAACCACTTATGGCGATGAAAAAGAGTTAGTGGTGGCAAAAAGTGCGGTACTTT
CTGAGTTTGAAAATTATCTTACCCTCAACAAAAAAGTGCCTACAGATATTCTCAATGCCCTTCAACGTATTGATGATGTT
GATCGCTTAGCTGACACAATGGCTGCCCATCTCCCTGTAAGCATTCGCCATAAACAAAATGCGTTAGAACTCGCTAATGT
GCAAGAACGTTTAGAATATTTGCTTGGTATGATGGAATCAGAGGCTGATATTCTCCAAGTGGAAAAACGGATTCGCGGTC
GTGTCAAAAAACAAATGGAGAAAAGCCAGCGTAACTATTATTTGAACGAGCAAATTAAAGCCATTCGTAAAGAAATGGAT
GGTGGCGAAAATGAAGATACCATTGATGAAGTTGAACAACTGCATCAAAAGGTAGAAGCGGCAGGCATGCCAGCTGATGT
ACGCGACAAAGTAGAAAATGAATTACAAAAACTTAAAATGATGTCAGCCATGTCTTCTGAAGCAACGGTAATACGCAGTT
ATATTGAATGGATGATCCAAGTGCCTTGGCATCAACGTTCTAAAGTGAAAAAAGACATTGTTAAAGCACAGCAAGTTTTA
GATACCGATCACTATGGTTTAGATCGCGTAAAAGAACGCATTCTTGAATATTTAGCAGTACAAGCGCGTTTAAACAAAGT
GAAAGGCCCGATTCTTTGTTTAGTTGGCCCTCCAGGTGTAGGTAAAACTTCTCTTGGTCAGTCTATTGCCAATGCTACTG
GTCGTAAATATGTACGTATGGCATTAGGCGGCGTGCGTGATGAAGCAGAAATCCGTGGTCACCGTAAAACCTATATTGGT
GCATTGCCAGGTAAATTAATTCAAAAGATGGCAAAAGTGGGCGTAAAAAATCCATTATTCTTGCTTGATGAAATCGACAA
AATGGCATCCGATATGCGAGGTGATCCAGCATCAGCATTGCTTGAAGTATTAGATCCCGAGCAAAACACCACATTTAACG
ATCACTATTTAGAAGTGGATTATGATCTTTCTGATGTGATGTTTGTGGCAACATCAAACTCTATGAATATTCCAGGCCCA
TTATTGGATCGTATGGAAGTTATTCGTCTTTCTGGTTATACAGAAGATGAAAAACTTAATATCGCAATGCGCCATTTATT
AGCAAAACAAATTGAACGTAATGGTTTGAAGAAAGGCGAACTTACCGTAGAAGAAAGTGCAATTTTAGATATTATCCGCT
ATTACACACGTGAAGCGGGCGTACGTGGATTAGAACGTGAAATTTCAAAAATCTGCCGTAAAGCCGTGAAAAATTTATTA
GTAAATCCAAAACTTAAATCTATCACGGTAAATTCAGATAATCTGCACGATTATCTTGGCGTAAAACGTTTTGAATTTGG
TAAAGCTGACACGCAAAACCGCATTGGTGAAGTGACTGGTTTAGCTTGGACAGAAGTGGGCGGCGATTTACTCACTATTG
AAACTGCCTCTGTTGTGGGCAAAGGAAAACTTTCTTTCACTGGTTCATTAGGCGATGTGATGAAAGAATCCATTCAAGCG
GCAATGACCGTTGTGCGTGCTCGTGCGGATAAACTGGGTATCAATGCTGAATTCCACGAAAAACGTGACATTCACATTCA
CGTGCCAGATGGTGCAACACCAAAAGATGGCCCAAGTGCAGGTATTGCAATGTGTACTGCATTAATTTCTTGTTTAACAG
GTAATCCTGTGCGTGCTGATGTGGCAATGACGGGAGAAATCAGTTTACGTGGTAAAGTATTACCAATCGGTGGATTAAAA
GAAAAACTTCTTGCGGCACATCGTGGTGGAATTAAAACCGTATTAATCCCAAAAGAAAACGTTAAAGATCTTGAAGAAAT
TCCAGAGAACGTAAAACAAAATCTTGCAATTCATGCGGTAGAAACCATTGATGAAGTGCTTGGTTTTGCATTGGAAAATC
CACCAGAGGGCATTGAGTTTGTTAAAGTGGAGGCTAAACCTAAAGCACCACGCCGTAAAGTGACGAGTAAATCAGAAAGA
GCGGTCAATTAA

Upstream 100 bases:

>100_bases
TTATAACTCAGATTTTGTTATAATCTTTTCCTTGAATTCCTTTTTCCCTACCCCAATATTTACCCAAATTATCGGAACGA
AATTATAAGAGAGACCAATT

Downstream 100 bases:

>100_bases
TTGAATGTTTTAGGGCTTGTGAAAACAAGCCTTTTATTGATTTTAGAGATGATAATTTCATCTTTACACAAGGTTAATTT
ATACTTTTCCAAATTGAAAA

Product: ATP-dependent proteinase

Products: NA

Alternate protein names: ATP-dependent protease La

Number of amino acids: Translated: 803; Mature: 802

Protein sequence:

>803_residues
MAKNTQRTMPVLPLRDVVVFPYMVMPLFVGRAKSINALEEAMNDDKQILLVSQREADLEEPTPEDLFDVGTIANIIQLLK
LPDDTVKVLVEGQNRAKINSLEDGEKCFSAQITPIETTYGDEKELVVAKSAVLSEFENYLTLNKKVPTDILNALQRIDDV
DRLADTMAAHLPVSIRHKQNALELANVQERLEYLLGMMESEADILQVEKRIRGRVKKQMEKSQRNYYLNEQIKAIRKEMD
GGENEDTIDEVEQLHQKVEAAGMPADVRDKVENELQKLKMMSAMSSEATVIRSYIEWMIQVPWHQRSKVKKDIVKAQQVL
DTDHYGLDRVKERILEYLAVQARLNKVKGPILCLVGPPGVGKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRKTYIG
ALPGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNTTFNDHYLEVDYDLSDVMFVATSNSMNIPGP
LLDRMEVIRLSGYTEDEKLNIAMRHLLAKQIERNGLKKGELTVEESAILDIIRYYTREAGVRGLEREISKICRKAVKNLL
VNPKLKSITVNSDNLHDYLGVKRFEFGKADTQNRIGEVTGLAWTEVGGDLLTIETASVVGKGKLSFTGSLGDVMKESIQA
AMTVVRARADKLGINAEFHEKRDIHIHVPDGATPKDGPSAGIAMCTALISCLTGNPVRADVAMTGEISLRGKVLPIGGLK
EKLLAAHRGGIKTVLIPKENVKDLEEIPENVKQNLAIHAVETIDEVLGFALENPPEGIEFVKVEAKPKAPRRKVTSKSER
AVN

Sequences:

>Translated_803_residues
MAKNTQRTMPVLPLRDVVVFPYMVMPLFVGRAKSINALEEAMNDDKQILLVSQREADLEEPTPEDLFDVGTIANIIQLLK
LPDDTVKVLVEGQNRAKINSLEDGEKCFSAQITPIETTYGDEKELVVAKSAVLSEFENYLTLNKKVPTDILNALQRIDDV
DRLADTMAAHLPVSIRHKQNALELANVQERLEYLLGMMESEADILQVEKRIRGRVKKQMEKSQRNYYLNEQIKAIRKEMD
GGENEDTIDEVEQLHQKVEAAGMPADVRDKVENELQKLKMMSAMSSEATVIRSYIEWMIQVPWHQRSKVKKDIVKAQQVL
DTDHYGLDRVKERILEYLAVQARLNKVKGPILCLVGPPGVGKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRKTYIG
ALPGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNTTFNDHYLEVDYDLSDVMFVATSNSMNIPGP
LLDRMEVIRLSGYTEDEKLNIAMRHLLAKQIERNGLKKGELTVEESAILDIIRYYTREAGVRGLEREISKICRKAVKNLL
VNPKLKSITVNSDNLHDYLGVKRFEFGKADTQNRIGEVTGLAWTEVGGDLLTIETASVVGKGKLSFTGSLGDVMKESIQA
AMTVVRARADKLGINAEFHEKRDIHIHVPDGATPKDGPSAGIAMCTALISCLTGNPVRADVAMTGEISLRGKVLPIGGLK
EKLLAAHRGGIKTVLIPKENVKDLEEIPENVKQNLAIHAVETIDEVLGFALENPPEGIEFVKVEAKPKAPRRKVTSKSER
AVN
>Mature_802_residues
AKNTQRTMPVLPLRDVVVFPYMVMPLFVGRAKSINALEEAMNDDKQILLVSQREADLEEPTPEDLFDVGTIANIIQLLKL
PDDTVKVLVEGQNRAKINSLEDGEKCFSAQITPIETTYGDEKELVVAKSAVLSEFENYLTLNKKVPTDILNALQRIDDVD
RLADTMAAHLPVSIRHKQNALELANVQERLEYLLGMMESEADILQVEKRIRGRVKKQMEKSQRNYYLNEQIKAIRKEMDG
GENEDTIDEVEQLHQKVEAAGMPADVRDKVENELQKLKMMSAMSSEATVIRSYIEWMIQVPWHQRSKVKKDIVKAQQVLD
TDHYGLDRVKERILEYLAVQARLNKVKGPILCLVGPPGVGKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRKTYIGA
LPGKLIQKMAKVGVKNPLFLLDEIDKMASDMRGDPASALLEVLDPEQNTTFNDHYLEVDYDLSDVMFVATSNSMNIPGPL
LDRMEVIRLSGYTEDEKLNIAMRHLLAKQIERNGLKKGELTVEESAILDIIRYYTREAGVRGLEREISKICRKAVKNLLV
NPKLKSITVNSDNLHDYLGVKRFEFGKADTQNRIGEVTGLAWTEVGGDLLTIETASVVGKGKLSFTGSLGDVMKESIQAA
MTVVRARADKLGINAEFHEKRDIHIHVPDGATPKDGPSAGIAMCTALISCLTGNPVRADVAMTGEISLRGKVLPIGGLKE
KLLAAHRGGIKTVLIPKENVKDLEEIPENVKQNLAIHAVETIDEVLGFALENPPEGIEFVKVEAKPKAPRRKVTSKSERA
VN

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain

Homologues:

Organism=Homo sapiens, GI31377667, Length=670, Percent_Identity=40.8955223880597, Blast_Score=517, Evalue=1e-146,
Organism=Homo sapiens, GI21396489, Length=646, Percent_Identity=41.4860681114551, Blast_Score=501, Evalue=1e-142,
Organism=Escherichia coli, GI1786643, Length=773, Percent_Identity=74.385510996119, Blast_Score=1187, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17505831, Length=637, Percent_Identity=41.7582417582418, Blast_Score=481, Evalue=1e-136,
Organism=Caenorhabditis elegans, GI17556486, Length=542, Percent_Identity=42.2509225092251, Blast_Score=445, Evalue=1e-125,
Organism=Saccharomyces cerevisiae, GI6319449, Length=685, Percent_Identity=39.7080291970803, Blast_Score=483, Evalue=1e-137,
Organism=Drosophila melanogaster, GI221513036, Length=707, Percent_Identity=40.3111739745403, Blast_Score=511, Evalue=1e-145,
Organism=Drosophila melanogaster, GI24666867, Length=707, Percent_Identity=40.3111739745403, Blast_Score=511, Evalue=1e-145,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): LON_HAEIN (P43864)

Other databases:

- EMBL:   L42023
- PIR:   A64070
- RefSeq:   NP_438623.1
- ProteinModelPortal:   P43864
- MEROPS:   S16.001
- GeneID:   949549
- GenomeReviews:   L42023_GR
- KEGG:   hin:HI0462
- NMPDR:   fig|71421.1.peg.436
- TIGR:   HI_0462
- HOGENOM:   HBG566281
- OMA:   IQKMSKV
- ProtClustDB:   CLSK870682
- BioCyc:   HINF71421:HI_0462-MONOMER
- BRENDA:   3.4.21.53
- GO:   GO:0005737
- GO:   GO:0006508
- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568
- PRINTS:   PR00830
- SMART:   SM00382
- SMART:   SM00464
- TIGRFAMs:   TIGR00763

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C; SSF88697 PUA-like; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =3.4.21.53

Molecular weight: Translated: 89348; Mature: 89217

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS01046 LON_SER

Important sites: ACT_SITE 679-679 ACT_SITE 722-722

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKNTQRTMPVLPLRDVVVFPYMVMPLFVGRAKSINALEEAMNDDKQILLVSQREADLEE
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
PTPEDLFDVGTIANIIQLLKLPDDTVKVLVEGQNRAKINSLEDGEKCFSAQITPIETTYG
CCHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCC
DEKELVVAKSAVLSEFENYLTLNKKVPTDILNALQRIDDVDRLADTMAAHLPVSIRHKQN
CCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCH
ALELANVQERLEYLLGMMESEADILQVEKRIRGRVKKQMEKSQRNYYLNEQIKAIRKEMD
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
GGENEDTIDEVEQLHQKVEAAGMPADVRDKVENELQKLKMMSAMSSEATVIRSYIEWMIQ
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPWHQRSKVKKDIVKAQQVLDTDHYGLDRVKERILEYLAVQARLNKVKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRKTYIGALPGKLIQKMAKVGVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCHH
LLDEIDKMASDMRGDPASALLEVLDPEQNTTFNDHYLEVDYDLSDVMFVATSNSMNIPGP
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAMRHLLAKQIERNGLKKGELTVEESAILDIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHC
VRGLEREISKICRKAVKNLLVNPKLKSITVNSDNLHDYLGVKRFEFGKADTQNRIGEVTG
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHC
LAWTEVGGDLLTIETASVVGKGKLSFTGSLGDVMKESIQAAMTVVRARADKLGINAEFHE
CCHHHCCCCEEEEEHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHIHVPDGATPKDGPSAGIAMCTALISCLTGNPVRADVAMTGEISLRGKVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEECCEEEECCCHH
EKLLAAHRGGIKTVLIPKENVKDLEEIPENVKQNLAIHAVETIDEVLGFALENPPEGIEF
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VKVEAKPKAPRRKVTSKSERAVN
EEEECCCCCCHHHHCCCHHCCCC
>Mature Secondary Structure 
AKNTQRTMPVLPLRDVVVFPYMVMPLFVGRAKSINALEEAMNDDKQILLVSQREADLEE
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCEEEEEECCCCCCCC
PTPEDLFDVGTIANIIQLLKLPDDTVKVLVEGQNRAKINSLEDGEKCFSAQITPIETTYG
CCHHHHHHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCCCCCCHHHHHCCCCEEECCCC
DEKELVVAKSAVLSEFENYLTLNKKVPTDILNALQRIDDVDRLADTMAAHLPVSIRHKQN
CCCHHHHHHHHHHHHHHHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCH
ALELANVQERLEYLLGMMESEADILQVEKRIRGRVKKQMEKSQRNYYLNEQIKAIRKEMD
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCC
GGENEDTIDEVEQLHQKVEAAGMPADVRDKVENELQKLKMMSAMSSEATVIRSYIEWMIQ
CCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VPWHQRSKVKKDIVKAQQVLDTDHYGLDRVKERILEYLAVQARLNKVKGPILCLVGPPGV
CCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCC
GKTSLGQSIANATGRKYVRMALGGVRDEAEIRGHRKTYIGALPGKLIQKMAKVGVKNPLF
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCHHHHHHCCCHHHHHHHHHCCCCCCHH
LLDEIDKMASDMRGDPASALLEVLDPEQNTTFNDHYLEVDYDLSDVMFVATSNSMNIPGP
HHHHHHHHHHHCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCCCHH
LLDRMEVIRLSGYTEDEKLNIAMRHLLAKQIERNGLKKGELTVEESAILDIIRYYTREAG
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHC
VRGLEREISKICRKAVKNLLVNPKLKSITVNSDNLHDYLGVKRFEFGKADTQNRIGEVTG
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHCCCCCCCCCCCHHHHHHHHHC
LAWTEVGGDLLTIETASVVGKGKLSFTGSLGDVMKESIQAAMTVVRARADKLGINAEFHE
CCHHHCCCCEEEEEHHHHHCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
KRDIHIHVPDGATPKDGPSAGIAMCTALISCLTGNPVRADVAMTGEISLRGKVLPIGGLK
CCCEEEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECEEEECCEEEECCCHH
EKLLAAHRGGIKTVLIPKENVKDLEEIPENVKQNLAIHAVETIDEVLGFALENPPEGIEF
HHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
VKVEAKPKAPRRKVTSKSERAVN
EEEECCCCCCHHHHCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800